Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAN6_LEIMA

TriTrypDb:

LmjF.24.0970 , LMJLV39_240015500 , LMJSD75_240015000

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.499
CLV_MEL_PAP_1	551	557	PF00089	0.441
CLV_NRD_NRD_1	173	175	PF00675	0.682
CLV_NRD_NRD_1	198	200	PF00675	0.612
CLV_NRD_NRD_1	287	289	PF00675	0.562
CLV_NRD_NRD_1	305	307	PF00675	0.635
CLV_NRD_NRD_1	533	535	PF00675	0.489
CLV_NRD_NRD_1	557	559	PF00675	0.474
CLV_NRD_NRD_1	605	607	PF00675	0.520
CLV_NRD_NRD_1	675	677	PF00675	0.491
CLV_NRD_NRD_1	691	693	PF00675	0.533
CLV_NRD_NRD_1	75	77	PF00675	0.652
CLV_PCSK_KEX2_1	173	175	PF00082	0.682
CLV_PCSK_KEX2_1	198	200	PF00082	0.618
CLV_PCSK_KEX2_1	287	289	PF00082	0.562
CLV_PCSK_KEX2_1	305	307	PF00082	0.635
CLV_PCSK_KEX2_1	533	535	PF00082	0.489
CLV_PCSK_KEX2_1	557	559	PF00082	0.474
CLV_PCSK_KEX2_1	605	607	PF00082	0.518
CLV_PCSK_KEX2_1	673	675	PF00082	0.485
CLV_PCSK_KEX2_1	691	693	PF00082	0.533
CLV_PCSK_KEX2_1	75	77	PF00082	0.694
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.467
CLV_PCSK_PC7_1	529	535	PF00082	0.439
CLV_PCSK_SKI1_1	267	271	PF00082	0.568
CLV_PCSK_SKI1_1	312	316	PF00082	0.579
CLV_PCSK_SKI1_1	338	342	PF00082	0.543
CLV_PCSK_SKI1_1	534	538	PF00082	0.511
CLV_PCSK_SKI1_1	572	576	PF00082	0.532
CLV_PCSK_SKI1_1	622	626	PF00082	0.494
CLV_PCSK_SKI1_1	67	71	PF00082	0.706
CLV_PCSK_SKI1_1	75	79	PF00082	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.382
DEG_SPOP_SBC_1	313	317	PF00917	0.389
DEG_SPOP_SBC_1	455	459	PF00917	0.459
DOC_CDC14_PxL_1	23	31	PF14671	0.463
DOC_CKS1_1	488	493	PF01111	0.578
DOC_CYCLIN_yCln2_LP_2	538	544	PF00134	0.619
DOC_PP2B_LxvP_1	493	496	PF13499	0.563
DOC_USP7_MATH_1	105	109	PF00917	0.582
DOC_USP7_MATH_1	313	317	PF00917	0.388
DOC_USP7_MATH_1	32	36	PF00917	0.435
DOC_USP7_MATH_1	403	407	PF00917	0.432
DOC_USP7_MATH_1	472	476	PF00917	0.319
DOC_USP7_MATH_1	496	500	PF00917	0.594
DOC_USP7_MATH_1	524	528	PF00917	0.505
DOC_USP7_MATH_1	583	587	PF00917	0.587
DOC_USP7_MATH_1	633	637	PF00917	0.704
DOC_USP7_MATH_1	682	686	PF00917	0.639
DOC_USP7_MATH_1	753	757	PF00917	0.622
DOC_WW_Pin1_4	238	243	PF00397	0.454
DOC_WW_Pin1_4	247	252	PF00397	0.523
DOC_WW_Pin1_4	292	297	PF00397	0.421
DOC_WW_Pin1_4	355	360	PF00397	0.492
DOC_WW_Pin1_4	41	46	PF00397	0.489
DOC_WW_Pin1_4	487	492	PF00397	0.570
DOC_WW_Pin1_4	537	542	PF00397	0.655
DOC_WW_Pin1_4	591	596	PF00397	0.739
DOC_WW_Pin1_4	680	685	PF00397	0.673
DOC_WW_Pin1_4	740	745	PF00397	0.696
