UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAH3_LEIMA

TriTrypDb:

LmjF.24.1580 , LMJLV39_240022700 , LMJSD75_240022000

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QAH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.616
CLV_NRD_NRD_1	191	193	PF00675	0.723
CLV_NRD_NRD_1	321	323	PF00675	0.486
CLV_NRD_NRD_1	347	349	PF00675	0.531
CLV_NRD_NRD_1	85	87	PF00675	0.359
CLV_PCSK_FUR_1	319	323	PF00082	0.517
CLV_PCSK_KEX2_1	191	193	PF00082	0.723
CLV_PCSK_KEX2_1	321	323	PF00082	0.486
CLV_PCSK_KEX2_1	346	348	PF00082	0.545
CLV_PCSK_KEX2_1	51	53	PF00082	0.620
CLV_PCSK_KEX2_1	85	87	PF00082	0.355
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.661
CLV_PCSK_PC7_1	317	323	PF00082	0.537
CLV_PCSK_PC7_1	81	87	PF00082	0.334
CLV_PCSK_SKI1_1	167	171	PF00082	0.331
CLV_PCSK_SKI1_1	176	180	PF00082	0.274
CLV_PCSK_SKI1_1	237	241	PF00082	0.372
CLV_PCSK_SKI1_1	244	248	PF00082	0.369
CLV_PCSK_SKI1_1	51	55	PF00082	0.692
DEG_APCC_DBOX_1	203	211	PF00400	0.335
DEG_APCC_DBOX_1	236	244	PF00400	0.556
DEG_APCC_DBOX_1	51	59	PF00400	0.431
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DEG_SPOP_SBC_1	17	21	PF00917	0.229
DOC_CYCLIN_RxL_1	48	57	PF00134	0.557
DOC_MAPK_gen_1	222	230	PF00069	0.528
DOC_MAPK_gen_1	241	251	PF00069	0.611
DOC_MAPK_HePTP_8	230	242	PF00069	0.589
DOC_MAPK_MEF2A_6	233	242	PF00069	0.548
DOC_PP1_RVXF_1	220	227	PF00149	0.525
DOC_PP2B_LxvP_1	40	43	PF13499	0.356
DOC_PP4_FxxP_1	242	245	PF00568	0.577
DOC_USP7_MATH_1	148	152	PF00917	0.683
DOC_USP7_MATH_1	17	21	PF00917	0.335
DOC_USP7_MATH_1	215	219	PF00917	0.356
DOC_WW_Pin1_4	177	182	PF00397	0.561
DOC_WW_Pin1_4	346	351	PF00397	0.683
LIG_14-3-3_CanoR_1	125	134	PF00244	0.290
LIG_14-3-3_CanoR_1	150	154	PF00244	0.676
LIG_14-3-3_CanoR_1	225	231	PF00244	0.575
LIG_14-3-3_CanoR_1	244	253	PF00244	0.494
LIG_Actin_WH2_2	132	147	PF00022	0.404
LIG_eIF4E_1	234	240	PF01652	0.630
LIG_FHA_1	10	16	PF00498	0.429
LIG_FHA_1	104	110	PF00498	0.263
LIG_FHA_1	139	145	PF00498	0.320
LIG_FHA_1	158	164	PF00498	0.514
LIG_FHA_1	230	236	PF00498	0.582
LIG_FHA_1	245	251	PF00498	0.577
LIG_FHA_1	96	102	PF00498	0.317
LIG_FHA_2	304	310	PF00498	0.694
LIG_GBD_Chelix_1	136	144	PF00786	0.399
LIG_GBD_Chelix_1	209	217	PF00786	0.324
LIG_IRF3_LxIS_1	11	16	PF10401	0.427
LIG_IRF3_LxIS_1	158	165	PF10401	0.656
LIG_IRF3_LxIS_1	59	66	PF10401	0.427
LIG_LIR_Gen_1	203	214	PF02991	0.378
LIG_LIR_Gen_1	69	78	PF02991	0.388
LIG_LIR_Gen_1	89	100	PF02991	0.370
LIG_LIR_Nem_3	203	209	PF02991	0.360
LIG_LIR_Nem_3	229	234	PF02991	0.603
