F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box domain/Galactose oxidase, central domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QAN1_LEIMA

TriTrypDb:

LmjF.24.1020 , LMJLV39_240016000 , LMJSD75_240015500

Length:

1010

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.726
CLV_C14_Caspase3-7	616	620	PF00656	0.790
CLV_NRD_NRD_1	207	209	PF00675	0.536
CLV_NRD_NRD_1	248	250	PF00675	0.530
CLV_NRD_NRD_1	344	346	PF00675	0.699
CLV_NRD_NRD_1	377	379	PF00675	0.756
CLV_NRD_NRD_1	606	608	PF00675	0.782
CLV_NRD_NRD_1	635	637	PF00675	0.834
CLV_NRD_NRD_1	638	640	PF00675	0.801
CLV_NRD_NRD_1	656	658	PF00675	0.546
CLV_NRD_NRD_1	718	720	PF00675	0.862
CLV_NRD_NRD_1	751	753	PF00675	0.750
CLV_PCSK_FUR_1	636	640	PF00082	0.839
CLV_PCSK_KEX2_1	112	114	PF00082	0.802
CLV_PCSK_KEX2_1	248	250	PF00082	0.530
CLV_PCSK_KEX2_1	285	287	PF00082	0.530
CLV_PCSK_KEX2_1	336	338	PF00082	0.784
CLV_PCSK_KEX2_1	344	346	PF00082	0.658
CLV_PCSK_KEX2_1	377	379	PF00082	0.756
CLV_PCSK_KEX2_1	608	610	PF00082	0.764
CLV_PCSK_KEX2_1	635	637	PF00082	0.834
CLV_PCSK_KEX2_1	638	640	PF00082	0.801
CLV_PCSK_KEX2_1	656	658	PF00082	0.546
CLV_PCSK_KEX2_1	718	720	PF00082	0.858
CLV_PCSK_KEX2_1	751	753	PF00082	0.750
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.802
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.530
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.784
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.838
CLV_PCSK_PC7_1	747	753	PF00082	0.700
CLV_PCSK_SKI1_1	109	113	PF00082	0.687
CLV_PCSK_SKI1_1	48	52	PF00082	0.501
CLV_PCSK_SKI1_1	696	700	PF00082	0.792
CLV_PCSK_SKI1_1	704	708	PF00082	0.670
CLV_Separin_Metazoa	947	951	PF03568	0.802
DEG_APCC_DBOX_1	47	55	PF00400	0.530
DEG_SPOP_SBC_1	132	136	PF00917	0.832
DEG_SPOP_SBC_1	478	482	PF00917	0.648
DEG_SPOP_SBC_1	492	496	PF00917	0.567
DEG_SPOP_SBC_1	885	889	PF00917	0.776
DEG_SPOP_SBC_1	890	894	PF00917	0.712
DOC_CKS1_1	483	488	PF01111	0.849
DOC_CKS1_1	726	731	PF01111	0.782
DOC_CYCLIN_RxL_1	816	824	PF00134	0.784
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.452
DOC_MAPK_FxFP_2	105	108	PF00069	0.753
DOC_MAPK_gen_1	668	678	PF00069	0.582
DOC_MAPK_gen_1	88	97	PF00069	0.729
DOC_PP1_RVXF_1	207	214	PF00149	0.535
DOC_PP1_RVXF_1	991	997	PF00149	0.763
DOC_PP2B_LxvP_1	536	539	PF13499	0.716
DOC_PP4_FxxP_1	105	108	PF00568	0.753
DOC_PP4_FxxP_1	562	565	PF00568	0.672
DOC_PP4_FxxP_1	787	790	PF00568	0.787
DOC_USP7_MATH_1	115	119	PF00917	0.793
