Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania major

UniProt:

Q4QAM5_LEIMA

TriTrypDb:

LmjF.24.1080 , LMJLV39_240016600 , LMJSD75_240016100

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QAM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.605
CLV_NRD_NRD_1	137	139	PF00675	0.404
CLV_NRD_NRD_1	293	295	PF00675	0.331
CLV_NRD_NRD_1	305	307	PF00675	0.450
CLV_NRD_NRD_1	343	345	PF00675	0.526
CLV_NRD_NRD_1	37	39	PF00675	0.432
CLV_NRD_NRD_1	397	399	PF00675	0.263
CLV_NRD_NRD_1	429	431	PF00675	0.308
CLV_PCSK_FUR_1	298	302	PF00082	0.427
CLV_PCSK_FUR_1	303	307	PF00082	0.373
CLV_PCSK_KEX2_1	293	295	PF00082	0.320
CLV_PCSK_KEX2_1	300	302	PF00082	0.361
CLV_PCSK_KEX2_1	305	307	PF00082	0.497
CLV_PCSK_KEX2_1	343	345	PF00082	0.540
CLV_PCSK_KEX2_1	37	39	PF00082	0.432
CLV_PCSK_KEX2_1	397	399	PF00082	0.317
CLV_PCSK_KEX2_1	428	430	PF00082	0.302
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.431
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.338
CLV_PCSK_PC7_1	301	307	PF00082	0.474
CLV_PCSK_PC7_1	393	399	PF00082	0.349
CLV_PCSK_PC7_1	425	431	PF00082	0.291
CLV_PCSK_SKI1_1	195	199	PF00082	0.346
CLV_PCSK_SKI1_1	398	402	PF00082	0.281
CLV_PCSK_SKI1_1	54	58	PF00082	0.341
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DEG_SCF_FBW7_2	49	55	PF00400	0.515
DEG_SPOP_SBC_1	318	322	PF00917	0.610
DEG_SPOP_SBC_1	354	358	PF00917	0.796
DEG_SPOP_SBC_1	78	82	PF00917	0.580
DOC_AGCK_PIF_1	194	199	PF00069	0.593
DOC_CKS1_1	12	17	PF01111	0.531
DOC_CKS1_1	49	54	PF01111	0.519
DOC_CYCLIN_RxL_1	376	387	PF00134	0.478
DOC_MAPK_gen_1	303	311	PF00069	0.663
DOC_PP1_RVXF_1	14	21	PF00149	0.554
DOC_PP2B_LxvP_1	259	262	PF13499	0.417
DOC_USP7_MATH_1	318	322	PF00917	0.657
DOC_USP7_MATH_1	354	358	PF00917	0.777
DOC_WW_Pin1_4	11	16	PF00397	0.550
DOC_WW_Pin1_4	202	207	PF00397	0.537
DOC_WW_Pin1_4	48	53	PF00397	0.615
LIG_14-3-3_CanoR_1	222	226	PF00244	0.586
LIG_14-3-3_CanoR_1	247	254	PF00244	0.318
LIG_14-3-3_CanoR_1	317	325	PF00244	0.656
LIG_14-3-3_CanoR_1	330	335	PF00244	0.604
LIG_14-3-3_CanoR_1	343	351	PF00244	0.721
LIG_14-3-3_CanoR_1	4	9	PF00244	0.610
LIG_14-3-3_CanoR_1	65	71	PF00244	0.526
LIG_14-3-3_CanoR_1	89	95	PF00244	0.632
LIG_APCC_ABBA_1	381	386	PF00400	0.453
LIG_BRCT_BRCA1_1	362	366	PF00533	0.730
LIG_BRCT_BRCA1_1	52	56	PF00533	0.523
LIG_FHA_1	144	150	PF00498	0.587
LIG_FHA_1	196	202	PF00498	0.546
LIG_FHA_1	222	228	PF00498	0.510
LIG_FHA_1	246	252	PF00498	0.353
LIG_FHA_1	3	9	PF00498	0.706
LIG_FHA_1	90	96	PF00498	0.638
