Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAG9_LEIMA

TriTrypDb:

LmjF.24.1620 , LMJLV39_240023100 , LMJSD75_240022400

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	10
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QAG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAG9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006626	protein targeting to mitochondrion	5	2
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.351
CLV_NRD_NRD_1	51	53	PF00675	0.456
CLV_NRD_NRD_1	80	82	PF00675	0.542
CLV_PCSK_KEX2_1	150	152	PF00082	0.541
CLV_PCSK_KEX2_1	239	241	PF00082	0.560
CLV_PCSK_KEX2_1	272	274	PF00082	0.537
CLV_PCSK_KEX2_1	326	328	PF00082	0.540
CLV_PCSK_KEX2_1	51	53	PF00082	0.451
CLV_PCSK_KEX2_1	79	81	PF00082	0.567
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.541
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.601
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.539
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.540
CLV_PCSK_SKI1_1	201	205	PF00082	0.487
CLV_PCSK_SKI1_1	273	277	PF00082	0.450
CLV_PCSK_SKI1_1	326	330	PF00082	0.509
CLV_PCSK_SKI1_1	51	55	PF00082	0.319
CLV_PCSK_SKI1_1	72	76	PF00082	0.608
DEG_APCC_DBOX_1	13	21	PF00400	0.641
DEG_APCC_DBOX_1	79	87	PF00400	0.347
DEG_Nend_UBRbox_1	1	4	PF02207	0.679
DOC_CYCLIN_RxL_1	270	280	PF00134	0.346
DOC_CYCLIN_RxL_1	323	331	PF00134	0.361
DOC_MAPK_gen_1	236	243	PF00069	0.334
DOC_MAPK_gen_1	79	85	PF00069	0.352
DOC_MAPK_MEF2A_6	92	100	PF00069	0.356
DOC_MAPK_RevD_3	226	239	PF00069	0.389
DOC_PP1_RVXF_1	199	205	PF00149	0.346
DOC_PP1_RVXF_1	338	344	PF00149	0.465
DOC_PP4_FxxP_1	99	102	PF00568	0.290
DOC_USP7_MATH_1	13	17	PF00917	0.672
DOC_USP7_MATH_1	171	175	PF00917	0.334
DOC_USP7_MATH_1	245	249	PF00917	0.420
DOC_USP7_MATH_1	30	34	PF00917	0.726
DOC_USP7_MATH_1	306	310	PF00917	0.356
DOC_USP7_MATH_1	68	72	PF00917	0.410
DOC_USP7_UBL2_3	34	38	PF12436	0.700
DOC_WW_Pin1_4	101	106	PF00397	0.340
DOC_WW_Pin1_4	108	113	PF00397	0.313
DOC_WW_Pin1_4	44	49	PF00397	0.670
LIG_14-3-3_CanoR_1	14	18	PF00244	0.559
LIG_14-3-3_CanoR_1	188	192	PF00244	0.321
LIG_14-3-3_CanoR_1	240	250	PF00244	0.365
LIG_14-3-3_CanoR_1	273	281	PF00244	0.324
LIG_14-3-3_CanoR_1	327	336	PF00244	0.357
LIG_14-3-3_CanoR_1	340	348	PF00244	0.487
LIG_14-3-3_CanoR_1	72	77	PF00244	0.408
LIG_Actin_WH2_2	69	86	PF00022	0.505
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.339
LIG_BRCT_BRCA1_1	70	74	PF00533	0.540
LIG_EH1_1	192	200	PF00400	0.290
LIG_eIF4E_1	193	199	PF01652	0.290
LIG_FHA_2	113	119	PF00498	0.318
LIG_FHA_2	127	133	PF00498	0.275
LIG_FHA_2	280	286	PF00498	0.242
LIG_FHA_2	308	314	PF00498	0.339
LIG_FHA_2	73	79	PF00498	0.355
LIG_LIR_Gen_1	294	302	PF02991	0.283
LIG_LIR_Gen_1	65	74	PF02991	0.418
LIG_LIR_Gen_1	94	105	PF02991	0.372
LIG_LIR_Nem_3	143	149	PF02991	0.339
LIG_LIR_Nem_3	244	249	PF02991	0.387
LIG_LIR_Nem_3	4	9	PF02991	0.561
LIG_LIR_Nem_3	65	70	PF02991	0.409
LIG_LIR_Nem_3	71	77	PF02991	0.379
LIG_LIR_Nem_3	94	100	PF02991	0.376
LIG_MYND_1	108	112	PF01753	0.337
LIG_Pex14_2	6	10	PF04695	0.676
LIG_SH2_CRK	200	204	PF00017	0.339
LIG_SH2_CRK	246	250	PF00017	0.352
LIG_SH2_CRK	289	293	PF00017	0.278
LIG_SH2_CRK	67	71	PF00017	0.432
LIG_SH2_GRB2like	320	323	PF00017	0.334
LIG_SH2_NCK_1	128	132	PF00017	0.327
LIG_SH2_NCK_1	67	71	PF00017	0.207
LIG_SH2_STAP1	284	288	PF00017	0.236
