Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAH2_LEIMA

TriTrypDb:

LmjF.24.1590 , LMJLV39_240022800 , LMJSD75_240022100

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.508
CLV_C14_Caspase3-7	410	414	PF00656	0.654
CLV_NRD_NRD_1	183	185	PF00675	0.526
CLV_NRD_NRD_1	289	291	PF00675	0.684
CLV_NRD_NRD_1	380	382	PF00675	0.762
CLV_PCSK_FUR_1	181	185	PF00082	0.494
CLV_PCSK_FUR_1	378	382	PF00082	0.731
CLV_PCSK_KEX2_1	183	185	PF00082	0.526
CLV_PCSK_KEX2_1	377	379	PF00082	0.743
CLV_PCSK_KEX2_1	380	382	PF00082	0.733
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.726
CLV_PCSK_PC7_1	373	379	PF00082	0.726
CLV_PCSK_SKI1_1	132	136	PF00082	0.457
CLV_PCSK_SKI1_1	145	149	PF00082	0.349
CLV_PCSK_SKI1_1	24	28	PF00082	0.656
CLV_PCSK_SKI1_1	279	283	PF00082	0.612
CLV_PCSK_SKI1_1	357	361	PF00082	0.642
CLV_PCSK_SKI1_1	373	377	PF00082	0.564
CLV_Separin_Metazoa	162	166	PF03568	0.455
DEG_APCC_DBOX_1	525	533	PF00400	0.558
DEG_APCC_DBOX_1	8	16	PF00400	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_CYCLIN_yClb5_NLxxxL_5	521	527	PF00134	0.565
DOC_MAPK_DCC_7	357	366	PF00069	0.563
DOC_MAPK_gen_1	143	152	PF00069	0.427
DOC_MAPK_MEF2A_6	143	152	PF00069	0.450
DOC_MAPK_NFAT4_5	143	151	PF00069	0.451
DOC_PP2B_LxvP_1	241	244	PF13499	0.543
DOC_PP2B_LxvP_1	34	37	PF13499	0.684
DOC_USP7_MATH_1	187	191	PF00917	0.604
DOC_USP7_MATH_1	44	48	PF00917	0.583
DOC_WW_Pin1_4	29	34	PF00397	0.618
DOC_WW_Pin1_4	305	310	PF00397	0.690
DOC_WW_Pin1_4	397	402	PF00397	0.760
DOC_WW_Pin1_4	483	488	PF00397	0.692
DOC_WW_Pin1_4	492	497	PF00397	0.658
DOC_WW_Pin1_4	500	505	PF00397	0.563
DOC_WW_Pin1_4	514	519	PF00397	0.538
LIG_14-3-3_CanoR_1	122	131	PF00244	0.474
LIG_14-3-3_CanoR_1	149	153	PF00244	0.416
LIG_14-3-3_CanoR_1	343	349	PF00244	0.672
LIG_14-3-3_CanoR_1	357	362	PF00244	0.549
LIG_14-3-3_CanoR_1	543	549	PF00244	0.490
LIG_Actin_WH2_2	360	375	PF00022	0.666
LIG_Actin_WH2_2	8	26	PF00022	0.545
LIG_BIR_III_4	396	400	PF00653	0.671
LIG_deltaCOP1_diTrp_1	205	210	PF00928	0.472
LIG_FHA_1	101	107	PF00498	0.630
LIG_FHA_1	413	419	PF00498	0.703
LIG_FHA_1	423	429	PF00498	0.638
LIG_FHA_1	60	66	PF00498	0.454
LIG_FHA_2	200	206	PF00498	0.471
LIG_FHA_2	256	262	PF00498	0.554
LIG_FHA_2	408	414	PF00498	0.603
LIG_FHA_2	463	469	PF00498	0.706
LIG_FHA_2	534	540	PF00498	0.579
LIG_FHA_2	545	551	PF00498	0.517
LIG_FHA_2	97	103	PF00498	0.558
LIG_GBD_Chelix_1	50	58	PF00786	0.503
LIG_LIR_Gen_1	204	215	PF02991	0.499
LIG_LIR_Nem_3	17	22	PF02991	0.467
LIG_LIR_Nem_3	204	210	PF02991	0.501
LIG_LYPXL_yS_3	19	22	PF13949	0.585
LIG_MYND_1	309	313	PF01753	0.599
LIG_MYND_1	514	518	PF01753	0.573
LIG_NRBOX	11	17	PF00104	0.491
LIG_SH2_NCK_1	257	261	PF00017	0.607
LIG_SH2_STAT3	256	259	PF00017	0.587
LIG_SH2_STAT5	129	132	PF00017	0.485
LIG_SH2_STAT5	257	260	PF00017	0.597
LIG_SH3_3	214	220	PF00018	0.488
LIG_SH3_3	266	272	PF00018	0.649
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.477
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.446
LIG_SUMO_SIM_par_1	78	84	PF11976	0.446
LIG_TRAF2_1	392	395	PF00917	0.602
LIG_TYR_ITSM	15	22	PF00017	0.393
MOD_CDC14_SPxK_1	503	506	PF00782	0.599
MOD_CDK_SPK_2	305	310	PF00069	0.575
MOD_CDK_SPxK_1	500	506	PF00069	0.600
MOD_CDK_SPxxK_3	399	406	PF00069	0.664
MOD_CDK_SPxxK_3	492	499	PF00069	0.608
