LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Hypothetical predicted multipass transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted multipass transmembrane protein
Gene product:
hypothetical predicted multipass transmembrane protein
Species:
Leishmania major
UniProt:
Q4QAM4_LEIMA
TriTrypDb:
LmjF.24.1090 , LMJLV39_240016700 , LMJSD75_240016200 *
Length:
518

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

Q4QAM4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAM4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 174 176 PF00675 0.320
CLV_NRD_NRD_1 484 486 PF00675 0.437
CLV_PCSK_KEX2_1 176 178 PF00082 0.325
CLV_PCSK_KEX2_1 321 323 PF00082 0.441
CLV_PCSK_KEX2_1 483 485 PF00082 0.437
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.338
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.466
CLV_PCSK_PC1ET2_1 483 485 PF00082 0.436
CLV_PCSK_SKI1_1 122 126 PF00082 0.270
CLV_PCSK_SKI1_1 335 339 PF00082 0.294
CLV_PCSK_SKI1_1 473 477 PF00082 0.332
DEG_APCC_DBOX_1 235 243 PF00400 0.514
DEG_Nend_UBRbox_1 1 4 PF02207 0.533
DOC_CYCLIN_yCln2_LP_2 244 250 PF00134 0.674
DOC_MAPK_gen_1 175 184 PF00069 0.499
DOC_MAPK_HePTP_8 387 399 PF00069 0.239
DOC_MAPK_HePTP_8 447 459 PF00069 0.332
DOC_MAPK_MEF2A_6 28 36 PF00069 0.577
DOC_MAPK_MEF2A_6 335 343 PF00069 0.480
DOC_MAPK_MEF2A_6 390 399 PF00069 0.309
DOC_MAPK_MEF2A_6 450 459 PF00069 0.332
DOC_MAPK_NFAT4_5 390 398 PF00069 0.300
DOC_PP2B_LxvP_1 244 247 PF13499 0.520
DOC_USP7_MATH_1 4 8 PF00917 0.534
DOC_USP7_MATH_1 426 430 PF00917 0.412
DOC_USP7_MATH_1 489 493 PF00917 0.602
DOC_USP7_MATH_1 70 74 PF00917 0.412
DOC_WW_Pin1_4 144 149 PF00397 0.286
DOC_WW_Pin1_4 262 267 PF00397 0.763
DOC_WW_Pin1_4 310 315 PF00397 0.689
DOC_WW_Pin1_4 410 415 PF00397 0.487
LIG_14-3-3_CanoR_1 28 36 PF00244 0.519
LIG_14-3-3_CanoR_1 376 380 PF00244 0.365
LIG_BIR_III_2 280 284 PF00653 0.604
LIG_BIR_III_2 357 361 PF00653 0.324
LIG_BRCT_BRCA1_1 180 184 PF00533 0.417
LIG_BRCT_BRCA1_1 224 228 PF00533 0.371
LIG_BRCT_BRCA1_1 377 381 PF00533 0.310
LIG_Clathr_ClatBox_1 300 304 PF01394 0.621
LIG_eIF4E_1 121 127 PF01652 0.515
LIG_FHA_1 284 290 PF00498 0.623
LIG_FHA_1 429 435 PF00498 0.346
LIG_FHA_1 64 70 PF00498 0.457
LIG_FHA_1 80 86 PF00498 0.317
LIG_FHA_2 14 20 PF00498 0.547
LIG_FHA_2 290 296 PF00498 0.712
LIG_GBD_Chelix_1 192 200 PF00786 0.320
LIG_GBD_Chelix_1 340 348 PF00786 0.298
LIG_GBD_Chelix_1 458 466 PF00786 0.261
LIG_LIR_Gen_1 178 186 PF02991 0.533
LIG_LIR_Gen_1 187 196 PF02991 0.281
LIG_LIR_Gen_1 214 223 PF02991 0.311
LIG_LIR_Gen_1 350 359 PF02991 0.384
LIG_LIR_Gen_1 385 394 PF02991 0.295
LIG_LIR_Gen_1 87 97 PF02991 0.452
LIG_LIR_Nem_3 167 173 PF02991 0.372
LIG_LIR_Nem_3 187 191 PF02991 0.321
LIG_LIR_Nem_3 214 220 PF02991 0.299
LIG_LIR_Nem_3 350 354 PF02991 0.308
LIG_LIR_Nem_3 385 389 PF02991 0.384
LIG_LIR_Nem_3 98 104 PF02991 0.387
LIG_MLH1_MIPbox_1 180 184 PF16413 0.261
LIG_NRBOX 343 349 PF00104 0.300
LIG_NRBOX 471 477 PF00104 0.594
LIG_Pex14_1 120 124 PF04695 0.550
LIG_Pex14_1 166 170 PF04695 0.428
LIG_Pex14_1 217 221 PF04695 0.265
LIG_Pex14_1 60 64 PF04695 0.285
LIG_Pex14_2 184 188 PF04695 0.426
LIG_Pex14_2 399 403 PF04695 0.378
LIG_Pex14_2 9 13 PF04695 0.542
LIG_REV1ctd_RIR_1 6 15 PF16727 0.537
LIG_SH2_CRK 101 105 PF00017 0.366
LIG_SH2_GRB2like 408 411 PF00017 0.454
LIG_SH2_SRC 238 241 PF00017 0.490
LIG_SH2_SRC 441 444 PF00017 0.364
LIG_SH2_STAT5 179 182 PF00017 0.500
LIG_SH2_STAT5 221 224 PF00017 0.361
LIG_SH2_STAT5 238 241 PF00017 0.505
LIG_SH2_STAT5 408 411 PF00017 0.497
LIG_SH3_3 113 119 PF00018 0.533
LIG_SH3_3 308 314 PF00018 0.638
LIG_SH3_3 349 355 PF00018 0.422
LIG_SH3_3 59 65 PF00018 0.412
LIG_Sin3_3 216 223 PF02671 0.441
LIG_SUMO_SIM_anti_2 428 434 PF11976 0.291
LIG_SUMO_SIM_par_1 82 87 PF11976 0.229
LIG_TRAF2_1 16 19 PF00917 0.617
LIG_UBA3_1 169 176 PF00899 0.572
LIG_WRC_WIRS_1 185 190 PF05994 0.288
LIG_WRC_WIRS_1 348 353 PF05994 0.356
LIG_WRC_WIRS_1 5 10 PF05994 0.509
LIG_WRC_WIRS_1 85 90 PF05994 0.204
MOD_CDC14_SPxK_1 265 268 PF00782 0.574
MOD_CDK_SPxK_1 262 268 PF00069 0.592
MOD_CK1_1 129 135 PF00069 0.356
MOD_CK1_1 198 204 PF00069 0.404
MOD_CK1_1 262 268 PF00069 0.700
MOD_CK2_1 13 19 PF00069 0.548
MOD_CK2_1 289 295 PF00069 0.714
MOD_GlcNHglycan 128 131 PF01048 0.321
MOD_GlcNHglycan 161 164 PF01048 0.474
MOD_GlcNHglycan 200 203 PF01048 0.592
MOD_GlcNHglycan 314 317 PF01048 0.484
MOD_GlcNHglycan 491 494 PF01048 0.486
MOD_GSK3_1 129 136 PF00069 0.390
MOD_GSK3_1 84 91 PF00069 0.288
MOD_GSK3_1 9 16 PF00069 0.579
MOD_N-GLC_1 71 76 PF02516 0.563
MOD_NEK2_1 126 131 PF00069 0.372
MOD_NEK2_1 184 189 PF00069 0.354
MOD_NEK2_1 196 201 PF00069 0.378
MOD_NEK2_1 222 227 PF00069 0.319
MOD_NEK2_1 259 264 PF00069 0.715
MOD_NEK2_1 271 276 PF00069 0.630
MOD_NEK2_1 347 352 PF00069 0.362
MOD_NEK2_1 393 398 PF00069 0.297
MOD_NEK2_1 399 404 PF00069 0.270
MOD_NEK2_1 84 89 PF00069 0.271
MOD_NEK2_1 9 14 PF00069 0.653
MOD_NEK2_2 4 9 PF00069 0.536
MOD_PIKK_1 283 289 PF00454 0.658
MOD_PIKK_1 323 329 PF00454 0.650
MOD_PIKK_1 71 77 PF00454 0.330
MOD_PKA_2 27 33 PF00069 0.605
MOD_PKA_2 375 381 PF00069 0.364
MOD_Plk_1 442 448 PF00069 0.352
MOD_Plk_1 71 77 PF00069 0.330
MOD_Plk_4 134 140 PF00069 0.343
MOD_Plk_4 178 184 PF00069 0.485
MOD_Plk_4 222 228 PF00069 0.324
MOD_Plk_4 347 353 PF00069 0.397
MOD_Plk_4 382 388 PF00069 0.287
MOD_Plk_4 399 405 PF00069 0.305
MOD_Plk_4 4 10 PF00069 0.558
MOD_Plk_4 415 421 PF00069 0.474
MOD_Plk_4 428 434 PF00069 0.293
MOD_Plk_4 79 85 PF00069 0.343
MOD_ProDKin_1 144 150 PF00069 0.286
MOD_ProDKin_1 262 268 PF00069 0.765
MOD_ProDKin_1 310 316 PF00069 0.681
MOD_ProDKin_1 410 416 PF00069 0.489
MOD_SUMO_for_1 477 480 PF00179 0.555
TRG_ENDOCYTIC_2 101 104 PF00928 0.417
TRG_ENDOCYTIC_2 121 124 PF00928 0.376
TRG_ENDOCYTIC_2 179 182 PF00928 0.482
TRG_ER_diArg_1 113 116 PF00400 0.529
TRG_NES_CRM1_1 346 357 PF08389 0.350

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4J6C9 Bodo saltans 24% 100%
A0A0S4J9G3 Bodo saltans 26% 100%
A0A0S4JFU7 Bodo saltans 26% 100%
A0A1X0NW47 Trypanosomatidae 48% 99%
A0A1X0P8U7 Trypanosomatidae 26% 99%
A0A3R7KUT2 Trypanosoma rangeli 48% 100%
A0A3S5H7D1 Leishmania donovani 92% 100%
A0A422NMM7 Trypanosoma rangeli 28% 97%
A4H3M6 Leishmania braziliensis 27% 67%
A4HDG5 Leishmania braziliensis 73% 89%
A4I0U6 Leishmania infantum 92% 100%
D0A268 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 96%
D0A775 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AWV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 98%
V5BAL2 Trypanosoma cruzi 52% 100%
V5C284 Trypanosoma cruzi 29% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS