Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAM1_LEIMA

TriTrypDb:

LmjF.24.1120 , LMJLV39_240017200 , LMJSD75_240016700

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.558
CLV_C14_Caspase3-7	42	46	PF00656	0.573
CLV_C14_Caspase3-7	491	495	PF00656	0.523
CLV_C14_Caspase3-7	630	634	PF00656	0.405
CLV_C14_Caspase3-7	865	869	PF00656	0.553
CLV_C14_Caspase3-7	908	912	PF00656	0.576
CLV_MEL_PAP_1	833	839	PF00089	0.645
CLV_NRD_NRD_1	215	217	PF00675	0.557
CLV_NRD_NRD_1	218	220	PF00675	0.538
CLV_NRD_NRD_1	372	374	PF00675	0.528
CLV_NRD_NRD_1	548	550	PF00675	0.700
CLV_NRD_NRD_1	673	675	PF00675	0.472
CLV_NRD_NRD_1	716	718	PF00675	0.503
CLV_NRD_NRD_1	777	779	PF00675	0.627
CLV_NRD_NRD_1	81	83	PF00675	0.643
CLV_NRD_NRD_1	845	847	PF00675	0.739
CLV_PCSK_FUR_1	216	220	PF00082	0.465
CLV_PCSK_KEX2_1	217	219	PF00082	0.549
CLV_PCSK_KEX2_1	372	374	PF00082	0.538
CLV_PCSK_KEX2_1	392	394	PF00082	0.503
CLV_PCSK_KEX2_1	419	421	PF00082	0.648
CLV_PCSK_KEX2_1	548	550	PF00082	0.700
CLV_PCSK_KEX2_1	645	647	PF00082	0.427
CLV_PCSK_KEX2_1	673	675	PF00082	0.468
CLV_PCSK_KEX2_1	718	720	PF00082	0.601
CLV_PCSK_KEX2_1	777	779	PF00082	0.627
CLV_PCSK_KEX2_1	81	83	PF00082	0.643
CLV_PCSK_KEX2_1	845	847	PF00082	0.693
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.503
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.573
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.648
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.427
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.601
CLV_PCSK_SKI1_1	336	340	PF00082	0.549
CLV_PCSK_SKI1_1	393	397	PF00082	0.636
CLV_PCSK_SKI1_1	451	455	PF00082	0.504
CLV_PCSK_SKI1_1	624	628	PF00082	0.427
CLV_PCSK_SKI1_1	99	103	PF00082	0.548
DEG_APCC_DBOX_1	218	226	PF00400	0.538
DEG_APCC_DBOX_1	431	439	PF00400	0.390
DEG_APCC_DBOX_1	450	458	PF00400	0.509
DEG_SCF_FBW7_1	464	471	PF00400	0.488
DEG_SCF_FBW7_1	584	590	PF00400	0.651
DOC_ANK_TNKS_1	233	240	PF00023	0.557
DOC_CKS1_1	273	278	PF01111	0.603
DOC_CKS1_1	584	589	PF01111	0.700
DOC_CKS1_1	69	74	PF01111	0.608
DOC_CYCLIN_RxL_1	448	456	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	353	359	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	812	815	PF00134	0.665
DOC_MAPK_gen_1	717	728	PF00069	0.564
DOC_MAPK_MEF2A_6	624	631	PF00069	0.556
DOC_PP1_RVXF_1	644	651	PF00149	0.393
DOC_PP2B_LxvP_1	186	189	PF13499	0.584
DOC_PP2B_LxvP_1	279	282	PF13499	0.583
DOC_PP2B_LxvP_1	309	312	PF13499	0.590
DOC_PP2B_LxvP_1	319	322	PF13499	0.555
DOC_PP2B_LxvP_1	812	815	PF13499	0.663
DOC_USP7_MATH_1	10	14	PF00917	0.660
DOC_USP7_MATH_1	164	168	PF00917	0.587
DOC_USP7_MATH_1	179	183	PF00917	0.533
DOC_USP7_MATH_1	237	241	PF00917	0.545
DOC_USP7_MATH_1	310	314	PF00917	0.531
DOC_USP7_MATH_1	397	401	PF00917	0.537
DOC_USP7_MATH_1	468	472	PF00917	0.523
DOC_USP7_MATH_1	49	53	PF00917	0.584
DOC_USP7_MATH_1	501	505	PF00917	0.524
DOC_USP7_MATH_1	533	537	PF00917	0.646
DOC_USP7_MATH_1	593	597	PF00917	0.733
DOC_USP7_MATH_1	730	734	PF00917	0.527
DOC_USP7_MATH_1	817	821	PF00917	0.708
DOC_USP7_UBL2_3	402	406	PF12436	0.664
DOC_USP7_UBL2_3	407	411	PF12436	0.640
DOC_USP7_UBL2_3	714	718	PF12436	0.500
DOC_WW_Pin1_4	104	109	PF00397	0.602
DOC_WW_Pin1_4	268	273	PF00397	0.646
DOC_WW_Pin1_4	3	8	PF00397	0.641
DOC_WW_Pin1_4	464	469	PF00397	0.543
DOC_WW_Pin1_4	580	585	PF00397	0.750
DOC_WW_Pin1_4	68	73	PF00397	0.588
DOC_WW_Pin1_4	731	736	PF00397	0.545
DOC_WW_Pin1_4	797	802	PF00397	0.646
DOC_WW_Pin1_4	813	818	PF00397	0.565
DOC_WW_Pin1_4	835	840	PF00397	0.608
DOC_WW_Pin1_4	855	860	PF00397	0.630
LIG_14-3-3_CanoR_1	372	376	PF00244	0.570
LIG_14-3-3_CanoR_1	41	47	PF00244	0.564
LIG_14-3-3_CanoR_1	432	436	PF00244	0.480
LIG_14-3-3_CanoR_1	742	750	PF00244	0.406
LIG_14-3-3_CanoR_1	789	796	PF00244	0.619
LIG_Actin_WH2_2	176	193	PF00022	0.567
LIG_AP2alpha_2	63	65	PF02296	0.544
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	455	459	PF00533	0.450
LIG_BRCT_BRCA1_1	61	65	PF00533	0.538
LIG_BRCT_BRCA1_1	697	701	PF00533	0.445
LIG_CaM_IQ_9	328	344	PF13499	0.571
LIG_CSL_BTD_1	768	771	PF09270	0.396
LIG_CtBP_PxDLS_1	76	80	PF00389	0.568
LIG_eIF4E_1	84	90	PF01652	0.502
LIG_FHA_1	149	155	PF00498	0.594
LIG_FHA_1	304	310	PF00498	0.541
LIG_FHA_1	431	437	PF00498	0.458
LIG_FHA_1	494	500	PF00498	0.593
LIG_FHA_1	504	510	PF00498	0.604
LIG_FHA_1	584	590	PF00498	0.700
LIG_FHA_1	642	648	PF00498	0.440
LIG_FHA_1	785	791	PF00498	0.525
LIG_FHA_1	808	814	PF00498	0.593
LIG_FHA_1	84	90	PF00498	0.520
LIG_FHA_2	704	710	PF00498	0.480
LIG_FHA_2	830	836	PF00498	0.647
LIG_FHA_2	906	912	PF00498	0.643
LIG_GBD_Chelix_1	242	250	PF00786	0.528
LIG_GBD_Chelix_1	475	483	PF00786	0.381
LIG_Integrin_isoDGR_2	775	777	PF01839	0.579
LIG_LIR_Gen_1	62	73	PF02991	0.525
LIG_LIR_Gen_1	651	658	PF02991	0.398
LIG_LIR_Gen_1	698	705	PF02991	0.382
LIG_LIR_Gen_1	747	755	PF02991	0.453
LIG_LIR_Nem_3	477	483	PF02991	0.484
LIG_LIR_Nem_3	62	68	PF02991	0.514
LIG_LIR_Nem_3	651	656	PF02991	0.388
LIG_LIR_Nem_3	698	704	PF02991	0.383
LIG_LIR_Nem_3	747	751	PF02991	0.464
LIG_LIR_Nem_3	87	93	PF02991	0.532
LIG_NRBOX	449	455	PF00104	0.498
LIG_NRBOX	634	640	PF00104	0.405
LIG_PCNA_yPIPBox_3	870	878	PF02747	0.611
LIG_Pex14_2	751	755	PF04695	0.361
LIG_Pex14_2	765	769	PF04695	0.386
LIG_PTAP_UEV_1	281	286	PF05743	0.566
LIG_Rb_LxCxE_1	433	448	PF01857	0.503
LIG_SH2_CRK	69	73	PF00017	0.552
LIG_SH2_NCK_1	69	73	PF00017	0.553
LIG_SH2_PTP2	187	190	PF00017	0.576
LIG_SH2_STAT5	187	190	PF00017	0.745
LIG_SH2_STAT5	231	234	PF00017	0.621
LIG_SH2_STAT5	663	666	PF00017	0.435
