Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAH6_LEIMA

TriTrypDb:

LmjF.24.1550 , LMJLV39_240022400 , LMJSD75_240021700

Length:

963

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.738
CLV_NRD_NRD_1	131	133	PF00675	0.821
CLV_NRD_NRD_1	201	203	PF00675	0.693
CLV_NRD_NRD_1	418	420	PF00675	0.747
CLV_NRD_NRD_1	569	571	PF00675	0.711
CLV_NRD_NRD_1	648	650	PF00675	0.751
CLV_NRD_NRD_1	73	75	PF00675	0.628
CLV_NRD_NRD_1	773	775	PF00675	0.780
CLV_NRD_NRD_1	795	797	PF00675	0.704
CLV_NRD_NRD_1	885	887	PF00675	0.666
CLV_NRD_NRD_1	96	98	PF00675	0.595
CLV_PCSK_KEX2_1	131	133	PF00082	0.821
CLV_PCSK_KEX2_1	201	203	PF00082	0.693
CLV_PCSK_KEX2_1	568	570	PF00082	0.705
CLV_PCSK_KEX2_1	648	650	PF00082	0.649
CLV_PCSK_KEX2_1	73	75	PF00082	0.628
CLV_PCSK_KEX2_1	773	775	PF00082	0.777
CLV_PCSK_KEX2_1	795	797	PF00082	0.704
CLV_PCSK_KEX2_1	885	887	PF00082	0.666
CLV_PCSK_KEX2_1	95	97	PF00082	0.603
CLV_PCSK_PC7_1	197	203	PF00082	0.631
CLV_PCSK_SKI1_1	160	164	PF00082	0.700
CLV_PCSK_SKI1_1	185	189	PF00082	0.745
CLV_PCSK_SKI1_1	63	67	PF00082	0.630
CLV_PCSK_SKI1_1	630	634	PF00082	0.595
CLV_PCSK_SKI1_1	696	700	PF00082	0.628
CLV_PCSK_SKI1_1	934	938	PF00082	0.675
CLV_PCSK_SKI1_1	944	948	PF00082	0.618
CLV_Separin_Metazoa	612	616	PF03568	0.590
DEG_APCC_DBOX_1	184	192	PF00400	0.745
DEG_APCC_DBOX_1	533	541	PF00400	0.654
DEG_APCC_DBOX_1	943	951	PF00400	0.760
DEG_Kelch_Keap1_1	489	494	PF01344	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DEG_SCF_FBW7_1	288	294	PF00400	0.836
DEG_SPOP_SBC_1	207	211	PF00917	0.593
DOC_CDC14_PxL_1	475	483	PF14671	0.691
DOC_CKS1_1	288	293	PF01111	0.765
DOC_CYCLIN_RxL_1	182	190	PF00134	0.756
DOC_MAPK_gen_1	615	622	PF00069	0.571
DOC_MAPK_gen_1	735	743	PF00069	0.671
DOC_MAPK_MEF2A_6	737	745	PF00069	0.696
DOC_PP1_RVXF_1	647	654	PF00149	0.510
DOC_PP2B_LxvP_1	387	390	PF13499	0.693
DOC_PP2B_LxvP_1	690	693	PF13499	0.631
DOC_PP4_FxxP_1	476	479	PF00568	0.555
DOC_PP4_FxxP_1	680	683	PF00568	0.550
DOC_USP7_MATH_1	121	125	PF00917	0.739
DOC_USP7_MATH_1	227	231	PF00917	0.742
DOC_USP7_MATH_1	291	295	PF00917	0.738
DOC_USP7_MATH_1	353	357	PF00917	0.770
DOC_USP7_MATH_1	360	364	PF00917	0.689
DOC_USP7_MATH_1	482	486	PF00917	0.681
DOC_USP7_MATH_1	747	751	PF00917	0.749
DOC_USP7_MATH_1	859	863	PF00917	0.789
DOC_USP7_MATH_1	866	870	PF00917	0.738
DOC_USP7_MATH_2	439	445	PF00917	0.830
DOC_WW_Pin1_4	112	117	PF00397	0.505
DOC_WW_Pin1_4	208	213	PF00397	0.741
DOC_WW_Pin1_4	214	219	PF00397	0.736
DOC_WW_Pin1_4	228	233	PF00397	0.507
DOC_WW_Pin1_4	287	292	PF00397	0.751
DOC_WW_Pin1_4	342	347	PF00397	0.848
DOC_WW_Pin1_4	364	369	PF00397	0.751
DOC_WW_Pin1_4	460	465	PF00397	0.794
DOC_WW_Pin1_4	675	680	PF00397	0.800
DOC_WW_Pin1_4	774	779	PF00397	0.817
DOC_WW_Pin1_4	908	913	PF00397	0.603
LIG_14-3-3_CanoR_1	283	289	PF00244	0.818
LIG_14-3-3_CanoR_1	304	312	PF00244	0.700
LIG_14-3-3_CanoR_1	371	380	PF00244	0.651
LIG_14-3-3_CanoR_1	630	637	PF00244	0.706
LIG_14-3-3_CanoR_1	648	654	PF00244	0.468
LIG_14-3-3_CanoR_1	73	78	PF00244	0.628
LIG_14-3-3_CanoR_1	813	821	PF00244	0.549
LIG_14-3-3_CanoR_1	893	897	PF00244	0.647
LIG_BRCT_BRCA1_1	641	645	PF00533	0.721
LIG_CaM_IQ_9	88	104	PF13499	0.651
LIG_deltaCOP1_diTrp_1	154	163	PF00928	0.583
LIG_FHA_1	223	229	PF00498	0.767
LIG_FHA_1	586	592	PF00498	0.722
LIG_FHA_1	60	66	PF00498	0.616
LIG_FHA_1	631	637	PF00498	0.697
LIG_FHA_1	684	690	PF00498	0.677
LIG_FHA_1	86	92	PF00498	0.709
LIG_FHA_1	918	924	PF00498	0.688
LIG_FHA_1	930	936	PF00498	0.577
LIG_FHA_2	156	162	PF00498	0.698
LIG_FHA_2	268	274	PF00498	0.694
LIG_FHA_2	803	809	PF00498	0.690
LIG_LIR_Apic_2	456	462	PF02991	0.810
LIG_LIR_Apic_2	678	683	PF02991	0.553
LIG_LIR_Gen_1	154	163	PF02991	0.694
LIG_LIR_Gen_1	384	394	PF02991	0.685
LIG_LIR_Gen_1	550	561	PF02991	0.586
LIG_LIR_Gen_1	608	618	PF02991	0.528
LIG_LIR_Gen_1	739	747	PF02991	0.725
LIG_LIR_Gen_1	851	860	PF02991	0.682
LIG_LIR_LC3C_4	851	856	PF02991	0.537
LIG_LIR_Nem_3	154	159	PF02991	0.696
LIG_LIR_Nem_3	384	389	PF02991	0.702
LIG_LIR_Nem_3	550	556	PF02991	0.536
LIG_LIR_Nem_3	608	613	PF02991	0.535
LIG_LIR_Nem_3	739	743	PF02991	0.717
LIG_LIR_Nem_3	851	855	PF02991	0.618
LIG_NRBOX	183	189	PF00104	0.754
LIG_NRBOX	254	260	PF00104	0.659
LIG_Pex14_1	803	807	PF04695	0.590
LIG_SH2_PTP2	459	462	PF00017	0.810
LIG_SH2_PTP2	852	855	PF00017	0.647
LIG_SH2_SRC	31	34	PF00017	0.616
LIG_SH2_STAP1	261	265	PF00017	0.631
LIG_SH2_STAP1	618	622	PF00017	0.583
LIG_SH2_STAT3	2	5	PF00017	0.719
LIG_SH2_STAT3	261	264	PF00017	0.786
LIG_SH2_STAT5	2	5	PF00017	0.719
LIG_SH2_STAT5	261	264	PF00017	0.591
LIG_SH2_STAT5	31	34	PF00017	0.616
LIG_SH2_STAT5	398	401	PF00017	0.747
LIG_SH2_STAT5	413	416	PF00017	0.753
LIG_SH2_STAT5	432	435	PF00017	0.549
LIG_SH2_STAT5	459	462	PF00017	0.810
LIG_SH2_STAT5	475	478	PF00017	0.528
LIG_SH2_STAT5	700	703	PF00017	0.605
LIG_SH2_STAT5	704	707	PF00017	0.610
LIG_SH2_STAT5	740	743	PF00017	0.722
LIG_SH2_STAT5	811	814	PF00017	0.623
LIG_SH2_STAT5	852	855	PF00017	0.598
LIG_SH3_3	170	176	PF00018	0.650
LIG_SH3_3	557	563	PF00018	0.700
LIG_SH3_3	74	80	PF00018	0.625
LIG_SH3_3	853	859	PF00018	0.617
LIG_Sin3_3	903	910	PF02671	0.726
LIG_SUMO_SIM_anti_2	851	857	PF11976	0.661
LIG_SUMO_SIM_par_1	741	746	PF11976	0.705
LIG_SUMO_SIM_par_1	851	857	PF11976	0.622
LIG_SUMO_SIM_par_1	877	883	PF11976	0.611
LIG_TRAF2_1	379	382	PF00917	0.772
LIG_TRAF2_1	528	531	PF00917	0.788
LIG_TRAF2_1	598	601	PF00917	0.634
LIG_TRAF2_1	750	753	PF00917	0.596
LIG_TRAF2_1	787	790	PF00917	0.685
LIG_WRC_WIRS_1	650	655	PF05994	0.503
MOD_CDK_SPK_2	228	233	PF00069	0.721
MOD_CDK_SPxxK_3	364	371	PF00069	0.618
MOD_CK1_1	122	128	PF00069	0.737
MOD_CK1_1	217	223	PF00069	0.824
MOD_CK1_1	23	29	PF00069	0.429
MOD_CK1_1	243	249	PF00069	0.726
MOD_CK1_1	284	290	PF00069	0.851
MOD_CK1_1	352	358	PF00069	0.769
MOD_CK1_1	367	373	PF00069	0.767
MOD_CK1_1	485	491	PF00069	0.768
MOD_CK1_1	492	498	PF00069	0.604
MOD_CK1_1	639	645	PF00069	0.699
MOD_CK1_1	832	838	PF00069	0.622
MOD_CK1_1	908	914	PF00069	0.595
MOD_CK2_1	155	161	PF00069	0.697
MOD_CK2_1	353	359	PF00069	0.730
MOD_CK2_1	488	494	PF00069	0.796
MOD_CK2_1	525	531	PF00069	0.757
MOD_CK2_1	747	753	PF00069	0.592
MOD_CK2_1	802	808	PF00069	0.671
MOD_DYRK1A_RPxSP_1	112	116	PF00069	0.503
MOD_DYRK1A_RPxSP_1	774	778	PF00069	0.742
MOD_GlcNHglycan	112	115	PF01048	0.642
MOD_GlcNHglycan	121	124	PF01048	0.721
MOD_GlcNHglycan	138	141	PF01048	0.653
MOD_GlcNHglycan	179	182	PF01048	0.755
MOD_GlcNHglycan	242	245	PF01048	0.828
MOD_GlcNHglycan	283	286	PF01048	0.801
MOD_GlcNHglycan	351	354	PF01048	0.804
MOD_GlcNHglycan	355	358	PF01048	0.770
MOD_GlcNHglycan	359	363	PF01048	0.746
MOD_GlcNHglycan	373	376	PF01048	0.742
MOD_GlcNHglycan	443	446	PF01048	0.834
MOD_GlcNHglycan	49	52	PF01048	0.589
MOD_GlcNHglycan	491	494	PF01048	0.680
MOD_GlcNHglycan	527	530	PF01048	0.760
MOD_GlcNHglycan	545	548	PF01048	0.429
MOD_GlcNHglycan	659	662	PF01048	0.655
MOD_GlcNHglycan	68	71	PF01048	0.566
MOD_GlcNHglycan	778	781	PF01048	0.753
MOD_GlcNHglycan	826	829	PF01048	0.626
MOD_GlcNHglycan	862	865	PF01048	0.738
MOD_GlcNHglycan	868	871	PF01048	0.697
MOD_GlcNHglycan	908	911	PF01048	0.654
MOD_GlcNHglycan	950	953	PF01048	0.778
MOD_GSK3_1	117	124	PF00069	0.650
MOD_GSK3_1	287	294	PF00069	0.784
MOD_GSK3_1	349	356	PF00069	0.803
MOD_GSK3_1	360	367	PF00069	0.822
MOD_GSK3_1	482	489	PF00069	0.672
MOD_GSK3_1	829	836	PF00069	0.626
MOD_GSK3_1	925	932	PF00069	0.645
MOD_NEK2_1	136	141	PF00069	0.820
MOD_NEK2_1	152	157	PF00069	0.460
MOD_NEK2_1	259	264	PF00069	0.585
MOD_NEK2_1	66	71	PF00069	0.615
MOD_NEK2_1	685	690	PF00069	0.653
MOD_NEK2_1	72	77	PF00069	0.626
MOD_NEK2_1	905	910	PF00069	0.655
MOD_NEK2_1	936	941	PF00069	0.714
MOD_NEK2_1	948	953	PF00069	0.600
MOD_NEK2_2	802	807	PF00069	0.616
MOD_PIKK_1	20	26	PF00454	0.482
MOD_PIKK_1	605	611	PF00454	0.695
MOD_PIKK_1	872	878	PF00454	0.557
MOD_PKA_1	73	79	PF00069	0.728
MOD_PKA_2	136	142	PF00069	0.764
MOD_PKA_2	152	158	PF00069	0.649
MOD_PKA_2	259	265	PF00069	0.778
MOD_PKA_2	303	309	PF00069	0.618
MOD_PKA_2	370	376	PF00069	0.682
MOD_PKA_2	411	417	PF00069	0.773
MOD_PKA_2	668	674	PF00069	0.717
MOD_PKA_2	72	78	PF00069	0.627
MOD_PKA_2	766	772	PF00069	0.761
MOD_PKA_2	892	898	PF00069	0.612
MOD_PKB_1	774	782	PF00069	0.696
MOD_Plk_1	20	26	PF00069	0.587
MOD_Plk_1	381	387	PF00069	0.692
MOD_Plk_1	532	538	PF00069	0.646
MOD_Plk_1	556	562	PF00069	0.693
MOD_Plk_1	639	645	PF00069	0.721
MOD_Plk_2-3	324	330	PF00069	0.688
MOD_Plk_4	36	42	PF00069	0.535
MOD_Plk_4	381	387	PF00069	0.809
MOD_Plk_4	492	498	PF00069	0.775
MOD_Plk_4	556	562	PF00069	0.693
MOD_Plk_4	639	645	PF00069	0.721
MOD_Plk_4	649	655	PF00069	0.572
MOD_Plk_4	685	691	PF00069	0.615
MOD_Plk_4	73	79	PF00069	0.728
MOD_Plk_4	802	808	PF00069	0.616
MOD_Plk_4	829	835	PF00069	0.672
MOD_Plk_4	892	898	PF00069	0.581
MOD_ProDKin_1	112	118	PF00069	0.511
MOD_ProDKin_1	208	214	PF00069	0.746
MOD_ProDKin_1	219	225	PF00069	0.731
MOD_ProDKin_1	228	234	PF00069	0.507
MOD_ProDKin_1	287	293	PF00069	0.750
MOD_ProDKin_1	342	348	PF00069	0.846
MOD_ProDKin_1	364	370	PF00069	0.753
MOD_ProDKin_1	460	466	PF00069	0.787
MOD_ProDKin_1	675	681	PF00069	0.799
MOD_ProDKin_1	774	780	PF00069	0.814
MOD_ProDKin_1	908	914	PF00069	0.602
MOD_SUMO_rev_2	161	170	PF00179	0.593
TRG_DiLeu_BaEn_1	757	762	PF01217	0.640
TRG_DiLeu_BaEn_1	902	907	PF01217	0.718
TRG_DiLeu_BaEn_4	532	538	PF01217	0.670
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.724
TRG_ENDOCYTIC_2	740	743	PF00928	0.722
TRG_ENDOCYTIC_2	842	845	PF00928	0.688
TRG_ENDOCYTIC_2	852	855	PF00928	0.521
TRG_ER_diArg_1	130	132	PF00400	0.823
TRG_ER_diArg_1	201	203	PF00400	0.693
TRG_ER_diArg_1	568	570	PF00400	0.705
TRG_ER_diArg_1	614	617	PF00400	0.564
TRG_ER_diArg_1	648	650	PF00400	0.751
TRG_ER_diArg_1	72	74	PF00400	0.633
TRG_ER_diArg_1	772	774	PF00400	0.781
TRG_ER_diArg_1	885	887	PF00400	0.593
TRG_ER_diArg_1	95	97	PF00400	0.603
TRG_NES_CRM1_1	316	329	PF08389	0.732
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.753
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I728	Leptomonas seymouri	39%	100%
A0A3S7WYF6	Leishmania donovani	90%	100%
A4HDI6	Leishmania braziliensis	74%	97%
E9AH62	Leishmania infantum	90%	100%
E9AX00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%