Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAN3_LEIMA

TriTrypDb:

LmjF.24.1000 , LMJLV39_240015800 , LMJSD75_240015300

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.701
CLV_NRD_NRD_1	178	180	PF00675	0.731
CLV_NRD_NRD_1	3	5	PF00675	0.650
CLV_NRD_NRD_1	343	345	PF00675	0.787
CLV_NRD_NRD_1	416	418	PF00675	0.593
CLV_NRD_NRD_1	423	425	PF00675	0.568
CLV_PCSK_FUR_1	343	347	PF00082	0.521
CLV_PCSK_KEX2_1	178	180	PF00082	0.751
CLV_PCSK_KEX2_1	19	21	PF00082	0.655
CLV_PCSK_KEX2_1	2	4	PF00082	0.675
CLV_PCSK_KEX2_1	342	344	PF00082	0.776
CLV_PCSK_KEX2_1	345	347	PF00082	0.741
CLV_PCSK_KEX2_1	416	418	PF00082	0.605
CLV_PCSK_KEX2_1	423	425	PF00082	0.597
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.655
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.675
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.519
CLV_PCSK_SKI1_1	416	420	PF00082	0.607
DEG_APCC_DBOX_1	3	11	PF00400	0.624
DEG_Nend_UBRbox_1	1	4	PF02207	0.670
DEG_SPOP_SBC_1	240	244	PF00917	0.616
DEG_SPOP_SBC_1	450	454	PF00917	0.646
DOC_ANK_TNKS_1	82	89	PF00023	0.499
DOC_CDC14_PxL_1	260	268	PF14671	0.674
DOC_MAPK_gen_1	2	10	PF00069	0.654
DOC_MAPK_gen_1	250	259	PF00069	0.572
DOC_PP2B_LxvP_1	401	404	PF13499	0.686
DOC_USP7_MATH_1	145	149	PF00917	0.769
DOC_USP7_MATH_1	169	173	PF00917	0.749
DOC_USP7_MATH_1	218	222	PF00917	0.699
DOC_USP7_MATH_1	280	284	PF00917	0.650
DOC_USP7_MATH_1	288	292	PF00917	0.553
DOC_USP7_MATH_1	310	314	PF00917	0.680
DOC_USP7_MATH_1	450	454	PF00917	0.731
DOC_USP7_MATH_1	492	496	PF00917	0.757
DOC_USP7_MATH_1	54	58	PF00917	0.520
DOC_WW_Pin1_4	114	119	PF00397	0.666
DOC_WW_Pin1_4	146	151	PF00397	0.674
DOC_WW_Pin1_4	266	271	PF00397	0.660
DOC_WW_Pin1_4	286	291	PF00397	0.490
DOC_WW_Pin1_4	88	93	PF00397	0.669
LIG_14-3-3_CanoR_1	185	191	PF00244	0.583
LIG_14-3-3_CanoR_1	481	491	PF00244	0.586
LIG_BRCT_BRCA1_1	291	295	PF00533	0.667
LIG_BRCT_BRCA1_1	436	440	PF00533	0.540
LIG_BRCT_BRCA1_1	517	521	PF00533	0.636
LIG_EVH1_1	401	405	PF00568	0.679
LIG_EVH1_2	126	130	PF00568	0.692
LIG_FHA_1	254	260	PF00498	0.650
LIG_FHA_1	304	310	PF00498	0.658
LIG_FHA_1	446	452	PF00498	0.611
LIG_FHA_1	460	466	PF00498	0.615
LIG_FHA_1	508	514	PF00498	0.633
LIG_FHA_1	518	524	PF00498	0.546
LIG_FHA_1	72	78	PF00498	0.528
LIG_FHA_2	100	106	PF00498	0.520
LIG_FHA_2	23	29	PF00498	0.664
LIG_FHA_2	292	298	PF00498	0.642
LIG_FHA_2	407	413	PF00498	0.640
LIG_FHA_2	520	526	PF00498	0.503
LIG_LIR_Gen_1	324	334	PF02991	0.637
LIG_LIR_Nem_3	28	34	PF02991	0.627
LIG_MYND_1	231	235	PF01753	0.675
LIG_NRBOX	105	111	PF00104	0.568
LIG_PDZ_Class_1	543	548	PF00595	0.500
LIG_PTB_Apo_2	157	164	PF02174	0.691
LIG_PTB_Phospho_1	157	163	PF10480	0.691
LIG_SH2_CRK	260	264	PF00017	0.682
LIG_SH2_PTP2	393	396	PF00017	0.653
LIG_SH2_SRC	393	396	PF00017	0.653
LIG_SH2_STAT5	393	396	PF00017	0.701
LIG_SH3_1	252	258	PF00018	0.567
LIG_SH3_2	466	471	PF14604	0.692
LIG_SH3_3	115	121	PF00018	0.717
LIG_SH3_3	129	135	PF00018	0.586
LIG_SH3_3	153	159	PF00018	0.680
LIG_SH3_3	228	234	PF00018	0.581
LIG_SH3_3	252	258	PF00018	0.591
LIG_SH3_3	264	270	PF00018	0.571
LIG_SH3_3	399	405	PF00018	0.796
LIG_SH3_3	463	469	PF00018	0.678
LIG_SUMO_SIM_anti_2	102	112	PF11976	0.529
LIG_SUMO_SIM_par_1	6	12	PF11976	0.634
LIG_TRFH_1	260	264	PF08558	0.682
LIG_WW_3	182	186	PF00397	0.674
LIG_WW_3	405	409	PF00397	0.647
MOD_CDK_SPK_2	117	122	PF00069	0.590
MOD_CK1_1	189	195	PF00069	0.725
MOD_CK1_1	239	245	PF00069	0.722
MOD_CK1_1	289	295	PF00069	0.633
MOD_CK1_1	373	379	PF00069	0.671
MOD_CK1_1	460	466	PF00069	0.600
MOD_CK1_1	495	501	PF00069	0.604
MOD_CK2_1	130	136	PF00069	0.576
MOD_CK2_1	22	28	PF00069	0.805
MOD_CK2_1	291	297	PF00069	0.693
MOD_CK2_1	406	412	PF00069	0.648
MOD_CK2_1	451	457	PF00069	0.654
MOD_CK2_1	79	85	PF00069	0.592
MOD_CK2_1	99	105	PF00069	0.367
MOD_GlcNHglycan	127	130	PF01048	0.751
MOD_GlcNHglycan	191	194	PF01048	0.726
MOD_GlcNHglycan	195	198	PF01048	0.680
MOD_GlcNHglycan	244	247	PF01048	0.726
MOD_GlcNHglycan	367	370	PF01048	0.674
MOD_GlcNHglycan	372	375	PF01048	0.598
MOD_GlcNHglycan	476	480	PF01048	0.612
MOD_GlcNHglycan	484	487	PF01048	0.635
MOD_GlcNHglycan	499	502	PF01048	0.574
MOD_GlcNHglycan	536	539	PF01048	0.583
MOD_GSK3_1	189	196	PF00069	0.697
MOD_GSK3_1	236	243	PF00069	0.707
MOD_GSK3_1	266	273	PF00069	0.589
MOD_GSK3_1	282	289	PF00069	0.565
MOD_GSK3_1	381	388	PF00069	0.592
MOD_GSK3_1	434	441	PF00069	0.580
MOD_GSK3_1	445	452	PF00069	0.586
MOD_GSK3_1	457	464	PF00069	0.597
MOD_GSK3_1	475	482	PF00069	0.530
MOD_GSK3_1	493	500	PF00069	0.603
MOD_GSK3_1	507	514	PF00069	0.552
MOD_GSK3_1	515	522	PF00069	0.661
MOD_LATS_1	18	24	PF00433	0.667
MOD_N-GLC_2	337	339	PF02516	0.627
MOD_N-GLC_2	540	542	PF02516	0.481
MOD_NEK2_1	236	241	PF00069	0.674
MOD_NEK2_1	347	352	PF00069	0.711
MOD_NEK2_1	451	456	PF00069	0.654
MOD_NEK2_1	519	524	PF00069	0.523
MOD_PIKK_1	183	189	PF00454	0.723
MOD_PIKK_1	511	517	PF00454	0.620
MOD_PIKK_1	71	77	PF00454	0.554
MOD_PKA_2	79	85	PF00069	0.465
MOD_Plk_1	460	466	PF00069	0.542
MOD_Plk_1	515	521	PF00069	0.601
MOD_Plk_4	186	192	PF00069	0.613
MOD_Plk_4	258	264	PF00069	0.651
MOD_Plk_4	273	279	PF00069	0.635
MOD_Plk_4	451	457	PF00069	0.598
MOD_ProDKin_1	114	120	PF00069	0.671
MOD_ProDKin_1	146	152	PF00069	0.674
MOD_ProDKin_1	266	272	PF00069	0.662
MOD_ProDKin_1	286	292	PF00069	0.490
MOD_ProDKin_1	88	94	PF00069	0.663
MOD_SUMO_rev_2	411	415	PF00179	0.483
TRG_DiLeu_BaEn_1	105	110	PF01217	0.515
TRG_ENDOCYTIC_2	260	263	PF00928	0.683
TRG_ENDOCYTIC_2	393	396	PF00928	0.653
TRG_ER_diArg_1	341	344	PF00400	0.656
TRG_ER_diArg_1	416	418	PF00400	0.562
TRG_NLS_MonoExtN_4	342	348	PF00514	0.519
TRG_NLS_MonoExtN_4	423	428	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEV1	Leishmania donovani	88%	100%
A4HDF6	Leishmania braziliensis	59%	100%
E9AH58	Leishmania infantum	88%	100%
E9AWU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%