YL1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAL2_LEIMA

TriTrypDb:

LmjF.24.1200 , LMJLV39_240018200 , LMJSD75_240017700

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QAL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAL2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	9
GO:0009889	regulation of biosynthetic process	4	9
GO:0010468	regulation of gene expression	5	9
GO:0010556	regulation of macromolecule biosynthetic process	5	9
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	9
GO:0019222	regulation of metabolic process	3	9
GO:0031323	regulation of cellular metabolic process	4	9
GO:0031326	regulation of cellular biosynthetic process	5	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0051171	regulation of nitrogen compound metabolic process	4	9
GO:0051252	regulation of RNA metabolic process	5	9
GO:0060255	regulation of macromolecule metabolic process	4	9
GO:0065007	biological regulation	1	9
GO:0080090	regulation of primary metabolic process	4	9
GO:1903506	regulation of nucleic acid-templated transcription	7	9
GO:2001141	regulation of RNA biosynthetic process	6	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	290	296	PF00089	0.525
CLV_NRD_NRD_1	12	14	PF00675	0.283
CLV_NRD_NRD_1	143	145	PF00675	0.425
CLV_NRD_NRD_1	243	245	PF00675	0.625
CLV_NRD_NRD_1	254	256	PF00675	0.624
CLV_NRD_NRD_1	85	87	PF00675	0.322
CLV_NRD_NRD_1	96	98	PF00675	0.256
CLV_PCSK_FUR_1	10	14	PF00082	0.283
CLV_PCSK_FUR_1	241	245	PF00082	0.660
CLV_PCSK_KEX2_1	12	14	PF00082	0.283
CLV_PCSK_KEX2_1	122	124	PF00082	0.386
CLV_PCSK_KEX2_1	126	128	PF00082	0.398
CLV_PCSK_KEX2_1	243	245	PF00082	0.630
CLV_PCSK_KEX2_1	254	256	PF00082	0.634
CLV_PCSK_KEX2_1	85	87	PF00082	0.362
CLV_PCSK_KEX2_1	96	98	PF00082	0.293
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.386
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.398
CLV_PCSK_PC7_1	239	245	PF00082	0.709
CLV_PCSK_PC7_1	92	98	PF00082	0.386
CLV_PCSK_SKI1_1	261	265	PF00082	0.694
CLV_PCSK_SKI1_1	283	287	PF00082	0.595
CLV_Separin_Metazoa	136	140	PF03568	0.217
DEG_Nend_UBRbox_2	1	3	PF02207	0.595
DOC_MAPK_gen_1	305	314	PF00069	0.614
DOC_PP2B_LxvP_1	264	267	PF13499	0.560
DOC_PP4_FxxP_1	306	309	PF00568	0.575
DOC_SPAK_OSR1_1	305	309	PF12202	0.522
DOC_USP7_MATH_1	245	249	PF00917	0.618
DOC_USP7_UBL2_3	122	126	PF12436	0.435
DOC_WW_Pin1_4	278	283	PF00397	0.586
LIG_14-3-3_CanoR_1	293	303	PF00244	0.483
LIG_BRCT_BRCA1_1	102	106	PF00533	0.304
LIG_BRCT_BRCA1_2	102	108	PF00533	0.304
LIG_FHA_1	23	29	PF00498	0.217
LIG_FHA_1	298	304	PF00498	0.440
LIG_FHA_2	269	275	PF00498	0.683
LIG_FHA_2	54	60	PF00498	0.390
LIG_LIR_Gen_1	103	111	PF02991	0.304
LIG_LIR_Nem_3	103	109	PF02991	0.304
LIG_MYND_1	320	324	PF01753	0.565
LIG_NRBOX	19	25	PF00104	0.317
LIG_SH2_PTP2	279	282	PF00017	0.421
LIG_SH2_STAT5	279	282	PF00017	0.486
LIG_SH3_1	179	185	PF00018	0.377
LIG_SH3_3	179	185	PF00018	0.377
LIG_SH3_3	318	324	PF00018	0.556
LIG_SH3_3	5	11	PF00018	0.564
LIG_TRAF2_1	52	55	PF00917	0.286
LIG_WRC_WIRS_1	311	316	PF05994	0.491
MOD_CDK_SPK_2	278	283	PF00069	0.586
MOD_CK1_1	219	225	PF00069	0.551
MOD_CK1_1	248	254	PF00069	0.652
MOD_CK1_1	297	303	PF00069	0.495
MOD_CK1_1	313	319	PF00069	0.430
MOD_CK1_1	40	46	PF00069	0.287
MOD_CK2_1	253	259	PF00069	0.692
MOD_CK2_1	268	274	PF00069	0.560
MOD_CK2_1	48	54	PF00069	0.286
MOD_GlcNHglycan	221	224	PF01048	0.669
MOD_GlcNHglycan	255	258	PF01048	0.632
MOD_GlcNHglycan	264	267	PF01048	0.533
MOD_GlcNHglycan	297	300	PF01048	0.521
MOD_GSK3_1	100	107	PF00069	0.348
MOD_GSK3_1	180	187	PF00069	0.348
MOD_GSK3_1	245	252	PF00069	0.683
MOD_GSK3_1	294	301	PF00069	0.526
MOD_GSK3_1	37	44	PF00069	0.286
MOD_GSK3_1	49	56	PF00069	0.277
MOD_N-GLC_1	104	109	PF02516	0.348
MOD_N-GLC_1	249	254	PF02516	0.711
MOD_NEK2_1	100	105	PF00069	0.405
MOD_NEK2_1	118	123	PF00069	0.261
MOD_PIKK_1	100	106	PF00454	0.348
MOD_PIKK_1	184	190	PF00454	0.348
MOD_PKA_2	128	134	PF00069	0.348
MOD_PKA_2	253	259	PF00069	0.559
MOD_PKB_1	305	313	PF00069	0.571
MOD_Plk_1	268	274	PF00069	0.605
MOD_Plk_1	44	50	PF00069	0.348
MOD_Plk_1	53	59	PF00069	0.391
MOD_Plk_1	80	86	PF00069	0.339
MOD_Plk_2-3	163	169	PF00069	0.348
MOD_Plk_2-3	53	59	PF00069	0.400
MOD_Plk_4	298	304	PF00069	0.497
MOD_Plk_4	307	313	PF00069	0.521
MOD_ProDKin_1	278	284	PF00069	0.584
MOD_SUMO_rev_2	29	36	PF00179	0.319
TRG_DiLeu_BaEn_4	31	37	PF01217	0.377
TRG_ENDOCYTIC_2	287	290	PF00928	0.584
TRG_ER_diArg_1	10	13	PF00400	0.285
TRG_ER_diArg_1	138	141	PF00400	0.416
TRG_ER_diArg_1	172	175	PF00400	0.302
TRG_ER_diArg_1	176	179	PF00400	0.266
TRG_ER_diArg_1	241	244	PF00400	0.683
TRG_ER_diArg_1	84	86	PF00400	0.362
TRG_NLS_Bipartite_1	85	101	PF00514	0.348
TRG_NLS_MonoExtN_4	96	101	PF00514	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKA2	Leptomonas seymouri	50%	100%
A0A3Q8IBX0	Leishmania donovani	94%	100%
A0A422NQ25	Trypanosoma rangeli	32%	100%
A4HDH7	Leishmania braziliensis	79%	100%
A4I0V8	Leishmania infantum	94%	100%
D0A789	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AWW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%