Putative replication factor C, subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

replication factor C, subunit 1, putative

Species:

Leishmania major

UniProt:

Q4QAN4_LEIMA

TriTrypDb:

LmjF.24.0990 , LMJLV39_240015700 , LMJSD75_240015200

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005663	DNA replication factor C complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAN4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006281	DNA repair	5	5
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5
GO:0033554	cellular response to stress	3	5
GO:0050896	response to stimulus	1	5
GO:0051716	cellular response to stimulus	2	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003689	DNA clamp loader activity	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0016887	ATP hydrolysis activity	7	9
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.249
CLV_C14_Caspase3-7	250	254	PF00656	0.493
CLV_C14_Caspase3-7	324	328	PF00656	0.291
CLV_C14_Caspase3-7	653	657	PF00656	0.711
CLV_NRD_NRD_1	101	103	PF00675	0.319
CLV_NRD_NRD_1	394	396	PF00675	0.397
CLV_NRD_NRD_1	511	513	PF00675	0.466
CLV_NRD_NRD_1	577	579	PF00675	0.743
CLV_NRD_NRD_1	619	621	PF00675	0.604
CLV_PCSK_KEX2_1	394	396	PF00082	0.252
CLV_PCSK_KEX2_1	511	513	PF00082	0.667
CLV_PCSK_KEX2_1	619	621	PF00082	0.595
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.616
CLV_PCSK_SKI1_1	103	107	PF00082	0.277
CLV_PCSK_SKI1_1	170	174	PF00082	0.376
CLV_PCSK_SKI1_1	207	211	PF00082	0.350
CLV_PCSK_SKI1_1	222	226	PF00082	0.325
CLV_PCSK_SKI1_1	376	380	PF00082	0.249
CLV_PCSK_SKI1_1	394	398	PF00082	0.344
CLV_PCSK_SKI1_1	429	433	PF00082	0.381
CLV_PCSK_SKI1_1	489	493	PF00082	0.249
CLV_PCSK_SKI1_1	599	603	PF00082	0.653
CLV_PCSK_SKI1_1	610	614	PF00082	0.558
DEG_APCC_DBOX_1	169	177	PF00400	0.361
DEG_APCC_DBOX_1	221	229	PF00400	0.317
DEG_APCC_DBOX_1	393	401	PF00400	0.325
DEG_APCC_KENBOX_2	105	109	PF00400	0.277
DEG_SPOP_SBC_1	346	350	PF00917	0.381
DEG_SPOP_SBC_1	567	571	PF00917	0.606
DEG_SPOP_SBC_1	600	604	PF00917	0.707
DEG_SPOP_SBC_1	614	618	PF00917	0.709
DEG_SPOP_SBC_1	639	643	PF00917	0.739
DEG_SPOP_SBC_1	647	651	PF00917	0.650
DOC_CYCLIN_RxL_1	164	177	PF00134	0.369
DOC_CYCLIN_RxL_1	204	212	PF00134	0.359
DOC_MAPK_gen_1	61	68	PF00069	0.518
DOC_PP1_RVXF_1	374	381	PF00149	0.249
DOC_PP2B_LxvP_1	431	434	PF13499	0.381
DOC_PP4_FxxP_1	181	184	PF00568	0.463
DOC_SPAK_OSR1_1	343	347	PF12202	0.381
DOC_USP7_MATH_1	14	18	PF00917	0.704
DOC_USP7_MATH_1	247	251	PF00917	0.439
DOC_USP7_MATH_1	319	323	PF00917	0.341
DOC_USP7_MATH_1	328	332	PF00917	0.268
DOC_USP7_MATH_1	487	491	PF00917	0.305
DOC_USP7_MATH_1	54	58	PF00917	0.511
DOC_USP7_MATH_1	568	572	PF00917	0.720
DOC_USP7_MATH_1	582	586	PF00917	0.633
DOC_USP7_MATH_1	600	604	PF00917	0.791
DOC_USP7_MATH_1	625	629	PF00917	0.583
DOC_USP7_MATH_1	639	643	PF00917	0.554
DOC_USP7_MATH_1	647	651	PF00917	0.719
DOC_USP7_MATH_1	657	661	PF00917	0.454
DOC_USP7_UBL2_3	558	562	PF12436	0.687
DOC_USP7_UBL2_3	579	583	PF12436	0.594
DOC_USP7_UBL2_3	615	619	PF12436	0.685
DOC_WW_Pin1_4	471	476	PF00397	0.334
DOC_WW_Pin1_4	48	53	PF00397	0.526
DOC_WW_Pin1_4	635	640	PF00397	0.742
DOC_WW_Pin1_4	68	73	PF00397	0.381
LIG_14-3-3_CanoR_1	100	106	PF00244	0.249
LIG_14-3-3_CanoR_1	121	126	PF00244	0.387
LIG_14-3-3_CanoR_1	180	184	PF00244	0.480
LIG_14-3-3_CanoR_1	235	239	PF00244	0.443
LIG_14-3-3_CanoR_1	275	279	PF00244	0.326
LIG_14-3-3_CanoR_1	429	434	PF00244	0.330
LIG_14-3-3_CanoR_1	581	587	PF00244	0.664
LIG_14-3-3_CanoR_1	606	612	PF00244	0.747
LIG_Actin_WH2_2	136	153	PF00022	0.470
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_CtBP_PxDLS_1	202	207	PF00389	0.372
LIG_DLG_GKlike_1	501	509	PF00625	0.533
LIG_eIF4E_1	125	131	PF01652	0.249
LIG_eIF4E_1	285	291	PF01652	0.459
LIG_FHA_1	124	130	PF00498	0.346
LIG_FHA_1	430	436	PF00498	0.249
LIG_FHA_1	497	503	PF00498	0.457
LIG_FHA_1	630	636	PF00498	0.623
LIG_FHA_1	75	81	PF00498	0.278
LIG_FHA_2	158	164	PF00498	0.308
LIG_FHA_2	234	240	PF00498	0.476
LIG_FHA_2	515	521	PF00498	0.667
LIG_FHA_2	88	94	PF00498	0.381
LIG_Integrin_RGD_1	512	514	PF01839	0.615
LIG_LIR_Apic_2	178	184	PF02991	0.463
LIG_LIR_Gen_1	123	132	PF02991	0.294
LIG_LIR_Gen_1	342	352	PF02991	0.357
LIG_LIR_Gen_1	451	459	PF02991	0.267
LIG_LIR_Nem_3	123	128	PF02991	0.294
LIG_LIR_Nem_3	263	267	PF02991	0.462
LIG_LIR_Nem_3	297	302	PF02991	0.313
LIG_LIR_Nem_3	342	347	PF02991	0.328
LIG_LIR_Nem_3	458	463	PF02991	0.261
LIG_LIR_Nem_3	48	53	PF02991	0.460
LIG_NRBOX	168	174	PF00104	0.392
LIG_Pex14_1	22	26	PF04695	0.351
LIG_Pex14_1	46	50	PF04695	0.355
LIG_Pex14_2	492	496	PF04695	0.249
LIG_PTB_Apo_2	112	119	PF02174	0.268
LIG_SH2_CRK	125	129	PF00017	0.328
LIG_SH2_GRB2like	125	128	PF00017	0.305
LIG_SH2_GRB2like	285	288	PF00017	0.460
LIG_SH2_SRC	422	425	PF00017	0.277
LIG_SH2_STAP1	125	129	PF00017	0.268
LIG_SH2_STAP1	361	365	PF00017	0.268
LIG_SH2_STAT3	302	305	PF00017	0.427
LIG_SH2_STAT3	334	337	PF00017	0.268
LIG_SH2_STAT5	125	128	PF00017	0.293
LIG_SH2_STAT5	175	178	PF00017	0.367
LIG_SH2_STAT5	192	195	PF00017	0.265
LIG_SH2_STAT5	264	267	PF00017	0.434
LIG_SH2_STAT5	299	302	PF00017	0.318
LIG_SH2_STAT5	356	359	PF00017	0.364
LIG_SH2_STAT5	422	425	PF00017	0.280
LIG_SH2_STAT5	81	84	PF00017	0.249
LIG_SH3_3	375	381	PF00018	0.249
LIG_SH3_3	57	63	PF00018	0.538
LIG_SH3_4	207	214	PF00018	0.483
LIG_SH3_4	579	586	PF00018	0.663
LIG_SUMO_SIM_anti_2	126	134	PF11976	0.332
LIG_SUMO_SIM_par_1	126	134	PF11976	0.296
LIG_SxIP_EBH_1	151	161	PF03271	0.356
LIG_TYR_ITSM	121	128	PF00017	0.325
LIG_UBA3_1	209	215	PF00899	0.485
LIG_WRC_WIRS_1	361	366	PF05994	0.249
LIG_WRC_WIRS_1	502	507	PF05994	0.548
MOD_CK1_1	101	107	PF00069	0.258
MOD_CK1_1	234	240	PF00069	0.568
MOD_CK1_1	474	480	PF00069	0.427
MOD_CK1_1	490	496	PF00069	0.210
MOD_CK1_1	634	640	PF00069	0.622
MOD_CK1_1	641	647	PF00069	0.651
MOD_CK1_1	648	654	PF00069	0.693
MOD_CK1_1	655	661	PF00069	0.481
MOD_CK2_1	101	107	PF00069	0.189
MOD_CK2_1	14	20	PF00069	0.589
MOD_CK2_1	233	239	PF00069	0.473
MOD_CK2_1	268	274	PF00069	0.407
MOD_CK2_1	27	33	PF00069	0.329
MOD_CK2_1	625	631	PF00069	0.579
MOD_CK2_1	655	661	PF00069	0.627
MOD_CK2_1	87	93	PF00069	0.296
MOD_GlcNHglycan	118	121	PF01048	0.447
MOD_GlcNHglycan	216	219	PF01048	0.381
MOD_GlcNHglycan	388	391	PF01048	0.308
MOD_GlcNHglycan	411	414	PF01048	0.249
MOD_GlcNHglycan	489	492	PF01048	0.329
MOD_GlcNHglycan	527	530	PF01048	0.697
MOD_GlcNHglycan	584	587	PF01048	0.669
MOD_GlcNHglycan	6	9	PF01048	0.655
MOD_GlcNHglycan	645	648	PF01048	0.740
MOD_GlcNHglycan	68	71	PF01048	0.249
MOD_GSK3_1	116	123	PF00069	0.264
MOD_GSK3_1	247	254	PF00069	0.529
MOD_GSK3_1	314	321	PF00069	0.493
MOD_GSK3_1	4	11	PF00069	0.631
MOD_GSK3_1	48	55	PF00069	0.533
MOD_GSK3_1	483	490	PF00069	0.265
MOD_GSK3_1	501	508	PF00069	0.585
MOD_GSK3_1	566	573	PF00069	0.771
MOD_GSK3_1	601	608	PF00069	0.727
MOD_GSK3_1	610	617	PF00069	0.707
MOD_GSK3_1	625	632	PF00069	0.512
MOD_GSK3_1	633	640	PF00069	0.612
MOD_GSK3_1	641	648	PF00069	0.616
MOD_GSK3_1	651	658	PF00069	0.649
MOD_GSK3_1	94	101	PF00069	0.257
MOD_LATS_1	166	172	PF00433	0.369
MOD_N-GLC_1	107	112	PF02516	0.249
MOD_N-GLC_1	337	342	PF02516	0.249
MOD_N-GLC_1	386	391	PF02516	0.268
MOD_N-GLC_1	496	501	PF02516	0.396
MOD_N-GLC_1	94	99	PF02516	0.249
MOD_NEK2_1	149	154	PF00069	0.353
MOD_NEK2_1	179	184	PF00069	0.409
