Actin-interacting protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-interacting protein-like protein

Species:

Leishmania major

UniProt:

Q4QAL9_LEIMA

TriTrypDb:

LmjF.24.1130 , LMJLV39_240017400 , LMJSD75_240016900

Length:

986

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.625
CLV_C14_Caspase3-7	181	185	PF00656	0.574
CLV_C14_Caspase3-7	241	245	PF00656	0.408
CLV_C14_Caspase3-7	588	592	PF00656	0.670
CLV_C14_Caspase3-7	719	723	PF00656	0.544
CLV_NRD_NRD_1	171	173	PF00675	0.600
CLV_NRD_NRD_1	20	22	PF00675	0.476
CLV_NRD_NRD_1	203	205	PF00675	0.463
CLV_NRD_NRD_1	230	232	PF00675	0.461
CLV_NRD_NRD_1	27	29	PF00675	0.367
CLV_NRD_NRD_1	396	398	PF00675	0.461
CLV_NRD_NRD_1	415	417	PF00675	0.458
CLV_NRD_NRD_1	475	477	PF00675	0.473
CLV_NRD_NRD_1	56	58	PF00675	0.430
CLV_NRD_NRD_1	618	620	PF00675	0.495
CLV_NRD_NRD_1	731	733	PF00675	0.525
CLV_NRD_NRD_1	75	77	PF00675	0.532
CLV_NRD_NRD_1	778	780	PF00675	0.662
CLV_NRD_NRD_1	781	783	PF00675	0.685
CLV_NRD_NRD_1	965	967	PF00675	0.658
CLV_PCSK_FUR_1	779	783	PF00082	0.494
CLV_PCSK_FUR_1	962	966	PF00082	0.591
CLV_PCSK_KEX2_1	170	172	PF00082	0.621
CLV_PCSK_KEX2_1	203	205	PF00082	0.463
CLV_PCSK_KEX2_1	230	232	PF00082	0.461
CLV_PCSK_KEX2_1	396	398	PF00082	0.461
CLV_PCSK_KEX2_1	415	417	PF00082	0.458
CLV_PCSK_KEX2_1	475	477	PF00082	0.473
CLV_PCSK_KEX2_1	618	620	PF00082	0.495
CLV_PCSK_KEX2_1	75	77	PF00082	0.532
CLV_PCSK_KEX2_1	778	780	PF00082	0.654
CLV_PCSK_KEX2_1	781	783	PF00082	0.681
CLV_PCSK_KEX2_1	964	966	PF00082	0.666
CLV_PCSK_SKI1_1	243	247	PF00082	0.633
CLV_PCSK_SKI1_1	8	12	PF00082	0.540
CLV_Separin_Metazoa	485	489	PF03568	0.530
DEG_APCC_DBOX_1	27	35	PF00400	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DEG_SIAH_1	758	766	PF03145	0.656
DEG_SPOP_SBC_1	304	308	PF00917	0.547
DOC_CKS1_1	68	73	PF01111	0.641
DOC_CKS1_1	958	963	PF01111	0.656
DOC_MAPK_gen_1	509	517	PF00069	0.459
DOC_PP1_RVXF_1	887	894	PF00149	0.523
DOC_USP7_MATH_1	137	141	PF00917	0.568
DOC_USP7_MATH_1	175	179	PF00917	0.684
DOC_USP7_MATH_1	182	186	PF00917	0.575
DOC_USP7_MATH_1	262	266	PF00917	0.443
DOC_USP7_MATH_1	280	284	PF00917	0.366
DOC_USP7_MATH_1	370	374	PF00917	0.669
DOC_USP7_MATH_1	579	583	PF00917	0.601
DOC_USP7_MATH_1	692	696	PF00917	0.590
DOC_USP7_MATH_1	809	813	PF00917	0.556
DOC_USP7_MATH_1	831	835	PF00917	0.592
DOC_USP7_MATH_1	837	841	PF00917	0.562
DOC_USP7_MATH_1	876	880	PF00917	0.605
DOC_USP7_UBL2_3	729	733	PF12436	0.443
DOC_WW_Pin1_4	149	154	PF00397	0.700
DOC_WW_Pin1_4	300	305	PF00397	0.649
DOC_WW_Pin1_4	577	582	PF00397	0.614
DOC_WW_Pin1_4	664	669	PF00397	0.639
DOC_WW_Pin1_4	67	72	PF00397	0.628
DOC_WW_Pin1_4	751	756	PF00397	0.574
DOC_WW_Pin1_4	842	847	PF00397	0.574
DOC_WW_Pin1_4	883	888	PF00397	0.663
DOC_WW_Pin1_4	904	909	PF00397	0.635
DOC_WW_Pin1_4	915	920	PF00397	0.636
DOC_WW_Pin1_4	924	929	PF00397	0.658
DOC_WW_Pin1_4	957	962	PF00397	0.618
LIG_14-3-3_CanoR_1	222	226	PF00244	0.475
LIG_14-3-3_CanoR_1	28	32	PF00244	0.463
LIG_14-3-3_CanoR_1	346	354	PF00244	0.487
LIG_14-3-3_CanoR_1	440	449	PF00244	0.547
LIG_14-3-3_CanoR_1	475	484	PF00244	0.462
LIG_14-3-3_CanoR_1	611	617	PF00244	0.436
LIG_14-3-3_CanoR_1	781	789	PF00244	0.472
LIG_14-3-3_CanoR_1	8	14	PF00244	0.467
LIG_14-3-3_CanoR_1	810	818	PF00244	0.656
LIG_14-3-3_CanoR_1	857	864	PF00244	0.663
LIG_APCC_ABBA_1	403	408	PF00400	0.452
LIG_APCC_ABBAyCdc20_2	764	770	PF00400	0.576
LIG_BIR_III_2	670	674	PF00653	0.636
LIG_BIR_III_4	591	595	PF00653	0.645
LIG_eIF4E_1	549	555	PF01652	0.543
LIG_FHA_1	116	122	PF00498	0.647
LIG_FHA_1	28	34	PF00498	0.539
LIG_FHA_1	285	291	PF00498	0.601
LIG_FHA_1	305	311	PF00498	0.488
LIG_FHA_1	481	487	PF00498	0.492
LIG_FHA_1	854	860	PF00498	0.625
LIG_FHA_2	109	115	PF00498	0.622
LIG_FHA_2	123	129	PF00498	0.705
LIG_FHA_2	239	245	PF00498	0.481
LIG_FHA_2	249	255	PF00498	0.437
LIG_FHA_2	480	486	PF00498	0.473
LIG_FHA_2	588	594	PF00498	0.591
LIG_FHA_2	717	723	PF00498	0.508
LIG_FHA_2	748	754	PF00498	0.650
LIG_FHA_2	942	948	PF00498	0.607
LIG_LYPXL_yS_3	977	980	PF13949	0.592
LIG_MYND_1	833	837	PF01753	0.614
LIG_MYND_1	919	923	PF01753	0.672
LIG_PTAP_UEV_1	755	760	PF05743	0.650
LIG_PTAP_UEV_1	912	917	PF05743	0.632
LIG_SH2_PTP2	606	609	PF00017	0.477
LIG_SH2_STAT5	388	391	PF00017	0.539
LIG_SH2_STAT5	549	552	PF00017	0.468
LIG_SH2_STAT5	606	609	PF00017	0.477
LIG_SH3_1	658	664	PF00018	0.591
LIG_SH3_1	843	849	PF00018	0.549
LIG_SH3_1	955	961	PF00018	0.664
LIG_SH3_2	653	658	PF14604	0.754
LIG_SH3_3	147	153	PF00018	0.546
LIG_SH3_3	364	370	PF00018	0.676
LIG_SH3_3	573	579	PF00018	0.633
LIG_SH3_3	650	656	PF00018	0.788
LIG_SH3_3	658	664	PF00018	0.746
LIG_SH3_3	753	759	PF00018	0.653
LIG_SH3_3	817	823	PF00018	0.762
LIG_SH3_3	843	849	PF00018	0.572
LIG_SH3_3	910	916	PF00018	0.674
LIG_SH3_3	920	926	PF00018	0.639
LIG_SH3_3	955	961	PF00018	0.704
LIG_SH3_3	972	978	PF00018	0.499
LIG_SUMO_SIM_anti_2	30	37	PF11976	0.656
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.530
LIG_SUMO_SIM_anti_2	722	728	PF11976	0.539
LIG_TRAF2_1	251	254	PF00917	0.456
LIG_TRAF2_1	317	320	PF00917	0.583
LIG_TRAF2_1	535	538	PF00917	0.464
LIG_TYR_ITIM	975	980	PF00017	0.591
LIG_WRC_WIRS_1	700	705	PF05994	0.412
LIG_WW_1	973	976	PF00397	0.663
LIG_WW_3	886	890	PF00397	0.510
MOD_CDC14_SPxK_1	72	75	PF00782	0.525
MOD_CDC14_SPxK_1	845	848	PF00782	0.550
MOD_CDC14_SPxK_1	886	889	PF00782	0.508
MOD_CDK_SPK_2	924	929	PF00069	0.703
MOD_CDK_SPK_2	957	962	PF00069	0.575
MOD_CDK_SPxK_1	69	75	PF00069	0.513
MOD_CDK_SPxK_1	842	848	PF00069	0.550
MOD_CDK_SPxK_1	883	889	PF00069	0.520
MOD_CDK_SPxxK_3	577	584	PF00069	0.556
MOD_CDK_SPxxK_3	69	76	PF00069	0.632
MOD_CDK_SPxxK_3	957	964	PF00069	0.660
MOD_CK1_1	152	158	PF00069	0.637
MOD_CK1_1	178	184	PF00069	0.672
MOD_CK1_1	27	33	PF00069	0.460
MOD_CK1_1	283	289	PF00069	0.487
MOD_CK1_1	303	309	PF00069	0.490
MOD_CK1_1	580	586	PF00069	0.710
MOD_CK1_1	640	646	PF00069	0.657
MOD_CK1_1	672	678	PF00069	0.757
MOD_CK1_1	757	763	PF00069	0.710
MOD_CK1_1	911	917	PF00069	0.627
MOD_CK1_1	924	930	PF00069	0.652
MOD_CK2_1	122	128	PF00069	0.731
MOD_CK2_1	248	254	PF00069	0.455
MOD_CK2_1	262	268	PF00069	0.449
MOD_CK2_1	303	309	PF00069	0.550
MOD_CK2_1	479	485	PF00069	0.474
MOD_CK2_1	587	593	PF00069	0.616
MOD_CK2_1	672	678	PF00069	0.577
MOD_CK2_1	699	705	PF00069	0.518
MOD_CK2_1	747	753	PF00069	0.639
MOD_CK2_1	87	93	PF00069	0.632
MOD_CK2_1	9	15	PF00069	0.473
MOD_CK2_1	924	930	PF00069	0.727
MOD_CK2_1	941	947	PF00069	0.558
MOD_DYRK1A_RPxSP_1	751	755	PF00069	0.560
MOD_GlcNHglycan	139	142	PF01048	0.666
MOD_GlcNHglycan	145	148	PF01048	0.611
MOD_GlcNHglycan	166	169	PF01048	0.626
MOD_GlcNHglycan	177	180	PF01048	0.585
MOD_GlcNHglycan	257	260	PF01048	0.430
MOD_GlcNHglycan	264	267	PF01048	0.423
MOD_GlcNHglycan	569	572	PF01048	0.624
MOD_GlcNHglycan	587	590	PF01048	0.579
MOD_GlcNHglycan	674	677	PF01048	0.593
MOD_GlcNHglycan	690	693	PF01048	0.373
MOD_GlcNHglycan	756	759	PF01048	0.664
MOD_GlcNHglycan	79	82	PF01048	0.620
MOD_GlcNHglycan	811	814	PF01048	0.684
MOD_GlcNHglycan	839	842	PF01048	0.654
MOD_GlcNHglycan	859	862	PF01048	0.518
MOD_GlcNHglycan	87	90	PF01048	0.694
MOD_GlcNHglycan	877	881	PF01048	0.485
MOD_GlcNHglycan	913	916	PF01048	0.768
MOD_GlcNHglycan	947	950	PF01048	0.821
MOD_GSK3_1	149	156	PF00069	0.653
MOD_GSK3_1	178	185	PF00069	0.593
MOD_GSK3_1	234	241	PF00069	0.403
MOD_GSK3_1	280	287	PF00069	0.499
MOD_GSK3_1	292	299	PF00069	0.547
MOD_GSK3_1	300	307	PF00069	0.710
MOD_GSK3_1	475	482	PF00069	0.473
MOD_GSK3_1	688	695	PF00069	0.535
MOD_GSK3_1	747	754	PF00069	0.578
MOD_GSK3_1	788	795	PF00069	0.535
MOD_GSK3_1	809	816	PF00069	0.684
MOD_GSK3_1	849	856	PF00069	0.589
MOD_GSK3_1	883	890	PF00069	0.603
MOD_GSK3_1	900	907	PF00069	0.560
MOD_GSK3_1	911	918	PF00069	0.626
MOD_GSK3_1	924	931	PF00069	0.664
MOD_GSK3_1	941	948	PF00069	0.607
MOD_N-GLC_1	143	148	PF02516	0.651
MOD_N-GLC_1	612	617	PF02516	0.401
MOD_N-GLC_1	716	721	PF02516	0.554
MOD_NEK2_1	232	237	PF00069	0.628
MOD_NEK2_1	24	29	PF00069	0.488
MOD_NEK2_1	328	333	PF00069	0.541
MOD_NEK2_1	567	572	PF00069	0.583
MOD_NEK2_1	699	704	PF00069	0.481
MOD_NEK2_2	153	158	PF00069	0.585
MOD_OFUCOSY	780	785	PF10250	0.480
MOD_PIKK_1	238	244	PF00454	0.408
MOD_PIKK_1	280	286	PF00454	0.477
MOD_PIKK_1	345	351	PF00454	0.474
MOD_PIKK_1	486	492	PF00454	0.525
MOD_PIKK_1	645	651	PF00454	0.722
MOD_PIKK_1	692	698	PF00454	0.475
MOD_PIKK_1	773	779	PF00454	0.773
MOD_PIKK_1	921	927	PF00454	0.724
MOD_PIKK_1	928	934	PF00454	0.665
MOD_PIKK_1	939	945	PF00454	0.544
MOD_PKA_1	203	209	PF00069	0.461
MOD_PKA_1	475	481	PF00069	0.466
MOD_PKA_1	781	787	PF00069	0.475
MOD_PKA_2	182	188	PF00069	0.518
MOD_PKA_2	203	209	PF00069	0.461
MOD_PKA_2	221	227	PF00069	0.447
MOD_PKA_2	27	33	PF00069	0.460
MOD_PKA_2	345	351	PF00069	0.474
MOD_PKA_2	474	480	PF00069	0.470
MOD_PKA_2	747	753	PF00069	0.659
MOD_PKA_2	781	787	PF00069	0.507
MOD_PKA_2	809	815	PF00069	0.649
MOD_PKA_2	928	934	PF00069	0.712
MOD_PKB_1	779	787	PF00069	0.604
MOD_PKB_1	794	802	PF00069	0.519
MOD_PKB_1	83	91	PF00069	0.536
MOD_Plk_1	513	519	PF00069	0.438
MOD_Plk_1	612	618	PF00069	0.404
MOD_Plk_1	716	722	PF00069	0.552
MOD_Plk_2-3	716	722	PF00069	0.552
MOD_Plk_4	900	906	PF00069	0.574
MOD_Plk_4	967	973	PF00069	0.608
MOD_Plk_4	976	982	PF00069	0.592
MOD_ProDKin_1	149	155	PF00069	0.699
MOD_ProDKin_1	300	306	PF00069	0.649
MOD_ProDKin_1	577	583	PF00069	0.615
MOD_ProDKin_1	664	670	PF00069	0.642
MOD_ProDKin_1	67	73	PF00069	0.633
MOD_ProDKin_1	751	757	PF00069	0.578
MOD_ProDKin_1	842	848	PF00069	0.576
MOD_ProDKin_1	883	889	PF00069	0.665
MOD_ProDKin_1	904	910	PF00069	0.637
MOD_ProDKin_1	915	921	PF00069	0.640
MOD_ProDKin_1	924	930	PF00069	0.658
MOD_ProDKin_1	957	963	PF00069	0.617
MOD_SUMO_for_1	274	277	PF00179	0.418
MOD_SUMO_for_1	527	530	PF00179	0.467
MOD_SUMO_rev_2	235	241	PF00179	0.550
MOD_SUMO_rev_2	757	765	PF00179	0.658
TRG_DiLeu_BaEn_1	709	714	PF01217	0.561
TRG_DiLeu_BaEn_2	14	20	PF01217	0.439
TRG_DiLeu_BaEn_4	15	21	PF01217	0.437
TRG_DiLeu_BaEn_4	408	414	PF01217	0.454
TRG_DiLeu_BaLyEn_6	905	910	PF01217	0.565
TRG_ENDOCYTIC_2	2	5	PF00928	0.492
TRG_ENDOCYTIC_2	606	609	PF00928	0.477
TRG_ENDOCYTIC_2	977	980	PF00928	0.592
TRG_ER_diArg_1	170	172	PF00400	0.597
TRG_ER_diArg_1	229	231	PF00400	0.488
TRG_ER_diArg_1	395	397	PF00400	0.458
TRG_ER_diArg_1	415	417	PF00400	0.328
TRG_ER_diArg_1	474	476	PF00400	0.482
TRG_ER_diArg_1	508	511	PF00400	0.451
TRG_ER_diArg_1	618	620	PF00400	0.495
TRG_ER_diArg_1	75	77	PF00400	0.544
TRG_ER_diArg_1	778	781	PF00400	0.629
TRG_ER_diArg_1	793	796	PF00400	0.501
TRG_ER_diArg_1	83	86	PF00400	0.499
TRG_ER_diArg_1	961	964	PF00400	0.654
TRG_ER_diArg_1	965	967	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P545	Leptomonas seymouri	43%	89%
A0A3Q8IBC2	Leishmania donovani	90%	100%
A4HDH0	Leishmania braziliensis	69%	97%
A4I0V1	Leishmania infantum	89%	100%
E9AWV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%