Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAH5_LEIMA

TriTrypDb:

LmjF.24.1560 , LMJLV39_240022500 , LMJSD75_240021800

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4QAH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.395
CLV_C14_Caspase3-7	311	315	PF00656	0.568
CLV_C14_Caspase3-7	396	400	PF00656	0.544
CLV_C14_Caspase3-7	429	433	PF00656	0.639
CLV_NRD_NRD_1	219	221	PF00675	0.581
CLV_NRD_NRD_1	486	488	PF00675	0.636
CLV_NRD_NRD_1	80	82	PF00675	0.394
CLV_PCSK_KEX2_1	221	223	PF00082	0.598
CLV_PCSK_KEX2_1	486	488	PF00082	0.634
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.519
CLV_PCSK_SKI1_1	178	182	PF00082	0.421
CLV_PCSK_SKI1_1	213	217	PF00082	0.519
CLV_PCSK_SKI1_1	266	270	PF00082	0.449
CLV_PCSK_SKI1_1	375	379	PF00082	0.494
CLV_PCSK_SKI1_1	524	528	PF00082	0.560
CLV_PCSK_SKI1_1	59	63	PF00082	0.495
CLV_Separin_Metazoa	405	409	PF03568	0.613
DEG_COP1_1	396	406	PF00400	0.636
DOC_CKS1_1	307	312	PF01111	0.484
DOC_CYCLIN_RxL_1	173	185	PF00134	0.510
DOC_CYCLIN_RxL_1	56	64	PF00134	0.524
DOC_CYCLIN_yClb5_NLxxxL_5	158	167	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.558
DOC_MAPK_gen_1	220	229	PF00069	0.457
DOC_MAPK_gen_1	375	383	PF00069	0.589
DOC_MAPK_gen_1	569	576	PF00069	0.490
DOC_MAPK_MEF2A_6	252	261	PF00069	0.444
DOC_PP2B_LxvP_1	366	369	PF13499	0.463
DOC_PP2B_LxvP_1	381	384	PF13499	0.464
DOC_PP2B_PxIxI_1	71	77	PF00149	0.500
DOC_PP4_FxxP_1	450	453	PF00568	0.527
DOC_PP4_FxxP_1	590	593	PF00568	0.563
DOC_USP7_MATH_1	19	23	PF00917	0.460
DOC_USP7_MATH_1	376	380	PF00917	0.446
DOC_USP7_MATH_1	388	392	PF00917	0.519
DOC_USP7_UBL2_3	217	221	PF12436	0.542
DOC_USP7_UBL2_3	466	470	PF12436	0.496
DOC_USP7_UBL2_3	489	493	PF12436	0.677
DOC_WW_Pin1_4	15	20	PF00397	0.427
DOC_WW_Pin1_4	306	311	PF00397	0.524
DOC_WW_Pin1_4	433	438	PF00397	0.776
DOC_WW_Pin1_4	479	484	PF00397	0.563
LIG_14-3-3_CanoR_1	220	229	PF00244	0.478
LIG_14-3-3_CanoR_1	375	381	PF00244	0.448
LIG_14-3-3_CanoR_1	412	417	PF00244	0.648
LIG_14-3-3_CanoR_1	446	451	PF00244	0.463
LIG_14-3-3_CanoR_1	554	559	PF00244	0.488
LIG_14-3-3_CanoR_1	81	86	PF00244	0.437
LIG_Actin_WH2_2	94	111	PF00022	0.493
LIG_APCC_ABBA_1	591	596	PF00400	0.595
LIG_BIR_III_4	185	189	PF00653	0.550
LIG_BRCT_BRCA1_1	390	394	PF00533	0.573
LIG_BRCT_BRCA1_1	410	414	PF00533	0.333
LIG_BRCT_BRCA1_1	419	423	PF00533	0.605
LIG_BRCT_BRCA1_1	502	506	PF00533	0.488
LIG_BRCT_BRCA1_1	90	94	PF00533	0.492
LIG_eIF4E_1	522	528	PF01652	0.586
LIG_FHA_1	187	193	PF00498	0.558
LIG_FHA_1	224	230	PF00498	0.444
LIG_FHA_1	369	375	PF00498	0.533
LIG_FHA_1	447	453	PF00498	0.520
LIG_FHA_1	52	58	PF00498	0.552
LIG_FHA_1	531	537	PF00498	0.465
LIG_FHA_2	240	246	PF00498	0.450
LIG_FHA_2	251	257	PF00498	0.455
LIG_FHA_2	307	313	PF00498	0.519
