Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAI5_LEIMA

TriTrypDb:

LmjF.24.1460 , LMJLV39_240021500 , LMJSD75_240020900

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.785
CLV_C14_Caspase3-7	223	227	PF00656	0.696
CLV_C14_Caspase3-7	232	236	PF00656	0.566
CLV_C14_Caspase3-7	511	515	PF00656	0.662
CLV_C14_Caspase3-7	516	520	PF00656	0.589
CLV_NRD_NRD_1	119	121	PF00675	0.702
CLV_NRD_NRD_1	146	148	PF00675	0.668
CLV_NRD_NRD_1	184	186	PF00675	0.823
CLV_NRD_NRD_1	340	342	PF00675	0.532
CLV_NRD_NRD_1	375	377	PF00675	0.766
CLV_NRD_NRD_1	423	425	PF00675	0.585
CLV_NRD_NRD_1	43	45	PF00675	0.678
CLV_NRD_NRD_1	448	450	PF00675	0.680
CLV_NRD_NRD_1	462	464	PF00675	0.518
CLV_NRD_NRD_1	505	507	PF00675	0.803
CLV_NRD_NRD_1	554	556	PF00675	0.540
CLV_NRD_NRD_1	668	670	PF00675	0.714
CLV_NRD_NRD_1	796	798	PF00675	0.712
CLV_PCSK_FUR_1	182	186	PF00082	0.671
CLV_PCSK_FUR_1	40	44	PF00082	0.578
CLV_PCSK_KEX2_1	119	121	PF00082	0.700
CLV_PCSK_KEX2_1	148	150	PF00082	0.707
CLV_PCSK_KEX2_1	184	186	PF00082	0.785
CLV_PCSK_KEX2_1	340	342	PF00082	0.532
CLV_PCSK_KEX2_1	410	412	PF00082	0.602
CLV_PCSK_KEX2_1	42	44	PF00082	0.697
CLV_PCSK_KEX2_1	422	424	PF00082	0.529
CLV_PCSK_KEX2_1	448	450	PF00082	0.680
CLV_PCSK_KEX2_1	462	464	PF00082	0.518
CLV_PCSK_KEX2_1	505	507	PF00082	0.692
CLV_PCSK_KEX2_1	541	543	PF00082	0.587
CLV_PCSK_KEX2_1	554	556	PF00082	0.470
CLV_PCSK_KEX2_1	668	670	PF00082	0.714
CLV_PCSK_KEX2_1	796	798	PF00082	0.712
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.707
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.579
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.584
CLV_PCSK_PC7_1	336	342	PF00082	0.504
CLV_PCSK_PC7_1	550	556	PF00082	0.527
CLV_PCSK_PC7_1	792	798	PF00082	0.695
CLV_PCSK_SKI1_1	102	106	PF00082	0.671
CLV_PCSK_SKI1_1	277	281	PF00082	0.708
CLV_PCSK_SKI1_1	313	317	PF00082	0.592
CLV_PCSK_SKI1_1	355	359	PF00082	0.661
CLV_PCSK_SKI1_1	463	467	PF00082	0.490
CLV_PCSK_SKI1_1	506	510	PF00082	0.756
CLV_PCSK_SKI1_1	586	590	PF00082	0.762
CLV_PCSK_SKI1_1	701	705	PF00082	0.533
CLV_PCSK_SKI1_1	785	789	PF00082	0.621
DEG_APCC_DBOX_1	101	109	PF00400	0.749
DEG_APCC_DBOX_1	261	269	PF00400	0.637
DEG_APCC_DBOX_1	423	431	PF00400	0.551
DEG_APCC_DBOX_1	741	749	PF00400	0.539
DEG_Nend_UBRbox_3	1	3	PF02207	0.662
DEG_SPOP_SBC_1	237	241	PF00917	0.639
DEG_SPOP_SBC_1	393	397	PF00917	0.613
DEG_SPOP_SBC_1	614	618	PF00917	0.632
DOC_AGCK_PIF_1	301	306	PF00069	0.609
DOC_CKS1_1	115	120	PF01111	0.660
DOC_CKS1_1	132	137	PF01111	0.602
DOC_CKS1_1	194	199	PF01111	0.848
DOC_CKS1_1	688	693	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.501
DOC_MAPK_DCC_7	554	562	PF00069	0.549
