Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania major

UniProt:

Q4QAK7_LEIMA

TriTrypDb:

LmjF.24.1250 , LMJLV39_240018700 , LMJSD75_240018200

Length:

186

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 127
NetGPI	no	yes: 0, no: 136

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	120
GO:0110165	cellular anatomical entity	1	120

Expansion

Sequence features

Q4QAK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	47	49	PF00675	0.509
CLV_NRD_NRD_1	68	70	PF00675	0.481
CLV_PCSK_KEX2_1	68	70	PF00082	0.484
DOC_CKS1_1	27	32	PF01111	0.368
DOC_CKS1_1	34	39	PF01111	0.317
DOC_PP4_FxxP_1	34	37	PF00568	0.336
DOC_WW_Pin1_4	26	31	PF00397	0.371
DOC_WW_Pin1_4	33	38	PF00397	0.320
LIG_14-3-3_CanoR_1	68	74	PF00244	0.271
LIG_CaM_NSCaTE_8	22	29	PF13499	0.198
LIG_LIR_Apic_2	169	174	PF02991	0.571
LIG_LIR_Apic_2	31	37	PF02991	0.333
LIG_LIR_Gen_1	122	130	PF02991	0.315
LIG_LIR_Gen_1	146	154	PF02991	0.375
LIG_LIR_Nem_3	122	126	PF02991	0.289
LIG_Pex14_2	20	24	PF04695	0.449
LIG_SH2_STAT5	145	148	PF00017	0.283
LIG_SH2_STAT5	42	45	PF00017	0.383
LIG_SH2_STAT5	8	11	PF00017	0.428
LIG_SH3_3	102	108	PF00018	0.534
LIG_SH3_3	111	117	PF00018	0.410
LIG_SH3_3	24	30	PF00018	0.396
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.305
LIG_TRAF2_1	175	178	PF00917	0.693
MOD_GlcNHglycan	83	86	PF01048	0.351
MOD_GlcNHglycan	92	95	PF01048	0.350
MOD_N-GLC_1	130	135	PF02516	0.615
MOD_N-GLC_1	169	174	PF02516	0.287
MOD_NEK2_1	12	17	PF00069	0.351
MOD_NEK2_1	152	157	PF00069	0.303
MOD_NEK2_1	166	171	PF00069	0.410
MOD_NEK2_2	125	130	PF00069	0.382
MOD_PIKK_1	96	102	PF00454	0.339
MOD_PKA_1	68	74	PF00069	0.240
MOD_PKA_2	67	73	PF00069	0.272
MOD_Plk_1	130	136	PF00069	0.408
MOD_Plk_4	116	122	PF00069	0.313
MOD_Plk_4	125	131	PF00069	0.361
MOD_Plk_4	40	46	PF00069	0.329
MOD_ProDKin_1	26	32	PF00069	0.371
MOD_ProDKin_1	33	39	PF00069	0.320
MOD_SUMO_for_1	175	178	PF00179	0.621
TRG_ENDOCYTIC_2	47	50	PF00928	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	34%	100%
A0A0N0P6P9	Leptomonas seymouri	20%	81%
A0A0N1I0E5	Leptomonas seymouri	31%	100%
A0A0N1I295	Leptomonas seymouri	29%	100%
A0A0N1PFN2	Leptomonas seymouri	24%	100%
A0A1X0NQ58	Trypanosomatidae	33%	100%
A0A1X0NUH1	Trypanosomatidae	28%	82%
A0A1X0NVN5	Trypanosomatidae	31%	100%
A0A1X0NVT7	Trypanosomatidae	32%	100%
A0A1X0NX02	Trypanosomatidae	28%	100%
A0A1X0NX81	Trypanosomatidae	31%	100%
A0A1X0P988	Trypanosomatidae	28%	100%
A0A381MTA7	Leishmania infantum	27%	97%
A0A381MTB8	Leishmania infantum	24%	100%
A0A381MTC7	Leishmania infantum	28%	91%
A0A381MVY0	Leishmania infantum	27%	97%
A0A3Q8ID16	Leishmania donovani	35%	100%
A0A3Q8IEC2	Leishmania donovani	25%	96%
A0A3Q8IEI1	Leishmania donovani	21%	97%
A0A3Q8IFH7	Leishmania donovani	28%	91%
A0A3Q8IH65	Leishmania donovani	24%	100%
A0A3Q8IHN2	Leishmania donovani	22%	97%
A0A3Q8IHW7	Leishmania donovani	30%	100%
A0A3Q8IHZ6	Leishmania donovani	27%	88%
A0A3Q8IIH1	Leishmania donovani	23%	100%
A0A3Q8IL03	Leishmania donovani	26%	97%
A0A3Q8IMR4	Leishmania donovani	95%	100%
A0A3Q8IUK8	Leishmania donovani	27%	97%
A0A3S5H666	Leishmania donovani	23%	96%
A0A3S5H7D2	Leishmania donovani	37%	100%
A0A3S5H7L2	Leishmania donovani	27%	91%
A0A3S5H7W6	Leishmania donovani	26%	100%
A0A3S7WQA8	Leishmania donovani	26%	100%
A0A3S7WQC1	Leishmania donovani	26%	96%
A0A3S7X2E6	Leishmania donovani	24%	96%