MOD_CDK_SPxxK_3	514	521	PF00069	0.588
MOD_CK1_1	190	196	PF00069	0.579
MOD_CK1_1	250	256	PF00069	0.566
MOD_CK1_1	347	353	PF00069	0.709
MOD_CK1_1	384	390	PF00069	0.739
MOD_CK1_1	412	418	PF00069	0.784
MOD_CK1_1	483	489	PF00069	0.668
MOD_CK2_1	255	261	PF00069	0.553
MOD_CK2_1	297	303	PF00069	0.709
MOD_CK2_1	331	337	PF00069	0.572
MOD_CK2_1	414	420	PF00069	0.751
MOD_CK2_1	462	468	PF00069	0.655
MOD_CK2_1	533	539	PF00069	0.578
MOD_CK2_1	75	81	PF00069	0.448
MOD_CK2_1	96	102	PF00069	0.547
MOD_CMANNOS	528	531	PF00535	0.601
MOD_Cter_Amidation	181	184	PF01082	0.489
MOD_GlcNHglycan	132	135	PF01048	0.428
MOD_GlcNHglycan	189	192	PF01048	0.617
MOD_GlcNHglycan	247	252	PF01048	0.592
MOD_GlcNHglycan	272	275	PF01048	0.616
MOD_GlcNHglycan	285	288	PF01048	0.502
MOD_GlcNHglycan	299	302	PF01048	0.589
MOD_GlcNHglycan	333	336	PF01048	0.596
MOD_GlcNHglycan	46	50	PF01048	0.579
MOD_GlcNHglycan	488	491	PF01048	0.562
MOD_GlcNHglycan	511	514	PF01048	0.641
MOD_GSK3_1	197	204	PF00069	0.494
MOD_GSK3_1	305	312	PF00069	0.700
MOD_GSK3_1	344	351	PF00069	0.716
MOD_GSK3_1	353	360	PF00069	0.617
MOD_GSK3_1	404	411	PF00069	0.777
MOD_GSK3_1	423	430	PF00069	0.536
MOD_GSK3_1	462	469	PF00069	0.635
MOD_GSK3_1	500	507	PF00069	0.645
MOD_GSK3_1	533	540	PF00069	0.511
MOD_GSK3_1	59	66	PF00069	0.459
MOD_GSK3_1	96	103	PF00069	0.587
MOD_N-GLC_1	344	349	PF02516	0.718
MOD_N-GLC_1	408	413	PF02516	0.706
MOD_N-GLC_1	504	509	PF02516	0.674
MOD_NEK2_1	130	135	PF00069	0.428
MOD_NEK2_1	148	153	PF00069	0.309
MOD_NEK2_1	206	211	PF00069	0.426
MOD_NEK2_1	423	428	PF00069	0.596
MOD_NEK2_1	508	513	PF00069	0.624
MOD_PIKK_1	122	128	PF00454	0.470
MOD_PIKK_1	255	261	PF00454	0.603
MOD_PIKK_1	37	43	PF00454	0.593
MOD_PK_1	63	69	PF00069	0.467
MOD_PKA_2	148	154	PF00069	0.421
MOD_PKA_2	270	276	PF00069	0.617
MOD_PKA_2	44	50	PF00069	0.448
MOD_PKA_2	544	550	PF00069	0.536
MOD_PKB_1	120	128	PF00069	0.474
MOD_PKB_1	379	387	PF00069	0.734
MOD_PKB_1	43	51	PF00069	0.449
MOD_Plk_1	292	298	PF00069	0.650
MOD_Plk_1	344	350	PF00069	0.715
MOD_Plk_1	45	51	PF00069	0.549
MOD_Plk_1	504	510	PF00069	0.652
MOD_Plk_1	59	65	PF00069	0.343
MOD_Plk_2-3	324	330	PF00069	0.565
MOD_Plk_4	14	20	PF00069	0.422
MOD_Plk_4	206	212	PF00069	0.495
MOD_Plk_4	362	368	PF00069	0.591
MOD_Plk_4	424	430	PF00069	0.720
MOD_ProDKin_1	29	35	PF00069	0.619
MOD_ProDKin_1	305	311	PF00069	0.692
MOD_ProDKin_1	397	403	PF00069	0.757
MOD_ProDKin_1	483	489	PF00069	0.693
MOD_ProDKin_1	492	498	PF00069	0.658
MOD_ProDKin_1	500	506	PF00069	0.566
MOD_ProDKin_1	514	520	PF00069	0.533
MOD_SUMO_rev_2	400	407	PF00179	0.661
TRG_DiLeu_BaEn_2	361	367	PF01217	0.564
TRG_ENDOCYTIC_2	19	22	PF00928	0.585
TRG_ENDOCYTIC_2	257	260	PF00928	0.597
TRG_ER_diArg_1	142	145	PF00400	0.450
TRG_ER_diArg_1	181	184	PF00400	0.489
TRG_ER_diArg_1	378	381	PF00400	0.760
TRG_ER_diArg_1	543	546	PF00400	0.538
TRG_NES_CRM1_1	317	329	PF08389	0.665
TRG_NES_CRM1_1	56	71	PF08389	0.398
TRG_NLS_MonoCore_2	375	380	PF00514	0.726
TRG_NLS_MonoExtC_3	375	380	PF00514	0.726
TRG_NLS_MonoExtN_4	373	380	PF00514	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYG0	Leishmania donovani	87%	100%
A4HDL9	Leishmania braziliensis	66%	99%
E9AH66	Leishmania infantum	87%	100%
E9AX04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%