Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAP1_LEIMA

TriTrypDb:

LmjF.24.0920 , LMJLV39_240015000 , LMJSD75_240014500

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.483
CLV_C14_Caspase3-7	332	336	PF00656	0.510
CLV_C14_Caspase3-7	380	384	PF00656	0.501
CLV_NRD_NRD_1	107	109	PF00675	0.392
CLV_NRD_NRD_1	199	201	PF00675	0.519
CLV_PCSK_KEX2_1	107	109	PF00082	0.367
CLV_PCSK_KEX2_1	199	201	PF00082	0.519
CLV_PCSK_KEX2_1	229	231	PF00082	0.525
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.525
CLV_PCSK_SKI1_1	131	135	PF00082	0.363
CLV_PCSK_SKI1_1	260	264	PF00082	0.530
CLV_PCSK_SKI1_1	389	393	PF00082	0.329
CLV_PCSK_SKI1_1	56	60	PF00082	0.539
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.424
DOC_MAPK_gen_1	136	145	PF00069	0.336
DOC_MAPK_gen_1	288	296	PF00069	0.336
DOC_PP1_RVXF_1	384	391	PF00149	0.466
DOC_USP7_MATH_1	190	194	PF00917	0.478
DOC_USP7_MATH_1	209	213	PF00917	0.388
DOC_USP7_MATH_1	258	262	PF00917	0.651
DOC_USP7_MATH_1	290	294	PF00917	0.427
DOC_USP7_MATH_1	64	68	PF00917	0.656
DOC_USP7_MATH_1	70	74	PF00917	0.638
DOC_WW_Pin1_4	242	247	PF00397	0.567
DOC_WW_Pin1_4	438	443	PF00397	0.455
LIG_14-3-3_CanoR_1	126	130	PF00244	0.451
LIG_14-3-3_CanoR_1	136	145	PF00244	0.439
LIG_14-3-3_CanoR_1	291	295	PF00244	0.423
LIG_14-3-3_CanoR_1	353	358	PF00244	0.410
LIG_14-3-3_CanoR_1	65	72	PF00244	0.634
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BIR_III_2	41	45	PF00653	0.503
LIG_BIR_III_4	153	157	PF00653	0.548
LIG_eIF4E_1	215	221	PF01652	0.407
LIG_EVH1_1	243	247	PF00568	0.516
LIG_FHA_1	138	144	PF00498	0.581
LIG_FHA_1	170	176	PF00498	0.318
LIG_FHA_1	261	267	PF00498	0.380
LIG_FHA_1	356	362	PF00498	0.495
LIG_FHA_2	330	336	PF00498	0.530
LIG_FHA_2	372	378	PF00498	0.469
LIG_GBD_Chelix_1	321	329	PF00786	0.401
LIG_LIR_Gen_1	111	118	PF02991	0.488
LIG_LIR_Gen_1	159	168	PF02991	0.481
LIG_LIR_Gen_1	212	223	PF02991	0.477
LIG_LIR_LC3C_4	293	296	PF02991	0.417
LIG_LIR_Nem_3	104	109	PF02991	0.353
LIG_LIR_Nem_3	111	116	PF02991	0.334
LIG_LIR_Nem_3	159	165	PF02991	0.498
LIG_LIR_Nem_3	212	218	PF02991	0.497
LIG_NRBOX	324	330	PF00104	0.384
LIG_PCNA_PIPBox_1	55	64	PF02747	0.416
LIG_PCNA_yPIPBox_3	53	62	PF02747	0.408
LIG_Pex14_1	299	303	PF04695	0.305
LIG_Pex14_2	367	371	PF04695	0.342
LIG_Rb_LxCxE_1	245	263	PF01857	0.402
LIG_REV1ctd_RIR_1	389	399	PF16727	0.499
LIG_SH2_CRK	113	117	PF00017	0.344
LIG_SH2_CRK	215	219	PF00017	0.473
LIG_SH2_STAP1	113	117	PF00017	0.329
LIG_SH2_STAP1	191	195	PF00017	0.382
LIG_SH2_STAP1	357	361	PF00017	0.490
LIG_SH2_STAT5	303	306	PF00017	0.361
LIG_SH2_STAT5	357	360	PF00017	0.496
LIG_SH3_1	439	445	PF00018	0.485
LIG_SH3_2	442	447	PF14604	0.543
LIG_SH3_3	241	247	PF00018	0.668
LIG_SH3_3	439	445	PF00018	0.485
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.412
LIG_SUMO_SIM_anti_2	324	330	PF11976	0.304
LIG_SUMO_SIM_par_1	324	330	PF11976	0.304
LIG_SUMO_SIM_par_1	337	343	PF11976	0.338
LIG_WRC_WIRS_1	95	100	PF05994	0.401
MOD_CK1_1	193	199	PF00069	0.517
MOD_CK1_1	237	243	PF00069	0.710