LIG_14-3-3_CanoR_1	338	348	PF00244	0.280
LIG_14-3-3_CanoR_1	413	420	PF00244	0.419
LIG_14-3-3_CanoR_1	446	451	PF00244	0.476
LIG_14-3-3_CanoR_1	529	533	PF00244	0.651
LIG_14-3-3_CanoR_1	534	539	PF00244	0.687
LIG_14-3-3_CanoR_1	691	697	PF00244	0.695
LIG_14-3-3_CanoR_1	75	80	PF00244	0.541
LIG_14-3-3_CanoR_1	752	758	PF00244	0.624
LIG_APCC_ABBA_1	20	25	PF00400	0.472
LIG_BRCT_BRCA1_1	469	473	PF00533	0.302
LIG_BRCT_BRCA1_1	497	501	PF00533	0.542
LIG_BRCT_BRCA1_1	513	517	PF00533	0.540
LIG_eIF4E_1	23	29	PF01652	0.469
LIG_EVH1_2	598	602	PF00568	0.686
LIG_FHA_1	154	160	PF00498	0.484
LIG_FHA_1	162	168	PF00498	0.364
LIG_FHA_1	243	249	PF00498	0.502
LIG_FHA_1	327	333	PF00498	0.439
LIG_FHA_1	335	341	PF00498	0.375
LIG_FHA_1	461	467	PF00498	0.372
LIG_FHA_1	478	484	PF00498	0.328
LIG_FHA_1	488	494	PF00498	0.571
LIG_FHA_1	5	11	PF00498	0.383
LIG_FHA_1	569	575	PF00498	0.700
LIG_FHA_1	613	619	PF00498	0.723
LIG_FHA_1	730	736	PF00498	0.714
LIG_FHA_1	741	747	PF00498	0.728
LIG_LIR_Apic_2	530	535	PF02991	0.646
LIG_LIR_Gen_1	5	15	PF02991	0.394
LIG_LIR_Gen_1	514	524	PF02991	0.534
LIG_LIR_Gen_1	732	740	PF02991	0.687
LIG_LIR_Nem_3	498	504	PF02991	0.537
LIG_LIR_Nem_3	5	11	PF02991	0.352
LIG_LIR_Nem_3	514	520	PF02991	0.545
LIG_LIR_Nem_3	732	736	PF02991	0.679
LIG_LIR_Nem_3	749	754	PF02991	0.672
LIG_PCNA_PIPBox_1	505	514	PF02747	0.582
LIG_PTB_Apo_2	348	355	PF02174	0.387
LIG_PTB_Phospho_1	348	354	PF10480	0.385
LIG_SH2_CRK	656	660	PF00017	0.666
LIG_SH2_CRK	733	737	PF00017	0.681
LIG_SH2_GRB2like	578	581	PF00017	0.626
LIG_SH2_NCK_1	404	408	PF00017	0.452
LIG_SH2_PTP2	177	180	PF00017	0.388
LIG_SH2_STAP1	186	190	PF00017	0.386
LIG_SH2_STAP1	209	213	PF00017	0.337
LIG_SH2_STAP1	656	660	PF00017	0.666
LIG_SH2_STAP1	729	733	PF00017	0.680
LIG_SH2_STAT5	166	169	PF00017	0.452
LIG_SH2_STAT5	177	180	PF00017	0.344
LIG_SH2_STAT5	339	342	PF00017	0.342
LIG_SH2_STAT5	440	443	PF00017	0.466
LIG_SH2_STAT5	578	581	PF00017	0.653
LIG_SH3_3	187	193	PF00018	0.332
LIG_SH3_3	438	444	PF00018	0.467
LIG_SH3_3	592	598	PF00018	0.751
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.312
LIG_SUMO_SIM_anti_2	547	552	PF11976	0.556
LIG_SUMO_SIM_par_1	25	31	PF11976	0.466
LIG_SUMO_SIM_par_1	534	540	PF11976	0.700
LIG_SUMO_SIM_par_1	734	739	PF11976	0.633
LIG_SUMO_SIM_par_1	97	103	PF11976	0.458
LIG_TRFH_1	8	12	PF08558	0.465
LIG_TYR_ITIM	731	736	PF00017	0.538
MOD_CDC14_SPxK_1	295	298	PF00782	0.455
MOD_CDK_SPxK_1	292	298	PF00069	0.487
MOD_CK1_1	108	114	PF00069	0.610
