Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAM0_LEIMA

TriTrypDb:

LmjF.24.1125 , LMJLV39_240017300 , LMJSD75_240016800

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.385
CLV_C14_Caspase3-7	3	7	PF00656	0.768
CLV_C14_Caspase3-7	324	328	PF00656	0.616
CLV_C14_Caspase3-7	691	695	PF00656	0.455
CLV_NRD_NRD_1	191	193	PF00675	0.557
CLV_NRD_NRD_1	198	200	PF00675	0.520
CLV_NRD_NRD_1	219	221	PF00675	0.546
CLV_NRD_NRD_1	293	295	PF00675	0.787
CLV_NRD_NRD_1	296	298	PF00675	0.770
CLV_NRD_NRD_1	311	313	PF00675	0.703
CLV_NRD_NRD_1	425	427	PF00675	0.686
CLV_NRD_NRD_1	57	59	PF00675	0.574
CLV_NRD_NRD_1	67	69	PF00675	0.553
CLV_PCSK_FUR_1	294	298	PF00082	0.721
CLV_PCSK_KEX2_1	191	193	PF00082	0.557
CLV_PCSK_KEX2_1	198	200	PF00082	0.520
CLV_PCSK_KEX2_1	292	294	PF00082	0.790
CLV_PCSK_KEX2_1	296	298	PF00082	0.762
CLV_PCSK_KEX2_1	311	313	PF00082	0.708
CLV_PCSK_KEX2_1	424	426	PF00082	0.678
CLV_PCSK_KEX2_1	57	59	PF00082	0.574
CLV_PCSK_KEX2_1	67	69	PF00082	0.553
CLV_PCSK_KEX2_1	727	729	PF00082	0.693
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.693
CLV_PCSK_PC7_1	194	200	PF00082	0.466
CLV_PCSK_PC7_1	292	298	PF00082	0.698
CLV_PCSK_PC7_1	63	69	PF00082	0.550
CLV_PCSK_SKI1_1	194	198	PF00082	0.471
CLV_PCSK_SKI1_1	570	574	PF00082	0.667
DEG_SCF_FBW7_1	732	738	PF00400	0.460
DOC_CKS1_1	369	374	PF01111	0.524
DOC_CKS1_1	732	737	PF01111	0.460
DOC_CKS1_1	99	104	PF01111	0.752
DOC_CYCLIN_yCln2_LP_2	787	793	PF00134	0.711
DOC_MAPK_gen_1	389	396	PF00069	0.551
DOC_MAPK_gen_1	473	480	PF00069	0.507
DOC_MAPK_MEF2A_6	786	795	PF00069	0.714
DOC_PP4_FxxP_1	350	353	PF00568	0.530
DOC_USP7_MATH_1	158	162	PF00917	0.823
DOC_USP7_MATH_1	180	184	PF00917	0.771
DOC_USP7_MATH_1	187	191	PF00917	0.708
DOC_USP7_MATH_1	418	422	PF00917	0.550
DOC_USP7_MATH_1	575	579	PF00917	0.458
DOC_USP7_MATH_1	636	640	PF00917	0.464
DOC_USP7_MATH_1	735	739	PF00917	0.495
DOC_USP7_MATH_2	308	314	PF00917	0.517
DOC_WW_Pin1_4	19	24	PF00397	0.769
DOC_WW_Pin1_4	278	283	PF00397	0.606
DOC_WW_Pin1_4	28	33	PF00397	0.724
DOC_WW_Pin1_4	286	291	PF00397	0.583
DOC_WW_Pin1_4	368	373	PF00397	0.544
DOC_WW_Pin1_4	384	389	PF00397	0.579
DOC_WW_Pin1_4	396	401	PF00397	0.457
DOC_WW_Pin1_4	432	437	PF00397	0.529
DOC_WW_Pin1_4	515	520	PF00397	0.578
DOC_WW_Pin1_4	581	586	PF00397	0.522
DOC_WW_Pin1_4	731	736	PF00397	0.491
