LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QAI3_LEIMA
TriTrypDb:
LmjF.24.1480 , LMJLV39_240021700 * , LMJSD75_240021100 *
Length:
632

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAI3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAI3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 272 274 PF00675 0.561
CLV_NRD_NRD_1 366 368 PF00675 0.521
CLV_NRD_NRD_1 528 530 PF00675 0.326
CLV_NRD_NRD_1 575 577 PF00675 0.516
CLV_NRD_NRD_1 622 624 PF00675 0.494
CLV_NRD_NRD_1 78 80 PF00675 0.701
CLV_PCSK_KEX2_1 272 274 PF00082 0.561
CLV_PCSK_KEX2_1 366 368 PF00082 0.521
CLV_PCSK_KEX2_1 622 624 PF00082 0.494
CLV_PCSK_KEX2_1 65 67 PF00082 0.780
CLV_PCSK_KEX2_1 78 80 PF00082 0.635
CLV_PCSK_PC1ET2_1 65 67 PF00082 0.714
CLV_PCSK_SKI1_1 273 277 PF00082 0.593
CLV_PCSK_SKI1_1 278 282 PF00082 0.581
CLV_PCSK_SKI1_1 39 43 PF00082 0.592
CLV_PCSK_SKI1_1 546 550 PF00082 0.510
CLV_PCSK_SKI1_1 594 598 PF00082 0.440
CLV_PCSK_SKI1_1 79 83 PF00082 0.681
CLV_Separin_Metazoa 163 167 PF03568 0.336
DEG_APCC_DBOX_1 165 173 PF00400 0.352
DEG_APCC_DBOX_1 78 86 PF00400 0.477
DOC_CKS1_1 230 235 PF01111 0.393
DOC_CKS1_1 406 411 PF01111 0.348
DOC_CYCLIN_RxL_1 36 45 PF00134 0.373
DOC_CYCLIN_yCln2_LP_2 165 171 PF00134 0.349
DOC_CYCLIN_yCln2_LP_2 505 511 PF00134 0.304
DOC_MAPK_DCC_7 442 452 PF00069 0.348
DOC_MAPK_gen_1 422 430 PF00069 0.311
DOC_MAPK_gen_1 78 85 PF00069 0.495
DOC_MAPK_MEF2A_6 78 85 PF00069 0.495
DOC_PP2B_LxvP_1 200 203 PF13499 0.534
DOC_PP2B_LxvP_1 280 283 PF13499 0.362
DOC_PP4_FxxP_1 108 111 PF00568 0.489
DOC_PP4_FxxP_1 406 409 PF00568 0.328
DOC_USP7_MATH_1 204 208 PF00917 0.471
DOC_USP7_MATH_1 220 224 PF00917 0.285
DOC_USP7_MATH_1 304 308 PF00917 0.497
DOC_USP7_MATH_1 343 347 PF00917 0.593
DOC_USP7_MATH_1 351 355 PF00917 0.445
DOC_USP7_MATH_1 418 422 PF00917 0.399
DOC_USP7_MATH_1 474 478 PF00917 0.548
DOC_USP7_MATH_1 575 579 PF00917 0.652
DOC_USP7_MATH_1 606 610 PF00917 0.694
DOC_USP7_MATH_1 96 100 PF00917 0.445
DOC_WW_Pin1_4 113 118 PF00397 0.508
DOC_WW_Pin1_4 119 124 PF00397 0.466
DOC_WW_Pin1_4 129 134 PF00397 0.464
DOC_WW_Pin1_4 174 179 PF00397 0.372
DOC_WW_Pin1_4 198 203 PF00397 0.512
DOC_WW_Pin1_4 229 234 PF00397 0.382
DOC_WW_Pin1_4 248 253 PF00397 0.228
DOC_WW_Pin1_4 278 283 PF00397 0.413
DOC_WW_Pin1_4 307 312 PF00397 0.464
DOC_WW_Pin1_4 326 331 PF00397 0.470
DOC_WW_Pin1_4 352 357 PF00397 0.481
DOC_WW_Pin1_4 374 379 PF00397 0.333
DOC_WW_Pin1_4 405 410 PF00397 0.337
DOC_WW_Pin1_4 569 574 PF00397 0.667
DOC_WW_Pin1_4 612 617 PF00397 0.694
LIG_14-3-3_CanoR_1 272 280 PF00244 0.410
LIG_14-3-3_CanoR_1 309 315 PF00244 0.527
LIG_14-3-3_CanoR_1 325 330 PF00244 0.428
LIG_14-3-3_CanoR_1 37 42 PF00244 0.452
LIG_Actin_WH2_2 256 274 PF00022 0.360
LIG_APCC_ABBAyCdc20_2 39 45 PF00400 0.380
LIG_BIR_II_1 1 5 PF00653 0.446
LIG_BIR_III_4 588 592 PF00653 0.658
LIG_EVH1_1 169 173 PF00568 0.386
LIG_EVH1_2 212 216 PF00568 0.394
LIG_FHA_1 284 290 PF00498 0.426
LIG_FHA_1 331 337 PF00498 0.555
LIG_FHA_1 398 404 PF00498 0.318
LIG_FHA_1 51 57 PF00498 0.542
LIG_FHA_1 591 597 PF00498 0.647
LIG_FHA_2 126 132 PF00498 0.504
LIG_FHA_2 157 163 PF00498 0.362
LIG_FHA_2 230 236 PF00498 0.397
LIG_FHA_2 279 285 PF00498 0.394
LIG_LIR_Apic_2 228 233 PF02991 0.331
LIG_LIR_Gen_1 157 165 PF02991 0.326
LIG_LIR_Gen_1 357 363 PF02991 0.364
LIG_LIR_Gen_1 384 395 PF02991 0.314
LIG_LIR_Nem_3 157 161 PF02991 0.325
LIG_LIR_Nem_3 357 362 PF02991 0.429
LIG_LIR_Nem_3 384 390 PF02991 0.318
LIG_LIR_Nem_3 501 505 PF02991 0.302
LIG_PDZ_Class_1 627 632 PF00595 0.659
LIG_SH2_CRK 230 234 PF00017 0.339
LIG_SH2_CRK 245 249 PF00017 0.304
LIG_SH2_CRK 412 416 PF00017 0.382
LIG_SH2_NCK_1 10 14 PF00017 0.491
LIG_SH2_NCK_1 230 234 PF00017 0.393
LIG_SH2_PTP2 502 505 PF00017 0.304
LIG_SH2_SRC 361 364 PF00017 0.387
LIG_SH2_STAP1 152 156 PF00017 0.379
LIG_SH2_STAT5 158 161 PF00017 0.369
LIG_SH2_STAT5 3 6 PF00017 0.460
LIG_SH2_STAT5 361 364 PF00017 0.406
LIG_SH2_STAT5 372 375 PF00017 0.283
LIG_SH2_STAT5 402 405 PF00017 0.309
LIG_SH2_STAT5 423 426 PF00017 0.312
LIG_SH2_STAT5 497 500 PF00017 0.290
LIG_SH2_STAT5 502 505 PF00017 0.304
LIG_SH3_1 412 418 PF00018 0.388
LIG_SH3_3 120 126 PF00018 0.500
LIG_SH3_3 131 137 PF00018 0.525
LIG_SH3_3 165 171 PF00018 0.349
LIG_SH3_3 200 206 PF00018 0.536
LIG_SH3_3 246 252 PF00018 0.306
LIG_SH3_3 342 348 PF00018 0.518
LIG_SH3_3 412 418 PF00018 0.388
LIG_SH3_3 431 437 PF00018 0.298
LIG_SH3_3 443 449 PF00018 0.334
LIG_SH3_3 488 494 PF00018 0.428
LIG_SH3_3 605 611 PF00018 0.674
LIG_SH3_3 78 84 PF00018 0.459
LIG_SUMO_SIM_par_1 426 431 PF11976 0.299
LIG_SUMO_SIM_par_1 563 570 PF11976 0.597
LIG_TRAF2_1 560 563 PF00917 0.690
LIG_TYR_ITIM 156 161 PF00017 0.324
LIG_TYR_ITIM 500 505 PF00017 0.269
MOD_CDC14_SPxK_1 574 577 PF00782 0.704
MOD_CDK_SPK_2 113 118 PF00069 0.506
MOD_CDK_SPK_2 326 331 PF00069 0.452
MOD_CDK_SPK_2 571 576 PF00069 0.677
MOD_CDK_SPxK_1 571 577 PF00069 0.696
MOD_CDK_SPxxK_3 129 136 PF00069 0.505
MOD_CDK_SPxxK_3 569 576 PF00069 0.715
MOD_CK1_1 116 122 PF00069 0.499
MOD_CK1_1 190 196 PF00069 0.473
MOD_CK1_1 228 234 PF00069 0.379
MOD_CK1_1 298 304 PF00069 0.507
MOD_CK1_1 307 313 PF00069 0.456
MOD_CK1_1 315 321 PF00069 0.428
MOD_CK1_1 329 335 PF00069 0.585
MOD_CK1_1 354 360 PF00069 0.462
MOD_CK1_1 567 573 PF00069 0.709
MOD_CK1_1 584 590 PF00069 0.721
MOD_CK1_1 60 66 PF00069 0.550
MOD_CK1_1 604 610 PF00069 0.707
MOD_CK1_1 71 77 PF00069 0.491
MOD_CK2_1 125 131 PF00069 0.500
MOD_CK2_1 147 153 PF00069 0.360
MOD_CK2_1 156 162 PF00069 0.337
MOD_CK2_1 229 235 PF00069 0.389
MOD_CK2_1 278 284 PF00069 0.419
MOD_CK2_1 74 80 PF00069 0.453
MOD_GlcNHglycan 138 141 PF01048 0.747
MOD_GlcNHglycan 184 187 PF01048 0.690
MOD_GlcNHglycan 207 210 PF01048 0.678
MOD_GlcNHglycan 273 276 PF01048 0.606
MOD_GlcNHglycan 314 317 PF01048 0.671
MOD_GlcNHglycan 341 344 PF01048 0.780
MOD_GlcNHglycan 345 348 PF01048 0.691
MOD_GlcNHglycan 430 433 PF01048 0.492
