Putative DNAJ-domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain protein, putative

Species:

Leishmania major

UniProt:

Q4QAK2_LEIMA

TriTrypDb:

LmjF.24.1300 , LMJLV39_240019300 , LMJSD75_240018700

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	491	495	PF00656	0.612
CLV_C14_Caspase3-7	652	656	PF00656	0.615
CLV_C14_Caspase3-7	746	750	PF00656	0.568
CLV_C14_Caspase3-7	774	778	PF00656	0.428
CLV_NRD_NRD_1	163	165	PF00675	0.458
CLV_NRD_NRD_1	215	217	PF00675	0.417
CLV_NRD_NRD_1	222	224	PF00675	0.463
CLV_NRD_NRD_1	273	275	PF00675	0.707
CLV_NRD_NRD_1	3	5	PF00675	0.706
CLV_NRD_NRD_1	607	609	PF00675	0.470
CLV_NRD_NRD_1	746	748	PF00675	0.616
CLV_NRD_NRD_1	85	87	PF00675	0.773
CLV_PCSK_KEX2_1	163	165	PF00082	0.462
CLV_PCSK_KEX2_1	215	217	PF00082	0.493
CLV_PCSK_KEX2_1	221	223	PF00082	0.524
CLV_PCSK_KEX2_1	273	275	PF00082	0.707
CLV_PCSK_KEX2_1	3	5	PF00082	0.689
CLV_PCSK_KEX2_1	557	559	PF00082	0.521
CLV_PCSK_KEX2_1	607	609	PF00082	0.570
CLV_PCSK_KEX2_1	85	87	PF00082	0.773
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.398
CLV_PCSK_SKI1_1	14	18	PF00082	0.414
CLV_PCSK_SKI1_1	216	220	PF00082	0.465
CLV_PCSK_SKI1_1	513	517	PF00082	0.459
CLV_PCSK_SKI1_1	543	547	PF00082	0.493
CLV_PCSK_SKI1_1	557	561	PF00082	0.528
CLV_PCSK_SKI1_1	67	71	PF00082	0.421
CLV_PCSK_SKI1_1	742	746	PF00082	0.452
CLV_PCSK_SKI1_1	9	13	PF00082	0.475
DEG_APCC_DBOX_1	13	21	PF00400	0.441
DEG_APCC_DBOX_1	542	550	PF00400	0.459
DEG_APCC_DBOX_1	66	74	PF00400	0.439
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SCF_TRCP1_1	401	406	PF00400	0.504
DEG_SPOP_SBC_1	121	125	PF00917	0.604
DOC_CKS1_1	10	15	PF01111	0.572
DOC_CKS1_1	143	148	PF01111	0.551
DOC_CKS1_1	434	439	PF01111	0.463
DOC_CYCLIN_RxL_1	14	25	PF00134	0.355
DOC_CYCLIN_yClb1_LxF_4	726	732	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	682	688	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	781	787	PF00134	0.370
DOC_MAPK_gen_1	332	339	PF00069	0.441
DOC_MAPK_gen_1	607	618	PF00069	0.399
DOC_MAPK_MEF2A_6	205	214	PF00069	0.391
DOC_MAPK_MEF2A_6	332	339	PF00069	0.424
DOC_MAPK_NFAT4_5	332	340	PF00069	0.388
DOC_PP2B_LxvP_1	781	784	PF13499	0.360
DOC_PP4_FxxP_1	143	146	PF00568	0.522
DOC_PP4_FxxP_1	263	266	PF00568	0.459
DOC_USP7_MATH_1	101	105	PF00917	0.589
DOC_USP7_MATH_1	122	126	PF00917	0.646
DOC_USP7_MATH_1	281	285	PF00917	0.566
DOC_USP7_MATH_1	311	315	PF00917	0.391
DOC_USP7_MATH_1	399	403	PF00917	0.497
DOC_USP7_MATH_1	430	434	PF00917	0.540
DOC_USP7_MATH_1	545	549	PF00917	0.330
DOC_USP7_UBL2_3	500	504	PF12436	0.674
DOC_WW_Pin1_4	126	131	PF00397	0.657
DOC_WW_Pin1_4	142	147	PF00397	0.457
DOC_WW_Pin1_4	20	25	PF00397	0.293
DOC_WW_Pin1_4	26	31	PF00397	0.252
DOC_WW_Pin1_4	433	438	PF00397	0.480
DOC_WW_Pin1_4	478	483	PF00397	0.642
DOC_WW_Pin1_4	584	589	PF00397	0.575
DOC_WW_Pin1_4	755	760	PF00397	0.503
DOC_WW_Pin1_4	766	771	PF00397	0.455
DOC_WW_Pin1_4	798	803	PF00397	0.643
DOC_WW_Pin1_4	9	14	PF00397	0.484
LIG_14-3-3_CanoR_1	114	122	PF00244	0.634
LIG_14-3-3_CanoR_1	163	169	PF00244	0.487
LIG_14-3-3_CanoR_1	18	23	PF00244	0.331
LIG_14-3-3_CanoR_1	3	7	PF00244	0.601
LIG_14-3-3_CanoR_1	300	308	PF00244	0.552
LIG_14-3-3_CanoR_1	344	352	PF00244	0.403
LIG_14-3-3_CanoR_1	39	43	PF00244	0.306
LIG_14-3-3_CanoR_1	60	68	PF00244	0.279
LIG_14-3-3_CanoR_1	650	655	PF00244	0.678
LIG_14-3-3_CanoR_1	85	93	PF00244	0.733
LIG_Actin_WH2_2	528	545	PF00022	0.405
LIG_APCC_ABBA_1	616	621	PF00400	0.557
LIG_APCC_ABBA_1	633	638	PF00400	0.410
LIG_BIR_III_2	505	509	PF00653	0.397
LIG_BIR_III_4	655	659	PF00653	0.545
LIG_FHA_1	143	149	PF00498	0.602
LIG_FHA_1	191	197	PF00498	0.487
LIG_FHA_1	23	29	PF00498	0.355
LIG_FHA_1	317	323	PF00498	0.357
LIG_FHA_1	404	410	PF00498	0.557
LIG_FHA_1	434	440	PF00498	0.579
LIG_FHA_1	465	471	PF00498	0.488
LIG_FHA_1	530	536	PF00498	0.459
LIG_FHA_1	687	693	PF00498	0.453
LIG_FHA_1	703	709	PF00498	0.533
LIG_FHA_2	145	151	PF00498	0.578
LIG_FHA_2	604	610	PF00498	0.424
LIG_FHA_2	678	684	PF00498	0.385
LIG_FHA_2	755	761	PF00498	0.454
LIG_HP1_1	254	258	PF01393	0.441
LIG_LIR_Apic_2	129	135	PF02991	0.651
LIG_LIR_Apic_2	142	146	PF02991	0.433
LIG_LIR_Gen_1	226	236	PF02991	0.575
LIG_LIR_Gen_1	329	338	PF02991	0.372
LIG_LIR_Gen_1	573	579	PF02991	0.510
LIG_LIR_Nem_3	226	232	PF02991	0.566
LIG_LIR_Nem_3	329	333	PF02991	0.364
LIG_LIR_Nem_3	461	465	PF02991	0.443
LIG_LIR_Nem_3	521	527	PF02991	0.451
LIG_LIR_Nem_3	56	62	PF02991	0.276
LIG_LIR_Nem_3	573	578	PF02991	0.591
LIG_LYPXL_L_2	309	318	PF13949	0.410
LIG_MYND_1	46	50	PF01753	0.279
LIG_NRBOX	791	797	PF00104	0.435
LIG_PDZ_Class_2	802	807	PF00595	0.627
LIG_Pex14_1	613	617	PF04695	0.449
LIG_Pex14_2	636	640	PF04695	0.552
LIG_Pex14_2	731	735	PF04695	0.372
LIG_REV1ctd_RIR_1	188	198	PF16727	0.414
LIG_REV1ctd_RIR_1	507	517	PF16727	0.379
LIG_SH2_CRK	229	233	PF00017	0.430
LIG_SH2_CRK	591	595	PF00017	0.510
LIG_SH2_NCK_1	229	233	PF00017	0.544
LIG_SH2_PTP2	786	789	PF00017	0.394
LIG_SH2_SRC	195	198	PF00017	0.426
LIG_SH2_SRC	786	789	PF00017	0.394
LIG_SH2_STAP1	229	233	PF00017	0.442
LIG_SH2_STAT3	37	40	PF00017	0.297
LIG_SH2_STAT5	195	198	PF00017	0.459
LIG_SH2_STAT5	224	227	PF00017	0.500
LIG_SH2_STAT5	37	40	PF00017	0.279
LIG_SH2_STAT5	617	620	PF00017	0.412
LIG_SH2_STAT5	622	625	PF00017	0.376
LIG_SH2_STAT5	716	719	PF00017	0.384
LIG_SH2_STAT5	728	731	PF00017	0.377
LIG_SH2_STAT5	786	789	PF00017	0.394
LIG_SH3_3	47	53	PF00018	0.297
LIG_SH3_3	638	644	PF00018	0.548
LIG_SH3_3	7	13	PF00018	0.613
LIG_SH3_3	718	724	PF00018	0.396
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.452
LIG_SUMO_SIM_par_1	18	23	PF11976	0.355
LIG_SUMO_SIM_par_1	791	798	PF11976	0.453
LIG_TRFH_1	561	565	PF08558	0.475
LIG_UBA3_1	539	547	PF00899	0.402
LIG_UBA3_1	791	800	PF00899	0.372
LIG_WRC_WIRS_1	165	170	PF05994	0.525
LIG_WRC_WIRS_1	728	733	PF05994	0.337
MOD_CDC14_SPxK_1	587	590	PF00782	0.513
MOD_CDC14_SPxK_1	769	772	PF00782	0.483
MOD_CDK_SPK_2	9	14	PF00069	0.466
MOD_CDK_SPxK_1	584	590	PF00069	0.530
MOD_CDK_SPxK_1	766	772	PF00069	0.461
MOD_CDK_SPxK_1	798	804	PF00069	0.449
MOD_CK1_1	123	129	PF00069	0.736
MOD_CK1_1	284	290	PF00069	0.673
MOD_CK1_1	358	364	PF00069	0.618
MOD_CK1_1	372	378	PF00069	0.324
MOD_CK1_1	433	439	PF00069	0.472
MOD_CK1_1	87	93	PF00069	0.732
MOD_CK2_1	320	326	PF00069	0.358
MOD_CK2_1	515	521	PF00069	0.529
MOD_CK2_1	603	609	PF00069	0.429
MOD_Cter_Amidation	83	86	PF01082	0.665
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.510
MOD_GlcNHglycan	180	183	PF01048	0.525
MOD_GlcNHglycan	199	202	PF01048	0.460
MOD_GlcNHglycan	229	232	PF01048	0.470
MOD_GlcNHglycan	283	286	PF01048	0.722
MOD_GlcNHglycan	346	349	PF01048	0.402
MOD_GlcNHglycan	354	360	PF01048	0.567
MOD_GlcNHglycan	373	377	PF01048	0.275
MOD_GlcNHglycan	401	404	PF01048	0.555
MOD_GlcNHglycan	494	497	PF01048	0.627
MOD_GlcNHglycan	665	668	PF01048	0.528
MOD_GlcNHglycan	80	83	PF01048	0.719
MOD_GlcNHglycan	89	92	PF01048	0.692
MOD_GSK3_1	116	123	PF00069	0.713
MOD_GSK3_1	18	25	PF00069	0.310
MOD_GSK3_1	281	288	PF00069	0.657
MOD_GSK3_1	316	323	PF00069	0.371
MOD_GSK3_1	354	361	PF00069	0.626
MOD_GSK3_1	399	406	PF00069	0.591
MOD_GSK3_1	488	495	PF00069	0.701
MOD_GSK3_1	515	522	PF00069	0.452
MOD_GSK3_1	523	530	PF00069	0.355
MOD_GSK3_1	545	552	PF00069	0.394
MOD_GSK3_1	573	580	PF00069	0.667
MOD_N-GLC_1	53	58	PF02516	0.394
MOD_N-GLC_1	553	558	PF02516	0.457
MOD_N-GLC_1	60	65	PF02516	0.427
MOD_NEK2_1	176	181	PF00069	0.574
MOD_NEK2_1	190	195	PF00069	0.551
MOD_NEK2_1	2	7	PF00069	0.593
MOD_NEK2_1	371	376	PF00069	0.509
MOD_NEK2_1	515	520	PF00069	0.480
MOD_NEK2_1	523	528	PF00069	0.371
MOD_NEK2_1	566	571	PF00069	0.415
MOD_NEK2_1	735	740	PF00069	0.437
MOD_NEK2_2	101	106	PF00069	0.579
MOD_NEK2_2	139	144	PF00069	0.485
MOD_PIKK_1	488	494	PF00454	0.661
MOD_PIKK_1	677	683	PF00454	0.425
MOD_PKA_1	85	91	PF00069	0.611
MOD_PKA_2	2	8	PF00069	0.609
MOD_PKA_2	299	305	PF00069	0.454
MOD_PKA_2	38	44	PF00069	0.306
MOD_PKA_2	566	572	PF00069	0.553
MOD_PKA_2	649	655	PF00069	0.685
MOD_PKA_2	702	708	PF00069	0.527
MOD_PKA_2	84	90	PF00069	0.658
MOD_Plk_1	149	155	PF00069	0.555
MOD_Plk_1	573	579	PF00069	0.560
MOD_Plk_2-3	326	332	PF00069	0.391
MOD_Plk_4	139	145	PF00069	0.625
MOD_Plk_4	519	525	PF00069	0.580
MOD_Plk_4	545	551	PF00069	0.302
MOD_Plk_4	566	572	PF00069	0.438
MOD_Plk_4	727	733	PF00069	0.354
MOD_Plk_4	791	797	PF00069	0.393
MOD_ProDKin_1	126	132	PF00069	0.657
MOD_ProDKin_1	142	148	PF00069	0.447
MOD_ProDKin_1	20	26	PF00069	0.293
MOD_ProDKin_1	433	439	PF00069	0.472
MOD_ProDKin_1	478	484	PF00069	0.648
MOD_ProDKin_1	584	590	PF00069	0.578
MOD_ProDKin_1	755	761	PF00069	0.502
MOD_ProDKin_1	766	772	PF00069	0.463
MOD_ProDKin_1	798	804	PF00069	0.649
MOD_ProDKin_1	9	15	PF00069	0.479
MOD_SUMO_for_1	333	336	PF00179	0.548
MOD_SUMO_for_1	471	474	PF00179	0.355
MOD_SUMO_for_1	571	574	PF00179	0.519
MOD_SUMO_rev_2	298	308	PF00179	0.404
MOD_SUMO_rev_2	605	612	PF00179	0.307
MOD_SUMO_rev_2	794	802	PF00179	0.411
TRG_DiLeu_BaEn_1	435	440	PF01217	0.454
TRG_ENDOCYTIC_2	229	232	PF00928	0.575
TRG_ENDOCYTIC_2	637	640	PF00928	0.521
TRG_ENDOCYTIC_2	728	731	PF00928	0.356
TRG_ER_diArg_1	162	164	PF00400	0.505
TRG_ER_diArg_1	2	4	PF00400	0.685
TRG_ER_diArg_1	214	216	PF00400	0.497
TRG_ER_diArg_1	221	223	PF00400	0.518
TRG_ER_diArg_1	540	543	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JIX4	Bodo saltans	29%	75%
A0A1X0NVN0	Trypanosomatidae	42%	97%
A0A3Q8ICX0	Leishmania donovani	96%	100%
A0A422NQ56	Trypanosoma rangeli	42%	96%
A4HDL7	Leishmania braziliensis	87%	100%
A4I0W8	Leishmania infantum	96%	100%
D0A799	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9AWX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BAJ1	Trypanosoma cruzi	39%	96%