LeishMANIAdb
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Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted transmembrane protein
Gene product:
hypothetical predicted transmembrane protein
Species:
Leishmania major
UniProt:
Q4QAJ0_LEIMA
TriTrypDb:
LmjF.24.1410 * , LMJLV39_240020600 * , LMJSD75_240020000 *
Length:
904

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 8, no: 2
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4QAJ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAJ0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.480
CLV_C14_Caspase3-7 474 478 PF00656 0.353
CLV_C14_Caspase3-7 493 497 PF00656 0.333
CLV_C14_Caspase3-7 58 62 PF00656 0.354
CLV_C14_Caspase3-7 840 844 PF00656 0.521
CLV_NRD_NRD_1 124 126 PF00675 0.711
CLV_NRD_NRD_1 162 164 PF00675 0.612
CLV_NRD_NRD_1 357 359 PF00675 0.518
CLV_NRD_NRD_1 392 394 PF00675 0.596
CLV_NRD_NRD_1 575 577 PF00675 0.670
CLV_NRD_NRD_1 588 590 PF00675 0.625
CLV_NRD_NRD_1 737 739 PF00675 0.732
CLV_PCSK_FUR_1 735 739 PF00082 0.653
CLV_PCSK_KEX2_1 124 126 PF00082 0.750
CLV_PCSK_KEX2_1 162 164 PF00082 0.611
CLV_PCSK_KEX2_1 392 394 PF00082 0.596
CLV_PCSK_KEX2_1 588 590 PF00082 0.655
CLV_PCSK_KEX2_1 737 739 PF00082 0.678
CLV_PCSK_SKI1_1 165 169 PF00082 0.554
CLV_PCSK_SKI1_1 265 269 PF00082 0.617
CLV_PCSK_SKI1_1 49 53 PF00082 0.559
CLV_PCSK_SKI1_1 605 609 PF00082 0.581
CLV_PCSK_SKI1_1 643 647 PF00082 0.539
CLV_PCSK_SKI1_1 900 904 PF00082 0.496
CLV_Separin_Metazoa 321 325 PF03568 0.319
DEG_SIAH_1 246 254 PF03145 0.385
DEG_SPOP_SBC_1 30 34 PF00917 0.476
DEG_SPOP_SBC_1 695 699 PF00917 0.373
DEG_SPOP_SBC_1 747 751 PF00917 0.423
DEG_SPOP_SBC_1 95 99 PF00917 0.379
DOC_ANK_TNKS_1 467 474 PF00023 0.348
DOC_CKS1_1 569 574 PF01111 0.429
DOC_CYCLIN_RxL_1 262 272 PF00134 0.366
DOC_CYCLIN_yCln2_LP_2 10 16 PF00134 0.367
DOC_MAPK_DCC_7 49 57 PF00069 0.349
DOC_MAPK_gen_1 192 202 PF00069 0.277
DOC_MAPK_gen_1 392 398 PF00069 0.339
DOC_MAPK_gen_1 805 814 PF00069 0.401
DOC_MAPK_MEF2A_6 758 765 PF00069 0.340
DOC_MAPK_MEF2A_6 807 816 PF00069 0.360
DOC_PP1_RVXF_1 263 270 PF00149 0.391
DOC_PP2B_LxvP_1 10 13 PF13499 0.373
DOC_PP2B_LxvP_1 396 399 PF13499 0.453
DOC_PP4_FxxP_1 691 694 PF00568 0.458
DOC_PP4_FxxP_1 715 718 PF00568 0.378
DOC_USP7_MATH_1 30 34 PF00917 0.494
DOC_USP7_MATH_1 570 574 PF00917 0.364
DOC_USP7_MATH_1 641 645 PF00917 0.389
DOC_USP7_MATH_1 667 671 PF00917 0.463
DOC_USP7_MATH_1 694 698 PF00917 0.413
