Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QAM9_LEIMA

TriTrypDb:

LmjF.24.1040 , LMJLV39_240016200 , LMJSD75_240015700

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAM9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	724	728	PF00656	0.541
CLV_NRD_NRD_1	115	117	PF00675	0.689
CLV_NRD_NRD_1	161	163	PF00675	0.654
CLV_NRD_NRD_1	164	166	PF00675	0.631
CLV_NRD_NRD_1	284	286	PF00675	0.621
CLV_NRD_NRD_1	481	483	PF00675	0.524
CLV_NRD_NRD_1	501	503	PF00675	0.601
CLV_NRD_NRD_1	549	551	PF00675	0.660
CLV_NRD_NRD_1	567	569	PF00675	0.570
CLV_NRD_NRD_1	614	616	PF00675	0.669
CLV_NRD_NRD_1	617	619	PF00675	0.629
CLV_PCSK_FUR_1	159	163	PF00082	0.611
CLV_PCSK_FUR_1	282	286	PF00082	0.620
CLV_PCSK_FUR_1	615	619	PF00082	0.657
CLV_PCSK_KEX2_1	115	117	PF00082	0.697
CLV_PCSK_KEX2_1	161	163	PF00082	0.651
CLV_PCSK_KEX2_1	164	166	PF00082	0.629
CLV_PCSK_KEX2_1	284	286	PF00082	0.621
CLV_PCSK_KEX2_1	481	483	PF00082	0.524
CLV_PCSK_KEX2_1	616	618	PF00082	0.665
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.665
CLV_PCSK_PC7_1	157	163	PF00082	0.611
CLV_PCSK_PC7_1	612	618	PF00082	0.623
CLV_PCSK_SKI1_1	135	139	PF00082	0.644
CLV_PCSK_SKI1_1	551	555	PF00082	0.635
CLV_PCSK_SKI1_1	581	585	PF00082	0.731
CLV_PCSK_SKI1_1	587	591	PF00082	0.635
CLV_Separin_Metazoa	755	759	PF03568	0.590
DEG_APCC_DBOX_1	295	303	PF00400	0.639
DEG_APCC_DBOX_1	877	885	PF00400	0.592
DEG_SPOP_SBC_1	212	216	PF00917	0.611
DEG_SPOP_SBC_1	37	41	PF00917	0.670
DEG_SPOP_SBC_1	511	515	PF00917	0.638
DEG_SPOP_SBC_1	627	631	PF00917	0.569
DOC_ANK_TNKS_1	637	644	PF00023	0.634
DOC_CDC14_PxL_1	709	717	PF14671	0.571
DOC_CKS1_1	218	223	PF01111	0.549
DOC_CKS1_1	519	524	PF01111	0.668
DOC_CKS1_1	848	853	PF01111	0.641
DOC_CKS1_1	877	882	PF01111	0.610
DOC_CYCLIN_RxL_1	548	555	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	539	545	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.652
DOC_CYCLIN_yCln2_LP_2	695	701	PF00134	0.677
DOC_MAPK_MEF2A_6	455	462	PF00069	0.624
DOC_MAPK_MEF2A_6	694	701	PF00069	0.670
DOC_MAPK_MEF2A_6	854	862	PF00069	0.703
DOC_MAPK_MEF2A_6	882	890	PF00069	0.550
DOC_MAPK_MEF2A_6	908	915	PF00069	0.599
DOC_PP2B_LxvP_1	144	147	PF13499	0.581
DOC_PP2B_LxvP_1	471	474	PF13499	0.646
DOC_PP2B_LxvP_1	539	542	PF13499	0.651
DOC_PP2B_LxvP_1	695	698	PF13499	0.680
DOC_PP2B_LxvP_1	793	796	PF13499	0.511
DOC_PP2B_LxvP_1	838	841	PF13499	0.647
DOC_PP4_FxxP_1	183	186	PF00568	0.596
DOC_PP4_FxxP_1	218	221	PF00568	0.550
DOC_USP7_MATH_1	117	121	PF00917	0.740
DOC_USP7_MATH_1	212	216	PF00917	0.671
DOC_USP7_MATH_1	287	291	PF00917	0.588
DOC_USP7_MATH_1	348	352	PF00917	0.770
DOC_USP7_MATH_1	37	41	PF00917	0.733
DOC_USP7_MATH_1	43	47	PF00917	0.655
DOC_USP7_MATH_1	440	444	PF00917	0.668
