Putative translation initiation factor IF-2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor IF-2, putative

Species:

Leishmania major

UniProt:

Q4QAJ7_LEIMA

TriTrypDb:

LmjF.24.1340 , LMJLV39_240019800 , LMJSD75_240019200

Length:

892

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.387
CLV_C14_Caspase3-7	795	799	PF00656	0.472
CLV_C14_Caspase3-7	835	839	PF00656	0.659
CLV_MEL_PAP_1	762	768	PF00089	0.359
CLV_NRD_NRD_1	166	168	PF00675	0.513
CLV_NRD_NRD_1	176	178	PF00675	0.470
CLV_NRD_NRD_1	179	181	PF00675	0.310
CLV_NRD_NRD_1	19	21	PF00675	0.510
CLV_NRD_NRD_1	3	5	PF00675	0.575
CLV_NRD_NRD_1	307	309	PF00675	0.314
CLV_NRD_NRD_1	380	382	PF00675	0.473
CLV_NRD_NRD_1	448	450	PF00675	0.603
CLV_NRD_NRD_1	459	461	PF00675	0.525
CLV_NRD_NRD_1	56	58	PF00675	0.590
CLV_NRD_NRD_1	754	756	PF00675	0.358
CLV_PCSK_FUR_1	177	181	PF00082	0.456
CLV_PCSK_KEX2_1	176	178	PF00082	0.474
CLV_PCSK_KEX2_1	179	181	PF00082	0.321
CLV_PCSK_KEX2_1	2	4	PF00082	0.580
CLV_PCSK_KEX2_1	307	309	PF00082	0.266
CLV_PCSK_KEX2_1	372	374	PF00082	0.615
CLV_PCSK_KEX2_1	450	452	PF00082	0.593
CLV_PCSK_KEX2_1	464	466	PF00082	0.471
CLV_PCSK_KEX2_1	56	58	PF00082	0.553
CLV_PCSK_KEX2_1	686	688	PF00082	0.707
CLV_PCSK_KEX2_1	86	88	PF00082	0.591
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.640
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.594
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.472
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.707
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.591
CLV_PCSK_PC7_1	172	178	PF00082	0.504
CLV_PCSK_PC7_1	446	452	PF00082	0.583
CLV_PCSK_PC7_1	460	466	PF00082	0.421
CLV_PCSK_SKI1_1	104	108	PF00082	0.432
CLV_PCSK_SKI1_1	133	137	PF00082	0.530
CLV_PCSK_SKI1_1	194	198	PF00082	0.391
CLV_PCSK_SKI1_1	21	25	PF00082	0.380
CLV_PCSK_SKI1_1	219	223	PF00082	0.245
CLV_PCSK_SKI1_1	277	281	PF00082	0.240
CLV_PCSK_SKI1_1	307	311	PF00082	0.361
CLV_PCSK_SKI1_1	346	350	PF00082	0.583
CLV_PCSK_SKI1_1	437	441	PF00082	0.437
CLV_PCSK_SKI1_1	686	690	PF00082	0.658
CLV_PCSK_SKI1_1	712	716	PF00082	0.538
CLV_PCSK_SKI1_1	876	880	PF00082	0.600
DEG_APCC_DBOX_1	166	174	PF00400	0.491
DEG_APCC_DBOX_1	306	314	PF00400	0.561
DEG_APCC_DBOX_1	474	482	PF00400	0.565
DEG_Nend_UBRbox_1	1	4	PF02207	0.614
DOC_CKS1_1	236	241	PF01111	0.453
DOC_CKS1_1	787	792	PF01111	0.372