MOD_CK1_1	256	262	PF00069	0.590
MOD_CK1_1	355	361	PF00069	0.483
MOD_CK1_1	60	66	PF00069	0.585
MOD_CK2_1	371	377	PF00069	0.462
MOD_CK2_1	438	444	PF00069	0.481
MOD_CMANNOS	433	436	PF00535	0.346
MOD_GlcNHglycan	19	23	PF01048	0.700
MOD_GlcNHglycan	207	210	PF01048	0.482
MOD_GlcNHglycan	211	214	PF01048	0.534
MOD_GlcNHglycan	225	228	PF01048	0.593
MOD_GlcNHglycan	260	263	PF01048	0.656
MOD_GlcNHglycan	3	6	PF01048	0.748
MOD_GlcNHglycan	347	350	PF01048	0.593
MOD_GlcNHglycan	406	409	PF01048	0.771
MOD_GlcNHglycan	419	422	PF01048	0.642
MOD_GlcNHglycan	50	53	PF01048	0.568
MOD_GlcNHglycan	62	65	PF01048	0.601
MOD_GlcNHglycan	66	69	PF01048	0.618
MOD_GlcNHglycan	72	75	PF01048	0.652
MOD_GSK3_1	11	18	PF00069	0.795
MOD_GSK3_1	205	212	PF00069	0.367
MOD_GSK3_1	228	235	PF00069	0.515
MOD_GSK3_1	256	263	PF00069	0.617
MOD_GSK3_1	317	324	PF00069	0.510
MOD_GSK3_1	345	352	PF00069	0.501
MOD_GSK3_1	367	374	PF00069	0.427
MOD_GSK3_1	427	434	PF00069	0.329
MOD_GSK3_1	446	453	PF00069	0.618
MOD_GSK3_1	60	67	PF00069	0.529
MOD_GSK3_1	72	79	PF00069	0.665
MOD_GSK3_1	90	97	PF00069	0.609
MOD_N-GLC_1	120	125	PF02516	0.476
MOD_N-GLC_1	345	350	PF02516	0.439
MOD_NEK2_1	1	6	PF00069	0.751
MOD_NEK2_1	11	16	PF00069	0.632
MOD_NEK2_1	202	207	PF00069	0.469
MOD_NEK2_1	284	289	PF00069	0.425
MOD_NEK2_1	329	334	PF00069	0.377
MOD_NEK2_1	365	370	PF00069	0.461
MOD_NEK2_1	427	432	PF00069	0.434
MOD_NEK2_1	450	455	PF00069	0.547
MOD_PIKK_1	156	162	PF00454	0.441
MOD_PIKK_1	282	288	PF00454	0.434
MOD_PIKK_1	355	361	PF00454	0.502
MOD_PK_1	174	180	PF00069	0.411
MOD_PKA_2	125	131	PF00069	0.412
MOD_PKA_2	290	296	PF00069	0.438
MOD_PKA_2	352	358	PF00069	0.472
MOD_PKA_2	398	404	PF00069	0.467
MOD_PKA_2	446	452	PF00069	0.607
MOD_PKA_2	64	70	PF00069	0.535
MOD_Plk_1	120	126	PF00069	0.396
MOD_Plk_1	193	199	PF00069	0.400
MOD_Plk_4	125	131	PF00069	0.402
MOD_Plk_4	174	180	PF00069	0.334
MOD_Plk_4	193	199	PF00069	0.477
MOD_Plk_4	216	222	PF00069	0.416
MOD_Plk_4	290	296	PF00069	0.327
MOD_Plk_4	299	305	PF00069	0.283
MOD_Plk_4	317	323	PF00069	0.437
MOD_Plk_4	45	51	PF00069	0.537
MOD_Plk_4	57	63	PF00069	0.553
MOD_Plk_4	90	96	PF00069	0.608
MOD_ProDKin_1	242	248	PF00069	0.560
MOD_ProDKin_1	438	444	PF00069	0.467
MOD_SUMO_for_1	5	8	PF00179	0.671
MOD_SUMO_rev_2	375	380	PF00179	0.495
MOD_SUMO_rev_2	51	61	PF00179	0.582
TRG_ENDOCYTIC_2	106	109	PF00928	0.360
TRG_ENDOCYTIC_2	113	116	PF00928	0.330
TRG_ENDOCYTIC_2	215	218	PF00928	0.470
TRG_ER_diArg_1	106	108	PF00400	0.393
TRG_ER_diArg_1	198	200	PF00400	0.536
TRG_NLS_MonoExtN_4	9	16	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYW2	Leptomonas seymouri	59%	100%
A0A0S4IXA1	Bodo saltans	34%	100%
A0A1X0NVG3	Trypanosomatidae	30%	89%
A0A3Q8ICU5	Leishmania donovani	92%	98%
A0A3R7KEJ9	Trypanosoma rangeli	44%	100%
A4HDE8	Leishmania braziliensis	75%	99%
A4I0T1	Leishmania infantum	92%	98%
D0A760	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AWT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BVT1	Trypanosoma cruzi	42%	100%