Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QAN8_LEIMA

TriTrypDb:

LmjF.24.0950 , LMJLV39_240015300 , LMJSD75_240014800

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAN8

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.404
CLV_C14_Caspase3-7	143	147	PF00656	0.530
CLV_NRD_NRD_1	380	382	PF00675	0.491
CLV_PCSK_SKI1_1	110	114	PF00082	0.591
CLV_PCSK_SKI1_1	283	287	PF00082	0.432
CLV_PCSK_SKI1_1	382	386	PF00082	0.479
CLV_PCSK_SKI1_1	393	397	PF00082	0.400
CLV_PCSK_SKI1_1	41	45	PF00082	0.386
DEG_APCC_DBOX_1	282	290	PF00400	0.432
DOC_CDC14_PxL_1	368	376	PF14671	0.484
DOC_CKS1_1	161	166	PF01111	0.575
DOC_CYCLIN_RxL_1	107	117	PF00134	0.562
DOC_MAPK_gen_1	22	31	PF00069	0.529
DOC_MAPK_MEF2A_6	41	48	PF00069	0.361
DOC_USP7_MATH_1	122	126	PF00917	0.734
DOC_USP7_MATH_1	330	334	PF00917	0.432
DOC_WW_Pin1_4	160	165	PF00397	0.591
LIG_14-3-3_CanoR_1	239	249	PF00244	0.432
LIG_Actin_WH2_2	9	26	PF00022	0.416
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_4	146	150	PF00653	0.639
LIG_BRCT_BRCA1_1	135	139	PF00533	0.659
LIG_EH1_1	106	114	PF00400	0.591
LIG_FHA_1	161	167	PF00498	0.602
LIG_FHA_1	351	357	PF00498	0.314
LIG_FHA_1	374	380	PF00498	0.477
LIG_FHA_1	71	77	PF00498	0.549
LIG_FHA_2	106	112	PF00498	0.598
LIG_FHA_2	297	303	PF00498	0.414
LIG_FHA_2	54	60	PF00498	0.563
LIG_LIR_Gen_1	299	308	PF02991	0.432
LIG_LIR_Gen_1	62	72	PF02991	0.409
LIG_LIR_Nem_3	136	142	PF02991	0.660
LIG_LIR_Nem_3	246	251	PF02991	0.336
LIG_LIR_Nem_3	299	304	PF02991	0.414
LIG_LIR_Nem_3	62	68	PF02991	0.411
LIG_NRBOX	228	234	PF00104	0.432
LIG_Pex14_2	278	282	PF04695	0.314
LIG_PTB_Apo_2	66	73	PF02174	0.533
LIG_PTB_Phospho_1	66	72	PF10480	0.527
LIG_Rb_LxCxE_1	363	376	PF01857	0.483
LIG_Rb_pABgroove_1	249	257	PF01858	0.337
LIG_REV1ctd_RIR_1	309	317	PF16727	0.432
LIG_SH2_CRK	167	171	PF00017	0.564
LIG_SH2_CRK	219	223	PF00017	0.485
LIG_SH2_CRK	343	347	PF00017	0.432
LIG_SH2_CRK	35	39	PF00017	0.371
LIG_SH2_CRK	40	44	PF00017	0.331
LIG_SH2_STAP1	343	347	PF00017	0.432
LIG_SH2_STAP1	391	395	PF00017	0.533
LIG_SH2_STAP1	72	76	PF00017	0.574
LIG_SH2_STAT5	194	197	PF00017	0.431
LIG_SH2_STAT5	219	222	PF00017	0.504
LIG_SH2_STAT5	328	331	PF00017	0.314
LIG_SH2_STAT5	366	369	PF00017	0.481
LIG_SH2_STAT5	42	45	PF00017	0.355
LIG_SH2_STAT5	72	75	PF00017	0.567
LIG_SH3_3	158	164	PF00018	0.710
LIG_SH3_3	282	288	PF00018	0.432