DOC_USP7_MATH_1 747 751 PF00917 0.490
DOC_USP7_MATH_1 792 796 PF00917 0.433
DOC_USP7_MATH_1 95 99 PF00917 0.379
DOC_WW_Pin1_4 26 31 PF00397 0.444
DOC_WW_Pin1_4 420 425 PF00397 0.419
DOC_WW_Pin1_4 504 509 PF00397 0.423
DOC_WW_Pin1_4 568 573 PF00397 0.401
DOC_WW_Pin1_4 654 659 PF00397 0.417
DOC_WW_Pin1_4 783 788 PF00397 0.455
LIG_14-3-3_CanoR_1 124 133 PF00244 0.461
LIG_14-3-3_CanoR_1 195 201 PF00244 0.376
LIG_14-3-3_CanoR_1 428 433 PF00244 0.492
LIG_14-3-3_CanoR_1 576 584 PF00244 0.433
LIG_14-3-3_CanoR_1 605 610 PF00244 0.325
LIG_14-3-3_CanoR_1 640 646 PF00244 0.417
LIG_14-3-3_CanoR_1 807 813 PF00244 0.362
LIG_Actin_WH2_2 271 289 PF00022 0.314
LIG_Actin_WH2_2 322 338 PF00022 0.327
LIG_APCC_ABBA_1 832 837 PF00400 0.369
LIG_BIR_III_2 896 900 PF00653 0.643
LIG_BIR_III_4 109 113 PF00653 0.518
LIG_BRCT_BRCA1_1 37 41 PF00533 0.461
LIG_deltaCOP1_diTrp_1 818 826 PF00928 0.314
LIG_FHA_1 197 203 PF00498 0.380
LIG_FHA_1 330 336 PF00498 0.390
LIG_FHA_1 376 382 PF00498 0.378
LIG_FHA_1 401 407 PF00498 0.473
LIG_FHA_1 505 511 PF00498 0.437
LIG_FHA_1 538 544 PF00498 0.431
LIG_FHA_1 564 570 PF00498 0.361
LIG_FHA_1 625 631 PF00498 0.355
LIG_FHA_1 697 703 PF00498 0.321
LIG_FHA_1 726 732 PF00498 0.524
LIG_FHA_1 747 753 PF00498 0.428
LIG_FHA_2 369 375 PF00498 0.287
LIG_FHA_2 491 497 PF00498 0.305
LIG_FHA_2 56 62 PF00498 0.367
LIG_FHA_2 606 612 PF00498 0.359
LIG_FHA_2 669 675 PF00498 0.461
LIG_FHA_2 757 763 PF00498 0.453
LIG_FHA_2 97 103 PF00498 0.431
LIG_LIR_Apic_2 222 226 PF02991 0.385
LIG_LIR_Apic_2 25 30 PF02991 0.508
LIG_LIR_Gen_1 168 178 PF02991 0.338
LIG_LIR_Gen_1 207 217 PF02991 0.349
LIG_LIR_Gen_1 261 268 PF02991 0.389
LIG_LIR_Gen_1 344 353 PF02991 0.361
LIG_LIR_Gen_1 488 499 PF02991 0.414
LIG_LIR_Gen_1 547 555 PF02991 0.427
LIG_LIR_Gen_1 61 70 PF02991 0.384
LIG_LIR_Gen_1 649 658 PF02991 0.425
LIG_LIR_Gen_1 720 726 PF02991 0.388
LIG_LIR_Gen_1 795 806 PF02991 0.417
LIG_LIR_Gen_1 818 828 PF02991 0.315
LIG_LIR_Gen_1 887 897 PF02991 0.282
LIG_LIR_Nem_3 168 174 PF02991 0.339
LIG_LIR_Nem_3 207 213 PF02991 0.383
LIG_LIR_Nem_3 215 220 PF02991 0.326
LIG_LIR_Nem_3 261 266 PF02991 0.328
LIG_LIR_Nem_3 344 349 PF02991 0.320
LIG_LIR_Nem_3 409 415 PF02991 0.350
LIG_LIR_Nem_3 451 456 PF02991 0.389
LIG_LIR_Nem_3 488 494 PF02991 0.365
LIG_LIR_Nem_3 547 552 PF02991 0.421
LIG_LIR_Nem_3 603 609 PF02991 0.414
LIG_LIR_Nem_3 649 653 PF02991 0.398
LIG_LIR_Nem_3 720 724 PF02991 0.291
LIG_LIR_Nem_3 795 801 PF02991 0.406
LIG_LIR_Nem_3 818 823 PF02991 0.477
LIG_LIR_Nem_3 887 893 PF02991 0.426
LIG_NRBOX 263 269 PF00104 0.249
LIG_NRBOX 877 883 PF00104 0.384
LIG_NRBOX 887 893 PF00104 0.325
LIG_PCNA_yPIPBox_3 265 278 PF02747 0.369
LIG_PDZ_Class_2 899 904 PF00595 0.654
LIG_Pex14_1 363 367 PF04695 0.371
LIG_Pex14_2 365 369 PF04695 0.259
LIG_SH2_CRK 210 214 PF00017 0.411
LIG_SH2_CRK 491 495 PF00017 0.377
LIG_SH2_CRK 798 802 PF00017 0.420
LIG_SH2_GRB2like 798 801 PF00017 0.362
LIG_SH2_NCK_1 664 668 PF00017 0.460
LIG_SH2_NCK_1 798 802 PF00017 0.368
LIG_SH2_PTP2 27 30 PF00017 0.424
LIG_SH2_SRC 609 612 PF00017 0.263
LIG_SH2_SRC 798 801 PF00017 0.345
LIG_SH2_SRC 836 839 PF00017 0.454
LIG_SH2_STAP1 210 214 PF00017 0.328
LIG_SH2_STAP1 3 7 PF00017 0.419
LIG_SH2_STAP1 609 613 PF00017 0.384
LIG_SH2_STAT5 146 149 PF00017 0.417
LIG_SH2_STAT5 263 266 PF00017 0.336
LIG_SH2_STAT5 27 30 PF00017 0.385
LIG_SH2_STAT5 549 552 PF00017 0.328
LIG_SH2_STAT5 660 663 PF00017 0.372
LIG_SH2_STAT5 867 870 PF00017 0.336
LIG_SH2_STAT5 890 893 PF00017 0.417
LIG_SH3_3 293 299 PF00018 0.395
LIG_SH3_3 369 375 PF00018 0.365
LIG_SH3_3 566 572 PF00018 0.416
LIG_Sin3_3 772 779 PF02671 0.347
LIG_SUMO_SIM_anti_2 311 317 PF11976 0.341
LIG_SUMO_SIM_par_1 53 59 PF11976 0.377
LIG_SUMO_SIM_par_1 629 637 PF11976 0.406
LIG_SUMO_SIM_par_1 881 887 PF11976 0.320
LIG_TRAF2_1 187 190 PF00917 0.421
LIG_TRAF2_1 727 730 PF00917 0.320
LIG_TYR_ITIM 888 893 PF00017 0.421
LIG_WRC_WIRS_1 362 367 PF05994 0.465
MOD_CDK_SPxxK_3 504 511 PF00069 0.386
MOD_CK1_1 126 132 PF00069 0.497
MOD_CK1_1 180 186 PF00069 0.367
MOD_CK1_1 236 242 PF00069 0.496
MOD_CK1_1 29 35 PF00069 0.523
MOD_CK1_1 339 345 PF00069 0.370
MOD_CK1_1 420 426 PF00069 0.520
MOD_CK1_1 431 437 PF00069 0.380
MOD_CK1_1 579 585 PF00069 0.453
MOD_CK1_1 665 671 PF00069 0.448
MOD_CK1_1 783 789 PF00069 0.394
MOD_CK1_1 842 848 PF00069 0.528
MOD_CK2_1 183 189 PF00069 0.403
MOD_CK2_1 339 345 PF00069 0.423
MOD_CK2_1 415 421 PF00069 0.436
MOD_CK2_1 579 585 PF00069 0.461
MOD_CK2_1 605 611 PF00069 0.362
MOD_CK2_1 668 674 PF00069 0.558
MOD_CK2_1 724 730 PF00069 0.506
MOD_CK2_1 756 762 PF00069 0.455
MOD_GlcNHglycan 129 132 PF01048 0.730
MOD_GlcNHglycan 138 141 PF01048 0.586
MOD_GlcNHglycan 179 182 PF01048 0.628
MOD_GlcNHglycan 206 209 PF01048 0.577
MOD_GlcNHglycan 240 243 PF01048 0.774
MOD_GlcNHglycan 274 277 PF01048 0.630
MOD_GlcNHglycan 37 40 PF01048 0.687
MOD_GlcNHglycan 424 427 PF01048 0.721
