PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAK9_LEIMA

TriTrypDb:

LmjF.24.1230 , LMJLV39_240018500 , LMJSD75_240018000

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.560
CLV_C14_Caspase3-7	308	312	PF00656	0.751
CLV_C14_Caspase3-7	742	746	PF00656	0.724
CLV_NRD_NRD_1	169	171	PF00675	0.700
CLV_NRD_NRD_1	433	435	PF00675	0.517
CLV_NRD_NRD_1	494	496	PF00675	0.514
CLV_NRD_NRD_1	577	579	PF00675	0.546
CLV_NRD_NRD_1	729	731	PF00675	0.726
CLV_PCSK_FUR_1	166	170	PF00082	0.811
CLV_PCSK_KEX2_1	166	168	PF00082	0.721
CLV_PCSK_KEX2_1	169	171	PF00082	0.688
CLV_PCSK_KEX2_1	433	435	PF00082	0.517
CLV_PCSK_KEX2_1	494	496	PF00082	0.514
CLV_PCSK_KEX2_1	627	629	PF00082	0.586
CLV_PCSK_KEX2_1	731	733	PF00082	0.715
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.586
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.715
CLV_PCSK_SKI1_1	133	137	PF00082	0.632
CLV_PCSK_SKI1_1	285	289	PF00082	0.637
CLV_PCSK_SKI1_1	345	349	PF00082	0.620
CLV_PCSK_SKI1_1	540	544	PF00082	0.551
CLV_PCSK_SKI1_1	600	604	PF00082	0.413
DEG_APCC_DBOX_1	421	429	PF00400	0.410
DEG_APCC_DBOX_1	577	585	PF00400	0.497
DEG_ODPH_VHL_1	425	438	PF01847	0.377
DEG_SPOP_SBC_1	387	391	PF00917	0.799
DOC_CYCLIN_RxL_1	133	143	PF00134	0.633
DOC_CYCLIN_RxL_1	404	418	PF00134	0.651
DOC_CYCLIN_RxL_1	535	546	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.546
DOC_MAPK_gen_1	598	607	PF00069	0.461
DOC_MAPK_gen_1	75	85	PF00069	0.713
DOC_PP1_RVXF_1	343	349	PF00149	0.612
DOC_PP1_RVXF_1	615	621	PF00149	0.524
DOC_PP2B_LxvP_1	159	162	PF13499	0.818
DOC_PP2B_LxvP_1	325	328	PF13499	0.767
DOC_PP2B_LxvP_1	451	454	PF13499	0.492
DOC_PP4_FxxP_1	287	290	PF00568	0.620
DOC_PP4_FxxP_1	320	323	PF00568	0.758
DOC_PP4_FxxP_1	620	623	PF00568	0.470
DOC_USP7_MATH_1	176	180	PF00917	0.735
DOC_USP7_MATH_1	197	201	PF00917	0.766
DOC_USP7_MATH_1	221	225	PF00917	0.791
DOC_USP7_MATH_1	309	313	PF00917	0.733
DOC_USP7_MATH_1	378	382	PF00917	0.805
DOC_USP7_MATH_1	503	507	PF00917	0.436
DOC_USP7_MATH_1	623	627	PF00917	0.505
DOC_USP7_MATH_1	717	721	PF00917	0.653
DOC_WW_Pin1_4	102	107	PF00397	0.814
DOC_WW_Pin1_4	117	122	PF00397	0.572
DOC_WW_Pin1_4	154	159	PF00397	0.706
DOC_WW_Pin1_4	182	187	PF00397	0.724
DOC_WW_Pin1_4	205	210	PF00397	0.722
DOC_WW_Pin1_4	226	231	PF00397	0.684
DOC_WW_Pin1_4	248	253	PF00397	0.584
DOC_WW_Pin1_4	294	299	PF00397	0.739
DOC_WW_Pin1_4	31	36	PF00397	0.709
DOC_WW_Pin1_4	319	324	PF00397	0.773
DOC_WW_Pin1_4	346	351	PF00397	0.633
DOC_WW_Pin1_4	420	425	PF00397	0.663
DOC_WW_Pin1_4	546	551	PF00397	0.601
DOC_WW_Pin1_4	619	624	PF00397	0.517
DOC_WW_Pin1_4	684	689	PF00397	0.716
LIG_14-3-3_CanoR_1	141	147	PF00244	0.749
LIG_14-3-3_CanoR_1	202	209	PF00244	0.797
LIG_14-3-3_CanoR_1	318	323	PF00244	0.829
LIG_14-3-3_CanoR_1	45	51	PF00244	0.590
LIG_14-3-3_CanoR_1	511	516	PF00244	0.548
LIG_14-3-3_CanoR_1	583	589	PF00244	0.483
LIG_14-3-3_CanoR_1	650	658	PF00244	0.553
LIG_14-3-3_CanoR_1	80	86	PF00244	0.692
LIG_Actin_WH2_2	228	244	PF00022	0.741
LIG_Actin_WH2_2	520	537	PF00022	0.604
LIG_Actin_WH2_2	577	594	PF00022	0.464
LIG_BIR_III_4	153	157	PF00653	0.727
LIG_BRCT_BRCA1_1	631	635	PF00533	0.460
LIG_Clathr_ClatBox_1	585	589	PF01394	0.430
LIG_FHA_1	134	140	PF00498	0.618
LIG_FHA_1	141	147	PF00498	0.648
LIG_FHA_1	335	341	PF00498	0.675
LIG_FHA_1	378	384	PF00498	0.738
LIG_FHA_1	585	591	PF00498	0.531
LIG_FHA_2	306	312	PF00498	0.825
LIG_FHA_2	455	461	PF00498	0.588
LIG_FHA_2	644	650	PF00498	0.569
LIG_FHA_2	754	760	PF00498	0.709
LIG_Integrin_isoDGR_2	164	166	PF01839	0.785
LIG_Integrin_isoDGR_2	509	511	PF01839	0.517
LIG_Integrin_RGD_1	732	734	PF01839	0.609
LIG_LIR_Apic_2	286	290	PF02991	0.582
LIG_LIR_Apic_2	619	623	PF02991	0.492
LIG_LIR_Gen_1	563	571	PF02991	0.410
LIG_LIR_Gen_1	632	642	PF02991	0.469
LIG_LIR_Nem_3	396	402	PF02991	0.813
LIG_LIR_Nem_3	480	486	PF02991	0.508
LIG_LIR_Nem_3	522	527	PF02991	0.620
LIG_LIR_Nem_3	563	567	PF02991	0.402
LIG_LIR_Nem_3	631	636	PF02991	0.469
LIG_LIR_Nem_3	637	642	PF02991	0.473
LIG_LYPXL_yS_3	399	402	PF13949	0.751
LIG_MYND_1	323	327	PF01753	0.709
LIG_MYND_1	384	388	PF01753	0.761
LIG_NRBOX	580	586	PF00104	0.464
LIG_PCNA_yPIPBox_3	509	521	PF02747	0.443
LIG_Pex14_2	287	291	PF04695	0.593
LIG_PTAP_UEV_1	105	110	PF05743	0.579
LIG_PTB_Apo_2	661	668	PF02174	0.475
LIG_SH2_CRK	448	452	PF00017	0.491
LIG_SH2_CRK	524	528	PF00017	0.610
LIG_SH2_CRK	642	646	PF00017	0.552
LIG_SH2_NCK_1	642	646	PF00017	0.552
LIG_SH2_SRC	642	645	PF00017	0.550
LIG_SH2_STAT5	486	489	PF00017	0.461
LIG_SH2_STAT5	498	501	PF00017	0.371
LIG_SH3_3	103	109	PF00018	0.756
LIG_SH3_3	118	124	PF00018	0.676
LIG_SH3_3	180	186	PF00018	0.732
LIG_SH3_3	311	317	PF00018	0.780
LIG_SH3_3	320	326	PF00018	0.736
LIG_SH3_3	381	387	PF00018	0.809
LIG_SH3_3	403	409	PF00018	0.787
LIG_SH3_3	421	427	PF00018	0.353
LIG_TRAF2_1	704	707	PF00917	0.707
LIG_TYR_ITIM	446	451	PF00017	0.469
LIG_UBA3_1	584	592	PF00899	0.381
LIG_ULM_U2AF65_1	647	652	PF00076	0.537
LIG_WRC_WIRS_1	630	635	PF05994	0.430
LIG_WW_2	323	326	PF00397	0.709
MOD_CDK_SPxxK_3	182	189	PF00069	0.570
MOD_CK1_1	104	110	PF00069	0.529
MOD_CK1_1	152	158	PF00069	0.691
MOD_CK1_1	204	210	PF00069	0.725
MOD_CK1_1	223	229	PF00069	0.726
MOD_CK1_1	300	306	PF00069	0.804
MOD_CK1_1	312	318	PF00069	0.818
MOD_CK1_1	335	341	PF00069	0.640
MOD_CK1_1	369	375	PF00069	0.716
MOD_CK1_1	392	398	PF00069	0.768
MOD_CK1_1	546	552	PF00069	0.579
MOD_CK1_1	710	716	PF00069	0.718
MOD_CK1_1	735	741	PF00069	0.775
MOD_CK1_1	753	759	PF00069	0.543
MOD_CK1_1	84	90	PF00069	0.767
MOD_CK1_1	92	98	PF00069	0.650
MOD_CK2_1	107	113	PF00069	0.781
MOD_CK2_1	248	254	PF00069	0.577
MOD_CK2_1	336	342	PF00069	0.771
MOD_CK2_1	454	460	PF00069	0.586
MOD_CK2_1	613	619	PF00069	0.562
MOD_CK2_1	643	649	PF00069	0.560
MOD_CK2_1	701	707	PF00069	0.821
MOD_CK2_1	741	747	PF00069	0.606
MOD_Cter_Amidation	164	167	PF01082	0.823
MOD_GlcNHglycan	106	109	PF01048	0.573
MOD_GlcNHglycan	172	175	PF01048	0.791
MOD_GlcNHglycan	195	198	PF01048	0.772
MOD_GlcNHglycan	204	207	PF01048	0.629
MOD_GlcNHglycan	210	213	PF01048	0.581
MOD_GlcNHglycan	222	226	PF01048	0.735
MOD_GlcNHglycan	267	270	PF01048	0.550
MOD_GlcNHglycan	299	302	PF01048	0.710
MOD_GlcNHglycan	369	372	PF01048	0.756
MOD_GlcNHglycan	380	383	PF01048	0.678
MOD_GlcNHglycan	391	394	PF01048	0.668
MOD_GlcNHglycan	479	482	PF01048	0.514
MOD_GlcNHglycan	518	521	PF01048	0.559
MOD_GlcNHglycan	544	548	PF01048	0.560
MOD_GlcNHglycan	569	572	PF01048	0.415
MOD_GlcNHglycan	684	687	PF01048	0.711
MOD_GlcNHglycan	702	706	PF01048	0.599
MOD_GlcNHglycan	712	715	PF01048	0.614
MOD_GlcNHglycan	721	724	PF01048	0.658
MOD_GlcNHglycan	734	737	PF01048	0.730
MOD_GlcNHglycan	88	91	PF01048	0.808
MOD_GSK3_1	104	111	PF00069	0.598
MOD_GSK3_1	113	120	PF00069	0.719
MOD_GSK3_1	189	196	PF00069	0.736
MOD_GSK3_1	197	204	PF00069	0.792
MOD_GSK3_1	217	224	PF00069	0.576
MOD_GSK3_1	290	297	PF00069	0.614
MOD_GSK3_1	300	307	PF00069	0.790
MOD_GSK3_1	327	334	PF00069	0.748
MOD_GSK3_1	336	343	PF00069	0.644
MOD_GSK3_1	363	370	PF00069	0.753
MOD_GSK3_1	373	380	PF00069	0.644
MOD_GSK3_1	387	394	PF00069	0.745
MOD_GSK3_1	511	518	PF00069	0.515
MOD_GSK3_1	529	536	PF00069	0.495
MOD_GSK3_1	565	572	PF00069	0.408
MOD_GSK3_1	619	626	PF00069	0.518
MOD_GSK3_1	84	91	PF00069	0.762
MOD_GSK3_1	92	99	PF00069	0.728
MOD_N-GLC_1	176	181	PF02516	0.742
MOD_N-GLC_1	682	687	PF02516	0.664
MOD_N-GLC_2	264	266	PF02516	0.496
MOD_NEK2_1	112	117	PF00069	0.599
MOD_NEK2_1	140	145	PF00069	0.732
MOD_NEK2_1	193	198	PF00069	0.763
MOD_NEK2_1	340	345	PF00069	0.617
MOD_NEK2_1	515	520	PF00069	0.379
MOD_NEK2_1	534	539	PF00069	0.438
MOD_NEK2_1	569	574	PF00069	0.481
MOD_NEK2_1	591	596	PF00069	0.503
MOD_NEK2_1	629	634	PF00069	0.429
MOD_NEK2_1	97	102	PF00069	0.735
MOD_PIKK_1	229	235	PF00454	0.688
MOD_PIKK_1	327	333	PF00454	0.831
MOD_PIKK_1	503	509	PF00454	0.576
MOD_PIKK_1	529	535	PF00454	0.493
MOD_PK_1	332	338	PF00069	0.721
MOD_PKA_1	168	174	PF00069	0.801
MOD_PKA_2	140	146	PF00069	0.739
MOD_PKA_2	168	174	PF00069	0.753
MOD_PKA_2	201	207	PF00069	0.800
MOD_PKA_2	649	655	PF00069	0.553
MOD_PKA_2	66	72	PF00069	0.721
MOD_PKA_2	707	713	PF00069	0.715
MOD_PKB_1	166	174	PF00069	0.806
MOD_PKB_1	730	738	PF00069	0.715
MOD_Plk_1	112	118	PF00069	0.670
MOD_Plk_1	176	182	PF00069	0.741
MOD_Plk_1	373	379	PF00069	0.707
MOD_Plk_1	475	481	PF00069	0.527
MOD_Plk_4	142	148	PF00069	0.651
MOD_Plk_4	177	183	PF00069	0.623
MOD_Plk_4	511	517	PF00069	0.428
MOD_Plk_4	97	103	PF00069	0.802
MOD_ProDKin_1	102	108	PF00069	0.813
MOD_ProDKin_1	117	123	PF00069	0.571
MOD_ProDKin_1	154	160	PF00069	0.710
MOD_ProDKin_1	182	188	PF00069	0.720
MOD_ProDKin_1	205	211	PF00069	0.725
MOD_ProDKin_1	226	232	PF00069	0.682
MOD_ProDKin_1	248	254	PF00069	0.577
MOD_ProDKin_1	294	300	PF00069	0.747
MOD_ProDKin_1	31	37	PF00069	0.699
MOD_ProDKin_1	319	325	PF00069	0.773
MOD_ProDKin_1	346	352	PF00069	0.634
MOD_ProDKin_1	420	426	PF00069	0.661
MOD_ProDKin_1	546	552	PF00069	0.591
MOD_ProDKin_1	619	625	PF00069	0.521
MOD_ProDKin_1	684	690	PF00069	0.719
TRG_DiLeu_BaEn_1	431	436	PF01217	0.586
TRG_DiLeu_BaEn_1	93	98	PF01217	0.588
TRG_DiLeu_BaEn_2	630	636	PF01217	0.449
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.590
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.571
TRG_DiLeu_LyEn_5	431	436	PF01217	0.509
TRG_ENDOCYTIC_2	399	402	PF00928	0.751
TRG_ENDOCYTIC_2	448	451	PF00928	0.486
TRG_ENDOCYTIC_2	524	527	PF00928	0.508
TRG_ENDOCYTIC_2	630	633	PF00928	0.464
TRG_ENDOCYTIC_2	642	645	PF00928	0.550
TRG_ER_diArg_1	166	169	PF00400	0.765
TRG_ER_diArg_1	2	5	PF00400	0.708
TRG_ER_diArg_1	278	281	PF00400	0.612
TRG_ER_diArg_1	432	434	PF00400	0.519
TRG_ER_diArg_1	50	53	PF00400	0.800
TRG_ER_diArg_1	595	598	PF00400	0.464
TRG_ER_diArg_1	62	65	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY8	Leptomonas seymouri	54%	91%
A0A3S7WYC3	Leishmania donovani	92%	100%
A4HDI0	Leishmania braziliensis	74%	100%
A4I0W1	Leishmania infantum	92%	100%
E9AWW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%