MOD_CK1_1	153	159	PF00069	0.569
MOD_CK1_1	221	227	PF00069	0.547
MOD_CK1_1	257	263	PF00069	0.487
MOD_CK1_1	334	340	PF00069	0.549
MOD_CK1_1	35	41	PF00069	0.557
MOD_CK1_1	43	49	PF00069	0.511
MOD_CK1_1	458	464	PF00069	0.691
MOD_CK1_1	477	483	PF00069	0.352
MOD_CK1_1	499	505	PF00069	0.527
MOD_CK1_1	519	525	PF00069	0.312
MOD_CK1_1	527	533	PF00069	0.545
MOD_CK1_1	594	600	PF00069	0.646
MOD_CK1_1	601	607	PF00069	0.657
MOD_CK1_1	683	689	PF00069	0.585
MOD_CK1_1	698	704	PF00069	0.632
MOD_CK1_1	81	87	PF00069	0.763
MOD_Cter_Amidation	171	174	PF01082	0.485
MOD_Cter_Amidation	555	558	PF01082	0.536
MOD_GlcNHglycan	110	113	PF01048	0.542
MOD_GlcNHglycan	136	139	PF01048	0.447
MOD_GlcNHglycan	143	146	PF01048	0.543
MOD_GlcNHglycan	223	226	PF01048	0.494
MOD_GlcNHglycan	229	232	PF01048	0.503
MOD_GlcNHglycan	32	35	PF01048	0.543
MOD_GlcNHglycan	343	346	PF01048	0.402
MOD_GlcNHglycan	374	377	PF01048	0.398
MOD_GlcNHglycan	378	381	PF01048	0.392
MOD_GlcNHglycan	405	408	PF01048	0.449
MOD_GlcNHglycan	421	424	PF01048	0.464
MOD_GlcNHglycan	437	440	PF01048	0.577
MOD_GlcNHglycan	441	444	PF01048	0.542
MOD_GlcNHglycan	474	477	PF01048	0.349
MOD_GlcNHglycan	501	504	PF01048	0.505
MOD_GlcNHglycan	513	516	PF01048	0.357
MOD_GlcNHglycan	615	618	PF01048	0.664
MOD_GlcNHglycan	70	73	PF01048	0.577
MOD_GlcNHglycan	700	703	PF01048	0.657
MOD_GlcNHglycan	83	86	PF01048	0.586
MOD_GSK3_1	147	154	PF00069	0.682
MOD_GSK3_1	227	234	PF00069	0.589
MOD_GSK3_1	238	245	PF00069	0.466
MOD_GSK3_1	28	35	PF00069	0.574
MOD_GSK3_1	292	299	PF00069	0.489
MOD_GSK3_1	315	322	PF00069	0.543
MOD_GSK3_1	372	379	PF00069	0.393
MOD_GSK3_1	435	442	PF00069	0.682
MOD_GSK3_1	446	453	PF00069	0.576
MOD_GSK3_1	454	461	PF00069	0.563
MOD_GSK3_1	467	474	PF00069	0.312
MOD_GSK3_1	495	502	PF00069	0.472
MOD_GSK3_1	524	531	PF00069	0.387
MOD_GSK3_1	594	601	PF00069	0.633
MOD_GSK3_1	75	82	PF00069	0.644
MOD_N-GLC_1	141	146	PF02516	0.573
MOD_N-GLC_1	455	460	PF02516	0.539
MOD_NEK2_1	134	139	PF00069	0.558
MOD_NEK2_1	218	223	PF00069	0.480
MOD_NEK2_1	233	238	PF00069	0.414
MOD_NEK2_1	270	275	PF00069	0.481
MOD_NEK2_1	28	33	PF00069	0.567
MOD_NEK2_1	341	346	PF00069	0.456
MOD_NEK2_1	353	358	PF00069	0.425
MOD_NEK2_1	372	377	PF00069	0.474
MOD_NEK2_1	419	424	PF00069	0.396
MOD_NEK2_1	445	450	PF00069	0.599
MOD_NEK2_1	471	476	PF00069	0.312
MOD_NEK2_1	528	533	PF00069	0.544
MOD_NEK2_1	56	61	PF00069	0.540
MOD_NEK2_1	79	84	PF00069	0.560
MOD_NEK2_2	105	110	PF00069	0.570