DOC_USP7_MATH_1	131	135	PF00917	0.584
DOC_USP7_MATH_1	146	150	PF00917	0.586
DOC_USP7_MATH_1	161	165	PF00917	0.644
DOC_USP7_MATH_1	185	189	PF00917	0.812
DOC_USP7_MATH_1	19	23	PF00917	0.491
DOC_USP7_MATH_1	2	6	PF00917	0.718
DOC_USP7_MATH_1	287	291	PF00917	0.530
DOC_USP7_MATH_1	405	409	PF00917	0.640
DOC_USP7_MATH_1	449	453	PF00917	0.819
DOC_USP7_MATH_1	478	482	PF00917	0.689
DOC_USP7_MATH_1	493	497	PF00917	0.567
DOC_USP7_MATH_1	615	619	PF00917	0.634
DOC_USP7_MATH_1	680	684	PF00917	0.843
DOC_USP7_MATH_1	761	765	PF00917	0.752
DOC_USP7_MATH_1	806	810	PF00917	0.779
DOC_USP7_MATH_1	815	819	PF00917	0.638
DOC_USP7_MATH_1	906	910	PF00917	0.720
DOC_USP7_UBL2_3	604	608	PF12436	0.810
DOC_WW_Pin1_4	121	126	PF00397	0.817
DOC_WW_Pin1_4	224	229	PF00397	0.805
DOC_WW_Pin1_4	24	29	PF00397	0.713
DOC_WW_Pin1_4	453	458	PF00397	0.701
DOC_WW_Pin1_4	482	487	PF00397	0.847
DOC_WW_Pin1_4	523	528	PF00397	0.788
DOC_WW_Pin1_4	553	558	PF00397	0.769
DOC_WW_Pin1_4	594	599	PF00397	0.762
DOC_WW_Pin1_4	725	730	PF00397	0.799
DOC_WW_Pin1_4	852	857	PF00397	0.824
DOC_WW_Pin1_4	886	891	PF00397	0.768
DOC_WW_Pin1_4	894	899	PF00397	0.642
LIG_14-3-3_CanoR_1	119	125	PF00244	0.743
LIG_14-3-3_CanoR_1	165	169	PF00244	0.768
LIG_14-3-3_CanoR_1	286	294	PF00244	0.530
LIG_14-3-3_CanoR_1	322	331	PF00244	0.706
LIG_14-3-3_CanoR_1	34	43	PF00244	0.721
LIG_14-3-3_CanoR_1	403	413	PF00244	0.697
LIG_14-3-3_CanoR_1	491	501	PF00244	0.608
LIG_14-3-3_CanoR_1	516	525	PF00244	0.769
LIG_14-3-3_CanoR_1	52	58	PF00244	0.232
LIG_14-3-3_CanoR_1	636	644	PF00244	0.843
LIG_14-3-3_CanoR_1	718	725	PF00244	0.851
LIG_14-3-3_CanoR_1	879	885	PF00244	0.624
LIG_14-3-3_CanoR_1	982	987	PF00244	0.743
LIG_14-3-3_CanoR_1	993	997	PF00244	0.614
LIG_Actin_WH2_2	10	27	PF00022	0.710
LIG_Actin_WH2_2	39	54	PF00022	0.530
LIG_Actin_WH2_2	97	114	PF00022	0.721
LIG_Actin_WH2_2	979	995	PF00022	0.732
LIG_APCC_ABBA_1	421	426	PF00400	0.718
LIG_BIR_III_2	577	581	PF00653	0.604
LIG_BIR_III_4	649	653	PF00653	0.775
LIG_BIR_III_4	705	709	PF00653	0.618
LIG_EVH1_2	330	334	PF00568	0.714
LIG_FHA_1	189	195	PF00498	0.806
LIG_FHA_1	197	203	PF00498	0.668
LIG_FHA_1	311	317	PF00498	0.530
LIG_FHA_1	478	484	PF00498	0.727
LIG_FHA_1	570	576	PF00498	0.746
LIG_FHA_1	627	633	PF00498	0.704
LIG_FHA_1	728	734	PF00498	0.779
LIG_FHA_1	778	784	PF00498	0.719
LIG_FHA_1	806	812	PF00498	0.777
LIG_FHA_1	861	867	PF00498	0.794
LIG_FHA_1	911	917	PF00498	0.785
LIG_FHA_1	987	993	PF00498	0.703
LIG_FHA_2	348	354	PF00498	0.724
LIG_FHA_2	532	538	PF00498	0.624
LIG_FHA_2	54	60	PF00498	0.530
LIG_FHA_2	611	617	PF00498	0.857
LIG_FHA_2	718	724	PF00498	0.815
LIG_FHA_2	964	970	PF00498	0.859
LIG_LIR_Apic_2	407	413	PF02991	0.792
LIG_LIR_Apic_2	559	565	PF02991	0.666
LIG_LIR_Apic_2	824	830	PF02991	0.785
LIG_LIR_Gen_1	187	194	PF02991	0.806
LIG_LIR_Gen_1	312	319	PF02991	0.530
LIG_LIR_Gen_1	37	47	PF02991	0.727
LIG_LIR_Gen_1	446	454	PF02991	0.819
LIG_LIR_Gen_1	504	512	PF02991	0.700
LIG_LIR_Gen_1	59	68	PF02991	0.501
LIG_LIR_Nem_3	187	192	PF02991	0.807
LIG_LIR_Nem_3	201	207	PF02991	0.549
LIG_LIR_Nem_3	256	261	PF02991	0.516
LIG_LIR_Nem_3	273	279	PF02991	0.245
LIG_LIR_Nem_3	312	317	PF02991	0.530
LIG_LIR_Nem_3	37	43	PF02991	0.727
LIG_LIR_Nem_3	446	450	PF02991	0.820
LIG_LIR_Nem_3	504	509	PF02991	0.716
LIG_LIR_Nem_3	56	60	PF02991	0.255
LIG_LIR_Nem_3	792	798	PF02991	0.689
LIG_LIR_Nem_3	844	849	PF02991	0.638
LIG_MYND_1	539	543	PF01753	0.732
LIG_NRBOX	31	37	PF00104	0.704
LIG_Pex14_2	506	510	PF04695	0.695
LIG_REV1ctd_RIR_1	332	341	PF16727	0.693
LIG_REV1ctd_RIR_1	83	92	PF16727	0.722
LIG_SH2_CRK	40	44	PF00017	0.736
LIG_SH2_CRK	447	451	PF00017	0.824
LIG_SH2_CRK	60	64	PF00017	0.199
LIG_SH2_CRK	834	838	PF00017	0.722
LIG_SH2_NCK_1	447	451	PF00017	0.824
LIG_SH2_NCK_1	60	64	PF00017	0.496
LIG_SH2_PTP2	563	566	PF00017	0.790
LIG_SH2_PTP2	798	801	PF00017	0.798
LIG_SH2_STAP1	246	250	PF00017	0.530
LIG_SH2_STAT5	106	109	PF00017	0.771
LIG_SH2_STAT5	53	56	PF00017	0.530
LIG_SH2_STAT5	547	550	PF00017	0.720
LIG_SH2_STAT5	563	566	PF00017	0.525
LIG_SH2_STAT5	798	801	PF00017	0.798
LIG_SH2_STAT5	834	837	PF00017	0.722
LIG_SH3_1	592	598	PF00018	0.601
LIG_SH3_3	125	131	PF00018	0.710
LIG_SH3_3	222	228	PF00018	0.806
LIG_SH3_3	480	486	PF00018	0.729
LIG_SH3_3	519	525	PF00018	0.787
LIG_SH3_3	537	543	PF00018	0.431
LIG_SH3_3	592	598	PF00018	0.667
LIG_SH3_3	796	802	PF00018	0.802
LIG_SH3_3	909	915	PF00018	0.667
LIG_SH3_3	958	964	PF00018	0.863
LIG_SUMO_SIM_anti_2	808	814	PF11976	0.778
LIG_SUMO_SIM_par_1	190	196	PF11976	0.804
LIG_SUMO_SIM_par_1	315	321	PF11976	0.530
LIG_SxIP_EBH_1	726	736	PF03271	0.622
LIG_TRAF2_1	645	648	PF00917	0.768
LIG_TRAF2_1	967	970	PF00917	0.857
LIG_TYR_ITIM	445	450	PF00017	0.820
LIG_TYR_ITIM	58	63	PF00017	0.501
LIG_TYR_ITIM	832	837	PF00017	0.719
LIG_WRC_WIRS_1	54	59	PF05994	0.530
LIG_WW_3	733	737	PF00397	0.609
MOD_CDK_SPK_2	523	528	PF00069	0.788
MOD_CDK_SPxK_1	482	488	PF00069	0.849
