Calmodulin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAJ6_LEIMA

TriTrypDb:

LmjF.24.1350 , LMJLV39_240019900 , LMJSD75_240019300

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.445
CLV_C14_Caspase3-7	134	138	PF00656	0.311
CLV_C14_Caspase3-7	495	499	PF00656	0.523
CLV_C14_Caspase3-7	526	530	PF00656	0.603
CLV_NRD_NRD_1	329	331	PF00675	0.467
CLV_NRD_NRD_1	344	346	PF00675	0.663
CLV_NRD_NRD_1	492	494	PF00675	0.643
CLV_NRD_NRD_1	51	53	PF00675	0.415
CLV_NRD_NRD_1	588	590	PF00675	0.472
CLV_NRD_NRD_1	637	639	PF00675	0.321
CLV_NRD_NRD_1	647	649	PF00675	0.382
CLV_NRD_NRD_1	651	653	PF00675	0.365
CLV_NRD_NRD_1	668	670	PF00675	0.348
CLV_NRD_NRD_1	792	794	PF00675	0.240
CLV_NRD_NRD_1	818	820	PF00675	0.634
CLV_NRD_NRD_1	853	855	PF00675	0.439
CLV_NRD_NRD_1	862	864	PF00675	0.455
CLV_PCSK_FUR_1	49	53	PF00082	0.413
CLV_PCSK_FUR_1	789	793	PF00082	0.252
CLV_PCSK_KEX2_1	344	346	PF00082	0.622
CLV_PCSK_KEX2_1	49	51	PF00082	0.449
CLV_PCSK_KEX2_1	588	590	PF00082	0.467
CLV_PCSK_KEX2_1	637	639	PF00082	0.315
CLV_PCSK_KEX2_1	647	649	PF00082	0.387
CLV_PCSK_KEX2_1	667	669	PF00082	0.271
CLV_PCSK_KEX2_1	791	793	PF00082	0.250
CLV_PCSK_KEX2_1	818	820	PF00082	0.672
CLV_PCSK_KEX2_1	852	854	PF00082	0.484
CLV_PCSK_KEX2_1	862	864	PF00082	0.451
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.505
CLV_PCSK_SKI1_1	167	171	PF00082	0.482
CLV_PCSK_SKI1_1	215	219	PF00082	0.413
CLV_PCSK_SKI1_1	466	470	PF00082	0.460
CLV_PCSK_SKI1_1	658	662	PF00082	0.382
CLV_PCSK_SKI1_1	746	750	PF00082	0.249
CLV_PCSK_SKI1_1	818	822	PF00082	0.484
CLV_PCSK_SKI1_1	834	838	PF00082	0.574
DEG_APCC_DBOX_1	214	222	PF00400	0.430
DEG_APCC_DBOX_1	465	473	PF00400	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.729
DOC_ANK_TNKS_1	155	162	PF00023	0.413
DOC_ANK_TNKS_1	821	828	PF00023	0.460
DOC_CDC14_PxL_1	803	811	PF14671	0.463
DOC_CKS1_1	365	370	PF01111	0.484
DOC_CKS1_1	438	443	PF01111	0.245
DOC_MAPK_gen_1	296	305	PF00069	0.399
DOC_MAPK_gen_1	588	598	PF00069	0.533
DOC_MAPK_HePTP_8	293	305	PF00069	0.466
DOC_MAPK_MEF2A_6	296	305	PF00069	0.487
DOC_MAPK_MEF2A_6	34	41	PF00069	0.412
DOC_MAPK_MEF2A_6	592	600	PF00069	0.553
DOC_MIT_MIM_1	533	542	PF04212	0.453
DOC_PP2B_LxvP_1	113	116	PF13499	0.477
DOC_PP4_FxxP_1	511	514	PF00568	0.570
DOC_PP4_FxxP_1	566	569	PF00568	0.438
DOC_USP7_MATH_1	20	24	PF00917	0.362
DOC_USP7_MATH_1	213	217	PF00917	0.498
DOC_USP7_MATH_1	232	236	PF00917	0.419
DOC_USP7_MATH_1	261	265	PF00917	0.464
DOC_USP7_MATH_1	279	283	PF00917	0.610
DOC_USP7_MATH_1	292	296	PF00917	0.503
DOC_USP7_MATH_1	340	344	PF00917	0.666