DOC_USP7_MATH_1	511	515	PF00917	0.691
DOC_USP7_MATH_1	573	577	PF00917	0.746
DOC_USP7_MATH_1	71	75	PF00917	0.666
DOC_USP7_UBL2_3	357	361	PF12436	0.553
DOC_WW_Pin1_4	145	150	PF00397	0.649
DOC_WW_Pin1_4	217	222	PF00397	0.702
DOC_WW_Pin1_4	429	434	PF00397	0.714
DOC_WW_Pin1_4	518	523	PF00397	0.677
DOC_WW_Pin1_4	56	61	PF00397	0.628
DOC_WW_Pin1_4	62	67	PF00397	0.576
DOC_WW_Pin1_4	73	78	PF00397	0.510
DOC_WW_Pin1_4	772	777	PF00397	0.660
DOC_WW_Pin1_4	806	811	PF00397	0.573
DOC_WW_Pin1_4	832	837	PF00397	0.694
DOC_WW_Pin1_4	847	852	PF00397	0.530
DOC_WW_Pin1_4	86	91	PF00397	0.581
DOC_WW_Pin1_4	872	877	PF00397	0.695
LIG_14-3-3_CanoR_1	116	122	PF00244	0.552
LIG_14-3-3_CanoR_1	143	147	PF00244	0.510
LIG_14-3-3_CanoR_1	178	186	PF00244	0.519
LIG_14-3-3_CanoR_1	226	232	PF00244	0.607
LIG_14-3-3_CanoR_1	237	245	PF00244	0.559
LIG_14-3-3_CanoR_1	289	299	PF00244	0.643
LIG_14-3-3_CanoR_1	391	396	PF00244	0.654
LIG_14-3-3_CanoR_1	431	439	PF00244	0.672
LIG_14-3-3_CanoR_1	442	449	PF00244	0.580
LIG_14-3-3_CanoR_1	587	595	PF00244	0.580
LIG_14-3-3_CanoR_1	686	692	PF00244	0.606
LIG_APCC_ABBA_1	303	308	PF00400	0.595
LIG_APCC_ABBA_1	697	702	PF00400	0.678
LIG_BIR_III_2	831	835	PF00653	0.661
LIG_BRCT_BRCA1_1	192	196	PF00533	0.618
LIG_BRCT_BRCA1_1	214	218	PF00533	0.628
LIG_DLG_GKlike_1	391	399	PF00625	0.658
LIG_eIF4E_1	526	532	PF01652	0.655
LIG_FHA_1	104	110	PF00498	0.500
LIG_FHA_1	226	232	PF00498	0.599
LIG_FHA_1	23	29	PF00498	0.649
LIG_FHA_1	237	243	PF00498	0.453
LIG_FHA_1	298	304	PF00498	0.669
LIG_FHA_1	31	37	PF00498	0.585
LIG_FHA_1	513	519	PF00498	0.666
LIG_FHA_1	52	58	PF00498	0.629
LIG_FHA_1	553	559	PF00498	0.611
LIG_FHA_1	578	584	PF00498	0.628
LIG_FHA_1	605	611	PF00498	0.572
LIG_FHA_1	785	791	PF00498	0.591
LIG_FHA_1	843	849	PF00498	0.667
LIG_FHA_1	92	98	PF00498	0.618
LIG_FHA_2	278	284	PF00498	0.610
LIG_FHA_2	750	756	PF00498	0.559
LIG_FHA_2	859	865	PF00498	0.708
LIG_LIR_Apic_2	181	186	PF02991	0.549
LIG_LIR_Apic_2	215	221	PF02991	0.552
LIG_LIR_Apic_2	32	37	PF02991	0.664
LIG_LIR_Gen_1	580	590	PF02991	0.491
LIG_LIR_Gen_1	59	68	PF02991	0.685
LIG_LIR_Gen_1	704	714	PF02991	0.637
LIG_LIR_Nem_3	167	173	PF02991	0.672
LIG_LIR_Nem_3	255	259	PF02991	0.506
LIG_LIR_Nem_3	330	335	PF02991	0.613
LIG_LIR_Nem_3	580	585	PF02991	0.491
LIG_LIR_Nem_3	59	64	PF02991	0.679
LIG_LIR_Nem_3	704	709	PF02991	0.656
LIG_MYND_3	712	716	PF01753	0.614
LIG_NRBOX	298	304	PF00104	0.621
LIG_PCNA_PIPBox_1	262	271	PF02747	0.623
LIG_Pex14_1	488	492	PF04695	0.666
LIG_Rb_LxCxE_1	879	898	PF01857	0.541
LIG_SH2_CRK	904	908	PF00017	0.639
LIG_SH2_CRK	909	913	PF00017	0.544
LIG_SH2_PTP2	34	37	PF00017	0.671
LIG_SH2_SRC	268	271	PF00017	0.638
LIG_SH2_SRC	492	495	PF00017	0.658
LIG_SH2_SRC	526	529	PF00017	0.659
LIG_SH2_STAP1	245	249	PF00017	0.533