LIG_FHA_2	331	337	PF00498	0.760
LIG_FHA_2	79	85	PF00498	0.694
LIG_Integrin_RGD_1	129	131	PF01839	0.319
LIG_LIR_Gen_1	278	286	PF02991	0.423
LIG_LIR_Gen_1	45	52	PF02991	0.558
LIG_LIR_Nem_3	111	117	PF02991	0.488
LIG_LIR_Nem_3	191	197	PF02991	0.514
LIG_LIR_Nem_3	221	226	PF02991	0.504
LIG_LIR_Nem_3	278	283	PF02991	0.423
LIG_LIR_Nem_3	394	399	PF02991	0.491
LIG_LIR_Nem_3	419	424	PF02991	0.491
LIG_LIR_Nem_3	45	49	PF02991	0.546
LIG_LIR_Nem_3	53	59	PF02991	0.486
LIG_LYPXL_yS_3	289	292	PF13949	0.599
LIG_Pex14_2	208	212	PF04695	0.572
LIG_Pex14_2	284	288	PF04695	0.392
LIG_PTB_Apo_2	238	245	PF02174	0.521
LIG_PTB_Apo_2	70	77	PF02174	0.508
LIG_PTB_Phospho_1	238	244	PF10480	0.536
LIG_PTB_Phospho_1	70	76	PF10480	0.502
LIG_REV1ctd_RIR_1	281	289	PF16727	0.315
LIG_SH2_CRK	378	382	PF00017	0.458
LIG_SH2_CRK	396	400	PF00017	0.491
LIG_SH2_CRK	421	425	PF00017	0.477
LIG_SH2_STAP1	223	227	PF00017	0.498
LIG_SH2_STAP1	280	284	PF00017	0.339
LIG_SH2_STAT5	10	13	PF00017	0.613
LIG_SH2_STAT5	223	226	PF00017	0.541
LIG_SH2_STAT5	238	241	PF00017	0.498
LIG_SH2_STAT5	244	247	PF00017	0.328
LIG_SH2_STAT5	46	49	PF00017	0.548
LIG_SH2_STAT5	60	63	PF00017	0.440
LIG_SH2_STAT5	94	97	PF00017	0.673
LIG_SH3_3	231	237	PF00018	0.509
LIG_SH3_3	368	374	PF00018	0.635
LIG_SH3_3	9	15	PF00018	0.574
LIG_TYR_ITIM	44	49	PF00017	0.630
LIG_WRC_WIRS_1	180	185	PF05994	0.599
MOD_CDK_SPK_2	11	16	PF00069	0.550
MOD_CDK_SPxK_1	48	54	PF00069	0.523
MOD_CK1_1	156	162	PF00069	0.532
MOD_CK1_1	186	192	PF00069	0.539
MOD_CK1_1	319	325	PF00069	0.599
MOD_CK1_1	353	359	PF00069	0.747
MOD_CK1_1	360	366	PF00069	0.737
MOD_CK1_1	367	373	PF00069	0.655
MOD_CK1_1	77	83	PF00069	0.601
MOD_CK1_1	87	93	PF00069	0.546
MOD_CK1_1	98	104	PF00069	0.522
MOD_CK2_1	101	107	PF00069	0.587
MOD_CK2_1	385	391	PF00069	0.457
MOD_Cter_Amidation	35	38	PF01082	0.431
MOD_GlcNHglycan	185	188	PF01048	0.374
MOD_GlcNHglycan	22	25	PF01048	0.415
MOD_GlcNHglycan	227	230	PF01048	0.305
MOD_GlcNHglycan	254	257	PF01048	0.291
MOD_GlcNHglycan	352	355	PF01048	0.548
MOD_GlcNHglycan	366	369	PF01048	0.441
MOD_GlcNHglycan	393	396	PF01048	0.284
MOD_GlcNHglycan	81	84	PF01048	0.410
MOD_GSK3_1	175	182	PF00069	0.580
MOD_GSK3_1	221	228	PF00069	0.522
MOD_GSK3_1	246	253	PF00069	0.344
MOD_GSK3_1	330	337	PF00069	0.662
MOD_GSK3_1	350	357	PF00069	0.769
MOD_GSK3_1	358	365	PF00069	0.755
MOD_GSK3_1	4	11	PF00069	0.524
MOD_GSK3_1	74	81	PF00069	0.569
MOD_GSK3_1	84	91	PF00069	0.600
MOD_GSK3_1	94	101	PF00069	0.525
MOD_LATS_1	341	347	PF00433	0.601
MOD_N-GLC_1	108	113	PF02516	0.325
MOD_N-GLC_1	72	77	PF02516	0.422
MOD_N-GLC_1	78	83	PF02516	0.494
MOD_NEK2_1	133	138	PF00069	0.579
MOD_NEK2_1	153	158	PF00069	0.531
MOD_NEK2_1	179	184	PF00069	0.571
MOD_NEK2_1	2	7	PF00069	0.636
MOD_NEK2_1	225	230	PF00069	0.501
MOD_NEK2_1	239	244	PF00069	0.470
MOD_NEK2_1	269	274	PF00069	0.448
MOD_NEK2_1	8	13	PF00069	0.561
MOD_PIKK_1	108	114	PF00454	0.515
MOD_PIKK_1	319	325	PF00454	0.679
MOD_PKA_1	343	349	PF00069	0.751
MOD_PKA_2	221	227	PF00069	0.584
MOD_PKA_2	246	252	PF00069	0.369
MOD_PKA_2	316	322	PF00069	0.591
MOD_PKA_2	329	335	PF00069	0.635
MOD_PKA_2	343	349	PF00069	0.684
MOD_PKA_2	88	94	PF00069	0.656
MOD_Plk_1	108	114	PF00069	0.506
MOD_Plk_1	195	201	PF00069	0.577
MOD_Plk_1	385	391	PF00069	0.530
MOD_Plk_1	72	78	PF00069	0.607
MOD_Plk_2-3	188	194	PF00069	0.606
MOD_Plk_4	101	107	PF00069	0.547
MOD_Plk_4	156	162	PF00069	0.579
MOD_Plk_4	204	210	PF00069	0.583
MOD_Plk_4	221	227	PF00069	0.397
MOD_Plk_4	239	245	PF00069	0.525
MOD_Plk_4	275	281	PF00069	0.289
MOD_Plk_4	330	336	PF00069	0.655
MOD_Plk_4	66	72	PF00069	0.556
MOD_ProDKin_1	11	17	PF00069	0.543
MOD_ProDKin_1	202	208	PF00069	0.536
MOD_ProDKin_1	48	54	PF00069	0.615
MOD_SUMO_for_1	214	217	PF00179	0.595
MOD_SUMO_rev_2	104	111	PF00179	0.591
MOD_SUMO_rev_2	188	197	PF00179	0.609
MOD_SUMO_rev_2	82	88	PF00179	0.699
TRG_ENDOCYTIC_2	280	283	PF00928	0.304
TRG_ENDOCYTIC_2	289	292	PF00928	0.499
TRG_ENDOCYTIC_2	378	381	PF00928	0.472
TRG_ENDOCYTIC_2	396	399	PF00928	0.491
TRG_ENDOCYTIC_2	421	424	PF00928	0.477
TRG_ENDOCYTIC_2	46	49	PF00928	0.591
TRG_ER_diArg_1	292	294	PF00400	0.540
TRG_ER_diArg_1	3	6	PF00400	0.719
TRG_ER_diArg_1	303	306	PF00400	0.702
TRG_ER_diArg_1	37	39	PF00400	0.633
TRG_ER_diArg_1	396	398	PF00400	0.516
TRG_ER_diArg_1	63	66	PF00400	0.421
TRG_NLS_MonoExtN_4	425	432	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	72%	100%
A0A0N1IK13	Leptomonas seymouri	25%	83%
A0A0S4IP86	Bodo saltans	45%	100%
A0A0S4ITI3	Bodo saltans	23%	85%
A0A1X0NQB1	Trypanosomatidae	25%	86%
A0A1X0NVK2	Trypanosomatidae	52%	100%
A0A3S7WSV3	Leishmania donovani	24%	83%
A0A3S7WYG6	Leishmania donovani	94%	100%
A0A422N8L2	Trypanosoma rangeli	53%	100%
A4H7H2	Leishmania braziliensis	23%	83%
A4HDG4	Leishmania braziliensis	89%	100%
A4HVV3	Leishmania infantum	25%	100%
A4I0U5	Leishmania infantum	94%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	83%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QFX4	Leishmania major	23%	83%
V5BD52	Trypanosoma cruzi	25%	86%
V5DSF1	Trypanosoma cruzi	54%	100%