HpcH_HpaI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HpcH/HpaI aldolase/citrate lyase family, putative

Species:

Leishmania major

UniProt:

Q4QAI7_LEIMA

TriTrypDb:

LmjF.24.1440 , LMJLV39_240021300 , LMJSD75_240020700

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAI7

Function

Biological processes
Term	Name	Level	Count
GO:0019222	regulation of metabolic process	3	2
GO:0030656	regulation of vitamin metabolic process	5	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0062012	regulation of small molecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0106064	regulation of cobalamin metabolic process	6	2
GO:1901401	regulation of tetrapyrrole metabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016829	lyase activity	2	4
GO:0016830	carbon-carbon lyase activity	3	2
GO:0016833	oxo-acid-lyase activity	4	2
GO:0047777	(S)-citramalyl-CoA lyase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.513
CLV_NRD_NRD_1	146	148	PF00675	0.636
CLV_NRD_NRD_1	198	200	PF00675	0.327
CLV_NRD_NRD_1	2	4	PF00675	0.656
CLV_NRD_NRD_1	402	404	PF00675	0.338
CLV_NRD_NRD_1	487	489	PF00675	0.629
CLV_PCSK_FUR_1	144	148	PF00082	0.582
CLV_PCSK_KEX2_1	146	148	PF00082	0.636
CLV_PCSK_KEX2_1	197	199	PF00082	0.347
CLV_PCSK_KEX2_1	2	4	PF00082	0.667
CLV_PCSK_KEX2_1	402	404	PF00082	0.338
CLV_PCSK_KEX2_1	449	451	PF00082	0.483
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.347
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.505
CLV_PCSK_SKI1_1	160	164	PF00082	0.245
CLV_PCSK_SKI1_1	472	476	PF00082	0.437
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DOC_CDC14_PxL_1	173	181	PF14671	0.493
DOC_CKS1_1	25	30	PF01111	0.570
DOC_CKS1_1	338	343	PF01111	0.549
DOC_CYCLIN_RxL_1	80	88	PF00134	0.421
DOC_MAPK_gen_1	469	477	PF00069	0.470
DOC_MAPK_gen_1	81	89	PF00069	0.385
DOC_MAPK_MEF2A_6	81	89	PF00069	0.385
DOC_PP1_RVXF_1	158	165	PF00149	0.396
DOC_PP2B_LxvP_1	163	166	PF13499	0.457
DOC_PP2B_LxvP_1	334	337	PF13499	0.490
DOC_PP4_FxxP_1	302	305	PF00568	0.453
DOC_PP4_FxxP_1	392	395	PF00568	0.527
DOC_USP7_MATH_1	339	343	PF00917	0.527
DOC_USP7_MATH_1	46	50	PF00917	0.684
DOC_USP7_MATH_1	70	74	PF00917	0.608
DOC_USP7_UBL2_3	485	489	PF12436	0.521
DOC_WW_Pin1_4	145	150	PF00397	0.656
DOC_WW_Pin1_4	24	29	PF00397	0.695
DOC_WW_Pin1_4	247	252	PF00397	0.444
DOC_WW_Pin1_4	301	306	PF00397	0.444
DOC_WW_Pin1_4	337	342	PF00397	0.540
DOC_WW_Pin1_4	429	434	PF00397	0.452
DOC_WW_Pin1_4	489	494	PF00397	0.484
DOC_WW_Pin1_4	526	531	PF00397	0.680
DOC_WW_Pin1_4	53	58	PF00397	0.654
DOC_WW_Pin1_4	61	66	PF00397	0.586
LIG_14-3-3_CanoR_1	402	406	PF00244	0.542
LIG_14-3-3_CanoR_1	48	57	PF00244	0.697
LIG_14-3-3_CterR_2	534	538	PF00244	0.663
LIG_APCC_ABBA_1	499	504	PF00400	0.532
LIG_APCC_ABBA_1	89	94	PF00400	0.453
LIG_BIR_III_2	239	243	PF00653	0.443
LIG_BRCT_BRCA1_1	160	164	PF00533	0.527
LIG_BRCT_BRCA1_1	57	61	PF00533	0.716
LIG_CaM_IQ_9	208	224	PF13499	0.631
LIG_Clathr_ClatBox_1	410	414	PF01394	0.467
LIG_FHA_1	223	229	PF00498	0.429
LIG_FHA_1	25	31	PF00498	0.746
LIG_FHA_1	255	261	PF00498	0.527
LIG_FHA_1	282	288	PF00498	0.461
LIG_FHA_1	371	377	PF00498	0.540
LIG_FHA_1	494	500	PF00498	0.612
LIG_FHA_2	430	436	PF00498	0.464
LIG_FHA_2	459	465	PF00498	0.433
LIG_LIR_Apic_2	290	294	PF02991	0.445
LIG_LIR_Apic_2	389	395	PF02991	0.527
LIG_LIR_Nem_3	239	244	PF02991	0.552
LIG_LIR_Nem_3	88	92	PF02991	0.516
LIG_LYPXL_yS_3	241	244	PF13949	0.488
LIG_MYND_1	155	159	PF01753	0.523
LIG_NRBOX	263	269	PF00104	0.486
LIG_SH2_GRB2like	114	117	PF00017	0.472
LIG_SH2_NCK_1	253	257	PF00017	0.555
LIG_SH2_NCK_1	431	435	PF00017	0.460
LIG_SH2_PTP2	291	294	PF00017	0.486
LIG_SH2_SRC	114	117	PF00017	0.472
LIG_SH2_SRC	253	256	PF00017	0.493
LIG_SH2_SRC	291	294	PF00017	0.461
LIG_SH2_SRC	320	323	PF00017	0.481
LIG_SH2_STAT5	291	294	PF00017	0.461
LIG_SH2_STAT5	431	434	PF00017	0.500
LIG_SH2_STAT5	86	89	PF00017	0.477
LIG_SH3_3	174	180	PF00018	0.467
LIG_SH3_3	22	28	PF00018	0.517
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.490
LIG_SUMO_SIM_par_1	184	191	PF11976	0.465
LIG_SUMO_SIM_par_1	454	459	PF11976	0.359
LIG_TRAF2_1	101	104	PF00917	0.596
LIG_TRAF2_1	404	407	PF00917	0.493
LIG_UBA3_1	410	416	PF00899	0.312
MOD_CDK_SPK_2	61	66	PF00069	0.646
MOD_CDK_SPxK_1	526	532	PF00069	0.681
MOD_CK1_1	121	127	PF00069	0.763
MOD_CK1_1	304	310	PF00069	0.396
MOD_CK1_1	49	55	PF00069	0.654
MOD_CK1_1	56	62	PF00069	0.704
MOD_CK2_1	401	407	PF00069	0.428
MOD_CK2_1	429	435	PF00069	0.405
MOD_CK2_1	458	464	PF00069	0.462
MOD_Cter_Amidation	144	147	PF01082	0.726
MOD_GlcNHglycan	329	333	PF01048	0.490
MOD_GlcNHglycan	450	453	PF01048	0.625
MOD_GlcNHglycan	479	482	PF01048	0.486
MOD_GlcNHglycan	58	61	PF01048	0.762
MOD_GlcNHglycan	68	71	PF01048	0.635
MOD_GSK3_1	145	152	PF00069	0.682
MOD_GSK3_1	277	284	PF00069	0.396
MOD_GSK3_1	36	43	PF00069	0.634
MOD_GSK3_1	454	461	PF00069	0.491
MOD_GSK3_1	46	53	PF00069	0.706
MOD_GSK3_1	483	490	PF00069	0.554
MOD_GSK3_1	55	62	PF00069	0.626
MOD_GSK3_1	66	73	PF00069	0.595
MOD_NEK2_1	188	193	PF00069	0.286
MOD_NEK2_1	35	40	PF00069	0.755
MOD_NEK2_1	369	374	PF00069	0.363
MOD_NEK2_1	401	406	PF00069	0.323
MOD_NEK2_1	483	488	PF00069	0.502
MOD_NEK2_1	50	55	PF00069	0.642
MOD_PKA_2	121	127	PF00069	0.629
MOD_PKA_2	35	41	PF00069	0.716
MOD_PKA_2	401	407	PF00069	0.494
MOD_PKA_2	487	493	PF00069	0.666
MOD_Plk_1	188	194	PF00069	0.396
MOD_Plk_1	36	42	PF00069	0.498
MOD_Plk_1	436	442	PF00069	0.369
MOD_Plk_1	483	489	PF00069	0.546
MOD_Plk_2-3	454	460	PF00069	0.461
MOD_Plk_4	26	32	PF00069	0.631
MOD_Plk_4	304	310	PF00069	0.303
MOD_Plk_4	414	420	PF00069	0.396
MOD_ProDKin_1	145	151	PF00069	0.650
MOD_ProDKin_1	24	30	PF00069	0.697
MOD_ProDKin_1	247	253	PF00069	0.279
MOD_ProDKin_1	301	307	PF00069	0.279
MOD_ProDKin_1	337	343	PF00069	0.413
MOD_ProDKin_1	429	435	PF00069	0.456
MOD_ProDKin_1	489	495	PF00069	0.485
MOD_ProDKin_1	526	532	PF00069	0.681
MOD_ProDKin_1	53	59	PF00069	0.654
MOD_ProDKin_1	61	67	PF00069	0.586
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.642
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.494
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.348
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.312
TRG_ENDOCYTIC_2	241	244	PF00928	0.519
TRG_ENDOCYTIC_2	322	325	PF00928	0.324
TRG_ENDOCYTIC_2	327	330	PF00928	0.324
TRG_ENDOCYTIC_2	86	89	PF00928	0.508
TRG_ER_diArg_1	1	3	PF00400	0.666
TRG_ER_diArg_1	144	147	PF00400	0.666
TRG_ER_diArg_1	198	201	PF00400	0.323
TRG_ER_diArg_1	401	403	PF00400	0.411
TRG_NLS_MonoExtC_3	196	201	PF00514	0.312
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHZ0	Leptomonas seymouri	59%	100%
A0A1X0NVS5	Trypanosomatidae	31%	100%
A0A3S7WYJ5	Leishmania donovani	89%	100%
A4HDJ6	Leishmania braziliensis	74%	100%
C9ZWG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AH59	Leishmania infantum	89%	100%
E9AWY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5DBJ5	Trypanosoma cruzi	34%	100%