SURF6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surfeit locus protein 6, putative

Species:

Leishmania major

UniProt:

Q4QAL4_LEIMA

TriTrypDb:

LmjF.24.1180 , LMJLV39_240018000 , LMJSD75_240017500

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8
GO:0005634	nucleus	5	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6

Expansion

Sequence features

Q4QAL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAL4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0042274	ribosomal small subunit biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.298
CLV_NRD_NRD_1	159	161	PF00675	0.291
CLV_NRD_NRD_1	16	18	PF00675	0.637
CLV_NRD_NRD_1	172	174	PF00675	0.295
CLV_NRD_NRD_1	197	199	PF00675	0.294
CLV_NRD_NRD_1	241	243	PF00675	0.661
CLV_NRD_NRD_1	4	6	PF00675	0.689
CLV_NRD_NRD_1	50	52	PF00675	0.732
CLV_PCSK_KEX2_1	109	111	PF00082	0.351
CLV_PCSK_KEX2_1	158	160	PF00082	0.311
CLV_PCSK_KEX2_1	16	18	PF00082	0.637
CLV_PCSK_KEX2_1	163	165	PF00082	0.325
CLV_PCSK_KEX2_1	168	170	PF00082	0.347
CLV_PCSK_KEX2_1	172	174	PF00082	0.298
CLV_PCSK_KEX2_1	209	211	PF00082	0.608
CLV_PCSK_KEX2_1	4	6	PF00082	0.689
CLV_PCSK_KEX2_1	52	54	PF00082	0.490
CLV_PCSK_KEX2_1	93	95	PF00082	0.301
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.336
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.363
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.616
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.357
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.301
CLV_PCSK_PC7_1	159	165	PF00082	0.300
CLV_PCSK_SKI1_1	151	155	PF00082	0.325
CLV_PCSK_SKI1_1	199	203	PF00082	0.332
CLV_PCSK_SKI1_1	210	214	PF00082	0.515
CLV_PCSK_SKI1_1	53	57	PF00082	0.387
DEG_Nend_UBRbox_1	1	4	PF02207	0.635
DOC_AGCK_PIF_2	80	85	PF00069	0.292
DOC_MAPK_MEF2A_6	53	62	PF00069	0.384
DOC_MAPK_MEF2A_6	71	80	PF00069	0.360
DOC_USP7_MATH_1	58	62	PF00917	0.388
DOC_USP7_UBL2_3	192	196	PF12436	0.404
DOC_USP7_UBL2_3	202	206	PF12436	0.278
DOC_USP7_UBL2_3	227	231	PF12436	0.647
DOC_USP7_UBL2_3	239	243	PF12436	0.478
DOC_USP7_UBL2_3	89	93	PF12436	0.351
LIG_14-3-3_CanoR_1	164	170	PF00244	0.292
LIG_14-3-3_CanoR_1	57	63	PF00244	0.395
LIG_14-3-3_CterR_2	247	252	PF00244	0.600
LIG_CtBP_PxDLS_1	75	79	PF00389	0.292
LIG_LIR_Gen_1	84	91	PF02991	0.351
LIG_LIR_Nem_3	77	83	PF02991	0.298
LIG_NRBOX	100	106	PF00104	0.351
LIG_NRP_CendR_1	249	252	PF00754	0.668
LIG_PTB_Apo_2	79	86	PF02174	0.292
LIG_SH3_3	31	37	PF00018	0.615
LIG_SUMO_SIM_par_1	74	79	PF11976	0.351
MOD_CK1_1	20	26	PF00069	0.555
MOD_CK1_1	7	13	PF00069	0.623
MOD_Cter_Amidation	14	17	PF01082	0.675
MOD_Cter_Amidation	2	5	PF01082	0.772
MOD_Cter_Amidation	224	227	PF01082	0.628
MOD_Cter_Amidation	91	94	PF01082	0.351
MOD_GlcNHglycan	139	142	PF01048	0.415
MOD_GlcNHglycan	165	168	PF01048	0.292
MOD_GlcNHglycan	19	22	PF01048	0.635
MOD_GlcNHglycan	9	12	PF01048	0.772
MOD_GSK3_1	20	27	PF00069	0.561
MOD_GSK3_1	215	222	PF00069	0.651
MOD_GSK3_1	243	250	PF00069	0.624
MOD_GSK3_1	3	10	PF00069	0.627
MOD_GSK3_1	43	50	PF00069	0.635
MOD_N-GLC_1	17	22	PF02516	0.611
MOD_NEK2_1	118	123	PF00069	0.478
MOD_NEK2_1	137	142	PF00069	0.194
MOD_NEK2_1	76	81	PF00069	0.340
MOD_PK_1	186	192	PF00069	0.351
MOD_PKA_1	158	164	PF00069	0.287
MOD_PKA_1	4	10	PF00069	0.757
MOD_PKA_2	158	164	PF00069	0.312
MOD_PKA_2	219	225	PF00069	0.547
MOD_PKA_2	3	9	PF00069	0.613
MOD_PKA_2	58	64	PF00069	0.308
MOD_PKB_1	51	59	PF00069	0.479
MOD_Plk_1	177	183	PF00069	0.351
MOD_Plk_1	186	192	PF00069	0.351
MOD_Plk_1	76	82	PF00069	0.340
MOD_Plk_1	99	105	PF00069	0.383
MOD_Plk_2-3	126	132	PF00069	0.313
MOD_Plk_4	100	106	PF00069	0.385
MOD_SUMO_rev_2	84	91	PF00179	0.292
TRG_DiLeu_BaEn_1	100	105	PF01217	0.351
TRG_ER_diArg_1	158	160	PF00400	0.245
TRG_ER_diArg_1	172	175	PF00400	0.253
TRG_ER_diArg_1	57	60	PF00400	0.391
TRG_NES_CRM1_1	64	77	PF08389	0.313
TRG_NLS_MonoExtN_4	159	166	PF00514	0.283
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P3	Leptomonas seymouri	71%	100%
A0A3S7WYB0	Leishmania donovani	91%	100%
A4HDH5	Leishmania braziliensis	78%	97%
A4I0V6	Leishmania infantum	90%	100%
D0A787	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AWW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%