Mnd1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mnd1 family, putative

Species:

Leishmania major

UniProt:

Q4QAN2_LEIMA

TriTrypDb:

LmjF.24.1010 , LMJLV39_240015900 , LMJSD75_240015400

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QAN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAN2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007131	reciprocal meiotic recombination	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035825	homologous recombination	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0140527	reciprocal homologous recombination	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1903046	meiotic cell cycle process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.512
CLV_C14_Caspase3-7	297	301	PF00656	0.648
CLV_NRD_NRD_1	12	14	PF00675	0.664
CLV_NRD_NRD_1	126	128	PF00675	0.619
CLV_NRD_NRD_1	279	281	PF00675	0.606
CLV_NRD_NRD_1	282	284	PF00675	0.572
CLV_NRD_NRD_1	311	313	PF00675	0.571
CLV_NRD_NRD_1	8	10	PF00675	0.709
CLV_PCSK_KEX2_1	12	14	PF00082	0.590
CLV_PCSK_KEX2_1	126	128	PF00082	0.606
CLV_PCSK_KEX2_1	279	281	PF00082	0.539
CLV_PCSK_KEX2_1	311	313	PF00082	0.643
CLV_PCSK_KEX2_1	356	358	PF00082	0.578
CLV_PCSK_KEX2_1	418	420	PF00082	0.757
CLV_PCSK_KEX2_1	423	425	PF00082	0.750
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.590
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.578
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.753
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.749
CLV_PCSK_PC7_1	419	425	PF00082	0.751
CLV_PCSK_SKI1_1	126	130	PF00082	0.605
CLV_PCSK_SKI1_1	21	25	PF00082	0.489
CLV_PCSK_SKI1_1	234	238	PF00082	0.597
CLV_PCSK_SKI1_1	283	287	PF00082	0.562
CLV_PCSK_SKI1_1	410	414	PF00082	0.816
CLV_Separin_Metazoa	123	127	PF03568	0.583
DEG_APCC_DBOX_1	180	188	PF00400	0.585
DEG_APCC_DBOX_1	233	241	PF00400	0.640
DEG_Kelch_Keap1_1	189	194	PF01344	0.515
DOC_CYCLIN_RxL_1	279	291	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	286	292	PF00134	0.570
DOC_MAPK_gen_1	279	290	PF00069	0.478
DOC_MAPK_gen_1	9	18	PF00069	0.581
DOC_MAPK_MEF2A_6	283	292	PF00069	0.565
DOC_MAPK_NFAT4_5	283	291	PF00069	0.568
DOC_PP1_RVXF_1	181	187	PF00149	0.646
DOC_PP1_RVXF_1	19	25	PF00149	0.340
DOC_PP2B_LxvP_1	286	289	PF13499	0.502
DOC_USP7_MATH_1	112	116	PF00917	0.735
DOC_USP7_MATH_1	173	177	PF00917	0.534
DOC_USP7_MATH_1	332	336	PF00917	0.749
DOC_USP7_MATH_1	387	391	PF00917	0.742
DOC_USP7_MATH_1	417	421	PF00917	0.704
DOC_USP7_MATH_1	91	95	PF00917	0.703
DOC_USP7_UBL2_3	10	14	PF12436	0.683
DOC_WW_Pin1_4	151	156	PF00397	0.592
DOC_WW_Pin1_4	322	327	PF00397	0.745
DOC_WW_Pin1_4	333	338	PF00397	0.655
DOC_WW_Pin1_4	46	51	PF00397	0.381
LIG_14-3-3_CanoR_1	126	135	PF00244	0.517
LIG_14-3-3_CanoR_1	246	250	PF00244	0.560
LIG_14-3-3_CanoR_1	257	264	PF00244	0.430
LIG_14-3-3_CanoR_1	349	358	PF00244	0.742
LIG_14-3-3_CanoR_1	73	83	PF00244	0.378
LIG_14-3-3_CterR_2	424	427	PF00244	0.807
LIG_BIR_II_1	1	5	PF00653	0.737
LIG_BIR_III_2	329	333	PF00653	0.629
LIG_BIR_III_2	367	371	PF00653	0.678
LIG_BRCT_BRCA1_1	76	80	PF00533	0.322
LIG_CtBP_PxDLS_1	289	293	PF00389	0.580
LIG_FHA_1	172	178	PF00498	0.415
LIG_FHA_1	47	53	PF00498	0.307
LIG_FHA_2	35	41	PF00498	0.307
LIG_LIR_Apic_2	78	84	PF02991	0.419
LIG_LIR_Gen_1	120	128	PF02991	0.544
LIG_LIR_Gen_1	148	157	PF02991	0.611
LIG_LIR_Gen_1	248	255	PF02991	0.462
LIG_LIR_Nem_3	120	124	PF02991	0.570
LIG_LIR_Nem_3	148	153	PF02991	0.616
LIG_LIR_Nem_3	248	252	PF02991	0.477
LIG_LIR_Nem_3	77	83	PF02991	0.322
LIG_Pex14_1	258	262	PF04695	0.516
LIG_Pex14_2	24	28	PF04695	0.235
LIG_RPA_C_Fungi	274	286	PF08784	0.523
LIG_SH2_STAP1	121	125	PF00017	0.573
LIG_SH2_STAT5	263	266	PF00017	0.478
LIG_SH2_STAT5	294	297	PF00017	0.495
LIG_SH2_STAT5	36	39	PF00017	0.307
LIG_SH3_2	389	394	PF14604	0.551
LIG_SH3_3	331	337	PF00018	0.682
LIG_SH3_3	383	389	PF00018	0.781
LIG_SUMO_SIM_par_1	288	293	PF11976	0.568
LIG_TRAF2_1	265	268	PF00917	0.544
LIG_TRAF2_1	55	58	PF00917	0.307
LIG_TYR_ITIM	51	56	PF00017	0.429
MOD_CK1_1	108	114	PF00069	0.717
MOD_CK1_1	143	149	PF00069	0.586
MOD_CK1_1	230	236	PF00069	0.603
MOD_CK1_1	293	299	PF00069	0.633
MOD_CK1_1	320	326	PF00069	0.648
MOD_CK1_1	92	98	PF00069	0.707
MOD_CK2_1	117	123	PF00069	0.565
MOD_CK2_1	128	134	PF00069	0.557
MOD_CK2_1	14	20	PF00069	0.475
MOD_CK2_1	198	204	PF00069	0.690
MOD_CK2_1	296	302	PF00069	0.641
MOD_CK2_1	34	40	PF00069	0.155
MOD_CK2_1	52	58	PF00069	0.307
MOD_Cter_Amidation	10	13	PF01082	0.684
MOD_Cter_Amidation	421	424	PF01082	0.824
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.555
MOD_GlcNHglycan	107	110	PF01048	0.684
MOD_GlcNHglycan	130	133	PF01048	0.552
MOD_GlcNHglycan	142	145	PF01048	0.635
MOD_GlcNHglycan	198	203	PF01048	0.677
MOD_GlcNHglycan	351	354	PF01048	0.695
MOD_GlcNHglycan	415	418	PF01048	0.752
MOD_GSK3_1	103	110	PF00069	0.769
MOD_GSK3_1	194	201	PF00069	0.668
MOD_GSK3_1	296	303	PF00069	0.650
MOD_GSK3_1	413	420	PF00069	0.727
MOD_GSK3_1	85	92	PF00069	0.581
MOD_N-GLC_2	343	345	PF02516	0.756
MOD_NEK2_1	104	109	PF00069	0.683
MOD_NEK2_1	128	133	PF00069	0.553
MOD_NEK2_1	275	280	PF00069	0.572
MOD_NEK2_1	290	295	PF00069	0.560
MOD_NEK2_2	75	80	PF00069	0.322
MOD_OFUCOSY	317	324	PF10250	0.726
MOD_PIKK_1	85	91	PF00454	0.515
MOD_PK_1	14	20	PF00069	0.573
MOD_PKA_1	126	132	PF00069	0.607
MOD_PKA_1	418	424	PF00069	0.754
MOD_PKA_2	126	132	PF00069	0.611
MOD_PKA_2	245	251	PF00069	0.543
MOD_PKA_2	256	262	PF00069	0.402
MOD_PKA_2	332	338	PF00069	0.551
MOD_PKA_2	348	354	PF00069	0.721
MOD_PKA_2	376	382	PF00069	0.693
MOD_PKA_2	418	424	PF00069	0.710
MOD_PKA_2	92	98	PF00069	0.646
MOD_Plk_1	290	296	PF00069	0.603
MOD_Plk_2-3	194	200	PF00069	0.629
MOD_Plk_4	245	251	PF00069	0.521
MOD_Plk_4	290	296	PF00069	0.583
MOD_Plk_4	75	81	PF00069	0.419
MOD_ProDKin_1	151	157	PF00069	0.589
MOD_ProDKin_1	322	328	PF00069	0.749
MOD_ProDKin_1	333	339	PF00069	0.656
MOD_ProDKin_1	46	52	PF00069	0.381
MOD_SUMO_rev_2	17	23	PF00179	0.424
TRG_DiLeu_BaEn_1	40	45	PF01217	0.235
TRG_DiLeu_BaEn_1	58	63	PF01217	0.368
TRG_DiLeu_BaEn_2	181	187	PF01217	0.649
TRG_DiLeu_BaEn_2	19	25	PF01217	0.340
TRG_ENDOCYTIC_2	121	124	PF00928	0.512
TRG_ENDOCYTIC_2	53	56	PF00928	0.423
TRG_ER_diArg_1	125	127	PF00400	0.598
TRG_NES_CRM1_1	210	223	PF08389	0.471
TRG_NLS_MonoExtC_3	8	13	PF00514	0.697
TRG_NLS_MonoExtN_4	9	16	PF00514	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI5	Leptomonas seymouri	50%	100%
A0A1X0NVH3	Trypanosomatidae	32%	100%
A0A3S7WY90	Leishmania donovani	89%	100%
A0A422N8J6	Trypanosoma rangeli	30%	100%
A4HDF7	Leishmania braziliensis	73%	100%
A4I0T8	Leishmania infantum	89%	100%
D0A770	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AWU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%