MOD_NEK2_2	18	23	PF00069	0.487
MOD_NEK2_2	32	37	PF00069	0.460
MOD_NEK2_2	496	501	PF00069	0.477
MOD_NEK2_2	524	529	PF00069	0.367
MOD_NEK2_2	635	640	PF00069	0.632
MOD_PIKK_1	257	263	PF00454	0.487
MOD_PIKK_1	633	639	PF00454	0.634
MOD_PIKK_1	690	696	PF00454	0.506
MOD_PK_1	446	452	PF00069	0.506
MOD_PKA_1	75	81	PF00069	0.615
MOD_PKA_2	1	7	PF00069	0.416
MOD_PKA_2	151	157	PF00069	0.641
MOD_PKA_2	218	224	PF00069	0.519
MOD_PKA_2	412	418	PF00069	0.518
MOD_PKA_2	445	451	PF00069	0.576
MOD_PKA_2	528	534	PF00069	0.523
MOD_PKA_2	690	696	PF00069	0.572
MOD_PKA_2	75	81	PF00069	0.639
MOD_Plk_1	18	24	PF00069	0.579
MOD_Plk_1	4	10	PF00069	0.399
MOD_Plk_1	455	461	PF00069	0.569
MOD_Plk_4	18	24	PF00069	0.579
MOD_Plk_4	218	224	PF00069	0.461
MOD_Plk_4	43	49	PF00069	0.575
MOD_Plk_4	450	456	PF00069	0.627
MOD_Plk_4	496	502	PF00069	0.410
MOD_Plk_4	516	522	PF00069	0.481
MOD_Plk_4	534	540	PF00069	0.443
MOD_Plk_4	598	604	PF00069	0.724
MOD_Plk_4	683	689	PF00069	0.625
MOD_Plk_4	695	701	PF00069	0.574
MOD_Plk_4	753	759	PF00069	0.496
MOD_ProDKin_1	238	244	PF00069	0.563
MOD_ProDKin_1	247	253	PF00069	0.662
MOD_ProDKin_1	292	298	PF00069	0.512
MOD_ProDKin_1	355	361	PF00069	0.615
MOD_ProDKin_1	41	47	PF00069	0.612
MOD_ProDKin_1	487	493	PF00069	0.446
MOD_ProDKin_1	537	543	PF00069	0.557
MOD_ProDKin_1	591	597	PF00069	0.682
MOD_ProDKin_1	680	686	PF00069	0.586
MOD_ProDKin_1	740	746	PF00069	0.621
TRG_DiLeu_BaEn_1	25	30	PF01217	0.529
TRG_DiLeu_BaEn_2	512	518	PF01217	0.397
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.591
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.549
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.507
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.364
TRG_ENDOCYTIC_2	656	659	PF00928	0.507
TRG_ENDOCYTIC_2	733	736	PF00928	0.541
TRG_ENDOCYTIC_2	751	754	PF00928	0.582
TRG_ER_diArg_1	197	199	PF00400	0.474
TRG_ER_diArg_1	286	288	PF00400	0.434
TRG_ER_diArg_1	304	306	PF00400	0.506
TRG_ER_diArg_1	532	534	PF00400	0.559
TRG_ER_diArg_1	605	608	PF00400	0.640
TRG_ER_diArg_1	619	622	PF00400	0.485
TRG_ER_diArg_1	674	676	PF00400	0.627
TRG_ER_diArg_1	75	77	PF00400	0.608
TRG_NLS_MonoCore_2	672	677	PF00514	0.584
TRG_NLS_MonoExtC_3	672	677	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM5	Leptomonas seymouri	38%	99%
A0A3Q8IG41	Leishmania donovani	91%	100%
A4HDF3	Leishmania braziliensis	70%	100%
A4I0T6	Leishmania infantum	91%	100%
E9AWT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%