AKAP7_NLS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AKAP7 2'5' RNA ligase-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QAM7_LEIMA

TriTrypDb:

LmjF.24.1060 , LMJLV39_240016400 , LMJSD75_240015900

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAM7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.723
CLV_NRD_NRD_1	307	309	PF00675	0.729
CLV_NRD_NRD_1	405	407	PF00675	0.355
CLV_NRD_NRD_1	520	522	PF00675	0.336
CLV_NRD_NRD_1	53	55	PF00675	0.523
CLV_NRD_NRD_1	532	534	PF00675	0.336
CLV_NRD_NRD_1	577	579	PF00675	0.309
CLV_NRD_NRD_1	60	62	PF00675	0.521
CLV_PCSK_KEX2_1	112	114	PF00082	0.612
CLV_PCSK_KEX2_1	135	137	PF00082	0.714
CLV_PCSK_KEX2_1	307	309	PF00082	0.724
CLV_PCSK_KEX2_1	405	407	PF00082	0.355
CLV_PCSK_KEX2_1	520	522	PF00082	0.336
CLV_PCSK_KEX2_1	53	55	PF00082	0.523
CLV_PCSK_KEX2_1	577	579	PF00082	0.309
CLV_PCSK_KEX2_1	60	62	PF00082	0.521
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.612
CLV_PCSK_SKI1_1	136	140	PF00082	0.702
CLV_PCSK_SKI1_1	225	229	PF00082	0.710
CLV_PCSK_SKI1_1	413	417	PF00082	0.336
CLV_PCSK_SKI1_1	520	524	PF00082	0.336
CLV_PCSK_SKI1_1	563	567	PF00082	0.342
DEG_APCC_DBOX_1	118	126	PF00400	0.614
DEG_APCC_DBOX_1	451	459	PF00400	0.536
DEG_COP1_1	291	301	PF00400	0.699
DEG_ODPH_VHL_1	447	458	PF01847	0.530
DEG_SPOP_SBC_1	581	585	PF00917	0.419
DOC_CDC14_PxL_1	565	573	PF14671	0.536
DOC_CKS1_1	230	235	PF01111	0.574
DOC_MAPK_DCC_7	563	573	PF00069	0.536
DOC_MAPK_gen_1	405	411	PF00069	0.521
DOC_MAPK_gen_1	518	527	PF00069	0.555
DOC_MAPK_MEF2A_6	393	400	PF00069	0.482
DOC_MAPK_MEF2A_6	518	527	PF00069	0.555
DOC_MAPK_NFAT4_5	393	401	PF00069	0.471
DOC_PP2B_LxvP_1	401	404	PF13499	0.483
DOC_PP2B_LxvP_1	90	93	PF13499	0.664
DOC_PP4_FxxP_1	227	230	PF00568	0.651
DOC_PP4_FxxP_1	473	476	PF00568	0.510
DOC_PP4_FxxP_1	566	569	PF00568	0.536
DOC_USP7_MATH_1	171	175	PF00917	0.470
DOC_USP7_MATH_1	239	243	PF00917	0.676
DOC_USP7_MATH_1	374	378	PF00917	0.510
DOC_USP7_MATH_1	382	386	PF00917	0.443
DOC_USP7_MATH_1	419	423	PF00917	0.560
DOC_USP7_MATH_1	516	520	PF00917	0.509
DOC_USP7_MATH_1	581	585	PF00917	0.444
DOC_USP7_MATH_1	62	66	PF00917	0.533
DOC_USP7_MATH_1	93	97	PF00917	0.664
DOC_USP7_UBL2_3	530	534	PF12436	0.536
DOC_WW_Pin1_4	165	170	PF00397	0.581
DOC_WW_Pin1_4	229	234	PF00397	0.572
DOC_WW_Pin1_4	280	285	PF00397	0.748
DOC_WW_Pin1_4	297	302	PF00397	0.625