A0A3S7X357	Leishmania donovani	25%	84%
A0A3S7X7E5	Leishmania donovani	28%	74%
A0A3S7X7M4	Leishmania donovani	27%	88%
A0A3S7X7U1	Leishmania donovani	26%	100%
A0A3S7X7W2	Leishmania donovani	26%	89%
A0A3S7X7Y0	Leishmania donovani	27%	96%
A4H5D1	Leishmania braziliensis	28%	95%
A4H5G0	Leishmania braziliensis	30%	99%
A4H5H2	Leishmania braziliensis	25%	100%
A4H6C8	Leishmania braziliensis	24%	100%
A4H7D7	Leishmania braziliensis	28%	96%
A4H9E8	Leishmania braziliensis	26%	100%
A4H9E9	Leishmania braziliensis	26%	100%
A4HAM2	Leishmania braziliensis	29%	97%
A4HAM4	Leishmania braziliensis	29%	97%
A4HAR1	Leishmania braziliensis	22%	97%
A4HAZ8	Leishmania braziliensis	27%	98%
A4HB00	Leishmania braziliensis	22%	97%
A4HB02	Leishmania braziliensis	25%	96%
A4HB47	Leishmania braziliensis	24%	92%
A4HBJ1	Leishmania braziliensis	29%	97%
A4HBJ2	Leishmania braziliensis	24%	89%
A4HDI2	Leishmania braziliensis	84%	100%
A4HDI3	Leishmania braziliensis	37%	77%
A4HDI4	Leishmania braziliensis	35%	100%
A4HDL3	Leishmania braziliensis	37%	100%
A4HDL4	Leishmania braziliensis	36%	100%
A4HI43	Leishmania braziliensis	25%	88%
A4HTM3	Leishmania infantum	25%	96%
A4HTM4	Leishmania infantum	26%	100%
A4HTM5	Leishmania infantum	24%	96%
A4I0W3	Leishmania infantum	95%	100%
A4I0W4	Leishmania infantum	37%	100%
A4I0W5	Leishmania infantum	35%	100%
A4I4J2	Leishmania infantum	27%	91%
A4I4J3	Leishmania infantum	22%	72%
A4I5B9	Leishmania infantum	25%	84%
A4I9R7	Leishmania infantum	28%	94%
A4I9X0	Leishmania infantum	26%	89%
A4IAL7	Leishmania infantum	27%	100%
A4IAM1	Leishmania infantum	21%	97%
A4IAM2	Leishmania infantum	22%	97%
C6K3X9	Leptomonas seymouri	73%	97%
E8NHD3	Leishmania infantum	27%	91%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	89%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	96%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	96%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	98%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	90%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	96%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	96%
E9AG83	Leishmania infantum	24%	93%
E9AHI9	Leishmania infantum	25%	96%
E9AHT2	Leishmania infantum	28%	88%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	97%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	89%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	94%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	95%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
Q4Q1U9	Leishmania major	27%	100%
Q4Q305	Leishmania major	26%	100%
Q4Q309	Leishmania major	24%	100%
Q4Q313	Leishmania major	26%	100%
Q4Q325	Leishmania major	24%	100%
Q4Q327	Leishmania major	29%	99%
Q4Q329	Leishmania major	25%	100%
Q4Q333	Leishmania major	25%	100%
Q4Q335	Leishmania major	26%	100%
Q4Q337	Leishmania major	28%	100%
Q4Q339	Leishmania major	26%	100%
Q4Q341	Leishmania major	29%	100%
Q4Q397	Leishmania major	26%	100%
Q4Q3A9	Leishmania major	26%	100%
Q4Q3F7	Leishmania major	24%	100%
Q4Q7L6	Leishmania major	26%	100%
Q4Q7L7	Leishmania major	24%	100%
Q4Q7L8	Leishmania major	24%	100%
Q4QAK4	Leishmania major	99%	100%
Q4QAK5	Leishmania major	34%	100%
Q4QAK6	Leishmania major	38%	100%
Q4QI84	Leishmania major	27%	100%
Q4QI85	Leishmania major	27%	96%
Q4QI86	Leishmania major	26%	100%
Q4QI87	Leishmania major	27%	96%
Q4QI88	Leishmania major	25%	99%