LIG_SH2_STAT5	712	715	PF00017	0.470
LIG_SH3_1	411	417	PF00018	0.625
LIG_SH3_2	282	287	PF14604	0.570
LIG_SH3_2	414	419	PF14604	0.663
LIG_SH3_3	1	7	PF00018	0.644
LIG_SH3_3	186	192	PF00018	0.622
LIG_SH3_3	279	285	PF00018	0.649
LIG_SH3_3	411	417	PF00018	0.717
LIG_SH3_3	581	587	PF00018	0.705
LIG_SH3_3	765	771	PF00018	0.451
LIG_SH3_3	811	817	PF00018	0.690
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.573
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.407
LIG_SUMO_SIM_anti_2	858	866	PF11976	0.630
LIG_SUMO_SIM_anti_2	893	902	PF11976	0.615
LIG_SUMO_SIM_par_1	496	504	PF11976	0.504
LIG_SUMO_SIM_par_1	625	630	PF11976	0.425
LIG_SUMO_SIM_par_1	654	659	PF11976	0.459
LIG_SxIP_EBH_1	729	742	PF03271	0.487
LIG_TRAF2_1	321	324	PF00917	0.607
LIG_TRAF2_1	682	685	PF00917	0.523
LIG_TRAF2_1	705	708	PF00917	0.403
LIG_TRAF2_2	192	197	PF00917	0.562
LIG_UBA3_1	479	485	PF00899	0.468
LIG_WRC_WIRS_1	199	204	PF05994	0.544
MOD_CDK_SPK_2	580	585	PF00069	0.717
MOD_CK1_1	148	154	PF00069	0.706
MOD_CK1_1	167	173	PF00069	0.452
MOD_CK1_1	201	207	PF00069	0.623
MOD_CK1_1	504	510	PF00069	0.636
MOD_CK1_1	538	544	PF00069	0.625
MOD_CK1_1	559	565	PF00069	0.739
MOD_CK1_1	576	582	PF00069	0.618
MOD_CK1_1	588	594	PF00069	0.685
MOD_CK1_1	641	647	PF00069	0.447
MOD_CK1_1	791	797	PF00069	0.569
MOD_CK1_1	816	822	PF00069	0.711
MOD_CK1_1	838	844	PF00069	0.661
MOD_CK1_1	905	911	PF00069	0.640
MOD_CK2_1	593	599	PF00069	0.694
MOD_CK2_1	678	684	PF00069	0.518
MOD_CK2_1	703	709	PF00069	0.546
MOD_CK2_1	855	861	PF00069	0.652
MOD_Cter_Amidation	404	407	PF01082	0.618
MOD_Cter_Amidation	775	778	PF01082	0.589
MOD_GlcNHglycan	168	172	PF01048	0.601
MOD_GlcNHglycan	18	21	PF01048	0.624
MOD_GlcNHglycan	260	263	PF01048	0.696
MOD_GlcNHglycan	300	303	PF01048	0.695
MOD_GlcNHglycan	490	493	PF01048	0.469
MOD_GlcNHglycan	520	523	PF01048	0.764
MOD_GlcNHglycan	679	683	PF01048	0.534
MOD_GlcNHglycan	804	807	PF01048	0.685
MOD_GlcNHglycan	819	822	PF01048	0.611
MOD_GlcNHglycan	904	907	PF01048	0.617
MOD_GSK3_1	197	204	PF00069	0.550
MOD_GSK3_1	268	275	PF00069	0.618
MOD_GSK3_1	286	293	PF00069	0.736
MOD_GSK3_1	298	305	PF00069	0.638
MOD_GSK3_1	393	400	PF00069	0.663
MOD_GSK3_1	460	467	PF00069	0.639
MOD_GSK3_1	484	491	PF00069	0.535
MOD_GSK3_1	533	540	PF00069	0.679
MOD_GSK3_1	576	583	PF00069	0.729
MOD_GSK3_1	588	595	PF00069	0.683
MOD_GSK3_1	736	743	PF00069	0.493
MOD_GSK3_1	784	791	PF00069	0.593
MOD_GSK3_1	813	820	PF00069	0.634
MOD_GSK3_1	893	900	PF00069	0.618
MOD_GSK3_1	905	912	PF00069	0.596
MOD_N-GLC_1	16	21	PF02516	0.604
MOD_N-GLC_1	518	523	PF02516	0.527
MOD_N-GLC_1	559	564	PF02516	0.797
MOD_N-GLC_1	855	860	PF02516	0.652
MOD_NEK2_1	158	163	PF00069	0.540
MOD_NEK2_1	382	387	PF00069	0.554
MOD_NEK2_1	431	436	PF00069	0.590
MOD_NEK2_1	453	458	PF00069	0.471