DOC_CYCLIN_RxL_1	395	408	PF00134	0.406
DOC_CYCLIN_RxL_1	72	84	PF00134	0.314
DOC_CYCLIN_RxL_1	871	883	PF00134	0.622
DOC_MAPK_gen_1	17	26	PF00069	0.557
DOC_MAPK_gen_1	176	183	PF00069	0.463
DOC_MAPK_gen_1	369	379	PF00069	0.546
DOC_MAPK_gen_1	381	388	PF00069	0.338
DOC_MAPK_gen_1	536	546	PF00069	0.492
DOC_MAPK_gen_1	598	606	PF00069	0.386
DOC_MAPK_gen_1	871	879	PF00069	0.587
DOC_MAPK_HePTP_8	39	51	PF00069	0.418
DOC_MAPK_MEF2A_6	372	379	PF00069	0.519
DOC_MAPK_MEF2A_6	42	51	PF00069	0.423
DOC_MAPK_MEF2A_6	539	548	PF00069	0.482
DOC_MAPK_MEF2A_6	598	606	PF00069	0.401
DOC_PP1_RVXF_1	150	157	PF00149	0.370
DOC_PP1_RVXF_1	580	586	PF00149	0.371
DOC_PP1_RVXF_1	753	760	PF00149	0.346
DOC_PP2B_LxvP_1	78	81	PF13499	0.459
DOC_PP2B_PxIxI_1	284	290	PF00149	0.535
DOC_PP2B_PxIxI_1	850	856	PF00149	0.674
DOC_PP4_FxxP_1	221	224	PF00568	0.463
DOC_PP4_FxxP_1	25	28	PF00568	0.393
DOC_PP4_FxxP_1	787	790	PF00568	0.493
DOC_SPAK_OSR1_1	248	252	PF12202	0.492
DOC_USP7_MATH_1	141	145	PF00917	0.524
DOC_USP7_MATH_1	339	343	PF00917	0.504
DOC_USP7_MATH_1	645	649	PF00917	0.721
DOC_USP7_MATH_1	867	871	PF00917	0.770
DOC_USP7_UBL2_3	34	38	PF12436	0.486
DOC_WW_Pin1_4	143	148	PF00397	0.533
DOC_WW_Pin1_4	235	240	PF00397	0.440
DOC_WW_Pin1_4	470	475	PF00397	0.670
DOC_WW_Pin1_4	56	61	PF00397	0.484
DOC_WW_Pin1_4	786	791	PF00397	0.358
LIG_14-3-3_CanoR_1	104	112	PF00244	0.374
LIG_14-3-3_CanoR_1	219	224	PF00244	0.399
LIG_14-3-3_CanoR_1	344	349	PF00244	0.601
LIG_14-3-3_CanoR_1	381	385	PF00244	0.549
LIG_14-3-3_CanoR_1	477	482	PF00244	0.580
LIG_14-3-3_CanoR_1	491	501	PF00244	0.631
LIG_14-3-3_CanoR_1	687	693	PF00244	0.656
LIG_14-3-3_CanoR_1	712	720	PF00244	0.559
LIG_14-3-3_CanoR_1	788	797	PF00244	0.466
LIG_14-3-3_CanoR_1	868	878	PF00244	0.534
LIG_APCC_ABBA_1	49	54	PF00400	0.459
LIG_APCC_ABBA_1	877	882	PF00400	0.604
LIG_APCC_ABBAyCdc20_2	876	882	PF00400	0.607
LIG_BRCT_BRCA1_1	32	36	PF00533	0.416
LIG_BRCT_BRCA1_1	465	469	PF00533	0.494
LIG_BRCT_BRCA1_1	63	67	PF00533	0.441
LIG_BRCT_BRCA1_2	32	38	PF00533	0.421
LIG_Clathr_ClatBox_1	733	737	PF01394	0.337
LIG_DLG_GKlike_1	128	135	PF00625	0.475
LIG_DLG_GKlike_1	344	351	PF00625	0.483
LIG_FHA_1	105	111	PF00498	0.407
LIG_FHA_1	193	199	PF00498	0.477
LIG_FHA_1	213	219	PF00498	0.438
LIG_FHA_1	273	279	PF00498	0.482
LIG_FHA_1	501	507	PF00498	0.354
LIG_FHA_1	589	595	PF00498	0.461
LIG_FHA_1	616	622	PF00498	0.480
LIG_FHA_1	683	689	PF00498	0.768
LIG_FHA_1	752	758	PF00498	0.345
LIG_FHA_2	232	238	PF00498	0.447
LIG_FHA_2	545	551	PF00498	0.375
LIG_FHA_2	826	832	PF00498	0.388
LIG_IRF3_LxIS_1	257	263	PF10401	0.492
LIG_LIR_Apic_2	356	360	PF02991	0.564
LIG_LIR_Gen_1	231	239	PF02991	0.530
LIG_LIR_Gen_1	33	40	PF02991	0.399
LIG_LIR_Gen_1	603	612	PF02991	0.446
LIG_LIR_Gen_1	811	821	PF02991	0.456
LIG_LIR_Nem_3	231	236	PF02991	0.530
LIG_LIR_Nem_3	33	39	PF02991	0.442
LIG_LIR_Nem_3	480	485	PF02991	0.575
LIG_LIR_Nem_3	603	609	PF02991	0.424
LIG_LIR_Nem_3	611	615	PF02991	0.462
LIG_LIR_Nem_3	811	817	PF02991	0.468
LIG_LYPXL_yS_3	541	544	PF13949	0.484
LIG_MAD2	852	860	PF02301	0.555
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.518
LIG_Pex14_1	153	157	PF04695	0.483
LIG_SH2_CRK	482	486	PF00017	0.543
LIG_SH2_CRK	612	616	PF00017	0.479
LIG_SH2_CRK	627	631	PF00017	0.529
LIG_SH2_NCK_1	586	590	PF00017	0.473
LIG_SH2_SRC	52	55	PF00017	0.431
LIG_SH2_SRC	586	589	PF00017	0.489
LIG_SH2_SRC	720	723	PF00017	0.450
LIG_SH2_STAP1	157	161	PF00017	0.460
LIG_SH2_STAP1	586	590	PF00017	0.500
LIG_SH2_STAP1	720	724	PF00017	0.424
LIG_SH2_STAT3	776	779	PF00017	0.467
LIG_SH2_STAT5	162	165	PF00017	0.442
LIG_SH2_STAT5	169	172	PF00017	0.432
LIG_SH2_STAT5	357	360	PF00017	0.498
LIG_SH2_STAT5	596	599	PF00017	0.421
LIG_SH2_STAT5	657	660	PF00017	0.518
LIG_SH2_STAT5	758	761	PF00017	0.473
LIG_SH2_STAT5	776	779	PF00017	0.526
LIG_SH2_STAT5	8	11	PF00017	0.725
LIG_SH2_STAT5	800	803	PF00017	0.395
LIG_SH3_1	627	633	PF00018	0.617
LIG_SH3_2	147	152	PF14604	0.497
LIG_SH3_3	144	150	PF00018	0.585
LIG_SH3_3	279	285	PF00018	0.471
LIG_SH3_3	627	633	PF00018	0.617
LIG_SH3_3	675	681	PF00018	0.631
LIG_SH3_3	851	857	PF00018	0.623
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.441
LIG_SUMO_SIM_par_1	260	266	PF11976	0.449
LIG_TRAF2_1	633	636	PF00917	0.751
LIG_TRAF2_2	768	773	PF00917	0.482
LIG_UBA3_1	119	126	PF00899	0.494
LIG_UBA3_1	774	782	PF00899	0.445
LIG_Vh1_VBS_1	261	279	PF01044	0.404
LIG_WRC_WIRS_1	232	237	PF05994	0.409
MOD_CDK_SPK_2	470	475	PF00069	0.670
MOD_CDK_SPxxK_3	235	242	PF00069	0.266
MOD_CDK_SPxxK_3	470	477	PF00069	0.648
MOD_CK1_1	389	395	PF00069	0.572
MOD_CK1_1	473	479	PF00069	0.670
MOD_CK1_1	484	490	PF00069	0.577
MOD_CK1_1	496	502	PF00069	0.422
MOD_CK1_1	552	558	PF00069	0.530
MOD_CK1_1	650	656	PF00069	0.642
MOD_CK1_1	674	680	PF00069	0.615
MOD_CK1_1	738	744	PF00069	0.340
MOD_CK1_1	792	798	PF00069	0.477
MOD_CK2_1	128	134	PF00069	0.536
MOD_CK2_1	260	266	PF00069	0.330
MOD_CK2_1	713	719	PF00069	0.594
MOD_CK2_1	796	802	PF00069	0.462
MOD_CK2_1	825	831	PF00069	0.371
MOD_CMANNOS	153	156	PF00535	0.473
MOD_Cter_Amidation	165	168	PF01082	0.524
MOD_GlcNHglycan	143	146	PF01048	0.579
MOD_GlcNHglycan	388	391	PF01048	0.323
MOD_GlcNHglycan	554	557	PF01048	0.489
MOD_GlcNHglycan	64	67	PF01048	0.454
MOD_GlcNHglycan	647	650	PF01048	0.641
MOD_GlcNHglycan	706	709	PF01048	0.526
MOD_GlcNHglycan	791	794	PF01048	0.493
MOD_GlcNHglycan	845	849	PF01048	0.672
MOD_GlcNHglycan	863	866	PF01048	0.687
MOD_GSK3_1	231	238	PF00069	0.328
MOD_GSK3_1	26	33	PF00069	0.495
MOD_GSK3_1	294	301	PF00069	0.369
MOD_GSK3_1	331	338	PF00069	0.539
MOD_GSK3_1	340	347	PF00069	0.542
MOD_GSK3_1	415	422	PF00069	0.500
MOD_GSK3_1	473	480	PF00069	0.610
MOD_GSK3_1	492	499	PF00069	0.385
MOD_GSK3_1	565	572	PF00069	0.421
MOD_GSK3_1	670	677	PF00069	0.635
MOD_GSK3_1	682	689	PF00069	0.588
MOD_GSK3_1	747	754	PF00069	0.397
MOD_GSK3_1	792	799	PF00069	0.553
MOD_GSK3_1	808	815	PF00069	0.281
MOD_N-GLC_1	492	497	PF02516	0.606
MOD_NEK2_1	201	206	PF00069	0.349
MOD_NEK2_1	244	249	PF00069	0.296
MOD_NEK2_1	260	265	PF00069	0.269
MOD_NEK2_1	380	385	PF00069	0.411
MOD_NEK2_1	415	420	PF00069	0.575
MOD_NEK2_1	433	438	PF00069	0.307
MOD_NEK2_1	500	505	PF00069	0.370
MOD_NEK2_1	544	549	PF00069	0.428
MOD_NEK2_1	602	607	PF00069	0.444
MOD_NEK2_1	62	67	PF00069	0.433
MOD_NEK2_1	670	675	PF00069	0.689
MOD_NEK2_1	701	706	PF00069	0.424
MOD_NEK2_1	9	14	PF00069	0.621
MOD_NEK2_2	15	20	PF00069	0.446
MOD_NEK2_2	81	86	PF00069	0.494
MOD_OFUCOSY	409	414	PF10250	0.444
MOD_PIKK_1	212	218	PF00454	0.277
MOD_PIKK_1	267	273	PF00454	0.295
MOD_PIKK_1	484	490	PF00454	0.606
MOD_PIKK_1	686	692	PF00454	0.656
MOD_PIKK_1	713	719	PF00454	0.493
MOD_PIKK_1	869	875	PF00454	0.656
MOD_PK_1	477	483	PF00069	0.592
MOD_PKA_1	686	692	PF00069	0.686
MOD_PKA_2	141	147	PF00069	0.645
MOD_PKA_2	171	177	PF00069	0.559
MOD_PKA_2	380	386	PF00069	0.548
MOD_PKA_2	493	499	PF00069	0.626
MOD_PKA_2	662	668	PF00069	0.571
MOD_PKA_2	686	692	PF00069	0.686
MOD_PKA_2	867	873	PF00069	0.619
MOD_PKB_1	344	352	PF00069	0.456
MOD_PKB_1	475	483	PF00069	0.645
MOD_Plk_1	128	134	PF00069	0.579
MOD_Plk_1	549	555	PF00069	0.444
MOD_Plk_1	602	608	PF00069	0.441
MOD_Plk_1	650	656	PF00069	0.549
MOD_Plk_1	747	753	PF00069	0.436
MOD_Plk_1	90	96	PF00069	0.468
MOD_Plk_2-3	134	140	PF00069	0.494
MOD_Plk_2-3	231	237	PF00069	0.409
MOD_Plk_2-3	796	802	PF00069	0.462
MOD_Plk_4	26	32	PF00069	0.356
MOD_Plk_4	477	483	PF00069	0.483
MOD_Plk_4	496	502	PF00069	0.415
MOD_Plk_4	544	550	PF00069	0.368
MOD_Plk_4	796	802	PF00069	0.445
MOD_ProDKin_1	143	149	PF00069	0.530
MOD_ProDKin_1	235	241	PF00069	0.277
MOD_ProDKin_1	470	476	PF00069	0.663
MOD_ProDKin_1	56	62	PF00069	0.486
MOD_ProDKin_1	786	792	PF00069	0.363
MOD_SUMO_for_1	135	138	PF00179	0.437
MOD_SUMO_for_1	45	48	PF00179	0.428
MOD_SUMO_for_1	85	88	PF00179	0.429
MOD_SUMO_rev_2	129	137	PF00179	0.516
MOD_SUMO_rev_2	29	36	PF00179	0.404
MOD_SUMO_rev_2	365	371	PF00179	0.455
TRG_DiLeu_BaEn_2	512	518	PF01217	0.496
TRG_DiLeu_BaEn_4	442	448	PF01217	0.630
TRG_DiLeu_BaLyEn_6	873	878	PF01217	0.627
TRG_ENDOCYTIC_2	482	485	PF00928	0.540
TRG_ENDOCYTIC_2	52	55	PF00928	0.496
TRG_ENDOCYTIC_2	541	544	PF00928	0.450
TRG_ENDOCYTIC_2	586	589	PF00928	0.442
TRG_ENDOCYTIC_2	612	615	PF00928	0.471
TRG_ENDOCYTIC_2	758	761	PF00928	0.428
TRG_ER_diArg_1	1	4	PF00400	0.614
TRG_ER_diArg_1	176	179	PF00400	0.459
TRG_ER_diArg_1	306	308	PF00400	0.312
TRG_ER_diArg_1	474	477	PF00400	0.665
TRG_ER_diArg_1	55	57	PF00400	0.544
TRG_ER_diArg_1	573	576	PF00400	0.399
TRG_ER_diArg_1	579	582	PF00400	0.329
TRG_ER_diArg_1	597	600	PF00400	0.312
TRG_ER_diArg_1	849	852	PF00400	0.747
TRG_ER_diArg_1	874	877	PF00400	0.650
TRG_NES_CRM1_1	252	266	PF08389	0.302
TRG_NES_CRM1_1	312	326	PF08389	0.409
TRG_NLS_MonoExtN_4	446	453	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	743	748	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	832	836	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	876	881	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH60	Leptomonas seymouri	65%	100%
A0A1X0NVX3	Trypanosomatidae	48%	100%
A0A3Q8IG60	Leishmania donovani	96%	100%
A0A3R7MK23	Trypanosoma rangeli	46%	100%
A4HDK8	Leishmania braziliensis	89%	100%
A4I0X3	Leishmania infantum	97%	100%
C9ZWH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AWX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BFL2	Trypanosoma cruzi	46%	100%