Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAK1_LEIMA

TriTrypDb:

LmjF.24.1310 , LMJLV39_240019400 , LMJSD75_240018800

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QAK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.470
CLV_NRD_NRD_1	3	5	PF00675	0.691
CLV_PCSK_KEX2_1	52	54	PF00082	0.595
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.595
CLV_PCSK_SKI1_1	127	131	PF00082	0.539
CLV_PCSK_SKI1_1	192	196	PF00082	0.481
CLV_PCSK_SKI1_1	44	48	PF00082	0.467
DEG_MDM2_SWIB_1	56	64	PF02201	0.453
DOC_MAPK_JIP1_4	19	25	PF00069	0.535
DOC_MAPK_MEF2A_6	19	27	PF00069	0.614
DOC_MAPK_MEF2A_6	205	212	PF00069	0.496
DOC_PP1_RVXF_1	125	131	PF00149	0.491
DOC_PP4_FxxP_1	232	235	PF00568	0.513
DOC_USP7_MATH_1	159	163	PF00917	0.633
DOC_USP7_MATH_1	8	12	PF00917	0.643
DOC_USP7_MATH_1	80	84	PF00917	0.459
DOC_USP7_UBL2_3	205	209	PF12436	0.495
LIG_14-3-3_CanoR_1	190	195	PF00244	0.525
LIG_14-3-3_CanoR_1	53	57	PF00244	0.564
LIG_AP2alpha_1	228	232	PF02296	0.551
LIG_BRCT_BRCA1_1	218	222	PF00533	0.436
LIG_EH_1	74	78	PF12763	0.583
LIG_FHA_1	121	127	PF00498	0.498
LIG_FHA_1	136	142	PF00498	0.341
LIG_FHA_1	161	167	PF00498	0.597
LIG_FHA_1	169	175	PF00498	0.504
LIG_FHA_2	142	148	PF00498	0.502
LIG_FHA_2	222	228	PF00498	0.382
LIG_FHA_2	52	58	PF00498	0.493
LIG_LIR_Apic_2	230	235	PF02991	0.597
LIG_LIR_Gen_1	57	67	PF02991	0.555
LIG_LIR_Gen_1	95	104	PF02991	0.437
LIG_LIR_LC3C_4	152	156	PF02991	0.368
LIG_LIR_Nem_3	219	225	PF02991	0.410
LIG_LIR_Nem_3	57	63	PF02991	0.566
LIG_LIR_Nem_3	92	96	PF02991	0.408
LIG_LYPXL_yS_3	203	206	PF13949	0.513
LIG_MYND_1	204	208	PF01753	0.431
LIG_Pex14_2	228	232	PF04695	0.525
LIG_Pex14_2	56	60	PF04695	0.528
LIG_SH2_GRB2like	216	219	PF00017	0.453
LIG_SH2_NCK_1	35	39	PF00017	0.580
LIG_SH2_SRC	216	219	PF00017	0.458
LIG_SH2_STAP1	35	39	PF00017	0.548
LIG_SH2_STAT3	96	99	PF00017	0.495
LIG_SH2_STAT5	107	110	PF00017	0.355
LIG_SH2_STAT5	216	219	PF00017	0.409
LIG_SH2_STAT5	96	99	PF00017	0.406
LIG_SH3_3	14	20	PF00018	0.575
LIG_SH3_3	198	204	PF00018	0.499
LIG_SH3_3	98	104	PF00018	0.416
LIG_SUMO_SIM_par_1	175	182	PF11976	0.520
LIG_SUMO_SIM_par_1	21	26	PF11976	0.592
LIG_TRAF2_1	162	165	PF00917	0.513
LIG_TYR_ITIM	201	206	PF00017	0.522
LIG_WW_3	1	5	PF00397	0.720
MOD_CK1_1	193	199	PF00069	0.538
MOD_CK1_1	221	227	PF00069	0.544
MOD_CK1_1	81	87	PF00069	0.579
MOD_CK2_1	154	160	PF00069	0.575
MOD_CK2_1	173	179	PF00069	0.535
MOD_CK2_1	221	227	PF00069	0.393
MOD_CK2_1	8	14	PF00069	0.595
MOD_Cter_Amidation	48	51	PF01082	0.416
MOD_GlcNHglycan	10	13	PF01048	0.492
MOD_GlcNHglycan	157	160	PF01048	0.641
MOD_GSK3_1	150	157	PF00069	0.525
MOD_GSK3_1	168	175	PF00069	0.540
MOD_GSK3_1	179	186	PF00069	0.442
MOD_GSK3_1	212	219	PF00069	0.384
MOD_GSK3_1	81	88	PF00069	0.515
MOD_N-GLC_2	231	233	PF02516	0.534
MOD_NEK2_1	120	125	PF00069	0.456
MOD_NEK2_1	154	159	PF00069	0.572
MOD_NEK2_1	212	217	PF00069	0.394
MOD_NEK2_1	23	28	PF00069	0.541
MOD_PIKK_1	179	185	PF00454	0.466
MOD_PIKK_1	78	84	PF00454	0.642
MOD_PK_1	190	196	PF00069	0.568
MOD_PKA_1	51	57	PF00069	0.568
MOD_PKA_2	18	24	PF00069	0.588
MOD_PKA_2	52	58	PF00069	0.566
MOD_Plk_1	172	178	PF00069	0.522
MOD_Plk_1	23	29	PF00069	0.584
MOD_Plk_2-3	160	166	PF00069	0.564
MOD_Plk_2-3	173	179	PF00069	0.390
MOD_Plk_2-3	18	24	PF00069	0.530
MOD_Plk_4	150	156	PF00069	0.598
MOD_Plk_4	173	179	PF00069	0.535
MOD_Plk_4	18	24	PF00069	0.477
MOD_Plk_4	190	196	PF00069	0.401
MOD_Plk_4	212	218	PF00069	0.475
MOD_Plk_4	85	91	PF00069	0.485
MOD_SUMO_for_1	208	211	PF00179	0.492
MOD_SUMO_rev_2	113	118	PF00179	0.526
MOD_SUMO_rev_2	61	69	PF00179	0.560
TRG_ENDOCYTIC_2	203	206	PF00928	0.513
TRG_ER_diArg_1	41	44	PF00400	0.457
TRG_NLS_MonoCore_2	49	54	PF00514	0.565
TRG_NLS_MonoExtN_4	50	55	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY5	Leptomonas seymouri	55%	100%
A0A0S4J677	Bodo saltans	23%	77%
A0A0S4JEV4	Bodo saltans	23%	77%
A0A1X0NX29	Trypanosomatidae	33%	96%
A0A3S7WYF1	Leishmania donovani	93%	100%
A4HDL2	Leishmania braziliensis	81%	100%
A4I0W9	Leishmania infantum	93%	100%
C9ZWH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9AWX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BAW4	Trypanosoma cruzi	33%	81%