MOD_GlcNHglycan 474 477 PF01048 0.754
MOD_GlcNHglycan 521 524 PF01048 0.433
MOD_GlcNHglycan 546 549 PF01048 0.457
MOD_GlcNHglycan 60 63 PF01048 0.719
MOD_GlcNHglycan 603 606 PF01048 0.525
MOD_GlcNHglycan 608 611 PF01048 0.474
MOD_GlcNHglycan 70 73 PF01048 0.660
MOD_GlcNHglycan 74 77 PF01048 0.641
MOD_GlcNHglycan 88 91 PF01048 0.694
MOD_GlcNHglycan 97 101 PF01048 0.653
MOD_GSK3_1 125 132 PF00069 0.528
MOD_GSK3_1 182 189 PF00069 0.462
MOD_GSK3_1 192 199 PF00069 0.542
MOD_GSK3_1 225 232 PF00069 0.365
MOD_GSK3_1 294 301 PF00069 0.480
MOD_GSK3_1 325 332 PF00069 0.503
MOD_GSK3_1 33 40 PF00069 0.488
MOD_GSK3_1 339 346 PF00069 0.577
MOD_GSK3_1 347 354 PF00069 0.462
MOD_GSK3_1 468 475 PF00069 0.450
MOD_GSK3_1 546 553 PF00069 0.663
MOD_GSK3_1 567 574 PF00069 0.692
MOD_GSK3_1 68 75 PF00069 0.600
MOD_N-GLC_1 129 134 PF02516 0.719
MOD_NEK2_1 271 276 PF00069 0.356
MOD_NEK2_1 295 300 PF00069 0.431
MOD_NEK2_1 4 9 PF00069 0.504
MOD_NEK2_1 519 524 PF00069 0.592
MOD_NEK2_1 564 569 PF00069 0.684
MOD_NEK2_2 539 544 PF00069 0.626
MOD_PIKK_1 304 310 PF00454 0.490
MOD_PIKK_1 315 321 PF00454 0.449
MOD_PIKK_1 581 587 PF00454 0.720
MOD_PK_1 51 57 PF00069 0.442
MOD_PKA_1 472 478 PF00069 0.456
MOD_PKA_1 576 582 PF00069 0.733
MOD_PKA_2 182 188 PF00069 0.475
MOD_PKA_2 271 277 PF00069 0.404
MOD_PKA_2 293 299 PF00069 0.477
MOD_PKA_2 324 330 PF00069 0.525
MOD_PKA_2 50 56 PF00069 0.488
MOD_PKA_2 575 581 PF00069 0.778
MOD_PKA_2 68 74 PF00069 0.431
MOD_PKB_1 264 272 PF00069 0.391
MOD_PKB_1 323 331 PF00069 0.519
MOD_PKB_1 544 552 PF00069 0.673
MOD_Plk_1 147 153 PF00069 0.369
MOD_Plk_1 397 403 PF00069 0.328
MOD_Plk_4 147 153 PF00069 0.369
MOD_Plk_4 51 57 PF00069 0.461
MOD_ProDKin_1 113 119 PF00069 0.508
MOD_ProDKin_1 129 135 PF00069 0.465
MOD_ProDKin_1 174 180 PF00069 0.380
MOD_ProDKin_1 198 204 PF00069 0.512
MOD_ProDKin_1 229 235 PF00069 0.389
MOD_ProDKin_1 248 254 PF00069 0.231
MOD_ProDKin_1 278 284 PF00069 0.419
MOD_ProDKin_1 307 313 PF00069 0.465
MOD_ProDKin_1 326 332 PF00069 0.469
MOD_ProDKin_1 352 358 PF00069 0.474
MOD_ProDKin_1 374 380 PF00069 0.337
MOD_ProDKin_1 405 411 PF00069 0.342
MOD_ProDKin_1 569 575 PF00069 0.669
MOD_ProDKin_1 612 618 PF00069 0.691
MOD_SUMO_for_1 596 599 PF00179 0.637
TRG_DiLeu_BaEn_1 501 506 PF01217 0.278
TRG_DiLeu_BaEn_2 96 102 PF01217 0.451
TRG_ENDOCYTIC_2 158 161 PF00928 0.367
TRG_ENDOCYTIC_2 245 248 PF00928 0.301
TRG_ENDOCYTIC_2 497 500 PF00928 0.302
TRG_ENDOCYTIC_2 502 505 PF00928 0.332
TRG_ER_diArg_1 263 266 PF00400 0.381
TRG_ER_diArg_1 271 273 PF00400 0.328
TRG_ER_diArg_1 322 325 PF00400 0.510
TRG_ER_diArg_1 366 368 PF00400 0.321
TRG_ER_diArg_1 543 546 PF00400 0.674
TRG_ER_diArg_1 621 623 PF00400 0.701

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM15 Leptomonas seymouri 49% 98%
A0A3S7WYF8 Leishmania donovani 88% 100%
A4HDJ2 Leishmania braziliensis 71% 100%
A4I0Y6 Leishmania infantum 89% 100%
E9AWZ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS