Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAL5_LEIMA

TriTrypDb:

LmjF.24.1170 , LMJLV39_240017900 , LMJSD75_240017400

Length:

1250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1018	1022	PF00656	0.745
CLV_C14_Caspase3-7	328	332	PF00656	0.712
CLV_C14_Caspase3-7	912	916	PF00656	0.770
CLV_NRD_NRD_1	1078	1080	PF00675	0.632
CLV_NRD_NRD_1	1234	1236	PF00675	0.539
CLV_NRD_NRD_1	244	246	PF00675	0.724
CLV_NRD_NRD_1	419	421	PF00675	0.661
CLV_NRD_NRD_1	447	449	PF00675	0.684
CLV_NRD_NRD_1	511	513	PF00675	0.616
CLV_NRD_NRD_1	546	548	PF00675	0.685
CLV_NRD_NRD_1	653	655	PF00675	0.608
CLV_NRD_NRD_1	666	668	PF00675	0.645
CLV_NRD_NRD_1	910	912	PF00675	0.589
CLV_PCSK_KEX2_1	1078	1080	PF00082	0.632
CLV_PCSK_KEX2_1	1224	1226	PF00082	0.538
CLV_PCSK_KEX2_1	419	421	PF00082	0.661
CLV_PCSK_KEX2_1	447	449	PF00082	0.684
CLV_PCSK_KEX2_1	510	512	PF00082	0.627
CLV_PCSK_KEX2_1	546	548	PF00082	0.733
CLV_PCSK_KEX2_1	653	655	PF00082	0.608
CLV_PCSK_KEX2_1	665	667	PF00082	0.634
CLV_PCSK_KEX2_1	910	912	PF00082	0.589
CLV_PCSK_PC1ET2_1	1224	1226	PF00082	0.590
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.635
CLV_PCSK_SKI1_1	1059	1063	PF00082	0.637
CLV_PCSK_SKI1_1	337	341	PF00082	0.778
CLV_PCSK_SKI1_1	385	389	PF00082	0.686
CLV_PCSK_SKI1_1	420	424	PF00082	0.672
CLV_PCSK_SKI1_1	514	518	PF00082	0.559
CLV_PCSK_SKI1_1	549	553	PF00082	0.586
CLV_PCSK_SKI1_1	783	787	PF00082	0.712
CLV_PCSK_SKI1_1	799	803	PF00082	0.505
CLV_PCSK_SKI1_1	8	12	PF00082	0.452
DEG_APCC_DBOX_1	75	83	PF00400	0.486
DEG_APCC_DBOX_1	782	790	PF00400	0.717
DEG_SPOP_SBC_1	174	178	PF00917	0.560
DEG_SPOP_SBC_1	607	611	PF00917	0.589
DEG_SPOP_SBC_1	792	796	PF00917	0.703
DOC_CKS1_1	475	480	PF01111	0.650
DOC_MAPK_gen_1	153	162	PF00069	0.797
DOC_MAPK_gen_1	546	552	PF00069	0.632
DOC_MAPK_gen_1	653	663	PF00069	0.596
DOC_MAPK_HePTP_8	651	663	PF00069	0.647
DOC_MAPK_MEF2A_6	638	646	PF00069	0.621
DOC_MAPK_MEF2A_6	654	663	PF00069	0.604
DOC_PP2B_LxvP_1	423	426	PF13499	0.694
DOC_PP2B_LxvP_1	45	48	PF13499	0.461
DOC_PP2B_LxvP_1	605	608	PF13499	0.597
DOC_PP2B_LxvP_1	713	716	PF13499	0.723
DOC_PP2B_LxvP_1	811	814	PF13499	0.708
DOC_PP4_FxxP_1	55	58	PF00568	0.504
DOC_USP7_MATH_1	1005	1009	PF00917	0.789
DOC_USP7_MATH_1	1096	1100	PF00917	0.709
DOC_USP7_MATH_1	1126	1130	PF00917	0.724
DOC_USP7_MATH_1	1145	1149	PF00917	0.731
DOC_USP7_MATH_1	144	148	PF00917	0.738
DOC_USP7_MATH_1	173	177	PF00917	0.757
DOC_USP7_MATH_1	231	235	PF00917	0.624
DOC_USP7_MATH_1	256	260	PF00917	0.601
DOC_USP7_MATH_1	325	329	PF00917	0.721
DOC_USP7_MATH_1	455	459	PF00917	0.714
DOC_USP7_MATH_1	608	612	PF00917	0.671
DOC_USP7_MATH_1	670	674	PF00917	0.707
DOC_USP7_MATH_1	791	795	PF00917	0.702
DOC_USP7_MATH_1	801	805	PF00917	0.627
DOC_USP7_UBL2_3	361	365	PF12436	0.619
DOC_WW_Pin1_4	1092	1097	PF00397	0.813
DOC_WW_Pin1_4	1116	1121	PF00397	0.767
DOC_WW_Pin1_4	140	145	PF00397	0.704
DOC_WW_Pin1_4	229	234	PF00397	0.685
DOC_WW_Pin1_4	471	476	PF00397	0.692
DOC_WW_Pin1_4	50	55	PF00397	0.633
DOC_WW_Pin1_4	57	62	PF00397	0.633
DOC_WW_Pin1_4	750	755	PF00397	0.624
DOC_WW_Pin1_4	771	776	PF00397	0.722
DOC_WW_Pin1_4	865	870	PF00397	0.547
DOC_WW_Pin1_4	966	971	PF00397	0.613
LIG_14-3-3_CanoR_1	1070	1080	PF00244	0.733
LIG_14-3-3_CanoR_1	1206	1216	PF00244	0.725
LIG_14-3-3_CanoR_1	18	24	PF00244	0.550
LIG_14-3-3_CanoR_1	385	394	PF00244	0.694
LIG_14-3-3_CanoR_1	514	520	PF00244	0.600
LIG_14-3-3_CanoR_1	638	642	PF00244	0.691
LIG_14-3-3_CanoR_1	761	769	PF00244	0.637
LIG_14-3-3_CanoR_1	910	917	PF00244	0.623
LIG_14-3-3_CanoR_1	94	99	PF00244	0.703
LIG_14-3-3_CanoR_1	956	965	PF00244	0.530
LIG_BIR_III_4	1019	1023	PF00653	0.686
LIG_BIR_III_4	631	635	PF00653	0.731
LIG_BRCT_BRCA1_1	204	208	PF00533	0.584
LIG_CSL_BTD_1	605	608	PF09270	0.549
LIG_CtBP_PxDLS_1	1025	1029	PF00389	0.623
LIG_CtBP_PxDLS_1	317	321	PF00389	0.802
LIG_deltaCOP1_diTrp_1	362	367	PF00928	0.637
LIG_deltaCOP1_diTrp_1	490	498	PF00928	0.682
LIG_eIF4E_1	1023	1029	PF01652	0.629
LIG_FHA_1	1053	1059	PF00498	0.735
LIG_FHA_1	1182	1188	PF00498	0.766
LIG_FHA_1	144	150	PF00498	0.672
LIG_FHA_1	209	215	PF00498	0.629
LIG_FHA_1	238	244	PF00498	0.700
LIG_FHA_1	284	290	PF00498	0.653
LIG_FHA_1	35	41	PF00498	0.634
LIG_FHA_1	353	359	PF00498	0.675
LIG_FHA_1	515	521	PF00498	0.692
LIG_FHA_1	66	72	PF00498	0.589
LIG_FHA_1	725	731	PF00498	0.648
LIG_FHA_1	743	749	PF00498	0.605
LIG_FHA_2	1208	1214	PF00498	0.497
LIG_FHA_2	303	309	PF00498	0.688
LIG_FHA_2	347	353	PF00498	0.690
LIG_FHA_2	386	392	PF00498	0.581
LIG_FHA_2	674	680	PF00498	0.635
LIG_FHA_2	772	778	PF00498	0.613
LIG_FHA_2	910	916	PF00498	0.780
LIG_FHA_2	983	989	PF00498	0.590
LIG_GBD_Chelix_1	1242	1250	PF00786	0.474
LIG_GBD_Chelix_1	989	997	PF00786	0.671
LIG_HP1_1	970	974	PF01393	0.584
LIG_LIR_Apic_2	1146	1152	PF02991	0.772
LIG_LIR_Apic_2	53	58	PF02991	0.496
LIG_LIR_Apic_2	81	87	PF02991	0.693
LIG_LIR_Gen_1	157	166	PF02991	0.688
LIG_LIR_Gen_1	370	379	PF02991	0.604
LIG_LIR_Gen_1	806	816	PF02991	0.739
LIG_LIR_Gen_1	887	897	PF02991	0.619
LIG_LIR_Nem_3	1021	1026	PF02991	0.723
LIG_LIR_Nem_3	157	162	PF02991	0.657
LIG_LIR_Nem_3	266	270	PF02991	0.574
LIG_LIR_Nem_3	362	367	PF02991	0.630
LIG_LIR_Nem_3	370	376	PF02991	0.565
LIG_LIR_Nem_3	492	498	PF02991	0.662
LIG_LIR_Nem_3	640	644	PF02991	0.535
LIG_LIR_Nem_3	806	811	PF02991	0.743
LIG_LIR_Nem_3	887	892	PF02991	0.561
LIG_LYPXL_yS_3	641	644	PF13949	0.598
LIG_MLH1_MIPbox_1	204	208	PF16413	0.470
LIG_MYND_1	44	48	PF01753	0.456
LIG_NRBOX	732	738	PF00104	0.638
LIG_PCNA_PIPBox_1	576	585	PF02747	0.651
LIG_PCNA_yPIPBox_3	574	583	PF02747	0.651
LIG_PTB_Apo_2	551	558	PF02174	0.538
LIG_PTB_Phospho_1	551	557	PF10480	0.537
LIG_REV1ctd_RIR_1	568	578	PF16727	0.695
LIG_SH2_CRK	159	163	PF00017	0.745
LIG_SH2_CRK	267	271	PF00017	0.617
LIG_SH2_CRK	434	438	PF00017	0.588
LIG_SH2_CRK	557	561	PF00017	0.598
LIG_SH2_GRB2like	848	851	PF00017	0.666
LIG_SH2_NCK_1	373	377	PF00017	0.615
LIG_SH2_PTP2	1023	1026	PF00017	0.709
LIG_SH2_PTP2	889	892	PF00017	0.634
LIG_SH2_SRC	1023	1026	PF00017	0.709
LIG_SH2_SRC	192	195	PF00017	0.685
LIG_SH2_STAP1	237	241	PF00017	0.484
LIG_SH2_STAP1	373	377	PF00017	0.560
LIG_SH2_STAP1	557	561	PF00017	0.549
LIG_SH2_STAP1	678	682	PF00017	0.594
LIG_SH2_STAT3	582	585	PF00017	0.668
LIG_SH2_STAT3	678	681	PF00017	0.436
LIG_SH2_STAT5	1023	1026	PF00017	0.709
LIG_SH2_STAT5	1162	1165	PF00017	0.479
LIG_SH2_STAT5	192	195	PF00017	0.656
LIG_SH2_STAT5	207	210	PF00017	0.392
LIG_SH2_STAT5	78	81	PF00017	0.655
LIG_SH2_STAT5	808	811	PF00017	0.749
LIG_SH2_STAT5	84	87	PF00017	0.650
LIG_SH2_STAT5	848	851	PF00017	0.604
LIG_SH2_STAT5	889	892	PF00017	0.634
LIG_SH2_STAT5	953	956	PF00017	0.686
LIG_SH2_STAT5	975	978	PF00017	0.555
LIG_SH3_2	3	8	PF14604	0.448
LIG_SH3_3	181	187	PF00018	0.740
LIG_SH3_3	216	222	PF00018	0.618
LIG_SH3_3	472	478	PF00018	0.774
LIG_SH3_3	517	523	PF00018	0.706
LIG_SH3_3	55	61	PF00018	0.498
LIG_SH3_3	557	563	PF00018	0.635
LIG_SH3_3	595	601	PF00018	0.614
LIG_SH3_3	687	693	PF00018	0.568
LIG_SUMO_SIM_anti_2	209	216	PF11976	0.605
LIG_SUMO_SIM_anti_2	548	554	PF11976	0.614
LIG_SUMO_SIM_anti_2	658	664	PF11976	0.589
LIG_SUMO_SIM_anti_2	968	975	PF11976	0.619
LIG_SUMO_SIM_par_1	209	216	PF11976	0.602
LIG_SUMO_SIM_par_1	43	50	PF11976	0.462
LIG_SUMO_SIM_par_1	67	72	PF11976	0.697
LIG_SUMO_SIM_par_1	78	83	PF11976	0.609
LIG_TRAF2_1	1089	1092	PF00917	0.823
LIG_TRAF2_1	775	778	PF00917	0.565
LIG_TRAF2_1	897	900	PF00917	0.596
LIG_UBA3_1	1216	1224	PF00899	0.477
LIG_UBA3_1	357	365	PF00899	0.630
LIG_WW_3	382	386	PF00397	0.674
MOD_CDK_SPK_2	750	755	PF00069	0.588
MOD_CDK_SPxxK_3	865	872	PF00069	0.547
MOD_CK1_1	1104	1110	PF00069	0.676
MOD_CK1_1	1129	1135	PF00069	0.646
MOD_CK1_1	249	255	PF00069	0.714
MOD_CK1_1	393	399	PF00069	0.778
MOD_CK1_1	414	420	PF00069	0.644
MOD_CK1_1	518	524	PF00069	0.726
MOD_CK1_1	610	616	PF00069	0.691
MOD_CK1_1	673	679	PF00069	0.594
MOD_CK1_1	795	801	PF00069	0.765
MOD_CK1_1	926	932	PF00069	0.697
MOD_CK2_1	1005	1011	PF00069	0.751
MOD_CK2_1	136	142	PF00069	0.709
MOD_CK2_1	385	391	PF00069	0.786
MOD_CK2_1	673	679	PF00069	0.640
MOD_CK2_1	771	777	PF00069	0.616
MOD_CK2_1	915	921	PF00069	0.735
MOD_CK2_1	982	988	PF00069	0.584
MOD_Cter_Amidation	417	420	PF01082	0.653
MOD_GlcNHglycan	1015	1018	PF01048	0.737
MOD_GlcNHglycan	1103	1106	PF01048	0.689
MOD_GlcNHglycan	1128	1131	PF01048	0.718
MOD_GlcNHglycan	1134	1137	PF01048	0.720
MOD_GlcNHglycan	1198	1202	PF01048	0.784
MOD_GlcNHglycan	138	141	PF01048	0.791
MOD_GlcNHglycan	198	201	PF01048	0.593
MOD_GlcNHglycan	251	254	PF01048	0.754
MOD_GlcNHglycan	289	292	PF01048	0.646
MOD_GlcNHglycan	395	398	PF01048	0.777
MOD_GlcNHglycan	403	406	PF01048	0.647
MOD_GlcNHglycan	413	416	PF01048	0.436
MOD_GlcNHglycan	479	482	PF01048	0.686
MOD_GlcNHglycan	592	595	PF01048	0.568
MOD_GlcNHglycan	610	613	PF01048	0.574
MOD_GlcNHglycan	672	675	PF01048	0.673
MOD_GlcNHglycan	799	802	PF01048	0.730
MOD_GlcNHglycan	803	806	PF01048	0.723
MOD_GlcNHglycan	826	830	PF01048	0.797
MOD_GlcNHglycan	872	875	PF01048	0.726
MOD_GlcNHglycan	923	926	PF01048	0.791
MOD_GSK3_1	1036	1043	PF00069	0.601
MOD_GSK3_1	1092	1099	PF00069	0.768
MOD_GSK3_1	1100	1107	PF00069	0.732
MOD_GSK3_1	1128	1135	PF00069	0.736
MOD_GSK3_1	1141	1148	PF00069	0.624
MOD_GSK3_1	127	134	PF00069	0.659
MOD_GSK3_1	136	143	PF00069	0.610
MOD_GSK3_1	144	151	PF00069	0.514
MOD_GSK3_1	202	209	PF00069	0.592
MOD_GSK3_1	247	254	PF00069	0.605
MOD_GSK3_1	283	290	PF00069	0.507
MOD_GSK3_1	30	37	PF00069	0.521
MOD_GSK3_1	316	323	PF00069	0.697
MOD_GSK3_1	451	458	PF00069	0.769
MOD_GSK3_1	46	53	PF00069	0.630
MOD_GSK3_1	467	474	PF00069	0.673
MOD_GSK3_1	514	521	PF00069	0.694
MOD_GSK3_1	57	64	PF00069	0.563
MOD_GSK3_1	606	613	PF00069	0.624
MOD_GSK3_1	65	72	PF00069	0.638
MOD_GSK3_1	791	798	PF00069	0.672
MOD_GSK3_1	870	877	PF00069	0.577
MOD_GSK3_1	929	936	PF00069	0.671
MOD_GSK3_1	956	963	PF00069	0.722
MOD_LATS_1	204	210	PF00433	0.454
MOD_N-GLC_1	1011	1016	PF02516	0.719
MOD_N-GLC_2	764	766	PF02516	0.682
MOD_NEK2_1	1052	1057	PF00069	0.622
MOD_NEK2_1	17	22	PF00069	0.658
MOD_NEK2_1	202	207	PF00069	0.601
MOD_NEK2_1	208	213	PF00069	0.542
MOD_NEK2_1	320	325	PF00069	0.665
MOD_NEK2_1	377	382	PF00069	0.740
MOD_NEK2_1	427	432	PF00069	0.598
MOD_NEK2_1	437	442	PF00069	0.516
MOD_NEK2_1	515	520	PF00069	0.603
MOD_NEK2_1	565	570	PF00069	0.588
MOD_NEK2_1	706	711	PF00069	0.776
MOD_NEK2_1	80	85	PF00069	0.622
