GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania major

UniProt:

Q4QAP6_LEIMA

TriTrypDb:

LmjF.24.0870 , LMJLV39_240014500 , LMJSD75_240014000

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QAP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.281
CLV_NRD_NRD_1	220	222	PF00675	0.401
CLV_PCSK_SKI1_1	221	225	PF00082	0.393
CLV_PCSK_SKI1_1	40	44	PF00082	0.470
CLV_PCSK_SKI1_1	60	64	PF00082	0.470
DEG_SCF_FBW7_1	62	67	PF00400	0.281
DOC_MAPK_JIP1_4	3	9	PF00069	0.473
DOC_MAPK_MEF2A_6	192	200	PF00069	0.356
DOC_MAPK_MEF2A_6	3	11	PF00069	0.498
DOC_MAPK_MEF2A_6	60	68	PF00069	0.281
DOC_MAPK_MEF2A_6	96	104	PF00069	0.298
DOC_PP1_RVXF_1	190	196	PF00149	0.347
DOC_SPAK_OSR1_1	31	35	PF12202	0.356
DOC_USP7_MATH_1	113	117	PF00917	0.289
DOC_USP7_MATH_1	64	68	PF00917	0.288
DOC_USP7_MATH_1	69	73	PF00917	0.281
DOC_USP7_UBL2_3	85	89	PF12436	0.356
DOC_WW_Pin1_4	140	145	PF00397	0.343
DOC_WW_Pin1_4	60	65	PF00397	0.264
LIG_14-3-3_CanoR_1	184	188	PF00244	0.313
LIG_14-3-3_CanoR_1	192	196	PF00244	0.296
LIG_14-3-3_CanoR_1	3	8	PF00244	0.456
LIG_14-3-3_CanoR_1	31	35	PF00244	0.301
LIG_14-3-3_CanoR_1	57	63	PF00244	0.333
LIG_BRCT_BRCA1_1	100	104	PF00533	0.356
LIG_DLG_GKlike_1	3	10	PF00625	0.423
LIG_FHA_1	118	124	PF00498	0.295
LIG_FHA_1	61	67	PF00498	0.274
LIG_FHA_2	175	181	PF00498	0.319
LIG_GBD_Chelix_1	11	19	PF00786	0.441
LIG_LIR_Gen_1	164	174	PF02991	0.331
LIG_LIR_Gen_1	182	193	PF02991	0.190
LIG_LIR_Gen_1	212	220	PF02991	0.380
LIG_LIR_Gen_1	63	70	PF02991	0.281
LIG_LIR_Nem_3	194	198	PF02991	0.375
LIG_LIR_Nem_3	212	216	PF02991	0.287
LIG_LIR_Nem_3	63	68	PF02991	0.272
LIG_OCRL_FandH_1	212	224	PF00620	0.303
LIG_Pex14_1	195	199	PF04695	0.338
LIG_SH2_PTP2	199	202	PF00017	0.345
LIG_SH2_STAP1	163	167	PF00017	0.373
LIG_SH2_STAP1	52	56	PF00017	0.295
LIG_SH2_STAT5	161	164	PF00017	0.270
LIG_SH2_STAT5	199	202	PF00017	0.347
LIG_SH3_4	85	92	PF00018	0.356
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.281
LIG_SUMO_SIM_par_1	119	125	PF11976	0.292
LIG_SxIP_EBH_1	192	202	PF03271	0.306
LIG_WRC_WIRS_1	163	168	PF05994	0.373
LIG_WRC_WIRS_1	210	215	PF05994	0.406
MOD_CK1_1	138	144	PF00069	0.282
MOD_CK1_1	98	104	PF00069	0.364
MOD_CK2_1	183	189	PF00069	0.308
MOD_DYRK1A_RPxSP_1	60	64	PF00069	0.270
MOD_GlcNHglycan	152	155	PF01048	0.495
MOD_GlcNHglycan	19	22	PF01048	0.418
MOD_GSK3_1	104	111	PF00069	0.318
MOD_GSK3_1	113	120	PF00069	0.274
MOD_GSK3_1	135	142	PF00069	0.295
MOD_GSK3_1	17	24	PF00069	0.388
MOD_GSK3_1	60	67	PF00069	0.268
MOD_N-GLC_1	117	122	PF02516	0.474
MOD_NEK2_1	30	35	PF00069	0.290
MOD_NEK2_1	58	63	PF00069	0.292
MOD_PKA_1	135	141	PF00069	0.295
MOD_PKA_2	183	189	PF00069	0.290
MOD_PKA_2	191	197	PF00069	0.273
MOD_PKA_2	30	36	PF00069	0.288
MOD_Plk_1	117	123	PF00069	0.283
MOD_Plk_1	129	135	PF00069	0.314
MOD_Plk_4	183	189	PF00069	0.373
MOD_Plk_4	191	197	PF00069	0.334
MOD_Plk_4	209	215	PF00069	0.294
MOD_Plk_4	95	101	PF00069	0.373
MOD_ProDKin_1	140	146	PF00069	0.343
MOD_ProDKin_1	60	66	PF00069	0.264
MOD_SUMO_rev_2	82	91	PF00179	0.306
TRG_ENDOCYTIC_2	163	166	PF00928	0.372
TRG_ENDOCYTIC_2	185	188	PF00928	0.333
TRG_ENDOCYTIC_2	199	202	PF00928	0.244
TRG_ENDOCYTIC_2	56	59	PF00928	0.331
TRG_ER_diLys_1	222	227	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X9	Leptomonas seymouri	73%	99%
A0A0S4J7E6	Bodo saltans	30%	100%
A0A1X0NX41	Trypanosomatidae	50%	93%
A0A3S7WY78	Leishmania donovani	98%	100%
A0A422NHH2	Trypanosoma rangeli	51%	100%
A4HDE3	Leishmania braziliensis	83%	100%
D0A756	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AWS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DSH1	Trypanosoma cruzi	56%	85%