LIG_FHA_2	394	400	PF00498	0.653
LIG_FHA_2	427	433	PF00498	0.696
LIG_FHA_2	483	489	PF00498	0.579
LIG_FHA_2	533	539	PF00498	0.416
LIG_LIR_Apic_2	120	125	PF02991	0.513
LIG_LIR_Apic_2	449	453	PF02991	0.414
LIG_LIR_Apic_2	587	593	PF02991	0.551
LIG_LIR_Gen_1	189	199	PF02991	0.415
LIG_LIR_Gen_1	231	240	PF02991	0.398
LIG_LIR_Gen_1	255	263	PF02991	0.399
LIG_LIR_Gen_1	37	47	PF02991	0.541
LIG_LIR_Gen_1	592	600	PF02991	0.698
LIG_LIR_Nem_3	189	194	PF02991	0.429
LIG_LIR_Nem_3	21	26	PF02991	0.502
LIG_LIR_Nem_3	231	235	PF02991	0.402
LIG_LIR_Nem_3	37	42	PF02991	0.436
LIG_LIR_Nem_3	391	395	PF02991	0.579
LIG_LIR_Nem_3	592	597	PF02991	0.692
LIG_LYPXL_yS_3	203	206	PF13949	0.495
LIG_PCNA_yPIPBox_3	132	143	PF02747	0.504
LIG_PCNA_yPIPBox_3	157	167	PF02747	0.512
LIG_Pex14_1	49	53	PF04695	0.560
LIG_Pex14_2	590	594	PF04695	0.573
LIG_PTB_Apo_2	197	204	PF02174	0.426
LIG_PTB_Phospho_1	197	203	PF10480	0.499
LIG_REV1ctd_RIR_1	461	470	PF16727	0.442
LIG_SH2_CRK	122	126	PF00017	0.512
LIG_SH2_CRK	23	27	PF00017	0.445
LIG_SH2_CRK	39	43	PF00017	0.454
LIG_SH2_GRB2like	237	240	PF00017	0.393
LIG_SH2_GRB2like	249	252	PF00017	0.436
LIG_SH2_STAP1	170	174	PF00017	0.463
LIG_SH2_STAP1	522	526	PF00017	0.572
LIG_SH2_STAP1	53	57	PF00017	0.550
LIG_SH2_STAT5	174	177	PF00017	0.436
LIG_SH2_STAT5	258	261	PF00017	0.501
LIG_SH2_STAT5	306	309	PF00017	0.548
LIG_SH2_STAT5	395	398	PF00017	0.538
LIG_SH2_STAT5	402	405	PF00017	0.422
LIG_SH2_STAT5	53	56	PF00017	0.558
LIG_SH3_3	285	291	PF00018	0.605
LIG_SH3_3	379	385	PF00018	0.506
LIG_SH3_3	40	46	PF00018	0.550
LIG_SH3_3	477	483	PF00018	0.617
LIG_Sin3_3	313	320	PF02671	0.402
LIG_SUMO_SIM_anti_2	379	384	PF11976	0.424
LIG_SUMO_SIM_par_1	117	123	PF11976	0.419
LIG_SUMO_SIM_par_1	223	231	PF11976	0.453
LIG_SUMO_SIM_par_1	53	58	PF11976	0.539
LIG_SUMO_SIM_par_1	530	538	PF11976	0.459
LIG_SUMO_SIM_par_1	553	560	PF11976	0.551
LIG_SUMO_SIM_par_1	72	79	PF11976	0.328
LIG_TRAF2_1	535	538	PF00917	0.413
LIG_TRAF2_2	291	296	PF00917	0.613
LIG_UBA3_1	555	562	PF00899	0.499
LIG_WRC_WIRS_1	229	234	PF05994	0.422
LIG_WRC_WIRS_1	498	503	PF05994	0.556
LIG_WRC_WIRS_1	573	578	PF05994	0.470
MOD_CDK_SPK_2	15	20	PF00069	0.440
MOD_CDK_SPxxK_3	479	486	PF00069	0.665
MOD_CK1_1	104	110	PF00069	0.515
MOD_CK1_1	223	229	PF00069	0.472
MOD_CK1_1	250	256	PF00069	0.545
MOD_CK1_1	393	399	PF00069	0.538
MOD_CK1_1	417	423	PF00069	0.517
MOD_CK1_1	433	439	PF00069	0.667
MOD_CK1_1	482	488	PF00069	0.558
MOD_CK1_1	572	578	PF00069	0.508
MOD_CK1_1	84	90	PF00069	0.542
MOD_CK2_1	111	117	PF00069	0.511
MOD_CK2_1	239	245	PF00069	0.449
MOD_CK2_1	250	256	PF00069	0.430
MOD_CK2_1	349	355	PF00069	0.575
MOD_CK2_1	505	511	PF00069	0.416
MOD_CK2_1	532	538	PF00069	0.426
MOD_CK2_1	586	592	PF00069	0.583
MOD_GlcNHglycan	122	125	PF01048	0.402
MOD_GlcNHglycan	327	330	PF01048	0.640
MOD_GlcNHglycan	339	342	PF01048	0.775
MOD_GlcNHglycan	423	426	PF01048	0.613
MOD_GlcNHglycan	432	435	PF01048	0.658
MOD_GlcNHglycan	442	445	PF01048	0.738
MOD_GlcNHglycan	502	505	PF01048	0.464
MOD_GSK3_1	107	114	PF00069	0.402
MOD_GSK3_1	142	149	PF00069	0.472
MOD_GSK3_1	15	22	PF00069	0.517
MOD_GSK3_1	349	356	PF00069	0.818
MOD_GSK3_1	408	415	PF00069	0.514
MOD_GSK3_1	417	424	PF00069	0.533
MOD_GSK3_1	426	433	PF00069	0.615
MOD_GSK3_1	448	455	PF00069	0.523
MOD_GSK3_1	470	477	PF00069	0.588
MOD_GSK3_1	72	79	PF00069	0.481
MOD_GSK3_1	84	91	PF00069	0.511
MOD_LATS_1	468	474	PF00433	0.569
MOD_N-GLC_1	132	137	PF02516	0.561
MOD_N-GLC_1	250	255	PF02516	0.515
MOD_N-GLC_1	337	342	PF02516	0.740
MOD_N-GLC_1	408	413	PF02516	0.669
MOD_NEK2_1	414	419	PF00069	0.554
MOD_NEK2_1	61	66	PF00069	0.470
MOD_NEK2_2	390	395	PF00069	0.594
MOD_PK_1	412	418	PF00069	0.547
MOD_PKA_1	220	226	PF00069	0.480
MOD_PKA_1	474	480	PF00069	0.596
MOD_PKA_1	81	87	PF00069	0.442
MOD_PKA_2	19	25	PF00069	0.480
MOD_PKA_2	417	423	PF00069	0.639
MOD_Plk_1	223	229	PF00069	0.558
MOD_Plk_1	250	256	PF00069	0.524
MOD_Plk_1	569	575	PF00069	0.612
MOD_Plk_1	586	592	PF00069	0.519
MOD_Plk_1	7	13	PF00069	0.496
MOD_Plk_2-3	349	355	PF00069	0.575
MOD_Plk_2-3	505	511	PF00069	0.485
MOD_Plk_2-3	586	592	PF00069	0.605
MOD_Plk_4	117	123	PF00069	0.429
MOD_Plk_4	193	199	PF00069	0.498
MOD_Plk_4	228	234	PF00069	0.422
MOD_Plk_4	376	382	PF00069	0.542
MOD_Plk_4	390	396	PF00069	0.531
MOD_Plk_4	452	458	PF00069	0.441
MOD_Plk_4	474	480	PF00069	0.677
MOD_Plk_4	497	503	PF00069	0.560
MOD_Plk_4	569	575	PF00069	0.621
MOD_ProDKin_1	15	21	PF00069	0.427
MOD_ProDKin_1	306	312	PF00069	0.523
MOD_ProDKin_1	433	439	PF00069	0.774
MOD_ProDKin_1	479	485	PF00069	0.559
MOD_SUMO_rev_2	462	471	PF00179	0.465
MOD_SUMO_rev_2	557	564	PF00179	0.502
TRG_DiLeu_BaEn_2	255	261	PF01217	0.423
TRG_DiLeu_BaEn_2	585	591	PF01217	0.553
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.440
TRG_ENDOCYTIC_2	174	177	PF00928	0.449
TRG_ENDOCYTIC_2	203	206	PF00928	0.531
TRG_ENDOCYTIC_2	23	26	PF00928	0.431
TRG_ENDOCYTIC_2	258	261	PF00928	0.373
TRG_ENDOCYTIC_2	39	42	PF00928	0.439
TRG_ER_diArg_1	219	222	PF00400	0.587
TRG_ER_diArg_1	301	304	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU8	Leptomonas seymouri	66%	100%
A0A0S4JJW4	Bodo saltans	30%	100%
A0A1X0NW77	Trypanosomatidae	39%	89%
A0A3S7WYG2	Leishmania donovani	96%	100%
A0A422N8J0	Trypanosoma rangeli	41%	97%
A4HDI5	Leishmania braziliensis	80%	100%
C9ZWF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AH63	Leishmania infantum	95%	100%
E9AX01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BK17	Trypanosoma cruzi	41%	100%