Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QAI2_LEIMA

TriTrypDb:

LmjF.24.1490 , LMJLV39_240021800 , LMJSD75_240021200

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

Q4QAI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAI2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.396
CLV_C14_Caspase3-7	377	381	PF00656	0.516
CLV_NRD_NRD_1	185	187	PF00675	0.486
CLV_NRD_NRD_1	196	198	PF00675	0.403
CLV_PCSK_KEX2_1	185	187	PF00082	0.546
CLV_PCSK_KEX2_1	192	194	PF00082	0.498
CLV_PCSK_KEX2_1	196	198	PF00082	0.453
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.587
CLV_PCSK_SKI1_1	192	196	PF00082	0.457
CLV_PCSK_SKI1_1	197	201	PF00082	0.421
CLV_PCSK_SKI1_1	228	232	PF00082	0.298
DEG_APCC_DBOX_1	286	294	PF00400	0.472
DEG_MDM2_SWIB_1	162	170	PF02201	0.359
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DEG_SCF_FBW7_1	1	8	PF00400	0.653
DOC_CKS1_1	338	343	PF01111	0.372
DOC_MAPK_gen_1	391	401	PF00069	0.427
DOC_MAPK_JIP1_4	98	104	PF00069	0.547
DOC_MAPK_MEF2A_6	394	403	PF00069	0.421
DOC_PP2B_PxIxI_1	160	166	PF00149	0.415
DOC_USP7_MATH_1	140	144	PF00917	0.479
DOC_USP7_MATH_1	222	226	PF00917	0.450
DOC_USP7_MATH_1	306	310	PF00917	0.549
DOC_USP7_MATH_1	315	319	PF00917	0.366
DOC_WW_Pin1_4	1	6	PF00397	0.657
DOC_WW_Pin1_4	337	342	PF00397	0.533
DOC_WW_Pin1_4	404	409	PF00397	0.410
LIG_14-3-3_CanoR_1	185	189	PF00244	0.522
LIG_APCC_ABBA_1	118	123	PF00400	0.393
LIG_APCC_ABBA_1	128	133	PF00400	0.400
LIG_APCC_ABBA_1	159	164	PF00400	0.342
LIG_BRCT_BRCA1_1	265	269	PF00533	0.336
LIG_BRCT_BRCA1_1	399	403	PF00533	0.391
LIG_BRCT_BRCA1_1	429	433	PF00533	0.327
LIG_FHA_1	2	8	PF00498	0.593
LIG_FHA_1	203	209	PF00498	0.520
LIG_FHA_1	227	233	PF00498	0.533
LIG_FHA_1	393	399	PF00498	0.403
LIG_FHA_1	424	430	PF00498	0.398
LIG_FHA_1	66	72	PF00498	0.681
LIG_FHA_1	98	104	PF00498	0.443
LIG_FHA_2	242	248	PF00498	0.393
LIG_FHA_2	25	31	PF00498	0.729
LIG_LIR_Apic_2	244	248	PF02991	0.372
LIG_LIR_Gen_1	210	221	PF02991	0.534
LIG_LIR_Nem_3	210	216	PF02991	0.534
LIG_LIR_Nem_3	298	302	PF02991	0.284
LIG_Pex14_2	162	166	PF04695	0.327
LIG_SH2_NCK_1	121	125	PF00017	0.428
LIG_SH2_NCK_1	245	249	PF00017	0.397
LIG_SH2_NCK_1	288	292	PF00017	0.306
LIG_SH2_SRC	121	124	PF00017	0.420
LIG_SH2_SRC	129	132	PF00017	0.398
LIG_SH2_STAP1	190	194	PF00017	0.601
LIG_SH2_STAT5	119	122	PF00017	0.391
LIG_SH2_STAT5	129	132	PF00017	0.398
LIG_SH2_STAT5	26	29	PF00017	0.583
LIG_SH2_STAT5	423	426	PF00017	0.383
LIG_SH2_STAT5	52	55	PF00017	0.775
LIG_SH3_3	335	341	PF00018	0.495
LIG_SH3_3	402	408	PF00018	0.404
LIG_SUMO_SIM_par_1	152	158	PF11976	0.483
LIG_SUMO_SIM_par_1	397	402	PF11976	0.533
LIG_TRAF2_1	27	30	PF00917	0.567
LIG_TRAF2_1	42	45	PF00917	0.749
MOD_CK1_1	144	150	PF00069	0.531
MOD_CK1_1	36	42	PF00069	0.630
MOD_CK1_1	392	398	PF00069	0.391
MOD_CK1_1	427	433	PF00069	0.342
MOD_CK1_1	8	14	PF00069	0.578
MOD_CK2_1	200	206	PF00069	0.409
MOD_CK2_1	24	30	PF00069	0.641
MOD_CK2_1	241	247	PF00069	0.386
MOD_CK2_1	83	89	PF00069	0.591
MOD_GlcNHglycan	222	225	PF01048	0.301
MOD_GlcNHglycan	265	268	PF01048	0.327
MOD_GlcNHglycan	308	311	PF01048	0.540
MOD_GlcNHglycan	317	320	PF01048	0.454
MOD_GlcNHglycan	380	384	PF01048	0.546
MOD_GlcNHglycan	416	419	PF01048	0.554
MOD_GSK3_1	1	8	PF00069	0.653
MOD_GSK3_1	140	147	PF00069	0.385
MOD_GSK3_1	184	191	PF00069	0.572
MOD_GSK3_1	222	229	PF00069	0.301
MOD_GSK3_1	324	331	PF00069	0.552
MOD_GSK3_1	350	357	PF00069	0.334
MOD_GSK3_1	36	43	PF00069	0.677
MOD_GSK3_1	423	430	PF00069	0.308
MOD_GSK3_1	93	100	PF00069	0.534
MOD_N-GLC_1	188	193	PF02516	0.589
MOD_NEK2_1	102	107	PF00069	0.457
MOD_NEK2_1	141	146	PF00069	0.436
MOD_NEK2_1	263	268	PF00069	0.331
MOD_NEK2_1	269	274	PF00069	0.354
MOD_NEK2_1	314	319	PF00069	0.370
MOD_NEK2_1	329	334	PF00069	0.515
MOD_NEK2_1	352	357	PF00069	0.433
MOD_NEK2_1	363	368	PF00069	0.368
MOD_NEK2_1	387	392	PF00069	0.551
MOD_NEK2_1	399	404	PF00069	0.458
MOD_NEK2_1	421	426	PF00069	0.391
MOD_NEK2_1	92	97	PF00069	0.596
MOD_NEK2_2	207	212	PF00069	0.374
MOD_NEK2_2	226	231	PF00069	0.163
MOD_PK_1	394	400	PF00069	0.464
MOD_PKA_2	184	190	PF00069	0.534
MOD_PKA_2	327	333	PF00069	0.372
MOD_PKA_2	378	384	PF00069	0.518
MOD_Plk_1	226	232	PF00069	0.301
MOD_Plk_1	269	275	PF00069	0.390
MOD_Plk_1	350	356	PF00069	0.364
MOD_Plk_1	65	71	PF00069	0.657
MOD_Plk_1	92	98	PF00069	0.547
MOD_Plk_2-3	83	89	PF00069	0.668
MOD_Plk_4	141	147	PF00069	0.477
MOD_Plk_4	149	155	PF00069	0.438
MOD_Plk_4	269	275	PF00069	0.412
MOD_Plk_4	394	400	PF00069	0.477
MOD_ProDKin_1	1	7	PF00069	0.651
MOD_ProDKin_1	337	343	PF00069	0.524
MOD_ProDKin_1	404	410	PF00069	0.403
MOD_SUMO_rev_2	29	39	PF00179	0.724
TRG_DiLeu_BaEn_1	260	265	PF01217	0.358
TRG_DiLeu_BaEn_2	294	300	PF01217	0.429
TRG_ER_diArg_1	195	197	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A8	Leptomonas seymouri	81%	100%
A0A0S4IX69	Bodo saltans	53%	98%
A0A1X0NW69	Trypanosomatidae	57%	100%
A0A3Q8IBY9	Leishmania donovani	96%	100%
A0A3R7K1J8	Trypanosoma rangeli	56%	100%
A1Z8D0	Drosophila melanogaster	28%	95%
A4HDJ1	Leishmania braziliensis	90%	98%
A4I0Y7	Leishmania infantum	96%	100%
C9ZWG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AWZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P21304	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	75%
Q13610	Homo sapiens	31%	87%
Q2HJ56	Bos taurus	31%	87%
Q99LL5	Mus musculus	32%	87%
Q9P775	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	84%
V5BFJ2	Trypanosoma cruzi	55%	100%