MOD_GlcNHglycan 436 440 PF01048 0.726
MOD_GlcNHglycan 523 526 PF01048 0.664
MOD_GlcNHglycan 533 536 PF01048 0.584
MOD_GlcNHglycan 545 549 PF01048 0.574
MOD_GlcNHglycan 558 561 PF01048 0.678
MOD_GlcNHglycan 572 575 PF01048 0.550
MOD_GlcNHglycan 600 603 PF01048 0.652
MOD_GlcNHglycan 615 618 PF01048 0.442
MOD_GlcNHglycan 667 670 PF01048 0.713
MOD_GlcNHglycan 676 679 PF01048 0.609
MOD_GlcNHglycan 691 694 PF01048 0.480
MOD_GlcNHglycan 70 73 PF01048 0.624
MOD_GlcNHglycan 707 710 PF01048 0.556
MOD_GlcNHglycan 738 741 PF01048 0.754
MOD_GlcNHglycan 766 770 PF01048 0.644
MOD_GlcNHglycan 777 780 PF01048 0.527
MOD_GlcNHglycan 794 797 PF01048 0.518
MOD_GlcNHglycan 846 850 PF01048 0.698
MOD_GlcNHglycan 854 857 PF01048 0.619
MOD_GSK3_1 123 130 PF00069 0.527
MOD_GSK3_1 157 164 PF00069 0.357
MOD_GSK3_1 180 187 PF00069 0.502
MOD_GSK3_1 22 29 PF00069 0.483
MOD_GSK3_1 232 239 PF00069 0.493
MOD_GSK3_1 31 38 PF00069 0.439
MOD_GSK3_1 331 338 PF00069 0.436
MOD_GSK3_1 398 405 PF00069 0.434
MOD_GSK3_1 431 438 PF00069 0.480
MOD_GSK3_1 486 493 PF00069 0.407
MOD_GSK3_1 605 612 PF00069 0.305
MOD_GSK3_1 613 620 PF00069 0.313
MOD_GSK3_1 624 631 PF00069 0.285
MOD_GSK3_1 639 646 PF00069 0.306
MOD_GSK3_1 665 672 PF00069 0.433
MOD_GSK3_1 747 754 PF00069 0.496
MOD_GSK3_1 761 768 PF00069 0.445
MOD_GSK3_1 841 848 PF00069 0.600
MOD_N-GLC_1 270 275 PF02516 0.567
MOD_N-GLC_1 336 341 PF02516 0.536
MOD_N-GLC_1 35 40 PF02516 0.643
MOD_N-GLC_1 415 420 PF02516 0.591
MOD_N-GLC_1 799 804 PF02516 0.608
MOD_NEK2_1 157 162 PF00069 0.386
MOD_NEK2_1 177 182 PF00069 0.339
MOD_NEK2_1 22 27 PF00069 0.444
MOD_NEK2_1 281 286 PF00069 0.330
MOD_NEK2_1 329 334 PF00069 0.443
MOD_NEK2_1 335 340 PF00069 0.400
MOD_NEK2_1 414 419 PF00069 0.407
MOD_NEK2_1 490 495 PF00069 0.363
MOD_NEK2_1 613 618 PF00069 0.305
MOD_NEK2_1 63 68 PF00069 0.408
MOD_NEK2_1 659 664 PF00069 0.408
MOD_NEK2_1 724 729 PF00069 0.398
MOD_NEK2_1 748 753 PF00069 0.419
MOD_NEK2_1 765 770 PF00069 0.406
MOD_NEK2_1 884 889 PF00069 0.317
MOD_NEK2_1 96 101 PF00069 0.495
MOD_NEK2_2 196 201 PF00069 0.272
MOD_NEK2_2 331 336 PF00069 0.339
MOD_NEK2_2 696 701 PF00069 0.380
MOD_NEK2_2 719 724 PF00069 0.465
MOD_PIKK_1 600 606 PF00454 0.395
MOD_PIKK_1 725 731 PF00454 0.463
MOD_PIKK_1 82 88 PF00454 0.441
MOD_PK_1 336 342 PF00069 0.332
MOD_PKA_1 124 130 PF00069 0.457
MOD_PKA_1 576 582 PF00069 0.435
MOD_PKA_2 123 129 PF00069 0.516
MOD_PKA_2 161 167 PF00069 0.378