MOD_PIKK_1	247	253	PF00454	0.741
MOD_PIKK_1	273	279	PF00454	0.604
MOD_PIKK_1	467	473	PF00454	0.776
MOD_PIKK_1	721	727	PF00454	0.678
MOD_PIKK_1	867	873	PF00454	0.792
MOD_PIKK_1	956	962	PF00454	0.679
MOD_PKA_1	910	916	PF00069	0.588
MOD_PKA_2	1069	1075	PF00069	0.773
MOD_PKA_2	1132	1138	PF00069	0.728
MOD_PKA_2	1139	1145	PF00069	0.626
MOD_PKA_2	17	23	PF00069	0.442
MOD_PKA_2	325	331	PF00069	0.718
MOD_PKA_2	545	551	PF00069	0.654
MOD_PKA_2	637	643	PF00069	0.687
MOD_PKA_2	760	766	PF00069	0.640
MOD_PKA_2	909	915	PF00069	0.750
MOD_PKA_2	955	961	PF00069	0.527
MOD_PKA_2	998	1004	PF00069	0.646
MOD_PKB_1	512	520	PF00069	0.671
MOD_Plk_1	1145	1151	PF00069	0.773
MOD_Plk_1	340	346	PF00069	0.791
MOD_Plk_1	390	396	PF00069	0.591
MOD_Plk_1	80	86	PF00069	0.637
MOD_Plk_4	1046	1052	PF00069	0.548
MOD_Plk_4	1145	1151	PF00069	0.721
MOD_Plk_4	175	181	PF00069	0.738
MOD_Plk_4	210	216	PF00069	0.640
MOD_Plk_4	34	40	PF00069	0.526
MOD_Plk_4	353	359	PF00069	0.675
MOD_Plk_4	437	443	PF00069	0.549
MOD_Plk_4	515	521	PF00069	0.663
MOD_Plk_4	65	71	PF00069	0.579
MOD_Plk_4	80	86	PF00069	0.608
MOD_Plk_4	844	850	PF00069	0.668
MOD_Plk_4	860	866	PF00069	0.693
MOD_Plk_4	929	935	PF00069	0.661
MOD_ProDKin_1	1092	1098	PF00069	0.811
MOD_ProDKin_1	1116	1122	PF00069	0.764
MOD_ProDKin_1	140	146	PF00069	0.705
MOD_ProDKin_1	229	235	PF00069	0.681
MOD_ProDKin_1	471	477	PF00069	0.684
MOD_ProDKin_1	50	56	PF00069	0.636
MOD_ProDKin_1	57	63	PF00069	0.629
MOD_ProDKin_1	750	756	PF00069	0.624
MOD_ProDKin_1	771	777	PF00069	0.719
MOD_ProDKin_1	865	871	PF00069	0.548
MOD_ProDKin_1	966	972	PF00069	0.605
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.443
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.463
TRG_ENDOCYTIC_2	1023	1026	PF00928	0.709
TRG_ENDOCYTIC_2	159	162	PF00928	0.664
TRG_ENDOCYTIC_2	267	270	PF00928	0.612
TRG_ENDOCYTIC_2	373	376	PF00928	0.637
TRG_ENDOCYTIC_2	434	437	PF00928	0.594
TRG_ENDOCYTIC_2	557	560	PF00928	0.608
TRG_ENDOCYTIC_2	641	644	PF00928	0.598
TRG_ENDOCYTIC_2	808	811	PF00928	0.749
TRG_ENDOCYTIC_2	889	892	PF00928	0.634
TRG_ER_diArg_1	1078	1081	PF00400	0.635
TRG_ER_diArg_1	446	448	PF00400	0.629
TRG_ER_diArg_1	509	512	PF00400	0.627
TRG_ER_diArg_1	546	549	PF00400	0.734
TRG_NLS_Bipartite_1	653	669	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I480	Leptomonas seymouri	36%	100%
A0A3S7WYG5	Leishmania donovani	88%	100%
A0A422NQA5	Trypanosoma rangeli	24%	100%
A4HDH4	Leishmania braziliensis	67%	100%
A4I0V5	Leishmania infantum	88%	98%
E9AWV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BVQ3	Trypanosoma cruzi	24%	100%