Putative ring-box protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ring-box protein, putative

Species:

Leishmania major

UniProt:

Q4QAH0_LEIMA

TriTrypDb:

LmjF.24.1610 , LMJLV39_240023000 , LMJSD75_240022300

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0005634	nucleus	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QAH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAH0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	7
GO:0005515	protein binding	2	2
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0097602	cullin family protein binding	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	26	30	PF00082	0.433
CLV_PCSK_SKI1_1	92	96	PF00082	0.242
DEG_SPOP_SBC_1	5	9	PF00917	0.573
DOC_USP7_MATH_1	10	14	PF00917	0.620
DOC_USP7_MATH_1	72	76	PF00917	0.564
LIG_14-3-3_CanoR_1	26	32	PF00244	0.486
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_Clathr_ClatBox_1	28	32	PF01394	0.477
LIG_deltaCOP1_diTrp_1	106	113	PF00928	0.457
LIG_FHA_1	85	91	PF00498	0.452
LIG_FHA_1	94	100	PF00498	0.447
LIG_FHA_2	28	34	PF00498	0.471
LIG_FHA_2	68	74	PF00498	0.448
LIG_FHA_2	75	81	PF00498	0.442
LIG_LIR_Nem_3	32	38	PF02991	0.404
LIG_SH2_STAT5	38	41	PF00017	0.481
LIG_SH3_1	95	101	PF00018	0.488
LIG_SH3_3	53	59	PF00018	0.442
LIG_SH3_3	95	101	PF00018	0.488
LIG_TRAF2_1	30	33	PF00917	0.402
MOD_CK2_1	27	33	PF00069	0.395
MOD_CK2_1	37	43	PF00069	0.434
MOD_CK2_1	62	68	PF00069	0.469
MOD_CK2_1	74	80	PF00069	0.491
MOD_GlcNHglycan	1	4	PF01048	0.692
MOD_GlcNHglycan	115	118	PF01048	0.509
MOD_GlcNHglycan	39	42	PF01048	0.426
MOD_GlcNHglycan	70	73	PF01048	0.245
MOD_GSK3_1	108	115	PF00069	0.452
MOD_GSK3_1	43	50	PF00069	0.390
MOD_GSK3_1	6	13	PF00069	0.580
MOD_GSK3_1	68	75	PF00069	0.488
MOD_N-GLC_1	113	118	PF02516	0.503
MOD_PKA_2	43	49	PF00069	0.394
MOD_Plk_1	72	78	PF00069	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V1	Leptomonas seymouri	87%	100%
A0A0S4IYF9	Bodo saltans	43%	86%
A0A0S4J7B6	Bodo saltans	37%	81%
A0A0S4JR26	Bodo saltans	33%	100%
A0A1X0NQI6	Trypanosomatidae	30%	100%
A0A1X0NXY1	Trypanosomatidae	42%	100%
A0A3S7WTW3	Leishmania donovani	32%	100%
A0A3S7WW78	Leishmania donovani	47%	100%
A0A3S7WYG9	Leishmania donovani	99%	100%
A0A422MZP5	Trypanosoma rangeli	48%	91%
A4HBJ7	Leishmania braziliensis	45%	100%
A4HDM1	Leishmania braziliensis	91%	100%
A4HWW4	Leishmania infantum	32%	100%
A4HZL7	Leishmania infantum	47%	100%
D0A1J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AH68	Leishmania infantum	99%	100%
E9AQM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AUW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AX06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O13959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P62877	Homo sapiens	48%	100%
P62878	Mus musculus	48%	100%
Q08273	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
Q20052	Caenorhabditis elegans	28%	88%
Q23457	Caenorhabditis elegans	41%	100%
Q4QCL6	Leishmania major	47%	100%
Q4QEV4	Leishmania major	32%	100%
Q54K33	Dictyostelium discoideum	45%	100%
Q8QG64	Salmo salar	48%	100%
Q940X7	Arabidopsis thaliana	51%	100%
Q9M2B0	Arabidopsis thaliana	48%	100%
Q9M9L0	Arabidopsis thaliana	31%	100%
Q9NHX0	Drosophila melanogaster	47%	98%
Q9UBF6	Homo sapiens	32%	100%
Q9W5E1	Drosophila melanogaster	48%	100%
Q9WTZ1	Mus musculus	36%	100%
V5BCN0	Trypanosoma cruzi	31%	100%
V5DH15	Trypanosoma cruzi	44%	78%