MOD_PKA_2 196 202 PF00069 0.365
MOD_PKA_2 434 440 PF00069 0.564
MOD_PKA_2 639 645 PF00069 0.370
MOD_PKA_2 705 711 PF00069 0.342
MOD_PKA_2 736 742 PF00069 0.461
MOD_PKB_1 163 171 PF00069 0.350
MOD_Plk_1 157 163 PF00069 0.461
MOD_Plk_1 270 276 PF00069 0.428
MOD_Plk_1 336 342 PF00069 0.393
MOD_Plk_1 35 41 PF00069 0.451
MOD_Plk_1 415 421 PF00069 0.458
MOD_Plk_1 485 491 PF00069 0.370
MOD_Plk_1 634 640 PF00069 0.393
MOD_Plk_1 761 767 PF00069 0.420
MOD_Plk_1 799 805 PF00069 0.377
MOD_Plk_4 219 225 PF00069 0.461
MOD_Plk_4 22 28 PF00069 0.509
MOD_Plk_4 259 265 PF00069 0.408
MOD_Plk_4 336 342 PF00069 0.380
MOD_Plk_4 406 412 PF00069 0.347
MOD_Plk_4 448 454 PF00069 0.356
MOD_Plk_4 47 53 PF00069 0.397
MOD_Plk_4 486 492 PF00069 0.389
MOD_Plk_4 579 585 PF00069 0.437
MOD_Plk_4 634 640 PF00069 0.294
MOD_Plk_4 719 725 PF00069 0.380
MOD_Plk_4 884 890 PF00069 0.327
MOD_ProDKin_1 26 32 PF00069 0.449
MOD_ProDKin_1 420 426 PF00069 0.418
MOD_ProDKin_1 504 510 PF00069 0.423
MOD_ProDKin_1 568 574 PF00069 0.403
MOD_ProDKin_1 654 660 PF00069 0.419
MOD_ProDKin_1 783 789 PF00069 0.451
MOD_SUMO_for_1 155 158 PF00179 0.431
MOD_SUMO_rev_2 573 579 PF00179 0.376
TRG_DiLeu_BaEn_1 189 194 PF01217 0.400
TRG_DiLeu_BaEn_1 6 11 PF01217 0.446
TRG_DiLeu_BaEn_4 189 195 PF01217 0.398
TRG_DiLeu_BaLyEn_6 262 267 PF01217 0.396
TRG_DiLeu_LyEn_5 189 194 PF01217 0.400
TRG_ENDOCYTIC_2 210 213 PF00928 0.364
TRG_ENDOCYTIC_2 217 220 PF00928 0.343
TRG_ENDOCYTIC_2 263 266 PF00928 0.407
TRG_ENDOCYTIC_2 411 414 PF00928 0.362
TRG_ENDOCYTIC_2 491 494 PF00928 0.358
TRG_ENDOCYTIC_2 549 552 PF00928 0.328
TRG_ENDOCYTIC_2 721 724 PF00928 0.329
TRG_ENDOCYTIC_2 798 801 PF00928 0.413
TRG_ENDOCYTIC_2 890 893 PF00928 0.421
TRG_ER_diArg_1 161 163 PF00400 0.404
TRG_ER_diArg_1 194 197 PF00400 0.422
TRG_ER_diArg_1 391 393 PF00400 0.385
TRG_ER_diArg_1 427 430 PF00400 0.544
TRG_ER_diArg_1 735 738 PF00400 0.458
TRG_ER_diArg_1 812 815 PF00400 0.398
TRG_NES_CRM1_1 308 321 PF08389 0.383

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3L3 Leptomonas seymouri 49% 100%
A0A1X0PBB4 Trypanosomatidae 25% 93%
A0A3R7KLJ4 Trypanosoma rangeli 27% 93%
A0A3S5H7D3 Leishmania donovani 94% 95%
A4HDK1 Leishmania braziliensis 77% 95%
A4I0Y0 Leishmania infantum 94% 95%
C9ZLZ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 97%
E9AWY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5BQI0 Trypanosoma cruzi 24% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS