Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania major

UniProt:

Q4QAK5_LEIMA

TriTrypDb:

LmjF.24.1270 , LMJLV39_240018900 , LMJSD75_240018400

Length:

174

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 203
NetGPI	no	yes: 0, no: 211

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	189
GO:0110165	cellular anatomical entity	1	189

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Expansion

Sequence features

Q4QAK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK5

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.199
CLV_NRD_NRD_1	51	53	PF00675	0.568
CLV_PCSK_KEX2_1	36	38	PF00082	0.459
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.440
CLV_PCSK_SKI1_1	61	65	PF00082	0.549
DEG_APCC_DBOX_1	67	75	PF00400	0.354
DOC_CYCLIN_yCln2_LP_2	3	6	PF00134	0.593
DOC_MAPK_RevD_3	22	37	PF00069	0.194
DOC_PP2B_LxvP_1	3	6	PF13499	0.593
LIG_14-3-3_CanoR_1	101	109	PF00244	0.462

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	58%	98%
A0A0N0P547	Leptomonas seymouri	28%	100%
A0A0N0P6P9	Leptomonas seymouri	25%	76%
A0A0N0P993	Leptomonas seymouri	23%	78%
A0A0N1HWY5	Leptomonas seymouri	21%	89%
A0A0N1I295	Leptomonas seymouri	35%	96%
A0A0N1PAD5	Leptomonas seymouri	27%	69%
A0A0N1PDH0	Leptomonas seymouri	24%	86%
A0A0N1PFN2	Leptomonas seymouri	26%	94%
A0A1X0NQ58	Trypanosomatidae	38%	97%

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