LIG_LIR_Nem_3	69	74	PF02991	0.455
LIG_LIR_Nem_3	89	95	PF02991	0.370
LIG_Pex14_1	227	231	PF04695	0.543
LIG_Pex14_2	251	255	PF04695	0.694
LIG_PTB_Apo_2	29	36	PF02174	0.686
LIG_RPA_C_Fungi	367	379	PF08784	0.377
LIG_SH2_STAT5	143	146	PF00017	0.436
LIG_SH2_STAT5	234	237	PF00017	0.527
LIG_SH2_STAT5	300	303	PF00017	0.560
LIG_SH3_3	175	181	PF00018	0.394
LIG_SH3_3	56	62	PF00018	0.495
LIG_SUMO_SIM_anti_2	9	16	PF11976	0.427
LIG_SUMO_SIM_par_1	11	16	PF11976	0.427
LIG_TRAF2_1	310	313	PF00917	0.643
LIG_TRAF2_1	349	352	PF00917	0.680
LIG_UBA3_1	171	176	PF00899	0.389
MOD_CK1_1	149	155	PF00069	0.636
MOD_CK1_1	16	22	PF00069	0.380
MOD_CK1_1	180	186	PF00069	0.613
MOD_CK1_1	218	224	PF00069	0.446
MOD_CK2_1	346	352	PF00069	0.699
MOD_CK2_1	368	374	PF00069	0.588
MOD_GlcNHglycan	113	116	PF01048	0.496
MOD_GlcNHglycan	127	130	PF01048	0.282
MOD_GlcNHglycan	15	18	PF01048	0.351
MOD_GlcNHglycan	98	101	PF01048	0.322
MOD_GSK3_1	109	116	PF00069	0.508
MOD_GSK3_1	125	132	PF00069	0.223
MOD_GSK3_1	9	16	PF00069	0.356
MOD_N-GLC_1	271	276	PF02516	0.781
MOD_NEK2_1	13	18	PF00069	0.380
MOD_NEK2_1	379	384	PF00069	0.572
MOD_NEK2_1	54	59	PF00069	0.569
MOD_NEK2_1	63	68	PF00069	0.341
MOD_NEK2_1	95	100	PF00069	0.302
MOD_NEK2_2	138	143	PF00069	0.420
MOD_NEK2_2	226	231	PF00069	0.487
MOD_PIKK_1	180	186	PF00454	0.561
MOD_PK_1	117	123	PF00069	0.595
MOD_PKA_2	149	155	PF00069	0.646
MOD_PKA_2	368	374	PF00069	0.486
MOD_Plk_4	129	135	PF00069	0.279
MOD_Plk_4	167	173	PF00069	0.394
MOD_Plk_4	18	24	PF00069	0.387
MOD_Plk_4	226	232	PF00069	0.493
MOD_Plk_4	88	94	PF00069	0.365
MOD_Plk_4	9	15	PF00069	0.427
MOD_ProDKin_1	177	183	PF00069	0.568
MOD_ProDKin_1	346	352	PF00069	0.613
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.481
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.622
TRG_ENDOCYTIC_2	30	33	PF00928	0.671
TRG_ENDOCYTIC_2	92	95	PF00928	0.420
TRG_ER_diArg_1	190	192	PF00400	0.649
TRG_ER_diArg_1	220	223	PF00400	0.569
TRG_ER_diArg_1	314	317	PF00400	0.611
TRG_ER_diArg_1	318	321	PF00400	0.593
TRG_ER_diArg_1	346	348	PF00400	0.687
TRG_ER_diArg_1	85	87	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM84	Leptomonas seymouri	63%	100%
A0A1X0NVU5	Trypanosomatidae	35%	100%
A0A3S7WYG8	Leishmania donovani	98%	100%
A0A422N8E9	Trypanosoma rangeli	33%	100%
A4HDL8	Leishmania braziliensis	83%	100%
C9ZWE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AH65	Leishmania infantum	97%	100%
E9AX03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AVK1	Trypanosoma cruzi	35%	100%