LIG_TRAF2_1	184	187	PF00917	0.508
LIG_TRAF2_1	56	59	PF00917	0.562
LIG_TYR_ITIM	217	222	PF00017	0.316
LIG_TYR_ITIM	38	43	PF00017	0.464
LIG_WRC_WIRS_1	112	117	PF05994	0.525
LIG_WW_1	32	35	PF00397	0.419
MOD_CK1_1	116	122	PF00069	0.499
MOD_CK1_1	148	154	PF00069	0.598
MOD_CK1_1	306	312	PF00069	0.448
MOD_CK1_1	350	356	PF00069	0.477
MOD_CK1_1	389	395	PF00069	0.407
MOD_CK1_1	53	59	PF00069	0.519
MOD_CK2_1	105	111	PF00069	0.572
MOD_CK2_1	122	128	PF00069	0.675
MOD_CK2_1	296	302	PF00069	0.337
MOD_CK2_1	348	354	PF00069	0.432
MOD_CK2_1	53	59	PF00069	0.561
MOD_GlcNHglycan	118	121	PF01048	0.633
MOD_GlcNHglycan	128	132	PF01048	0.635
MOD_GlcNHglycan	136	139	PF01048	0.552
MOD_GlcNHglycan	143	146	PF01048	0.513
MOD_GlcNHglycan	147	150	PF01048	0.497
MOD_GlcNHglycan	155	158	PF01048	0.591
MOD_GlcNHglycan	170	173	PF01048	0.397
MOD_GlcNHglycan	178	181	PF01048	0.534
MOD_GlcNHglycan	209	212	PF01048	0.432
MOD_GlcNHglycan	242	245	PF01048	0.432
MOD_GlcNHglycan	93	96	PF01048	0.712
MOD_GSK3_1	111	118	PF00069	0.394
MOD_GSK3_1	141	148	PF00069	0.644
MOD_GSK3_1	153	160	PF00069	0.742
MOD_GSK3_1	240	247	PF00069	0.369
MOD_GSK3_1	46	53	PF00069	0.419
MOD_GSK3_1	91	98	PF00069	0.670
MOD_N-GLC_1	220	225	PF02516	0.487
MOD_NEK2_1	113	118	PF00069	0.627
MOD_NEK2_1	133	138	PF00069	0.450
MOD_NEK2_1	281	286	PF00069	0.315
MOD_NEK2_1	348	353	PF00069	0.432
MOD_NEK2_1	67	72	PF00069	0.450
MOD_NEK2_2	105	110	PF00069	0.580
MOD_NEK2_2	244	249	PF00069	0.432
MOD_PIKK_1	256	262	PF00454	0.369
MOD_PKA_2	244	250	PF00069	0.483
MOD_PKA_2	386	392	PF00069	0.491
MOD_Plk_1	220	226	PF00069	0.485
MOD_Plk_1	24	30	PF00069	0.479
MOD_Plk_1	53	59	PF00069	0.439
MOD_Plk_2-3	291	297	PF00069	0.374
MOD_Plk_4	244	250	PF00069	0.374
MOD_Plk_4	303	309	PF00069	0.360
MOD_Plk_4	386	392	PF00069	0.399
MOD_ProDKin_1	160	166	PF00069	0.583
TRG_ENDOCYTIC_2	219	222	PF00928	0.486
TRG_ENDOCYTIC_2	290	293	PF00928	0.314
TRG_ENDOCYTIC_2	343	346	PF00928	0.327
TRG_ENDOCYTIC_2	35	38	PF00928	0.387
TRG_ENDOCYTIC_2	40	43	PF00928	0.321
TRG_ENDOCYTIC_2	72	75	PF00928	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WY95	Leishmania donovani	98%	100%
A0A422NHQ9	Trypanosoma rangeli	39%	100%
A4HDF1	Leishmania braziliensis	87%	84%
A4I0T4	Leishmania infantum	98%	100%
D0A763	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BAM9	Trypanosoma cruzi	37%	92%