LIG_SH2_STAP1	30	34	PF00017	0.664
LIG_SH2_STAT5	268	271	PF00017	0.638
LIG_SH2_STAT5	34	37	PF00017	0.661
LIG_SH2_STAT5	526	529	PF00017	0.659
LIG_SH2_STAT5	545	548	PF00017	0.462
LIG_SH2_STAT5	717	720	PF00017	0.643
LIG_SH2_STAT5	750	753	PF00017	0.759
LIG_SH3_2	873	878	PF14604	0.563
LIG_SH3_3	757	763	PF00018	0.637
LIG_SH3_3	764	770	PF00018	0.599
LIG_SH3_3	795	801	PF00018	0.627
LIG_SH3_3	831	837	PF00018	0.703
LIG_SH3_3	870	876	PF00018	0.598
LIG_SUMO_SIM_anti_2	752	759	PF11976	0.490
LIG_SUMO_SIM_par_1	105	110	PF11976	0.611
LIG_SUMO_SIM_par_1	835	842	PF11976	0.620
LIG_SUMO_SIM_par_1	885	892	PF11976	0.601
LIG_SUMO_SIM_par_1	911	917	PF11976	0.520
LIG_TRAF2_1	809	812	PF00917	0.585
LIG_TYR_ITIM	242	247	PF00017	0.501
LIG_TYR_ITIM	907	912	PF00017	0.539
MOD_CDC14_SPxK_1	875	878	PF00782	0.562
MOD_CDK_SPxK_1	872	878	PF00069	0.640
MOD_CDK_SPxxK_3	806	813	PF00069	0.620
MOD_CDK_SPxxK_3	847	854	PF00069	0.692
MOD_CK1_1	103	109	PF00069	0.614
MOD_CK1_1	227	233	PF00069	0.638
MOD_CK1_1	290	296	PF00069	0.573
MOD_CK1_1	349	355	PF00069	0.818
MOD_CK1_1	443	449	PF00069	0.762
MOD_CK1_1	484	490	PF00069	0.585
MOD_CK1_1	626	632	PF00069	0.674
MOD_CK1_1	669	675	PF00069	0.740
MOD_CK1_1	67	73	PF00069	0.542
MOD_CK1_1	690	696	PF00069	0.647
MOD_CK1_1	707	713	PF00069	0.448
MOD_CK1_1	75	81	PF00069	0.544
MOD_CK1_1	791	797	PF00069	0.603
MOD_CK1_1	839	845	PF00069	0.667
MOD_CK2_1	17	23	PF00069	0.623
MOD_CK2_1	277	283	PF00069	0.605
MOD_CK2_1	304	310	PF00069	0.529
MOD_CK2_1	568	574	PF00069	0.630
MOD_CK2_1	588	594	PF00069	0.451
MOD_CK2_1	616	622	PF00069	0.653
MOD_CK2_1	749	755	PF00069	0.559
MOD_CK2_1	806	812	PF00069	0.645
MOD_CK2_1	892	898	PF00069	0.603
MOD_GlcNHglycan	175	178	PF01048	0.436
MOD_GlcNHglycan	336	339	PF01048	0.638
MOD_GlcNHglycan	342	346	PF01048	0.642
MOD_GlcNHglycan	445	448	PF01048	0.769
MOD_GlcNHglycan	45	48	PF01048	0.638
MOD_GlcNHglycan	452	455	PF01048	0.600
MOD_GlcNHglycan	515	518	PF01048	0.695
MOD_GlcNHglycan	523	526	PF01048	0.572
MOD_GlcNHglycan	570	573	PF01048	0.670
MOD_GlcNHglycan	625	628	PF01048	0.581
MOD_GlcNHglycan	69	72	PF01048	0.567
MOD_GlcNHglycan	7	10	PF01048	0.588
MOD_GlcNHglycan	705	709	PF01048	0.605
MOD_GlcNHglycan	723	726	PF01048	0.523
MOD_GlcNHglycan	779	782	PF01048	0.618
MOD_GlcNHglycan	793	796	PF01048	0.498
MOD_GlcNHglycan	864	868	PF01048	0.716
MOD_GSK3_1	122	129	PF00069	0.653
MOD_GSK3_1	138	145	PF00069	0.483
MOD_GSK3_1	19	26	PF00069	0.549
MOD_GSK3_1	190	197	PF00069	0.649
MOD_GSK3_1	203	210	PF00069	0.557
MOD_GSK3_1	213	220	PF00069	0.594
MOD_GSK3_1	225	232	PF00069	0.541
MOD_GSK3_1	346	353	PF00069	0.788
MOD_GSK3_1	35	42	PF00069	0.536
MOD_GSK3_1	441	448	PF00069	0.812
MOD_GSK3_1	477	484	PF00069	0.630
MOD_GSK3_1	5	12	PF00069	0.623
MOD_GSK3_1	573	580	PF00069	0.612
MOD_GSK3_1	623	630	PF00069	0.634
MOD_GSK3_1	67	74	PF00069	0.625
MOD_GSK3_1	717	724	PF00069	0.615
MOD_GSK3_1	75	82	PF00069	0.637
MOD_GSK3_1	784	791	PF00069	0.575
MOD_GSK3_1	832	839	PF00069	0.673
MOD_GSK3_1	842	849	PF00069	0.620
MOD_GSK3_1	858	865	PF00069	0.600
MOD_GSK3_1	872	879	PF00069	0.561
MOD_N-GLC_2	916	918	PF02516	0.605
MOD_NEK2_1	138	143	PF00069	0.671
MOD_NEK2_1	173	178	PF00069	0.498
MOD_NEK2_1	225	230	PF00069	0.643
MOD_NEK2_1	512	517	PF00069	0.596
MOD_NEK2_1	777	782	PF00069	0.618
MOD_NEK2_1	846	851	PF00069	0.692
MOD_NEK2_1	858	863	PF00069	0.581
MOD_NEK2_1	911	916	PF00069	0.588
MOD_NEK2_2	213	218	PF00069	0.579
MOD_PIKK_1	225	231	PF00454	0.681
MOD_PIKK_1	312	318	PF00454	0.637
MOD_PIKK_1	322	328	PF00454	0.593
MOD_PIKK_1	350	356	PF00454	0.656
MOD_PIKK_1	360	366	PF00454	0.488
MOD_PIKK_1	397	403	PF00454	0.689
MOD_PIKK_1	463	469	PF00454	0.624
MOD_PIKK_1	666	672	PF00454	0.735
MOD_PIKK_1	865	871	PF00454	0.673
MOD_PK_1	481	487	PF00069	0.586
MOD_PKA_1	481	487	PF00069	0.514
MOD_PKA_1	568	574	PF00069	0.618
MOD_PKA_1	616	622	PF00069	0.604
MOD_PKA_2	139	145	PF00069	0.524
MOD_PKA_2	225	231	PF00069	0.609
MOD_PKA_2	236	242	PF00069	0.566
MOD_PKA_2	441	447	PF00069	0.693
MOD_PKA_2	481	487	PF00069	0.514
MOD_PKA_2	501	507	PF00069	0.480
MOD_PKA_2	616	622	PF00069	0.604
MOD_PKA_2	623	629	PF00069	0.562
MOD_PKA_2	721	727	PF00069	0.540
MOD_PKA_2	862	868	PF00069	0.667
MOD_Plk_1	573	579	PF00069	0.615
MOD_Plk_1	704	710	PF00069	0.578
MOD_Plk_4	213	219	PF00069	0.656
MOD_Plk_4	30	36	PF00069	0.496
MOD_Plk_4	391	397	PF00069	0.656
MOD_Plk_4	484	490	PF00069	0.663
MOD_Plk_4	526	532	PF00069	0.655
MOD_Plk_4	53	59	PF00069	0.604
MOD_Plk_4	839	845	PF00069	0.674
MOD_ProDKin_1	145	151	PF00069	0.648
MOD_ProDKin_1	217	223	PF00069	0.702
MOD_ProDKin_1	429	435	PF00069	0.715
MOD_ProDKin_1	518	524	PF00069	0.671
MOD_ProDKin_1	56	62	PF00069	0.628
MOD_ProDKin_1	73	79	PF00069	0.511
MOD_ProDKin_1	772	778	PF00069	0.660
MOD_ProDKin_1	806	812	PF00069	0.568
MOD_ProDKin_1	832	838	PF00069	0.692
MOD_ProDKin_1	847	853	PF00069	0.530
MOD_ProDKin_1	86	92	PF00069	0.575
MOD_ProDKin_1	872	878	PF00069	0.692
MOD_SUMO_for_1	153	156	PF00179	0.647
MOD_SUMO_rev_2	270	278	PF00179	0.595
TRG_ENDOCYTIC_2	244	247	PF00928	0.573
TRG_ENDOCYTIC_2	256	259	PF00928	0.462
TRG_ENDOCYTIC_2	306	309	PF00928	0.628
TRG_ENDOCYTIC_2	904	907	PF00928	0.638
TRG_ENDOCYTIC_2	909	912	PF00928	0.548
TRG_ER_diArg_1	114	116	PF00400	0.672
TRG_ER_diArg_1	157	160	PF00400	0.614
TRG_ER_diArg_1	615	618	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYA9	Leishmania donovani	89%	100%
A4HDG0	Leishmania braziliensis	69%	96%
A4I0U1	Leishmania infantum	89%	100%
E9AWU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	91%