DOC_WW_Pin1_4	9	14	PF00397	0.453
LIG_14-3-3_CanoR_1	225	230	PF00244	0.650
LIG_14-3-3_CanoR_1	35	42	PF00244	0.563
LIG_14-3-3_CanoR_1	48	52	PF00244	0.501
LIG_APCC_ABBA_1	123	128	PF00400	0.621
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_BIR_III_2	543	547	PF00653	0.522
LIG_BRCT_BRCA1_1	323	327	PF00533	0.501
LIG_BRCT_BRCA1_1	538	542	PF00533	0.510
LIG_BRCT_BRCA1_2	323	329	PF00533	0.487
LIG_CaM_IQ_9	105	121	PF13499	0.557
LIG_FHA_1	221	227	PF00498	0.644
LIG_FHA_1	318	324	PF00498	0.329
LIG_FHA_1	336	342	PF00498	0.522
LIG_FHA_1	387	393	PF00498	0.526
LIG_FHA_1	395	401	PF00498	0.531
LIG_FHA_1	436	442	PF00498	0.544
LIG_FHA_2	204	210	PF00498	0.737
LIG_FHA_2	524	530	PF00498	0.587
LIG_FHA_2	62	68	PF00498	0.535
LIG_FHA_2	99	105	PF00498	0.610
LIG_LIR_Apic_2	472	476	PF02991	0.507
LIG_LIR_Gen_1	320	330	PF02991	0.475
LIG_LIR_Gen_1	71	81	PF02991	0.438
LIG_LIR_Nem_3	223	227	PF02991	0.648
LIG_LIR_Nem_3	320	325	PF02991	0.475
LIG_LIR_Nem_3	480	486	PF02991	0.502
LIG_LIR_Nem_3	71	76	PF02991	0.444
LIG_PDZ_Class_2	589	594	PF00595	0.496
LIG_Pex14_2	420	424	PF04695	0.536
LIG_PTB_Apo_2	218	225	PF02174	0.604
LIG_PTB_Phospho_1	218	224	PF10480	0.604
LIG_SH2_PTP2	7	10	PF00017	0.528
LIG_SH2_STAP1	352	356	PF00017	0.487
LIG_SH2_STAT5	586	589	PF00017	0.555
LIG_SH2_STAT5	7	10	PF00017	0.582
LIG_SH3_1	7	13	PF00018	0.460
LIG_SH3_3	191	197	PF00018	0.771
LIG_SH3_3	198	204	PF00018	0.754
LIG_SH3_3	227	233	PF00018	0.595
LIG_SH3_3	295	301	PF00018	0.721
LIG_SH3_3	320	326	PF00018	0.504
LIG_SH3_3	7	13	PF00018	0.508
LIG_SH3_CIN85_PxpxPR_1	233	238	PF14604	0.653
LIG_SUMO_SIM_anti_2	101	109	PF11976	0.567
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.545
LIG_SUMO_SIM_par_1	396	402	PF11976	0.458
LIG_TRAF2_1	550	553	PF00917	0.510
LIG_TRFH_1	165	169	PF08558	0.566
LIG_TYR_ITIM	481	486	PF00017	0.471
LIG_WRC_WIRS_1	344	349	PF05994	0.536
LIG_WW_3	308	312	PF00397	0.654
MOD_CDK_SPxxK_3	229	236	PF00069	0.576
MOD_CK1_1	24	30	PF00069	0.532
MOD_CK1_1	242	248	PF00069	0.729
MOD_CK1_1	251	257	PF00069	0.639
MOD_CK1_1	376	382	PF00069	0.554
MOD_CK1_1	434	440	PF00069	0.588
MOD_CK1_1	47	53	PF00069	0.563
MOD_CK1_1	65	71	PF00069	0.455
MOD_CK2_1	502	508	PF00069	0.496
MOD_CK2_1	65	71	PF00069	0.556
MOD_Cter_Amidation	133	136	PF01082	0.745
MOD_GlcNHglycan	1	4	PF01048	0.482
MOD_GlcNHglycan	155	158	PF01048	0.506
MOD_GlcNHglycan	244	247	PF01048	0.757