DOC_WW_Pin1_4	742	747	PF00397	0.460
DOC_WW_Pin1_4	95	100	PF00397	0.703
LIG_14-3-3_CanoR_1	160	168	PF00244	0.692
LIG_14-3-3_CanoR_1	208	217	PF00244	0.696
LIG_14-3-3_CanoR_1	220	224	PF00244	0.694
LIG_14-3-3_CanoR_1	311	321	PF00244	0.491
LIG_14-3-3_CanoR_1	559	565	PF00244	0.510
LIG_14-3-3_CanoR_1	94	99	PF00244	0.744
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_BRCT_BRCA1_1	749	753	PF00533	0.484
LIG_FHA_1	174	180	PF00498	0.720
LIG_FHA_1	700	706	PF00498	0.424
LIG_FHA_2	129	135	PF00498	0.721
LIG_FHA_2	160	166	PF00498	0.748
LIG_FHA_2	268	274	PF00498	0.424
LIG_FHA_2	385	391	PF00498	0.576
LIG_FHA_2	689	695	PF00498	0.462
LIG_Integrin_RGD_1	271	273	PF01839	0.332
LIG_LIR_Apic_2	276	282	PF02991	0.549
LIG_LIR_Gen_1	399	408	PF02991	0.522
LIG_LIR_Gen_1	598	607	PF02991	0.519
LIG_LIR_Nem_3	245	251	PF02991	0.691
LIG_LIR_Nem_3	399	404	PF02991	0.528
LIG_LIR_Nem_3	506	511	PF02991	0.524
LIG_LIR_Nem_3	598	604	PF02991	0.518
LIG_LIR_Nem_3	750	755	PF02991	0.494
LIG_LIR_Nem_3	87	92	PF02991	0.779
LIG_LYPXL_yS_3	789	792	PF13949	0.715
LIG_MYND_1	23	27	PF01753	0.764
LIG_MYND_1	282	286	PF01753	0.552
LIG_PTB_Apo_2	600	607	PF02174	0.486
LIG_SH2_CRK	248	252	PF00017	0.699
LIG_SH2_CRK	279	283	PF00017	0.553
LIG_SH2_CRK	601	605	PF00017	0.521
LIG_SH2_CRK	607	611	PF00017	0.476
LIG_SH2_CRK	685	689	PF00017	0.495
LIG_SH2_GRB2like	601	604	PF00017	0.488
LIG_SH2_NCK_1	601	605	PF00017	0.487
LIG_SH2_SRC	19	22	PF00017	0.667
LIG_SH2_SRC	515	518	PF00017	0.510
LIG_SH2_STAP1	413	417	PF00017	0.425
LIG_SH2_STAP1	701	705	PF00017	0.426
LIG_SH2_STAT5	19	22	PF00017	0.667
LIG_SH2_STAT5	241	244	PF00017	0.675
LIG_SH2_STAT5	255	258	PF00017	0.559
LIG_SH2_STAT5	401	404	PF00017	0.534
LIG_SH2_STAT5	487	490	PF00017	0.510
LIG_SH2_STAT5	509	512	PF00017	0.523
LIG_SH2_STAT5	515	518	PF00017	0.461
LIG_SH2_STAT5	646	649	PF00017	0.509
LIG_SH2_STAT5	701	704	PF00017	0.456
LIG_SH3_1	279	285	PF00018	0.579
LIG_SH3_1	359	365	PF00018	0.561
LIG_SH3_1	67	73	PF00018	0.786
LIG_SH3_2	282	287	PF14604	0.571
LIG_SH3_2	288	293	PF14604	0.505
LIG_SH3_2	372	377	PF14604	0.550
LIG_SH3_3	248	254	PF00018	0.686
LIG_SH3_3	26	32	PF00018	0.768
LIG_SH3_3	279	285	PF00018	0.572
LIG_SH3_3	298	304	PF00018	0.573
LIG_SH3_3	357	363	PF00018	0.626
LIG_SH3_3	366	372	PF00018	0.586
LIG_SH3_3	579	585	PF00018	0.522