MOD_NEK2_1	233	238	PF00069	0.515
MOD_NEK2_1	267	272	PF00069	0.356
MOD_NEK2_1	347	352	PF00069	0.328
MOD_NEK2_1	402	407	PF00069	0.271
MOD_NEK2_1	496	501	PF00069	0.407
MOD_NEK2_1	505	510	PF00069	0.485
MOD_NEK2_1	87	92	PF00069	0.330
MOD_NEK2_2	506	511	PF00069	0.603
MOD_PIKK_1	314	320	PF00454	0.418
MOD_PIKK_1	411	417	PF00454	0.354
MOD_PIKK_1	514	520	PF00454	0.657
MOD_PK_1	27	33	PF00069	0.468
MOD_PKA_2	101	107	PF00069	0.293
MOD_PKA_2	120	126	PF00069	0.293
MOD_PKA_2	179	185	PF00069	0.352
MOD_PKA_2	234	240	PF00069	0.450
MOD_PKA_2	274	280	PF00069	0.513
MOD_PKA_2	546	552	PF00069	0.708
MOD_PKA_2	592	598	PF00069	0.732
MOD_PKA_2	605	611	PF00069	0.677
MOD_Plk_1	337	343	PF00069	0.249
MOD_Plk_2-3	274	280	PF00069	0.505
MOD_Plk_4	184	190	PF00069	0.226
MOD_Plk_4	328	334	PF00069	0.253
MOD_Plk_4	360	366	PF00069	0.261
MOD_Plk_4	379	385	PF00069	0.249
MOD_Plk_4	76	82	PF00069	0.249
MOD_ProDKin_1	471	477	PF00069	0.334
MOD_ProDKin_1	48	54	PF00069	0.538
MOD_ProDKin_1	635	641	PF00069	0.741
MOD_ProDKin_1	68	74	PF00069	0.381
MOD_SUMO_rev_2	55	63	PF00179	0.596
TRG_DiLeu_BaEn_2	444	450	PF01217	0.290
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.479
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.293
TRG_ENDOCYTIC_2	125	128	PF00928	0.293
TRG_ENDOCYTIC_2	264	267	PF00928	0.434
TRG_ENDOCYTIC_2	361	364	PF00928	0.264
TRG_ENDOCYTIC_2	453	456	PF00928	0.271
TRG_ENDOCYTIC_2	469	472	PF00928	0.249
TRG_ER_diArg_1	394	396	PF00400	0.381
TRG_ER_diArg_1	510	512	PF00400	0.452
TRG_ER_diArg_1	99	102	PF00400	0.321
TRG_NLS_Bipartite_1	583	601	PF00514	0.616
TRG_NLS_MonoCore_2	577	582	PF00514	0.717
TRG_NLS_MonoCore_2	618	623	PF00514	0.627
TRG_NLS_MonoExtC_3	619	624	PF00514	0.609
TRG_NLS_MonoExtN_4	594	601	PF00514	0.701
TRG_NLS_MonoExtN_4	619	625	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X2	Leptomonas seymouri	75%	100%
A0A1X0NVJ4	Trypanosomatidae	67%	100%
A0A3R7KMZ0	Trypanosoma rangeli	64%	100%
A0A3S7WYE5	Leishmania donovani	94%	100%
A4HDF5	Leishmania braziliensis	88%	100%
A4I0T7	Leishmania infantum	94%	100%
D0A768	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AWU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O60182	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	71%
P35600	Drosophila melanogaster	32%	67%
P38630	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	77%
Q9C587	Arabidopsis thaliana	31%	69%
V5BAM4	Trypanosoma cruzi	65%	100%