Putative mismatch repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mismatch repair protein, putative

Species:

Leishmania major

UniProt:

Q4QAI9_LEIMA

TriTrypDb:

LmjF.24.1420 , LMJLV39_240020700 , LMJSD75_240020100

Length:

1370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	2
GO:0032300	mismatch repair complex	2	7
GO:0032389	MutLalpha complex	3	2
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4QAI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006298	mismatch repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003690	double-stranded DNA binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	735	739	PF00656	0.579
CLV_C14_Caspase3-7	781	785	PF00656	0.648
CLV_C14_Caspase3-7	904	908	PF00656	0.635
CLV_NRD_NRD_1	1134	1136	PF00675	0.380
CLV_NRD_NRD_1	1138	1140	PF00675	0.388
CLV_NRD_NRD_1	115	117	PF00675	0.349
CLV_NRD_NRD_1	180	182	PF00675	0.452
CLV_NRD_NRD_1	368	370	PF00675	0.594
CLV_NRD_NRD_1	395	397	PF00675	0.367
CLV_NRD_NRD_1	414	416	PF00675	0.367

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I302	Leptomonas seymouri	52%	100%
A0A3S7WYI2	Leishmania donovani	92%	100%
A4HDK0	Leishmania braziliensis	76%	100%
A4I0Y1	Leishmania infantum	92%	100%
E9AWY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%

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