LIG_SH2_STAP1	289	293	PF00017	0.236
LIG_SH2_STAT3	149	152	PF00017	0.346
LIG_SH2_STAT5	128	131	PF00017	0.210
LIG_SH2_STAT5	233	236	PF00017	0.352
LIG_SH2_STAT5	274	277	PF00017	0.320
LIG_SH2_STAT5	320	323	PF00017	0.302
LIG_SH2_STAT5	5	8	PF00017	0.614
LIG_SH3_3	99	105	PF00018	0.333
LIG_TYR_ITIM	126	131	PF00017	0.431
LIG_TYR_ITIM	198	203	PF00017	0.362
LIG_TYR_ITSM	63	70	PF00017	0.367
LIG_UBA3_1	317	326	PF00899	0.433
LIG_WRC_WIRS_1	117	122	PF05994	0.263
LIG_WRC_WIRS_1	292	297	PF05994	0.207
MOD_CDK_SPxxK_3	44	51	PF00069	0.607
MOD_CK1_1	174	180	PF00069	0.360
MOD_CK1_1	248	254	PF00069	0.545
MOD_CK1_1	277	283	PF00069	0.264
MOD_CK1_1	300	306	PF00069	0.246
MOD_CK1_1	342	348	PF00069	0.585
MOD_CK1_1	44	50	PF00069	0.608
MOD_CK2_1	112	118	PF00069	0.402
MOD_CK2_1	126	132	PF00069	0.382
MOD_CK2_1	72	78	PF00069	0.459
MOD_GlcNHglycan	304	307	PF01048	0.439
MOD_GlcNHglycan	313	316	PF01048	0.377
MOD_GlcNHglycan	333	336	PF01048	0.443
MOD_GSK3_1	108	115	PF00069	0.435
MOD_GSK3_1	126	133	PF00069	0.250
MOD_GSK3_1	183	190	PF00069	0.395
MOD_GSK3_1	241	248	PF00069	0.495
MOD_GSK3_1	276	283	PF00069	0.335
MOD_GSK3_1	302	309	PF00069	0.435
MOD_GSK3_1	327	334	PF00069	0.478
MOD_GSK3_1	339	346	PF00069	0.601
MOD_GSK3_1	62	69	PF00069	0.391
MOD_NEK2_1	172	177	PF00069	0.382
MOD_NEK2_1	219	224	PF00069	0.532
MOD_NEK2_1	241	246	PF00069	0.468
MOD_NEK2_1	276	281	PF00069	0.344
MOD_NEK2_1	291	296	PF00069	0.110
MOD_NEK2_1	343	348	PF00069	0.632
MOD_PIKK_1	46	52	PF00454	0.440
MOD_PKA_1	51	57	PF00069	0.207
MOD_PKA_2	13	19	PF00069	0.574
MOD_PKA_2	187	193	PF00069	0.403
MOD_PKA_2	30	36	PF00069	0.673
MOD_PKA_2	322	328	PF00069	0.356
MOD_PKA_2	339	345	PF00069	0.611
MOD_PKA_2	51	57	PF00069	0.287
MOD_PKA_2	91	97	PF00069	0.468
MOD_Plk_1	172	178	PF00069	0.452
MOD_Plk_1	191	197	PF00069	0.234
MOD_Plk_1	277	283	PF00069	0.350
MOD_Plk_4	116	122	PF00069	0.249
MOD_Plk_4	245	251	PF00069	0.518
MOD_ProDKin_1	101	107	PF00069	0.430
MOD_ProDKin_1	108	114	PF00069	0.393
MOD_ProDKin_1	44	50	PF00069	0.608
TRG_DiLeu_BaEn_1	143	148	PF01217	0.440
TRG_DiLeu_BaEn_2	92	98	PF01217	0.497
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.362
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.457
TRG_ENDOCYTIC_2	128	131	PF00928	0.419
TRG_ENDOCYTIC_2	200	203	PF00928	0.408
TRG_ENDOCYTIC_2	246	249	PF00928	0.448
TRG_ENDOCYTIC_2	289	292	PF00928	0.291
TRG_ENDOCYTIC_2	67	70	PF00928	0.363
TRG_ER_diArg_1	151	154	PF00400	0.440
TRG_ER_diArg_1	224	227	PF00400	0.437
TRG_ER_diArg_1	25	28	PF00400	0.563
TRG_ER_diArg_1	51	53	PF00400	0.593
TRG_ER_diArg_1	79	81	PF00400	0.451
TRG_NLS_MonoExtC_3	149	155	PF00514	0.440
TRG_NLS_MonoExtN_4	236	242	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM13	Leptomonas seymouri	62%	80%
A0A0N1PD54	Leptomonas seymouri	30%	100%
A0A0S4JQS8	Bodo saltans	30%	100%
A0A1X0NVQ5	Trypanosomatidae	26%	100%
A0A1X0NVR0	Trypanosomatidae	34%	100%
A0A1X0NVT0	Trypanosomatidae	28%	76%
A0A3S5H7D4	Leishmania donovani	91%	100%
A0A422N8G9	Trypanosoma rangeli	29%	100%
A0A422N8I7	Trypanosoma rangeli	30%	88%
A4HDM2	Leishmania braziliensis	78%	94%
C9ZWE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AH69	Leishmania infantum	91%	100%
E9AX07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	92%
Q95RI5	Drosophila melanogaster	21%	84%
V5BK31	Trypanosoma cruzi	30%	100%
V5DBK9	Trypanosoma cruzi	28%	86%