Inhibitor of apoptosis-promoting Bax1-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inhibitor of apoptosis-promoting Bax1, putative

Species:

Leishmania major

UniProt:

Q4QAL3_LEIMA

TriTrypDb:

LmjF.24.1190 , LMJLV39_240018100 , LMJSD75_240017600

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QAL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.618
CLV_PCSK_SKI1_1	194	198	PF00082	0.458
DEG_APCC_DBOX_1	108	116	PF00400	0.458
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DEG_SPOP_SBC_1	196	200	PF00917	0.423
DEG_SPOP_SBC_1	93	97	PF00917	0.699
DOC_CKS1_1	134	139	PF01111	0.331
DOC_PP4_FxxP_1	160	163	PF00568	0.412
DOC_USP7_MATH_1	13	17	PF00917	0.675
DOC_USP7_MATH_1	164	168	PF00917	0.510
DOC_USP7_MATH_1	219	223	PF00917	0.458
DOC_USP7_MATH_1	29	33	PF00917	0.734
DOC_USP7_MATH_1	58	62	PF00917	0.662
DOC_USP7_MATH_1	93	97	PF00917	0.728
DOC_WW_Pin1_4	102	107	PF00397	0.578
DOC_WW_Pin1_4	133	138	PF00397	0.321
DOC_WW_Pin1_4	85	90	PF00397	0.636
LIG_14-3-3_CanoR_1	114	119	PF00244	0.423
LIG_14-3-3_CanoR_1	220	224	PF00244	0.458
LIG_14-3-3_CanoR_1	24	29	PF00244	0.722
LIG_14-3-3_CanoR_1	8	18	PF00244	0.650
LIG_FHA_1	103	109	PF00498	0.553
LIG_FHA_1	123	129	PF00498	0.423
LIG_FHA_1	196	202	PF00498	0.315
LIG_HP1_1	186	190	PF01393	0.423
LIG_LIR_Apic_2	159	163	PF02991	0.374
LIG_LIR_Gen_1	130	138	PF02991	0.354
LIG_LIR_Gen_1	175	184	PF02991	0.354
LIG_LIR_Nem_3	130	134	PF02991	0.410
LIG_LIR_Nem_3	175	179	PF02991	0.354
LIG_PTB_Apo_2	241	248	PF02174	0.311
LIG_PTB_Phospho_1	241	247	PF10480	0.311
LIG_SH2_CRK	116	120	PF00017	0.311
LIG_SH2_CRK	258	262	PF00017	0.311
LIG_SH2_STAT5	116	119	PF00017	0.423
LIG_SH2_STAT5	216	219	PF00017	0.510
LIG_SH2_STAT5	66	69	PF00017	0.706
LIG_SH3_3	131	137	PF00018	0.423
LIG_SH3_3	160	166	PF00018	0.311
LIG_SH3_3	242	248	PF00018	0.456
LIG_SH3_3	28	34	PF00018	0.615
LIG_SUMO_SIM_par_1	185	192	PF11976	0.357
LIG_SUMO_SIM_par_1	236	241	PF11976	0.311
LIG_SUMO_SIM_par_1	265	272	PF11976	0.384
LIG_TYR_ITIM	256	261	PF00017	0.311
LIG_UBA3_1	189	194	PF00899	0.456
LIG_WRC_WIRS_1	128	133	PF05994	0.354
LIG_WRC_WIRS_1	173	178	PF05994	0.346
MOD_CDK_SPxxK_3	102	109	PF00069	0.547
MOD_CDK_SPxxK_3	133	140	PF00069	0.332
MOD_CK1_1	32	38	PF00069	0.711
MOD_CK1_1	82	88	PF00069	0.683
MOD_CK1_1	96	102	PF00069	0.574
MOD_GlcNHglycan	15	18	PF01048	0.465
MOD_GlcNHglycan	211	214	PF01048	0.310
MOD_GlcNHglycan	96	99	PF01048	0.460
MOD_GSK3_1	197	204	PF00069	0.423
MOD_GSK3_1	45	52	PF00069	0.652
MOD_GSK3_1	9	16	PF00069	0.654
MOD_GSK3_1	92	99	PF00069	0.639
MOD_NEK2_1	156	161	PF00069	0.328
MOD_NEK2_1	172	177	PF00069	0.288
MOD_NEK2_1	189	194	PF00069	0.291
MOD_NEK2_1	197	202	PF00069	0.311
MOD_NEK2_1	251	256	PF00069	0.307
MOD_PIKK_1	269	275	PF00454	0.311
MOD_PIKK_1	96	102	PF00454	0.671
MOD_PKA_2	219	225	PF00069	0.458
MOD_PKA_2	23	29	PF00069	0.723
MOD_PKA_2	79	85	PF00069	0.669
MOD_Plk_4	114	120	PF00069	0.377
MOD_Plk_4	127	133	PF00069	0.224
MOD_Plk_4	197	203	PF00069	0.410
MOD_Plk_4	219	225	PF00069	0.458
MOD_Plk_4	251	257	PF00069	0.289
MOD_Plk_4	58	64	PF00069	0.654
MOD_ProDKin_1	102	108	PF00069	0.566
MOD_ProDKin_1	133	139	PF00069	0.321
MOD_ProDKin_1	85	91	PF00069	0.638
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.311
TRG_ENDOCYTIC_2	116	119	PF00928	0.311
TRG_ENDOCYTIC_2	258	261	PF00928	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P543	Leptomonas seymouri	76%	98%
A0A1X0NWZ2	Trypanosomatidae	69%	99%
A0A3Q8IG51	Leishmania donovani	96%	100%
A0A422NQ32	Trypanosoma rangeli	61%	100%
A4HDH6	Leishmania braziliensis	87%	100%
A4I0V7	Leishmania infantum	96%	100%
D0A788	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AWW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O25578	Helicobacter pylori (strain ATCC 700392 / 26695)	25%	100%
P0DA10	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	26%	100%
P0DA11	Streptococcus pyogenes serotype M3 (strain SSI-1)	26%	100%
P55061	Homo sapiens	29%	100%
Q0V882	Bos taurus	29%	100%
Q5R7R1	Pongo abelii	30%	100%
Q5XDQ1	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	26%	100%
Q66RM2	Sus scrofa	29%	100%
Q8P2D4	Streptococcus pyogenes serotype M18 (strain MGAS8232)	26%	100%
Q9A1B9	Streptococcus pyogenes serotype M1	26%	100%
Q9D2C7	Mus musculus	30%	100%
Q9IA79	Paralichthys olivaceus	29%	100%
Q9LD45	Arabidopsis thaliana	36%	100%
Q9MBD8	Oryza sativa subsp. japonica	31%	100%
Q9PIQ8	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	24%	100%
Q9VSH3	Drosophila melanogaster	27%	100%
Q9ZE15	Rickettsia prowazekii (strain Madrid E)	26%	100%
Q9ZKT1	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5BAK0	Trypanosoma cruzi	70%	100%