MOD_NEK2_1	525	530	PF00069	0.701
MOD_NEK2_1	537	542	PF00069	0.725
MOD_NEK2_1	556	561	PF00069	0.614
MOD_NEK2_1	564	569	PF00069	0.598
MOD_NEK2_1	573	578	PF00069	0.750
MOD_NEK2_1	67	72	PF00069	0.688
MOD_NEK2_1	741	746	PF00069	0.430
MOD_NEK2_1	862	867	PF00069	0.563
MOD_NEK2_2	784	789	PF00069	0.529
MOD_NEK2_2	85	90	PF00069	0.490
MOD_PIKK_1	10	16	PF00454	0.609
MOD_PIKK_1	201	207	PF00454	0.550
MOD_PIKK_1	326	332	PF00454	0.513
MOD_PIKK_1	664	670	PF00454	0.404
MOD_PIKK_1	838	844	PF00454	0.709
MOD_PKA_1	407	413	PF00069	0.690
MOD_PKA_1	777	783	PF00069	0.642
MOD_PKA_2	137	143	PF00069	0.660
MOD_PKA_2	286	292	PF00069	0.633
MOD_PKA_2	298	304	PF00069	0.665
MOD_PKA_2	371	377	PF00069	0.479
MOD_PKA_2	40	46	PF00069	0.541
MOD_PKA_2	431	437	PF00069	0.482
MOD_PKA_2	538	544	PF00069	0.669
MOD_PKA_2	741	747	PF00069	0.424
MOD_PKA_2	777	783	PF00069	0.642
MOD_PKA_2	788	794	PF00069	0.553
MOD_Plk_1	167	173	PF00069	0.550
MOD_Plk_1	559	565	PF00069	0.796
MOD_Plk_1	829	835	PF00069	0.644
MOD_Plk_4	179	185	PF00069	0.724
MOD_Plk_4	431	437	PF00069	0.602
MOD_Plk_4	50	56	PF00069	0.608
MOD_Plk_4	559	565	PF00069	0.790
MOD_Plk_4	736	742	PF00069	0.490
MOD_Plk_4	808	814	PF00069	0.640
MOD_Plk_4	85	91	PF00069	0.488
MOD_Plk_4	893	899	PF00069	0.561
MOD_ProDKin_1	104	110	PF00069	0.602
MOD_ProDKin_1	268	274	PF00069	0.647
MOD_ProDKin_1	3	9	PF00069	0.644
MOD_ProDKin_1	464	470	PF00069	0.542
MOD_ProDKin_1	580	586	PF00069	0.743
MOD_ProDKin_1	68	74	PF00069	0.587
MOD_ProDKin_1	731	737	PF00069	0.546
MOD_ProDKin_1	797	803	PF00069	0.641
MOD_ProDKin_1	813	819	PF00069	0.568
MOD_ProDKin_1	835	841	PF00069	0.607
MOD_ProDKin_1	855	861	PF00069	0.629
MOD_SUMO_for_1	418	421	PF00179	0.642
MOD_SUMO_rev_2	641	647	PF00179	0.447
TRG_DiLeu_BaEn_4	708	714	PF01217	0.420
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.590
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.405
TRG_ENDOCYTIC_2	187	190	PF00928	0.624
TRG_ENDOCYTIC_2	748	751	PF00928	0.583
TRG_ENDOCYTIC_2	92	95	PF00928	0.537
TRG_ENDOCYTIC_2	98	101	PF00928	0.507
TRG_ER_diArg_1	216	219	PF00400	0.545
TRG_ER_diArg_1	672	674	PF00400	0.531
TRG_ER_diArg_1	845	847	PF00400	0.691
TRG_NLS_Bipartite_1	392	412	PF00514	0.587
TRG_NLS_MonoCore_2	405	410	PF00514	0.628
TRG_NLS_MonoCore_2	716	721	PF00514	0.593
TRG_NLS_MonoExtC_3	406	411	PF00514	0.634
TRG_NLS_MonoExtC_3	716	721	PF00514	0.517
TRG_NLS_MonoExtN_4	406	412	PF00514	0.604
TRG_NLS_MonoExtN_4	714	721	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	875	880	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX7	Leptomonas seymouri	39%	97%
A0A3Q8ICV2	Leishmania donovani	85%	99%
A4HDG8	Leishmania braziliensis	66%	96%
A4I0U9	Leishmania infantum	88%	100%
E9AWV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%