LeishMANIAdb
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Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted transmembrane protein
Gene product:
hypothetical predicted transmembrane protein
Species:
Leishmania major
UniProt:
Q4QAP5_LEIMA
TriTrypDb:
LmjF.24.0880 , LMJLV39_240014600 , LMJSD75_240014100
Length:
117

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4QAP5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAP5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 87 89 PF00675 0.475
CLV_PCSK_KEX2_1 87 89 PF00082 0.475
CLV_PCSK_SKI1_1 53 57 PF00082 0.430
DEG_Nend_UBRbox_3 1 3 PF02207 0.419
DOC_MAPK_gen_1 66 75 PF00069 0.656
DOC_PP1_RVXF_1 85 92 PF00149 0.617
DOC_PP4_FxxP_1 74 77 PF00568 0.647
DOC_WW_Pin1_4 82 87 PF00397 0.669
LIG_14-3-3_CanoR_1 53 62 PF00244 0.611
LIG_Actin_WH2_2 40 55 PF00022 0.655
LIG_BRCT_BRCA1_1 70 74 PF00533 0.644
LIG_FHA_1 14 20 PF00498 0.350
LIG_LIR_Apic_2 71 77 PF02991 0.646
LIG_LIR_Gen_1 15 25 PF02991 0.284
LIG_LIR_Nem_3 15 21 PF02991 0.484
LIG_PCNA_PIPBox_1 11 20 PF02747 0.284
LIG_PTB_Apo_2 37 44 PF02174 0.567
LIG_SH2_STAT5 18 21 PF00017 0.295
LIG_SH3_3 74 80 PF00018 0.620
LIG_TYR_ITSM 14 21 PF00017 0.338
MOD_CDC14_SPxK_1 85 88 PF00782 0.610
MOD_CDK_SPK_2 82 87 PF00069 0.607
MOD_CDK_SPxK_1 82 88 PF00069 0.609
MOD_GlcNHglycan 28 31 PF01048 0.435
MOD_GlcNHglycan 70 73 PF01048 0.491
MOD_GSK3_1 60 67 PF00069 0.631
MOD_NEK2_1 43 48 PF00069 0.611
MOD_NEK2_1 64 69 PF00069 0.635
MOD_NEK2_2 13 18 PF00069 0.338
MOD_PKA_2 60 66 PF00069 0.601
MOD_PKA_2 68 74 PF00069 0.641
MOD_Plk_4 13 19 PF00069 0.383
MOD_Plk_4 43 49 PF00069 0.582
MOD_ProDKin_1 82 88 PF00069 0.670
TRG_ENDOCYTIC_2 18 21 PF00928 0.335
TRG_ER_diArg_1 59 62 PF00400 0.641
TRG_ER_diArg_1 86 88 PF00400 0.661

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I448 Leptomonas seymouri 73% 100%
A0A0S4J172 Bodo saltans 37% 90%
A0A1X0NVP0 Trypanosomatidae 34% 100%
A0A3R7MLX5 Trypanosoma rangeli 45% 82%
A0A3S5H7D0 Leishmania donovani 97% 100%
A4HDE4 Leishmania braziliensis 81% 100%
E9AWS9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS