Putative cyclophilin 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 8, putative

Species:

Leishmania major

UniProt:

Q4QAK0_LEIMA

TriTrypDb:

LmjF.24.1315 , LMJLV39_240019500 , LMJSD75_240018900

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAK0

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	13
GO:0006457	protein folding	2	6
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	6
GO:0018193	peptidyl-amino acid modification	5	13
GO:0018208	peptidyl-proline modification	6	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0016853	isomerase activity	2	13
GO:0016859	cis-trans isomerase activity	3	13
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.550
CLV_NRD_NRD_1	48	50	PF00675	0.648
DEG_Nend_Nbox_1	1	3	PF02207	0.446
DEG_SPOP_SBC_1	9	13	PF00917	0.403
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.382
DOC_PP1_RVXF_1	193	200	PF00149	0.281
DOC_PP2B_LxvP_1	44	47	PF13499	0.468
DOC_PP4_FxxP_1	6	9	PF00568	0.393
DOC_USP7_MATH_1	10	14	PF00917	0.373
DOC_USP7_MATH_1	211	215	PF00917	0.379
DOC_USP7_UBL2_3	112	116	PF12436	0.260
DOC_USP7_UBL2_3	50	54	PF12436	0.572
DOC_WW_Pin1_4	90	95	PF00397	0.261
LIG_14-3-3_CanoR_1	168	174	PF00244	0.342
LIG_BRCT_BRCA1_1	169	173	PF00533	0.267
LIG_BRCT_BRCA1_1	175	179	PF00533	0.263
LIG_Clathr_ClatBox_1	71	75	PF01394	0.315
LIG_DCNL_PONY_1	1	4	PF03556	0.444
LIG_EVH1_1	6	10	PF00568	0.353
LIG_FHA_1	133	139	PF00498	0.367
LIG_FHA_2	169	175	PF00498	0.347
LIG_LIR_Apic_2	5	9	PF02991	0.385
LIG_LIR_Gen_1	12	21	PF02991	0.424
LIG_LIR_Gen_1	176	187	PF02991	0.367
LIG_LIR_Gen_1	22	29	PF02991	0.447
LIG_LIR_Gen_1	236	242	PF02991	0.449
LIG_LIR_LC3C_4	33	38	PF02991	0.443
LIG_LIR_Nem_3	12	18	PF02991	0.453
LIG_LIR_Nem_3	176	182	PF02991	0.308
LIG_LIR_Nem_3	22	28	PF02991	0.416
LIG_LIR_Nem_3	78	84	PF02991	0.296
LIG_MLH1_MIPbox_1	175	179	PF16413	0.265
LIG_Pex14_2	15	19	PF04695	0.431
LIG_PTB_Apo_2	119	126	PF02174	0.311
LIG_SH2_CRK	161	165	PF00017	0.261
LIG_SH2_CRK	81	85	PF00017	0.367
LIG_SH2_STAT5	232	235	PF00017	0.402
LIG_SH3_3	34	40	PF00018	0.461
LIG_SH3_3	4	10	PF00018	0.365
LIG_SUMO_SIM_par_1	35	41	PF11976	0.443
LIG_SUMO_SIM_par_1	82	87	PF11976	0.261
LIG_TRFH_1	6	10	PF08558	0.353
LIG_UBA3_1	71	76	PF00899	0.334
LIG_WW_3	46	50	PF00397	0.538
MOD_CDK_SPK_2	90	95	PF00069	0.261
MOD_CK1_1	107	113	PF00069	0.141
MOD_CK1_1	126	132	PF00069	0.127
MOD_CK1_1	169	175	PF00069	0.373
MOD_CK1_1	59	65	PF00069	0.494
MOD_CK1_1	90	96	PF00069	0.437
MOD_GlcNHglycan	218	222	PF01048	0.384
MOD_GlcNHglycan	25	28	PF01048	0.469
MOD_GlcNHglycan	58	61	PF01048	0.576
MOD_GlcNHglycan	89	92	PF01048	0.301
MOD_GSK3_1	10	17	PF00069	0.407
MOD_GSK3_1	106	113	PF00069	0.377
MOD_GSK3_1	162	169	PF00069	0.321
MOD_N-GLC_1	107	112	PF02516	0.249
MOD_NEK2_1	14	19	PF00069	0.443
MOD_NEK2_1	166	171	PF00069	0.273
MOD_NEK2_1	173	178	PF00069	0.281
MOD_NEK2_2	10	15	PF00069	0.372
MOD_PIKK_1	173	179	PF00454	0.301
MOD_PKA_2	123	129	PF00069	0.296
MOD_PKA_2	167	173	PF00069	0.299
MOD_PKA_2	23	29	PF00069	0.617
MOD_Plk_1	235	241	PF00069	0.339
MOD_Plk_4	10	16	PF00069	0.456
MOD_ProDKin_1	90	96	PF00069	0.261
TRG_DiLeu_BaEn_1	32	37	PF01217	0.458
TRG_ENDOCYTIC_2	161	164	PF00928	0.261
TRG_ENDOCYTIC_2	239	242	PF00928	0.569
TRG_ENDOCYTIC_2	25	28	PF00928	0.469
TRG_ENDOCYTIC_2	81	84	PF00928	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D1	Leptomonas seymouri	68%	100%
A0A0N0P523	Leptomonas seymouri	32%	88%
A0A0S4J351	Bodo saltans	28%	91%
A0A1X0ND98	Trypanosomatidae	40%	100%
A0A3R7RE54	Trypanosoma rangeli	31%	94%
A0A3S7WXF4	Leishmania donovani	31%	82%
A0A3S7WYD9	Leishmania donovani	93%	100%
A4H4H8	Leishmania braziliensis	32%	100%
A4HCL8	Leishmania braziliensis	29%	82%
A4HDL1	Leishmania braziliensis	79%	100%
A4HLM4	Leishmania braziliensis	27%	100%
A4I042	Leishmania infantum	31%	82%
A4I0X0	Leishmania infantum	93%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
C9ZWH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P29117	Rattus norvegicus	31%	100%
P52011	Caenorhabditis elegans	30%	100%
Q38867	Arabidopsis thaliana	30%	100%
Q4G338	Haemonchus contortus	30%	75%
Q4Q424	Leishmania major	28%	100%
Q4QBH1	Leishmania major	31%	82%
Q99KR7	Mus musculus	30%	100%
V5B2A0	Trypanosoma cruzi	33%	94%
V5D532	Trypanosoma cruzi	28%	100%