MOD_CK1_1	124	130	PF00069	0.786
MOD_CK1_1	134	140	PF00069	0.701
MOD_CK1_1	142	148	PF00069	0.578
MOD_CK1_1	164	170	PF00069	0.814
MOD_CK1_1	188	194	PF00069	0.735
MOD_CK1_1	383	389	PF00069	0.677
MOD_CK1_1	404	410	PF00069	0.710
MOD_CK1_1	452	458	PF00069	0.701
MOD_CK1_1	476	482	PF00069	0.725
MOD_CK1_1	596	602	PF00069	0.675
MOD_CK1_1	61	67	PF00069	0.530
MOD_CK1_1	710	716	PF00069	0.826
MOD_CK1_1	855	861	PF00069	0.766
MOD_CK1_1	889	895	PF00069	0.797
MOD_CK1_1	910	916	PF00069	0.757
MOD_CK2_1	531	537	PF00069	0.602
MOD_CK2_1	610	616	PF00069	0.852
MOD_CK2_1	652	658	PF00069	0.732
MOD_CK2_1	689	695	PF00069	0.775
MOD_CK2_1	717	723	PF00069	0.819
MOD_CK2_1	963	969	PF00069	0.859
MOD_Cter_Amidation	633	636	PF01082	0.773
MOD_GlcNHglycan	139	142	PF01048	0.814
MOD_GlcNHglycan	148	151	PF01048	0.699
MOD_GlcNHglycan	166	169	PF01048	0.539
MOD_GlcNHglycan	179	182	PF01048	0.588
MOD_GlcNHglycan	289	292	PF01048	0.530
MOD_GlcNHglycan	382	385	PF01048	0.744
MOD_GlcNHglycan	389	392	PF01048	0.718
MOD_GlcNHglycan	399	402	PF01048	0.649
MOD_GlcNHglycan	403	406	PF01048	0.658
MOD_GlcNHglycan	447	450	PF01048	0.821
MOD_GlcNHglycan	451	454	PF01048	0.753
MOD_GlcNHglycan	495	498	PF01048	0.627
MOD_GlcNHglycan	598	601	PF01048	0.598
MOD_GlcNHglycan	63	66	PF01048	0.530
MOD_GlcNHglycan	740	743	PF01048	0.712
MOD_GlcNHglycan	759	762	PF01048	0.601
MOD_GlcNHglycan	763	766	PF01048	0.785
MOD_GlcNHglycan	857	860	PF01048	0.771
MOD_GlcNHglycan	9	12	PF01048	0.657
MOD_GlcNHglycan	950	953	PF01048	0.806
MOD_GSK3_1	120	127	PF00069	0.778
MOD_GSK3_1	131	138	PF00069	0.691
MOD_GSK3_1	142	149	PF00069	0.656
MOD_GSK3_1	163	170	PF00069	0.743
MOD_GSK3_1	184	191	PF00069	0.809
MOD_GSK3_1	236	243	PF00069	0.587
MOD_GSK3_1	3	10	PF00069	0.739
MOD_GSK3_1	376	383	PF00069	0.763
MOD_GSK3_1	397	404	PF00069	0.799
MOD_GSK3_1	445	452	PF00069	0.821
MOD_GSK3_1	468	475	PF00069	0.705
MOD_GSK3_1	478	485	PF00069	0.621
MOD_GSK3_1	59	66	PF00069	0.522
MOD_GSK3_1	624	631	PF00069	0.819
MOD_GSK3_1	757	764	PF00069	0.752
MOD_GSK3_1	817	824	PF00069	0.784
MOD_GSK3_1	851	858	PF00069	0.829
MOD_GSK3_1	867	874	PF00069	0.571
MOD_GSK3_1	880	887	PF00069	0.697
MOD_GSK3_1	890	897	PF00069	0.705
MOD_GSK3_1	906	913	PF00069	0.681
MOD_GSK3_1	982	989	PF00069	0.704
MOD_LATS_1	877	883	PF00433	0.619
MOD_N-GLC_1	370	375	PF02516	0.698
MOD_N-GLC_1	747	752	PF02516	0.739
MOD_N-GLC_1	880	885	PF02516	0.621
MOD_N-GLC_1	986	991	PF02516	0.701
MOD_NEK2_1	18	23	PF00069	0.531
MOD_NEK2_1	502	507	PF00069	0.585
MOD_NEK2_1	58	63	PF00069	0.476
MOD_NEK2_1	637	642	PF00069	0.766
MOD_NEK2_1	7	12	PF00069	0.573
MOD_NEK2_1	738	743	PF00069	0.710
MOD_NEK2_1	821	826	PF00069	0.783
MOD_NEK2_1	948	953	PF00069	0.688
MOD_NEK2_1	986	991	PF00069	0.756
MOD_NEK2_1	992	997	PF00069	0.682
MOD_PIKK_1	193	199	PF00454	0.804
MOD_PIKK_1	236	242	PF00454	0.705
MOD_PIKK_1	323	329	PF00454	0.705
MOD_PIKK_1	34	40	PF00454	0.715
MOD_PIKK_1	405	411	PF00454	0.828
MOD_PIKK_1	516	522	PF00454	0.643
MOD_PKA_2	164	170	PF00069	0.822
MOD_PKA_2	376	382	PF00069	0.827
MOD_PKA_2	637	643	PF00069	0.841
MOD_PKA_2	717	723	PF00069	0.858
MOD_PKA_2	992	998	PF00069	0.758
MOD_Plk_1	440	446	PF00069	0.815
MOD_Plk_1	58	64	PF00069	0.530
MOD_Plk_1	777	783	PF00069	0.746
MOD_Plk_1	871	877	PF00069	0.724
MOD_Plk_1	880	886	PF00069	0.636
MOD_Plk_4	185	191	PF00069	0.808
MOD_Plk_4	19	25	PF00069	0.715
MOD_Plk_4	502	508	PF00069	0.734
MOD_Plk_4	53	59	PF00069	0.413
MOD_Plk_4	531	537	PF00069	0.639
MOD_Plk_4	806	812	PF00069	0.777
MOD_Plk_4	987	993	PF00069	0.780
MOD_ProDKin_1	121	127	PF00069	0.820
MOD_ProDKin_1	224	230	PF00069	0.799
MOD_ProDKin_1	24	30	PF00069	0.709
MOD_ProDKin_1	453	459	PF00069	0.704
MOD_ProDKin_1	482	488	PF00069	0.849
MOD_ProDKin_1	523	529	PF00069	0.790
MOD_ProDKin_1	553	559	PF00069	0.769
MOD_ProDKin_1	594	600	PF00069	0.762
MOD_ProDKin_1	725	731	PF00069	0.801
MOD_ProDKin_1	852	858	PF00069	0.827
MOD_ProDKin_1	886	892	PF00069	0.770
MOD_ProDKin_1	894	900	PF00069	0.642
MOD_SUMO_rev_2	969	974	PF00179	0.812
TRG_DiLeu_BaEn_3	777	783	PF01217	0.561
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.700
TRG_ENDOCYTIC_2	222	225	PF00928	0.809
TRG_ENDOCYTIC_2	258	261	PF00928	0.530
TRG_ENDOCYTIC_2	269	272	PF00928	0.348
TRG_ENDOCYTIC_2	314	317	PF00928	0.464
TRG_ENDOCYTIC_2	40	43	PF00928	0.733
TRG_ENDOCYTIC_2	447	450	PF00928	0.821
TRG_ENDOCYTIC_2	563	566	PF00928	0.790
TRG_ENDOCYTIC_2	60	63	PF00928	0.199
TRG_ENDOCYTIC_2	798	801	PF00928	0.798
TRG_ENDOCYTIC_2	834	837	PF00928	0.722
TRG_ER_diArg_1	248	250	PF00400	0.530
TRG_ER_diArg_1	635	638	PF00400	0.841
TRG_ER_diArg_1	751	753	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	573	577	PF00026	0.817
TRG_Pf-PMV_PEXEL_1	781	785	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYA7	Leishmania donovani	88%	100%
A4HDF8	Leishmania braziliensis	72%	93%
A4I0T9	Leishmania infantum	88%	100%
E9AWU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%