DOC_MAPK_DCC_7	577	585	PF00069	0.667
DOC_MAPK_gen_1	344	353	PF00069	0.498
DOC_MAPK_gen_1	422	430	PF00069	0.615
DOC_MAPK_gen_1	554	562	PF00069	0.549
DOC_MAPK_HePTP_8	552	564	PF00069	0.542
DOC_MAPK_MEF2A_6	423	432	PF00069	0.539
DOC_MAPK_MEF2A_6	554	562	PF00069	0.549
DOC_MAPK_MEF2A_6	577	585	PF00069	0.667
DOC_PP2B_LxvP_1	28	31	PF13499	0.743
DOC_PP2B_LxvP_1	320	323	PF13499	0.436
DOC_PP2B_LxvP_1	402	405	PF13499	0.508
DOC_SPAK_OSR1_1	336	340	PF12202	0.558
DOC_USP7_MATH_1	12	16	PF00917	0.729
DOC_USP7_MATH_1	133	137	PF00917	0.835
DOC_USP7_MATH_1	151	155	PF00917	0.714
DOC_USP7_MATH_1	19	23	PF00917	0.653
DOC_USP7_MATH_1	237	241	PF00917	0.692
DOC_USP7_MATH_1	393	397	PF00917	0.601
DOC_USP7_MATH_1	614	618	PF00917	0.723
DOC_USP7_MATH_1	639	643	PF00917	0.524
DOC_USP7_MATH_1	720	724	PF00917	0.740
DOC_USP7_MATH_1	732	736	PF00917	0.594
DOC_WW_Pin1_4	114	119	PF00397	0.635
DOC_WW_Pin1_4	131	136	PF00397	0.732
DOC_WW_Pin1_4	193	198	PF00397	0.751
DOC_WW_Pin1_4	433	438	PF00397	0.466
DOC_WW_Pin1_4	620	625	PF00397	0.679
DOC_WW_Pin1_4	642	647	PF00397	0.699
DOC_WW_Pin1_4	687	692	PF00397	0.689
DOC_WW_Pin1_4	69	74	PF00397	0.742
LIG_14-3-3_CanoR_1	109	115	PF00244	0.724
LIG_14-3-3_CanoR_1	120	126	PF00244	0.603
LIG_14-3-3_CanoR_1	259	269	PF00244	0.562
LIG_14-3-3_CanoR_1	328	332	PF00244	0.514
LIG_14-3-3_CanoR_1	490	498	PF00244	0.774
LIG_14-3-3_CanoR_1	738	746	PF00244	0.687
LIG_Actin_WH2_2	704	720	PF00022	0.501
LIG_BIR_III_2	204	208	PF00653	0.843
LIG_BRCT_BRCA1_1	333	337	PF00533	0.551
LIG_BRCT_BRCA1_1	644	648	PF00533	0.722
LIG_CtBP_PxDLS_1	624	628	PF00389	0.563
LIG_FHA_1	189	195	PF00498	0.690
LIG_FHA_1	54	60	PF00498	0.736
LIG_FHA_1	590	596	PF00498	0.741
LIG_FHA_1	684	690	PF00498	0.712
LIG_FHA_1	72	78	PF00498	0.496
LIG_FHA_1	734	740	PF00498	0.565
LIG_FHA_1	99	105	PF00498	0.557
LIG_FHA_2	194	200	PF00498	0.836
LIG_FHA_2	213	219	PF00498	0.534
LIG_FHA_2	261	267	PF00498	0.578
LIG_FHA_2	360	366	PF00498	0.778
LIG_FHA_2	386	392	PF00498	0.688
LIG_FHA_2	445	451	PF00498	0.698
LIG_FHA_2	483	489	PF00498	0.761
LIG_FHA_2	514	520	PF00498	0.611
LIG_FHA_2	647	653	PF00498	0.826
LIG_FHA_2	728	734	PF00498	0.821
LIG_Integrin_isoDGR_2	420	422	PF01839	0.648
LIG_Integrin_RGD_1	660	662	PF01839	0.601
LIG_IRF3_LxIS_1	557	563	PF10401	0.528
LIG_LIR_Gen_1	546	552	PF02991	0.496
LIG_LIR_Gen_1	704	715	PF02991	0.583
LIG_LIR_Nem_3	296	301	PF02991	0.446
LIG_LIR_Nem_3	310	315	PF02991	0.509
LIG_LIR_Nem_3	546	551	PF02991	0.503
LIG_LIR_Nem_3	704	710	PF02991	0.587
LIG_MYND_1	69	73	PF01753	0.699
LIG_Pex14_1	333	337	PF04695	0.551
LIG_Pex14_2	297	301	PF04695	0.464
LIG_Pex14_2	783	787	PF04695	0.678
LIG_SH2_CRK	312	316	PF00017	0.490
LIG_SH2_CRK	475	479	PF00017	0.516
LIG_SH2_SRC	597	600	PF00017	0.596
LIG_SH2_STAP1	269	273	PF00017	0.507
LIG_SH2_STAP1	304	308	PF00017	0.623
LIG_SH2_STAT3	304	307	PF00017	0.525
LIG_SH2_STAT5	121	124	PF00017	0.753
LIG_SH2_STAT5	162	165	PF00017	0.761
LIG_SH2_STAT5	526	529	PF00017	0.539
LIG_SH2_STAT5	763	766	PF00017	0.527
LIG_SH3_1	475	481	PF00018	0.532
LIG_SH3_2	180	185	PF14604	0.779
LIG_SH3_3	129	135	PF00018	0.824
LIG_SH3_3	177	183	PF00018	0.780
LIG_SH3_3	204	210	PF00018	0.778
LIG_SH3_3	28	34	PF00018	0.735
LIG_SH3_3	282	288	PF00018	0.637
LIG_SH3_3	434	440	PF00018	0.538
LIG_SH3_3	474	480	PF00018	0.497
LIG_SH3_3	670	676	PF00018	0.805
LIG_SH3_3	685	691	PF00018	0.525
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.530
LIG_SUMO_SIM_par_1	558	563	PF11976	0.497
LIG_SUMO_SIM_par_1	623	628	PF11976	0.619
LIG_TRAF2_1	588	591	PF00917	0.706
LIG_WW_3	179	183	PF00397	0.650
MOD_CDK_SPK_2	114	119	PF00069	0.597
MOD_CDK_SPK_2	136	141	PF00069	0.621
MOD_CDK_SPxK_1	114	120	PF00069	0.715
MOD_CDK_SPxxK_3	136	143	PF00069	0.751
MOD_CDK_SPxxK_3	687	694	PF00069	0.675
MOD_CK1_1	136	142	PF00069	0.759
MOD_CK1_1	154	160	PF00069	0.547
MOD_CK1_1	395	401	PF00069	0.772
MOD_CK1_1	483	489	PF00069	0.737
MOD_CK1_1	534	540	PF00069	0.529
MOD_CK1_1	616	622	PF00069	0.658
MOD_CK1_1	642	648	PF00069	0.690
MOD_CK1_1	727	733	PF00069	0.744
MOD_CK2_1	205	211	PF00069	0.846
MOD_CK2_1	260	266	PF00069	0.557
MOD_CK2_1	359	365	PF00069	0.763
MOD_CK2_1	444	450	PF00069	0.613
MOD_CK2_1	620	626	PF00069	0.633
MOD_CK2_1	652	658	PF00069	0.674
MOD_CK2_1	727	733	PF00069	0.823
MOD_Cter_Amidation	374	377	PF01082	0.627
MOD_Cter_Amidation	420	423	PF01082	0.661
MOD_GlcNHglycan	125	128	PF01048	0.598
MOD_GlcNHglycan	14	17	PF01048	0.691
MOD_GlcNHglycan	157	160	PF01048	0.712
MOD_GlcNHglycan	176	179	PF01048	0.704
MOD_GlcNHglycan	198	204	PF01048	0.749
MOD_GlcNHglycan	21	24	PF01048	0.661
MOD_GlcNHglycan	231	234	PF01048	0.704
MOD_GlcNHglycan	240	243	PF01048	0.576
MOD_GlcNHglycan	333	336	PF01048	0.559
MOD_GlcNHglycan	397	400	PF01048	0.733
MOD_GlcNHglycan	467	470	PF01048	0.496
MOD_GlcNHglycan	482	485	PF01048	0.612
MOD_GlcNHglycan	492	495	PF01048	0.573
MOD_GlcNHglycan	618	621	PF01048	0.704
MOD_GlcNHglycan	626	630	PF01048	0.452
MOD_GlcNHglycan	655	658	PF01048	0.768
MOD_GlcNHglycan	725	729	PF01048	0.720
MOD_GlcNHglycan	801	806	PF01048	0.709
MOD_GlcNHglycan	94	98	PF01048	0.713
MOD_GSK3_1	10	17	PF00069	0.610
MOD_GSK3_1	150	157	PF00069	0.671
MOD_GSK3_1	327	334	PF00069	0.511
MOD_GSK3_1	365	372	PF00069	0.635
MOD_GSK3_1	393	400	PF00069	0.678
MOD_GSK3_1	482	489	PF00069	0.720
MOD_GSK3_1	509	516	PF00069	0.651
MOD_GSK3_1	562	569	PF00069	0.475
MOD_GSK3_1	612	619	PF00069	0.740
MOD_GSK3_1	642	649	PF00069	0.710
MOD_GSK3_1	67	74	PF00069	0.591
MOD_GSK3_1	679	686	PF00069	0.674
MOD_GSK3_1	695	702	PF00069	0.445
MOD_GSK3_1	720	727	PF00069	0.683
MOD_GSK3_1	733	740	PF00069	0.591
MOD_LATS_1	587	593	PF00433	0.731
MOD_N-GLC_1	486	491	PF02516	0.596
MOD_NEK2_1	108	113	PF00069	0.702
MOD_NEK2_1	142	147	PF00069	0.843
MOD_NEK2_1	229	234	PF00069	0.823
MOD_NEK2_1	428	433	PF00069	0.650
MOD_NEK2_1	444	449	PF00069	0.426
MOD_NEK2_1	496	501	PF00069	0.741
MOD_NEK2_1	560	565	PF00069	0.518
MOD_NEK2_1	613	618	PF00069	0.685
MOD_NEK2_1	627	632	PF00069	0.520
MOD_NEK2_1	737	742	PF00069	0.730
MOD_PIKK_1	163	169	PF00454	0.766
MOD_PIKK_1	205	211	PF00454	0.845
MOD_PIKK_1	260	266	PF00454	0.683
MOD_PKA_2	108	114	PF00069	0.646
MOD_PKA_2	142	148	PF00069	0.749
MOD_PKA_2	160	166	PF00069	0.543
MOD_PKA_2	327	333	PF00069	0.506
MOD_PKA_2	365	371	PF00069	0.624
MOD_PKA_2	385	391	PF00069	0.695
MOD_PKA_2	489	495	PF00069	0.690
MOD_PKA_2	67	73	PF00069	0.797
MOD_PKA_2	737	743	PF00069	0.719
MOD_PKB_1	147	155	PF00069	0.760
MOD_Plk_1	732	738	PF00069	0.709
MOD_Plk_1	779	785	PF00069	0.587
MOD_Plk_2-3	220	226	PF00069	0.814
MOD_Plk_4	428	434	PF00069	0.641
MOD_Plk_4	522	528	PF00069	0.571
MOD_Plk_4	684	690	PF00069	0.781
MOD_ProDKin_1	114	120	PF00069	0.636
MOD_ProDKin_1	131	137	PF00069	0.735
MOD_ProDKin_1	193	199	PF00069	0.751
MOD_ProDKin_1	433	439	PF00069	0.470
MOD_ProDKin_1	620	626	PF00069	0.669
MOD_ProDKin_1	642	648	PF00069	0.710
MOD_ProDKin_1	687	693	PF00069	0.674
MOD_ProDKin_1	69	75	PF00069	0.737
MOD_SUMO_for_1	588	591	PF00179	0.614
MOD_SUMO_rev_2	591	598	PF00179	0.621
TRG_DiLeu_BaEn_4	759	765	PF01217	0.587
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.630
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.546
TRG_ENDOCYTIC_2	312	315	PF00928	0.496
TRG_ER_diArg_1	118	120	PF00400	0.724
TRG_ER_diArg_1	140	143	PF00400	0.713
TRG_ER_diArg_1	146	149	PF00400	0.666
TRG_ER_diArg_1	181	184	PF00400	0.691
TRG_ER_diArg_1	192	195	PF00400	0.661
TRG_ER_diArg_1	339	341	PF00400	0.519
TRG_ER_diArg_1	39	42	PF00400	0.726
TRG_ER_diArg_1	422	424	PF00400	0.569
TRG_ER_diArg_1	461	463	PF00400	0.498
TRG_ER_diArg_1	667	669	PF00400	0.718
TRG_ER_diArg_1	796	799	PF00400	0.614
TRG_NLS_MonoExtC_3	146	151	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.715
TRG_Pf-PMV_PEXEL_1	796	801	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM86	Leptomonas seymouri	49%	100%
A0A3Q8IBE1	Leishmania donovani	88%	100%
A4HDJ4	Leishmania braziliensis	69%	100%
E9AH60	Leishmania infantum	88%	100%
E9AWZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%