RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 38, putative

Species:

Leishmania major

UniProt:

Q4QAL0_LEIMA

TriTrypDb:

LmjF.24.1220 , LMJLV39_240018400 , LMJSD75_240017900

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAL0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003723	RNA binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.585
CLV_C14_Caspase3-7	90	94	PF00656	0.607
CLV_NRD_NRD_1	110	112	PF00675	0.610
CLV_NRD_NRD_1	176	178	PF00675	0.558
CLV_NRD_NRD_1	298	300	PF00675	0.510
CLV_NRD_NRD_1	465	467	PF00675	0.460
CLV_PCSK_KEX2_1	110	112	PF00082	0.637
CLV_PCSK_KEX2_1	298	300	PF00082	0.516
CLV_PCSK_KEX2_1	410	412	PF00082	0.553
CLV_PCSK_KEX2_1	465	467	PF00082	0.459
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.714
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.553
CLV_PCSK_SKI1_1	14	18	PF00082	0.566
CLV_PCSK_SKI1_1	172	176	PF00082	0.559
CLV_PCSK_SKI1_1	291	295	PF00082	0.446
CLV_PCSK_SKI1_1	312	316	PF00082	0.442
CLV_PCSK_SKI1_1	354	358	PF00082	0.427
CLV_PCSK_SKI1_1	380	384	PF00082	0.418
CLV_PCSK_SKI1_1	386	390	PF00082	0.407
CLV_PCSK_SKI1_1	438	442	PF00082	0.419
CLV_PCSK_SKI1_1	465	469	PF00082	0.540
CLV_PCSK_SKI1_1	532	536	PF00082	0.698
CLV_Separin_Metazoa	415	419	PF03568	0.523
DEG_SPOP_SBC_1	117	121	PF00917	0.597
DEG_SPOP_SBC_1	189	193	PF00917	0.724
DEG_SPOP_SBC_1	62	66	PF00917	0.637
DOC_CKS1_1	159	164	PF01111	0.558
DOC_CKS1_1	341	346	PF01111	0.504
DOC_CKS1_1	493	498	PF01111	0.524
DOC_CYCLIN_yCln2_LP_2	80	83	PF00134	0.591
DOC_MAPK_gen_1	96	103	PF00069	0.523
DOC_PP1_RVXF_1	170	176	PF00149	0.551
DOC_PP1_RVXF_1	289	296	PF00149	0.494
DOC_PP1_RVXF_1	356	363	PF00149	0.345
DOC_PP1_RVXF_1	387	393	PF00149	0.381
DOC_PP2B_LxvP_1	221	224	PF13499	0.707
DOC_PP2B_LxvP_1	80	83	PF13499	0.638
DOC_USP7_MATH_1	117	121	PF00917	0.779
DOC_USP7_MATH_1	162	166	PF00917	0.624
DOC_USP7_MATH_1	18	22	PF00917	0.503
DOC_USP7_MATH_1	198	202	PF00917	0.678
DOC_USP7_MATH_1	236	240	PF00917	0.741
DOC_USP7_MATH_1	247	251	PF00917	0.536
DOC_USP7_MATH_1	266	270	PF00917	0.467
DOC_USP7_MATH_1	303	307	PF00917	0.457
DOC_USP7_MATH_1	308	312	PF00917	0.476
DOC_USP7_MATH_1	36	40	PF00917	0.617
DOC_USP7_MATH_1	398	402	PF00917	0.613
DOC_USP7_MATH_1	76	80	PF00917	0.770
DOC_USP7_MATH_1	88	92	PF00917	0.592
DOC_USP7_MATH_1	94	98	PF00917	0.784
DOC_USP7_UBL2_3	108	112	PF12436	0.741
DOC_USP7_UBL2_3	389	393	PF12436	0.407
DOC_USP7_UBL2_3	438	442	PF12436	0.400
DOC_USP7_UBL2_3	92	96	PF12436	0.702
DOC_WW_Pin1_4	158	163	PF00397	0.476
DOC_WW_Pin1_4	185	190	PF00397	0.669
DOC_WW_Pin1_4	204	209	PF00397	0.592
DOC_WW_Pin1_4	22	27	PF00397	0.573
DOC_WW_Pin1_4	28	33	PF00397	0.625
DOC_WW_Pin1_4	340	345	PF00397	0.500
DOC_WW_Pin1_4	38	43	PF00397	0.704
DOC_WW_Pin1_4	476	481	PF00397	0.570
DOC_WW_Pin1_4	492	497	PF00397	0.558
LIG_14-3-3_CanoR_1	310	315	PF00244	0.421
LIG_14-3-3_CanoR_1	348	357	PF00244	0.498
LIG_14-3-3_CanoR_1	421	429	PF00244	0.462
LIG_14-3-3_CanoR_1	483	488	PF00244	0.620
LIG_14-3-3_CanoR_1	514	523	PF00244	0.660
LIG_Actin_WH2_2	149	166	PF00022	0.546
LIG_BIR_III_2	186	190	PF00653	0.570
LIG_BRCT_BRCA1_1	279	283	PF00533	0.393
LIG_EH1_1	136	144	PF00400	0.462
LIG_eIF4E_1	277	283	PF01652	0.472
LIG_FHA_1	119	125	PF00498	0.517
LIG_FHA_1	158	164	PF00498	0.454
LIG_FHA_1	190	196	PF00498	0.700
LIG_FHA_1	300	306	PF00498	0.393
LIG_FHA_1	316	322	PF00498	0.404
LIG_FHA_1	328	334	PF00498	0.414
LIG_FHA_1	517	523	PF00498	0.676
LIG_FHA_1	68	74	PF00498	0.737
LIG_FHA_2	215	221	PF00498	0.573
LIG_LIR_Gen_1	135	144	PF02991	0.389
LIG_LIR_Gen_1	343	350	PF02991	0.390
LIG_LIR_Nem_3	135	141	PF02991	0.389
LIG_LIR_Nem_3	343	349	PF02991	0.424
LIG_LIR_Nem_3	450	454	PF02991	0.501
LIG_LIR_Nem_3	503	507	PF02991	0.542
LIG_LIR_Nem_3	508	513	PF02991	0.511
LIG_LIR_Nem_3	6	10	PF02991	0.528
LIG_MYND_1	480	484	PF01753	0.587
LIG_SH2_CRK	451	455	PF00017	0.471
LIG_SH2_GRB2like	365	368	PF00017	0.418
LIG_SH2_PTP2	346	349	PF00017	0.376
LIG_SH2_PTP2	7	10	PF00017	0.637
LIG_SH2_STAT5	346	349	PF00017	0.376
LIG_SH2_STAT5	7	10	PF00017	0.637
LIG_SH3_3	165	171	PF00018	0.485
LIG_SH3_3	173	179	PF00018	0.525
LIG_SH3_3	202	208	PF00018	0.692
LIG_SH3_3	338	344	PF00018	0.468
LIG_SH3_3	490	496	PF00018	0.588
LIG_SH3_3	522	528	PF00018	0.559
LIG_Sin3_3	317	324	PF02671	0.390
LIG_TRAF2_1	412	415	PF00917	0.515
MOD_CDK_SPxK_1	158	164	PF00069	0.510
MOD_CDK_SPxxK_3	476	483	PF00069	0.567
MOD_CK1_1	115	121	PF00069	0.733
MOD_CK1_1	145	151	PF00069	0.546
MOD_CK1_1	188	194	PF00069	0.688
MOD_CK1_1	206	212	PF00069	0.618
MOD_CK1_1	239	245	PF00069	0.755
MOD_CK1_1	306	312	PF00069	0.463
MOD_CK1_1	409	415	PF00069	0.502
MOD_CK1_1	515	521	PF00069	0.612
MOD_CK2_1	214	220	PF00069	0.488
MOD_CK2_1	409	415	PF00069	0.471
MOD_Cter_Amidation	105	108	PF01082	0.714
MOD_GlcNHglycan	114	117	PF01048	0.757
MOD_GlcNHglycan	126	129	PF01048	0.651
MOD_GlcNHglycan	200	203	PF01048	0.764
MOD_GlcNHglycan	247	250	PF01048	0.736
MOD_GlcNHglycan	263	266	PF01048	0.597
MOD_GlcNHglycan	268	271	PF01048	0.588
MOD_GlcNHglycan	38	41	PF01048	0.669
MOD_GlcNHglycan	402	405	PF01048	0.596
MOD_GlcNHglycan	422	425	PF01048	0.417
MOD_GlcNHglycan	535	538	PF01048	0.661
MOD_GSK3_1	112	119	PF00069	0.733
MOD_GSK3_1	120	127	PF00069	0.645
MOD_GSK3_1	158	165	PF00069	0.524
MOD_GSK3_1	18	25	PF00069	0.549
MOD_GSK3_1	185	192	PF00069	0.675
MOD_GSK3_1	299	306	PF00069	0.453
MOD_GSK3_1	394	401	PF00069	0.551
MOD_GSK3_1	472	479	PF00069	0.607
MOD_GSK3_1	512	519	PF00069	0.587
MOD_GSK3_1	61	68	PF00069	0.708
MOD_N-GLC_1	28	33	PF02516	0.708
MOD_N-GLC_1	315	320	PF02516	0.390
MOD_NEK2_1	315	320	PF00069	0.386
MOD_NEK2_1	429	434	PF00069	0.527
MOD_NEK2_1	447	452	PF00069	0.401
MOD_PIKK_1	512	518	PF00454	0.586
MOD_PK_1	310	316	PF00069	0.474
MOD_PKA_1	393	399	PF00069	0.528
MOD_PKA_2	420	426	PF00069	0.439
MOD_Plk_1	219	225	PF00069	0.690
MOD_Plk_1	289	295	PF00069	0.527
MOD_Plk_1	315	321	PF00069	0.386
MOD_Plk_4	277	283	PF00069	0.495
MOD_Plk_4	291	297	PF00069	0.553
MOD_Plk_4	315	321	PF00069	0.405
MOD_Plk_4	329	335	PF00069	0.517
MOD_Plk_4	342	348	PF00069	0.379
MOD_Plk_4	76	82	PF00069	0.652
MOD_ProDKin_1	158	164	PF00069	0.476
MOD_ProDKin_1	185	191	PF00069	0.671
MOD_ProDKin_1	204	210	PF00069	0.594
MOD_ProDKin_1	22	28	PF00069	0.575
MOD_ProDKin_1	340	346	PF00069	0.499
MOD_ProDKin_1	38	44	PF00069	0.704
MOD_ProDKin_1	476	482	PF00069	0.568
MOD_ProDKin_1	492	498	PF00069	0.558
MOD_SUMO_for_1	328	331	PF00179	0.447
MOD_SUMO_for_1	388	391	PF00179	0.391
MOD_SUMO_rev_2	369	376	PF00179	0.362
MOD_SUMO_rev_2	403	412	PF00179	0.530
MOD_SUMO_rev_2	529	534	PF00179	0.681
MOD_SUMO_rev_2	89	94	PF00179	0.680
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.498
TRG_ENDOCYTIC_2	346	349	PF00928	0.404
TRG_ENDOCYTIC_2	451	454	PF00928	0.523
TRG_ENDOCYTIC_2	7	10	PF00928	0.637
TRG_ER_diArg_1	298	300	PF00400	0.496
TRG_ER_diArg_1	464	466	PF00400	0.423
TRG_ER_diArg_1	539	542	PF00400	0.599
TRG_NLS_MonoCore_2	106	111	PF00514	0.713
TRG_NLS_MonoExtC_3	106	111	PF00514	0.713
TRG_NLS_MonoExtN_4	107	114	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC49	Leptomonas seymouri	66%	100%
A0A0S4J510	Bodo saltans	37%	100%
A0A1X0NW66	Trypanosomatidae	45%	100%
A0A3S7WYC8	Leishmania donovani	95%	100%
A4HDH9	Leishmania braziliensis	79%	100%
A4I0W0	Leishmania infantum	95%	100%
D0A792	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AWW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%