LIG_SH3_3	67	73	PF00018	0.872
LIG_SH3_3	790	796	PF00018	0.714
LIG_SH3_3	96	102	PF00018	0.746
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.550
LIG_SUMO_SIM_anti_2	392	397	PF11976	0.484
LIG_SUMO_SIM_par_1	789	794	PF11976	0.679
LIG_TRFH_1	685	689	PF08558	0.588
LIG_TYR_ITIM	787	792	PF00017	0.640
LIG_WW_3	284	288	PF00397	0.729
LIG_WW_3	289	293	PF00397	0.655
MOD_CDC14_SPxK_1	289	292	PF00782	0.687
MOD_CDK_SPK_2	278	283	PF00069	0.693
MOD_CDK_SPK_2	384	389	PF00069	0.682
MOD_CDK_SPK_2	95	100	PF00069	0.602
MOD_CDK_SPxK_1	286	292	PF00069	0.688
MOD_CDK_SPxxK_3	286	293	PF00069	0.689
MOD_CDK_SPxxK_3	384	391	PF00069	0.678
MOD_CK1_1	153	159	PF00069	0.828
MOD_CK1_1	183	189	PF00069	0.684
MOD_CK1_1	219	225	PF00069	0.550
MOD_CK1_1	313	319	PF00069	0.720
MOD_CK1_1	33	39	PF00069	0.670
MOD_CK1_1	330	336	PF00069	0.567
MOD_CK1_1	340	346	PF00069	0.654
MOD_CK1_1	432	438	PF00069	0.701
MOD_CK1_1	584	590	PF00069	0.589
MOD_CK1_1	624	630	PF00069	0.629
MOD_CK1_1	731	737	PF00069	0.572
MOD_CK1_1	745	751	PF00069	0.579
MOD_CK1_1	98	104	PF00069	0.668
MOD_CK2_1	128	134	PF00069	0.653
MOD_CK2_1	159	165	PF00069	0.685
MOD_CK2_1	33	39	PF00069	0.753
MOD_CK2_1	384	390	PF00069	0.737
MOD_GlcNHglycan	107	110	PF01048	0.693
MOD_GlcNHglycan	125	128	PF01048	0.583
MOD_GlcNHglycan	165	171	PF01048	0.739
MOD_GlcNHglycan	185	188	PF01048	0.524
MOD_GlcNHglycan	210	213	PF01048	0.645
MOD_GlcNHglycan	315	318	PF01048	0.670
MOD_GlcNHglycan	329	332	PF01048	0.565
MOD_GlcNHglycan	455	458	PF01048	0.524
MOD_GlcNHglycan	612	615	PF01048	0.607
MOD_GlcNHglycan	619	622	PF01048	0.586
MOD_GlcNHglycan	721	724	PF01048	0.633
MOD_GSK3_1	183	190	PF00069	0.699
MOD_GSK3_1	19	26	PF00069	0.812
MOD_GSK3_1	243	250	PF00069	0.665
MOD_GSK3_1	274	281	PF00069	0.675
MOD_GSK3_1	311	318	PF00069	0.785
MOD_GSK3_1	396	403	PF00069	0.705
MOD_GSK3_1	533	540	PF00069	0.719
MOD_GSK3_1	606	613	PF00069	0.618
MOD_GSK3_1	617	624	PF00069	0.571
MOD_GSK3_1	706	713	PF00069	0.590
MOD_GSK3_1	731	738	PF00069	0.594
MOD_GSK3_1	94	101	PF00069	0.684
MOD_LATS_1	309	315	PF00433	0.691
MOD_N-GLC_1	4	9	PF02516	0.672
MOD_NEK2_1	242	247	PF00069	0.580
MOD_NEK2_1	507	512	PF00069	0.651
MOD_NEK2_1	533	538	PF00069	0.595
MOD_NEK2_1	606	611	PF00069	0.579
MOD_NEK2_1	753	758	PF00069	0.402
MOD_NEK2_2	180	185	PF00069	0.672
MOD_NEK2_2	274	279	PF00069	0.687
MOD_OFUCOSY	629	635	PF10250	0.597
MOD_OFUCOSY	661	668	PF10250	0.488
MOD_OFUCOSY	703	710	PF10250	0.523
MOD_PIKK_1	173	179	PF00454	0.672
MOD_PIKK_1	337	343	PF00454	0.737
MOD_PIKK_1	537	543	PF00454	0.673
MOD_PK_1	389	395	PF00069	0.564
MOD_PK_1	728	734	PF00069	0.513
MOD_PKA_1	311	317	PF00069	0.686
MOD_PKA_2	150	156	PF00069	0.770
MOD_PKA_2	159	165	PF00069	0.656
MOD_PKA_2	219	225	PF00069	0.638
MOD_PKA_2	267	273	PF00069	0.414
MOD_PKA_2	295	301	PF00069	0.736
MOD_PKA_2	310	316	PF00069	0.603
MOD_PKA_2	42	48	PF00069	0.593
MOD_PKA_2	558	564	PF00069	0.634
MOD_PKA_2	610	616	PF00069	0.614
MOD_Plk_1	243	249	PF00069	0.621
MOD_Plk_1	274	280	PF00069	0.688
MOD_Plk_1	389	395	PF00069	0.564
MOD_Plk_2-3	118	124	PF00069	0.692
MOD_Plk_4	243	249	PF00069	0.604
MOD_Plk_4	274	280	PF00069	0.688
MOD_Plk_4	30	36	PF00069	0.580
MOD_Plk_4	389	395	PF00069	0.564
MOD_Plk_4	584	590	PF00069	0.679
MOD_ProDKin_1	19	25	PF00069	0.718
MOD_ProDKin_1	278	284	PF00069	0.769
MOD_ProDKin_1	28	34	PF00069	0.657
MOD_ProDKin_1	286	292	PF00069	0.738
MOD_ProDKin_1	368	374	PF00069	0.681
MOD_ProDKin_1	384	390	PF00069	0.728
MOD_ProDKin_1	396	402	PF00069	0.560
MOD_ProDKin_1	432	438	PF00069	0.656
MOD_ProDKin_1	515	521	PF00069	0.729
MOD_ProDKin_1	581	587	PF00069	0.651
MOD_ProDKin_1	731	737	PF00069	0.607
MOD_ProDKin_1	742	748	PF00069	0.561
MOD_ProDKin_1	95	101	PF00069	0.625
MOD_SUMO_for_1	336	339	PF00179	0.660
TRG_DiLeu_BaEn_1	474	479	PF01217	0.625
TRG_DiLeu_BaLyEn_6	675	680	PF01217	0.556
TRG_ENDOCYTIC_2	248	251	PF00928	0.618
TRG_ENDOCYTIC_2	401	404	PF00928	0.667
TRG_ENDOCYTIC_2	508	511	PF00928	0.658
TRG_ENDOCYTIC_2	601	604	PF00928	0.700
TRG_ENDOCYTIC_2	607	610	PF00928	0.600
TRG_ENDOCYTIC_2	685	688	PF00928	0.612
TRG_ENDOCYTIC_2	789	792	PF00928	0.640
TRG_ER_diArg_1	140	143	PF00400	0.639
TRG_ER_diArg_1	191	194	PF00400	0.707
TRG_ER_diArg_1	197	199	PF00400	0.667
TRG_ER_diArg_1	291	294	PF00400	0.742
TRG_ER_diArg_1	424	426	PF00400	0.591
TRG_ER_diArg_1	483	486	PF00400	0.580
TRG_ER_diArg_1	57	59	PF00400	0.723
TRG_ER_diArg_1	67	69	PF00400	0.694
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICW0	Leishmania donovani	89%	100%
A4HDG9	Leishmania braziliensis	64%	96%
A4I0V0	Leishmania infantum	90%	100%
E9AWV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%