MOD_GlcNHglycan	250	253	PF01048	0.759
MOD_GlcNHglycan	37	40	PF01048	0.499
MOD_GlcNHglycan	380	383	PF01048	0.297
MOD_GlcNHglycan	421	424	PF01048	0.385
MOD_GlcNHglycan	441	444	PF01048	0.310
MOD_GlcNHglycan	64	67	PF01048	0.561
MOD_GSK3_1	225	232	PF00069	0.703
MOD_GSK3_1	317	324	PF00069	0.372
MOD_GSK3_1	370	377	PF00069	0.533
MOD_GSK3_1	378	385	PF00069	0.515
MOD_GSK3_1	431	438	PF00069	0.516
MOD_GSK3_1	439	446	PF00069	0.523
MOD_GSK3_1	61	68	PF00069	0.528
MOD_GSK3_1	9	16	PF00069	0.519
MOD_N-GLC_1	220	225	PF02516	0.708
MOD_N-GLC_1	335	340	PF02516	0.296
MOD_NEK2_1	21	26	PF00069	0.515
MOD_NEK2_1	215	220	PF00069	0.716
MOD_NEK2_1	378	383	PF00069	0.562
MOD_NEK2_1	394	399	PF00069	0.413
MOD_NEK2_1	46	51	PF00069	0.532
MOD_NEK2_1	502	507	PF00069	0.513
MOD_NEK2_1	523	528	PF00069	0.471
MOD_NEK2_1	587	592	PF00069	0.589
MOD_NEK2_2	588	593	PF00069	0.510
MOD_PKA_2	24	30	PF00069	0.541
MOD_PKA_2	47	53	PF00069	0.554
MOD_PKA_2	62	68	PF00069	0.533
MOD_Plk_1	220	226	PF00069	0.589
MOD_Plk_1	335	341	PF00069	0.496
MOD_Plk_1	435	441	PF00069	0.586
MOD_Plk_1	443	449	PF00069	0.472
MOD_Plk_1	581	587	PF00069	0.507
MOD_Plk_1	588	594	PF00069	0.535
MOD_Plk_4	336	342	PF00069	0.539
MOD_Plk_4	394	400	PF00069	0.509
MOD_Plk_4	477	483	PF00069	0.534
MOD_Plk_4	523	529	PF00069	0.476
MOD_Plk_4	582	588	PF00069	0.587
MOD_ProDKin_1	165	171	PF00069	0.588
MOD_ProDKin_1	229	235	PF00069	0.573
MOD_ProDKin_1	280	286	PF00069	0.748
MOD_ProDKin_1	297	303	PF00069	0.623
MOD_ProDKin_1	9	15	PF00069	0.453
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.595
TRG_ENDOCYTIC_2	224	227	PF00928	0.584
TRG_ENDOCYTIC_2	352	355	PF00928	0.442
TRG_ENDOCYTIC_2	483	486	PF00928	0.484
TRG_ER_diArg_1	135	137	PF00400	0.729
TRG_ER_diArg_1	23	26	PF00400	0.514
TRG_ER_diArg_1	307	309	PF00400	0.671
TRG_ER_diArg_1	404	406	PF00400	0.555
TRG_ER_diArg_1	520	522	PF00400	0.542
TRG_ER_diArg_1	53	55	PF00400	0.523
TRG_ER_diArg_1	576	578	PF00400	0.522
TRG_ER_diArg_1	60	63	PF00400	0.525
TRG_NES_CRM1_1	158	170	PF08389	0.513
TRG_NLS_Bipartite_1	520	537	PF00514	0.522
TRG_NLS_MonoExtN_4	530	537	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X3	Leptomonas seymouri	58%	100%
A0A3S7WYE0	Leishmania donovani	92%	100%
A0A422MP50	Trypanosoma rangeli	28%	100%
A4HDG2	Leishmania braziliensis	77%	100%
A4I0U3	Leishmania infantum	93%	100%
C9ZVE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%