DOC_USP7_MATH_1	427	431	PF00917	0.580
DOC_USP7_MATH_1	787	791	PF00917	0.451
DOC_USP7_MATH_1	9	13	PF00917	0.524
DOC_USP7_UBL2_3	327	331	PF12436	0.446
DOC_WW_Pin1_4	364	369	PF00397	0.569
DOC_WW_Pin1_4	437	442	PF00397	0.352
LIG_14-3-3_CanoR_1	215	221	PF00244	0.378
LIG_14-3-3_CanoR_1	354	364	PF00244	0.771
LIG_14-3-3_CanoR_1	459	463	PF00244	0.637
LIG_14-3-3_CanoR_1	52	62	PF00244	0.362
LIG_14-3-3_CanoR_1	538	542	PF00244	0.511
LIG_14-3-3_CanoR_1	558	566	PF00244	0.323
LIG_14-3-3_CanoR_1	811	820	PF00244	0.497
LIG_14-3-3_CanoR_1	876	882	PF00244	0.519
LIG_Actin_WH2_2	140	158	PF00022	0.329
LIG_APCC_ABBA_1	301	306	PF00400	0.490
LIG_APCC_ABBA_1	821	826	PF00400	0.534
LIG_APCC_ABBAyCdc20_2	300	306	PF00400	0.410
LIG_BIR_III_2	129	133	PF00653	0.393
LIG_BIR_III_4	450	454	PF00653	0.424
LIG_BRCT_BRCA1_1	816	820	PF00533	0.553
LIG_CaM_IQ_9	629	645	PF13499	0.374
LIG_CaM_IQ_9	659	675	PF13499	0.395
LIG_CaM_IQ_9	699	714	PF13499	0.434
LIG_CaM_IQ_9	738	753	PF13499	0.436
LIG_CaM_IQ_9	768	784	PF13499	0.330
LIG_CaM_IQ_9	839	855	PF13499	0.449
LIG_Clathr_ClatBox_1	435	439	PF01394	0.244
LIG_FHA_1	186	192	PF00498	0.411
LIG_FHA_1	255	261	PF00498	0.432
LIG_FHA_1	365	371	PF00498	0.600
LIG_FHA_1	382	388	PF00498	0.312
LIG_FHA_1	443	449	PF00498	0.473
LIG_FHA_1	485	491	PF00498	0.746
LIG_FHA_1	554	560	PF00498	0.449
LIG_FHA_1	563	569	PF00498	0.422
LIG_FHA_1	77	83	PF00498	0.555
LIG_FHA_1	878	884	PF00498	0.566
LIG_FHA_2	116	122	PF00498	0.629
LIG_FHA_2	217	223	PF00498	0.459
LIG_FHA_2	263	269	PF00498	0.506
LIG_FHA_2	490	496	PF00498	0.622
LIG_LIR_Apic_2	565	569	PF02991	0.438
LIG_LIR_Gen_1	103	113	PF02991	0.463
LIG_LIR_Gen_1	137	147	PF02991	0.436
LIG_LIR_Gen_1	395	405	PF02991	0.368
LIG_LIR_Gen_1	429	438	PF02991	0.498
LIG_LIR_Gen_1	66	76	PF02991	0.364
LIG_LIR_Gen_1	817	828	PF02991	0.533
LIG_LIR_Gen_1	93	102	PF02991	0.364
LIG_LIR_Nem_3	100	105	PF02991	0.397
LIG_LIR_Nem_3	137	143	PF02991	0.443
LIG_LIR_Nem_3	188	192	PF02991	0.491
LIG_LIR_Nem_3	395	400	PF02991	0.561
LIG_LIR_Nem_3	429	435	PF02991	0.428
LIG_LIR_Nem_3	64	68	PF02991	0.388
LIG_LIR_Nem_3	817	823	PF02991	0.565
LIG_LIR_Nem_3	93	98	PF02991	0.354
LIG_NRBOX	468	474	PF00104	0.394
LIG_NRBOX	538	544	PF00104	0.443
LIG_PCNA_yPIPBox_3	190	203	PF02747	0.328
LIG_PCNA_yPIPBox_3	742	756	PF02747	0.466
LIG_Pex14_2	432	436	PF04695	0.525
LIG_Pex14_2	549	553	PF04695	0.455
LIG_PTB_Apo_2	349	356	PF02174	0.605
LIG_REV1ctd_RIR_1	598	606	PF16727	0.432
LIG_RPA_C_Fungi	47	59	PF08784	0.360
LIG_SH2_CRK	106	110	PF00017	0.363
LIG_SH2_CRK	200	204	PF00017	0.249
LIG_SH2_CRK	737	741	PF00017	0.289
LIG_SH2_STAP1	243	247	PF00017	0.354
LIG_SH2_STAP1	274	278	PF00017	0.515
LIG_SH2_STAP1	397	401	PF00017	0.402
LIG_SH2_STAP1	44	48	PF00017	0.387
LIG_SH2_STAP1	737	741	PF00017	0.294
LIG_SH2_STAT3	304	307	PF00017	0.310
LIG_SH2_STAT3	769	772	PF00017	0.469
LIG_SH2_STAT5	256	259	PF00017	0.381
LIG_SH2_STAT5	304	307	PF00017	0.510
LIG_SH2_STAT5	377	380	PF00017	0.428
LIG_SH2_STAT5	635	638	PF00017	0.468
LIG_SH2_STAT5	655	658	PF00017	0.256
LIG_SH2_STAT5	68	71	PF00017	0.435
LIG_SH2_STAT5	94	97	PF00017	0.375
LIG_SH3_3	105	111	PF00018	0.450
LIG_SH3_3	365	371	PF00018	0.496
LIG_SH3_3	459	465	PF00018	0.541
LIG_SH3_3	478	484	PF00018	0.592
LIG_SH3_3	81	87	PF00018	0.526
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.381
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.344
LIG_SUMO_SIM_anti_2	657	664	PF11976	0.373
LIG_SUMO_SIM_par_1	249	254	PF11976	0.388
LIG_SUMO_SIM_par_1	657	664	PF11976	0.373
LIG_TRAF2_1	548	551	PF00917	0.444
LIG_TRAF2_1	641	644	PF00917	0.507
LIG_TRAF2_1	868	871	PF00917	0.506
LIG_UBA3_1	38	42	PF00899	0.373
LIG_WRC_WIRS_1	21	26	PF05994	0.430
LIG_WRC_WIRS_1	563	568	PF05994	0.466
MOD_CK1_1	216	222	PF00069	0.429
MOD_CK1_1	234	240	PF00069	0.705
MOD_CK1_1	266	272	PF00069	0.420
MOD_CK1_1	810	816	PF00069	0.590
MOD_CK1_1	879	885	PF00069	0.521
MOD_CK2_1	205	211	PF00069	0.395
MOD_CK2_1	216	222	PF00069	0.374
MOD_CK2_1	234	240	PF00069	0.493
MOD_CK2_1	262	268	PF00069	0.427
MOD_CK2_1	353	359	PF00069	0.669
MOD_CK2_1	418	424	PF00069	0.464
MOD_CK2_1	489	495	PF00069	0.622
MOD_Cter_Amidation	328	331	PF01082	0.450
MOD_Cter_Amidation	645	648	PF01082	0.407
MOD_GlcNHglycan	100	105	PF01048	0.352
MOD_GlcNHglycan	11	14	PF01048	0.539
MOD_GlcNHglycan	215	218	PF01048	0.572
MOD_GlcNHglycan	55	58	PF01048	0.476
MOD_GlcNHglycan	560	563	PF01048	0.575
MOD_GlcNHglycan	591	595	PF01048	0.417
MOD_GSK3_1	177	184	PF00069	0.556
MOD_GSK3_1	216	223	PF00069	0.515
MOD_GSK3_1	259	266	PF00069	0.532
MOD_GSK3_1	279	286	PF00069	0.430
MOD_GSK3_1	330	337	PF00069	0.665
MOD_GSK3_1	558	565	PF00069	0.557
MOD_GSK3_1	754	761	PF00069	0.363
MOD_GSK3_1	807	814	PF00069	0.546
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	143	148	PF00069	0.343
MOD_NEK2_1	169	174	PF00069	0.460
MOD_NEK2_1	185	190	PF00069	0.460
MOD_NEK2_1	220	225	PF00069	0.490
MOD_NEK2_1	251	256	PF00069	0.396
MOD_NEK2_1	400	405	PF00069	0.399
MOD_NEK2_1	418	423	PF00069	0.297
MOD_NEK2_1	442	447	PF00069	0.504
MOD_NEK2_1	458	463	PF00069	0.578
MOD_NEK2_1	661	666	PF00069	0.459
MOD_NEK2_1	678	683	PF00069	0.520
MOD_NEK2_1	730	735	PF00069	0.617
MOD_NEK2_1	845	850	PF00069	0.507
MOD_NEK2_2	427	432	PF00069	0.418
MOD_NEK2_2	754	759	PF00069	0.362
MOD_PIKK_1	205	211	PF00454	0.556
MOD_PIKK_1	22	28	PF00454	0.550
MOD_PIKK_1	353	359	PF00454	0.627
MOD_PIKK_1	768	774	PF00454	0.469
MOD_PK_1	131	137	PF00069	0.424
MOD_PKA_1	330	336	PF00069	0.669
MOD_PKA_2	307	313	PF00069	0.626
MOD_PKA_2	353	359	PF00069	0.669
MOD_PKA_2	458	464	PF00069	0.530
MOD_PKA_2	484	490	PF00069	0.587
MOD_PKA_2	537	543	PF00069	0.468
MOD_PKA_2	678	684	PF00069	0.525
MOD_PKA_2	730	736	PF00069	0.526
MOD_PKA_2	810	816	PF00069	0.714
MOD_PKA_2	877	883	PF00069	0.568
MOD_Plk_1	100	106	PF00069	0.410
MOD_Plk_1	267	273	PF00069	0.494
MOD_Plk_1	612	618	PF00069	0.594
MOD_Plk_1	63	69	PF00069	0.510
MOD_Plk_1	774	780	PF00069	0.371
MOD_Plk_4	216	222	PF00069	0.361
MOD_Plk_4	267	273	PF00069	0.534
MOD_Plk_4	413	419	PF00069	0.515
MOD_Plk_4	427	433	PF00069	0.335
MOD_Plk_4	43	49	PF00069	0.524
MOD_Plk_4	458	464	PF00069	0.602
MOD_Plk_4	468	474	PF00069	0.443
MOD_Plk_4	537	543	PF00069	0.502
MOD_Plk_4	612	618	PF00069	0.462
MOD_Plk_4	736	742	PF00069	0.298
MOD_ProDKin_1	364	370	PF00069	0.558
MOD_ProDKin_1	437	443	PF00069	0.352
MOD_SUMO_for_1	543	546	PF00179	0.548
MOD_SUMO_for_1	575	578	PF00179	0.445
MOD_SUMO_rev_2	124	132	PF00179	0.475
MOD_SUMO_rev_2	403	413	PF00179	0.330
MOD_SUMO_rev_2	826	836	PF00179	0.520
TRG_DiLeu_BaEn_1	166	171	PF01217	0.361
TRG_DiLeu_BaEn_1	657	662	PF01217	0.372
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.516
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.479
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.549
TRG_ENDOCYTIC_2	106	109	PF00928	0.497
TRG_ENDOCYTIC_2	200	203	PF00928	0.242
TRG_ENDOCYTIC_2	397	400	PF00928	0.430
TRG_ENDOCYTIC_2	675	678	PF00928	0.447
TRG_ENDOCYTIC_2	68	71	PF00928	0.435
TRG_ENDOCYTIC_2	737	740	PF00928	0.298
TRG_ENDOCYTIC_2	94	97	PF00928	0.445
TRG_ER_diArg_1	298	301	PF00400	0.394
TRG_ER_diArg_1	48	51	PF00400	0.398
TRG_ER_diArg_1	619	622	PF00400	0.544
TRG_ER_diArg_1	636	638	PF00400	0.277
TRG_ER_diArg_1	667	669	PF00400	0.505
TRG_ER_diArg_1	788	791	PF00400	0.311
TRG_ER_diArg_1	792	794	PF00400	0.287
TRG_ER_diArg_1	818	820	PF00400	0.705
TRG_ER_diArg_1	853	855	PF00400	0.454
TRG_ER_diArg_1	875	878	PF00400	0.496
TRG_NES_CRM1_1	557	571	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSD4	Leptomonas seymouri	48%	100%
A0A1X0NVS1	Trypanosomatidae	28%	100%
A0A3Q8IBX8	Leishmania donovani	93%	100%
A0A422NP16	Trypanosoma rangeli	28%	100%
A4HDK7	Leishmania braziliensis	75%	100%
A4I0X4	Leishmania infantum	92%	100%
C9ZWH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5AVI0	Trypanosoma cruzi	29%	100%