RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAK8_LEIMA

TriTrypDb:

LmjF.24.1240 , LMJLV39_240018600 , LMJSD75_240018100

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	547	551	PF00656	0.526
CLV_NRD_NRD_1	17	19	PF00675	0.429
CLV_NRD_NRD_1	185	187	PF00675	0.381
CLV_NRD_NRD_1	360	362	PF00675	0.470
CLV_NRD_NRD_1	405	407	PF00675	0.396
CLV_NRD_NRD_1	447	449	PF00675	0.606
CLV_PCSK_KEX2_1	185	187	PF00082	0.400
CLV_PCSK_KEX2_1	362	364	PF00082	0.478
CLV_PCSK_KEX2_1	405	407	PF00082	0.441
CLV_PCSK_KEX2_1	482	484	PF00082	0.475
CLV_PCSK_KEX2_1	571	573	PF00082	0.401
CLV_PCSK_KEX2_1	601	603	PF00082	0.541
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.525
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.523
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.416
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.541
CLV_PCSK_SKI1_1	122	126	PF00082	0.454
CLV_PCSK_SKI1_1	18	22	PF00082	0.446
CLV_PCSK_SKI1_1	363	367	PF00082	0.467
CLV_PCSK_SKI1_1	396	400	PF00082	0.388
CLV_PCSK_SKI1_1	475	479	PF00082	0.473
CLV_PCSK_SKI1_1	532	536	PF00082	0.458
CLV_PCSK_SKI1_1	601	605	PF00082	0.461
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DOC_ANK_TNKS_1	453	460	PF00023	0.351
DOC_CYCLIN_RxL_1	599	606	PF00134	0.506
DOC_CYCLIN_yClb5_NLxxxL_5	408	417	PF00134	0.356
DOC_MAPK_gen_1	185	193	PF00069	0.348
DOC_MAPK_gen_1	293	303	PF00069	0.351
DOC_MAPK_gen_1	419	426	PF00069	0.330
DOC_MAPK_gen_1	516	525	PF00069	0.446
DOC_MAPK_gen_1	570	576	PF00069	0.401
DOC_MAPK_JIP1_4	260	266	PF00069	0.492
DOC_MAPK_MEF2A_6	185	193	PF00069	0.364
DOC_MAPK_MEF2A_6	293	301	PF00069	0.397
DOC_MAPK_MEF2A_6	518	527	PF00069	0.443
DOC_PP1_RVXF_1	447	454	PF00149	0.446
DOC_PP1_RVXF_1	458	464	PF00149	0.292
DOC_PP2B_LxvP_1	333	336	PF13499	0.354
DOC_PP4_FxxP_1	311	314	PF00568	0.427
DOC_SPAK_OSR1_1	186	190	PF12202	0.385
DOC_SPAK_OSR1_1	275	279	PF12202	0.486
DOC_USP7_MATH_1	314	318	PF00917	0.475
DOC_USP7_MATH_1	59	63	PF00917	0.584
DOC_USP7_UBL2_3	410	414	PF12436	0.390
DOC_USP7_UBL2_3	478	482	PF12436	0.458
DOC_WW_Pin1_4	113	118	PF00397	0.450
DOC_WW_Pin1_4	378	383	PF00397	0.502
DOC_WW_Pin1_4	63	68	PF00397	0.656
DOC_WW_Pin1_4	86	91	PF00397	0.600
LIG_14-3-3_CanoR_1	185	190	PF00244	0.430
LIG_14-3-3_CanoR_1	376	380	PF00244	0.484
LIG_14-3-3_CanoR_1	460	464	PF00244	0.479
LIG_APCC_ABBA_1	115	120	PF00400	0.511
LIG_APCC_ABBA_1	523	528	PF00400	0.401
LIG_BRCT_BRCA1_1	577	581	PF00533	0.373
LIG_Clathr_ClatBox_1	190	194	PF01394	0.306
LIG_FHA_1	205	211	PF00498	0.532
LIG_FHA_1	217	223	PF00498	0.720
LIG_FHA_1	558	564	PF00498	0.645
LIG_GBD_Chelix_1	426	434	PF00786	0.455
LIG_HCF-1_HBM_1	428	431	PF13415	0.503
LIG_Integrin_RGD_1	176	178	PF01839	0.391
LIG_LIR_Apic_2	309	314	PF02991	0.424
LIG_LIR_Gen_1	327	336	PF02991	0.460
LIG_LIR_Gen_1	428	439	PF02991	0.567
LIG_LIR_Gen_1	578	589	PF02991	0.360
LIG_LIR_Gen_1	594	605	PF02991	0.483
LIG_LIR_LC3C_4	188	193	PF02991	0.397
LIG_LIR_Nem_3	327	331	PF02991	0.406
LIG_LIR_Nem_3	370	375	PF02991	0.313
LIG_LIR_Nem_3	428	434	PF02991	0.517
LIG_LIR_Nem_3	578	584	PF02991	0.484
LIG_LIR_Nem_3	594	600	PF02991	0.298
LIG_Pex14_2	276	280	PF04695	0.329
LIG_Pex14_2	593	597	PF04695	0.546
LIG_Pex14_2	78	82	PF04695	0.452
LIG_RPA_C_Fungi	2	14	PF08784	0.494
LIG_SH2_CRK	431	435	PF00017	0.554
LIG_SH2_SRC	233	236	PF00017	0.608
LIG_SH2_STAP1	218	222	PF00017	0.720
LIG_SH2_STAT5	174	177	PF00017	0.406
LIG_SH2_STAT5	200	203	PF00017	0.369
LIG_SH2_STAT5	218	221	PF00017	0.579
LIG_SH2_STAT5	233	236	PF00017	0.460
LIG_SH3_2	232	237	PF14604	0.670
LIG_SH3_3	199	205	PF00018	0.382
LIG_SH3_3	229	235	PF00018	0.693
LIG_SH3_3	558	564	PF00018	0.611
LIG_SH3_3	586	592	PF00018	0.350
LIG_SUMO_SIM_anti_2	188	196	PF11976	0.414
LIG_SUMO_SIM_par_1	188	196	PF11976	0.334
LIG_SUMO_SIM_par_1	199	207	PF11976	0.374
LIG_SUMO_SIM_par_1	301	307	PF11976	0.377
LIG_TRAF2_1	327	330	PF00917	0.375
LIG_UBA3_1	16	21	PF00899	0.397
LIG_UBA3_1	473	482	PF00899	0.375
LIG_WRC_WIRS_1	484	489	PF05994	0.376
LIG_WRC_WIRS_1	541	546	PF05994	0.404
MOD_CK1_1	269	275	PF00069	0.453
MOD_CK1_1	304	310	PF00069	0.383
MOD_CK1_1	510	516	PF00069	0.381
MOD_CK1_1	557	563	PF00069	0.595
MOD_CK1_1	62	68	PF00069	0.652
MOD_CK2_1	200	206	PF00069	0.383
MOD_CK2_1	268	274	PF00069	0.400
MOD_CK2_1	324	330	PF00069	0.417
MOD_GlcNHglycan	101	104	PF01048	0.678
MOD_GlcNHglycan	169	172	PF01048	0.458
MOD_GlcNHglycan	431	434	PF01048	0.406
MOD_GlcNHglycan	436	439	PF01048	0.510
MOD_GlcNHglycan	443	446	PF01048	0.559
MOD_GlcNHglycan	492	495	PF01048	0.430
MOD_GlcNHglycan	556	559	PF01048	0.595
MOD_GlcNHglycan	585	588	PF01048	0.388
MOD_GSK3_1	196	203	PF00069	0.359
MOD_GSK3_1	206	213	PF00069	0.530
MOD_GSK3_1	314	321	PF00069	0.424
MOD_GSK3_1	434	441	PF00069	0.667
MOD_GSK3_1	459	466	PF00069	0.393
MOD_GSK3_1	540	547	PF00069	0.392
MOD_GSK3_1	553	560	PF00069	0.502
MOD_GSK3_1	59	66	PF00069	0.635
MOD_GSK3_1	99	106	PF00069	0.560
MOD_N-GLC_1	463	468	PF02516	0.386
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	167	172	PF00069	0.471
MOD_NEK2_1	266	271	PF00069	0.423
MOD_NEK2_1	331	336	PF00069	0.397
MOD_NEK2_1	439	444	PF00069	0.685
MOD_NEK2_1	463	468	PF00069	0.390
MOD_NEK2_1	530	535	PF00069	0.355
MOD_NEK2_1	544	549	PF00069	0.409
MOD_NEK2_1	553	558	PF00069	0.550
MOD_NEK2_1	60	65	PF00069	0.571
MOD_NEK2_1	603	608	PF00069	0.632
MOD_PIKK_1	204	210	PF00454	0.613
MOD_PIKK_1	384	390	PF00454	0.429
MOD_PIKK_1	54	60	PF00454	0.667
MOD_PK_1	185	191	PF00069	0.423
MOD_PKA_1	185	191	PF00069	0.423
MOD_PKA_2	185	191	PF00069	0.423
MOD_PKA_2	295	301	PF00069	0.422
MOD_PKA_2	375	381	PF00069	0.494
MOD_PKA_2	439	445	PF00069	0.618
MOD_PKA_2	459	465	PF00069	0.409
MOD_PKA_2	54	60	PF00069	0.524
MOD_PKB_1	361	369	PF00069	0.437
MOD_Plk_1	177	183	PF00069	0.472
MOD_Plk_1	399	405	PF00069	0.502
MOD_Plk_1	463	469	PF00069	0.389
MOD_Plk_1	507	513	PF00069	0.376
MOD_Plk_4	151	157	PF00069	0.472
MOD_Plk_4	169	175	PF00069	0.327
MOD_Plk_4	196	202	PF00069	0.421
MOD_Plk_4	235	241	PF00069	0.522
MOD_Plk_4	314	320	PF00069	0.419
MOD_Plk_4	41	47	PF00069	0.431
MOD_Plk_4	463	469	PF00069	0.435
MOD_Plk_4	540	546	PF00069	0.356
MOD_Plk_4	557	563	PF00069	0.485
MOD_ProDKin_1	113	119	PF00069	0.452
MOD_ProDKin_1	378	384	PF00069	0.502
MOD_ProDKin_1	63	69	PF00069	0.653
MOD_ProDKin_1	86	92	PF00069	0.607
MOD_SUMO_for_1	398	401	PF00179	0.385
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.573
TRG_ENDOCYTIC_2	138	141	PF00928	0.453
TRG_ENDOCYTIC_2	431	434	PF00928	0.502
TRG_ER_diArg_1	184	186	PF00400	0.390
TRG_ER_diArg_1	404	406	PF00400	0.497
TRG_NES_CRM1_1	182	196	PF08389	0.375
TRG_NES_CRM1_1	370	380	PF08389	0.371
TRG_NLS_MonoExtN_4	568	574	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JET7	Bodo saltans	48%	100%
A0A1X0NW11	Trypanosomatidae	56%	100%
A0A3Q8IC34	Leishmania donovani	96%	100%
A0A422NQ83	Trypanosoma rangeli	59%	100%
A4HDI1	Leishmania braziliensis	88%	100%
C6K3X8	Leptomonas seymouri	80%	100%
D0A795	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AWW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5C0H3	Trypanosoma cruzi	61%	100%