Basal body-orientation factor 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAG6_LEIMA

TriTrypDb:

LmjF.24.1650 , LMJLV39_240024100 , LMJSD75_240023400

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.521
CLV_C14_Caspase3-7	361	365	PF00656	0.458
CLV_MEL_PAP_1	337	343	PF00089	0.412
CLV_NRD_NRD_1	14	16	PF00675	0.705
CLV_NRD_NRD_1	153	155	PF00675	0.494
CLV_NRD_NRD_1	232	234	PF00675	0.402
CLV_NRD_NRD_1	272	274	PF00675	0.417
CLV_NRD_NRD_1	303	305	PF00675	0.401
CLV_NRD_NRD_1	323	325	PF00675	0.633
CLV_NRD_NRD_1	64	66	PF00675	0.688
CLV_PCSK_FUR_1	270	274	PF00082	0.411
CLV_PCSK_KEX2_1	153	155	PF00082	0.506
CLV_PCSK_KEX2_1	272	274	PF00082	0.417
CLV_PCSK_KEX2_1	303	305	PF00082	0.398
CLV_PCSK_KEX2_1	323	325	PF00082	0.540
CLV_PCSK_PC7_1	299	305	PF00082	0.548
CLV_PCSK_SKI1_1	110	114	PF00082	0.559
CLV_PCSK_SKI1_1	16	20	PF00082	0.748
CLV_PCSK_SKI1_1	233	237	PF00082	0.497
CLV_PCSK_SKI1_1	388	392	PF00082	0.571
CLV_PCSK_SKI1_1	499	503	PF00082	0.429
CLV_Separin_Metazoa	165	169	PF03568	0.445
DEG_APCC_DBOX_1	380	388	PF00400	0.458
DEG_ODPH_VHL_1	35	46	PF01847	0.565
DEG_SCF_TRCP1_1	445	451	PF00400	0.553
DOC_MAPK_gen_1	233	240	PF00069	0.410
DOC_MAPK_gen_1	323	334	PF00069	0.499
DOC_MAPK_gen_1	497	506	PF00069	0.436
DOC_PP1_RVXF_1	500	507	PF00149	0.428
DOC_PP2B_LxvP_1	35	38	PF13499	0.573
DOC_PP4_FxxP_1	463	466	PF00568	0.612
DOC_USP7_MATH_1	38	42	PF00917	0.709
DOC_USP7_MATH_1	396	400	PF00917	0.544
DOC_USP7_MATH_1	473	477	PF00917	0.672
DOC_USP7_MATH_1	69	73	PF00917	0.640
DOC_USP7_UBL2_3	329	333	PF12436	0.415
DOC_USP7_UBL2_3	495	499	PF12436	0.569
DOC_WW_Pin1_4	469	474	PF00397	0.630
DOC_WW_Pin1_4	514	519	PF00397	0.680
DOC_WW_Pin1_4	523	528	PF00397	0.594
LIG_14-3-3_CanoR_1	15	23	PF00244	0.671
LIG_14-3-3_CanoR_1	176	181	PF00244	0.445
LIG_14-3-3_CanoR_1	263	268	PF00244	0.471
LIG_14-3-3_CanoR_1	374	378	PF00244	0.481
LIG_14-3-3_CanoR_1	388	395	PF00244	0.418
LIG_14-3-3_CanoR_1	457	465	PF00244	0.749
LIG_14-3-3_CanoR_1	68	77	PF00244	0.676
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BIR_III_2	530	534	PF00653	0.674
LIG_BRCT_BRCA1_1	484	488	PF00533	0.692
LIG_BRCT_BRCA1_1	502	506	PF00533	0.398
LIG_Clathr_ClatBox_1	237	241	PF01394	0.413
LIG_EH1_1	282	290	PF00400	0.562
LIG_FHA_1	144	150	PF00498	0.500
LIG_FHA_1	179	185	PF00498	0.507
LIG_FHA_1	200	206	PF00498	0.546
LIG_FHA_1	269	275	PF00498	0.448
LIG_FHA_1	280	286	PF00498	0.372
LIG_FHA_1	290	296	PF00498	0.407
LIG_FHA_1	389	395	PF00498	0.583
LIG_FHA_1	5	11	PF00498	0.746
LIG_FHA_2	291	297	PF00498	0.447
LIG_FHA_2	457	463	PF00498	0.733
LIG_FHA_2	69	75	PF00498	0.712
LIG_GBD_Chelix_1	123	131	PF00786	0.451
LIG_LIR_Apic_2	462	466	PF02991	0.602
LIG_LIR_Gen_1	247	256	PF02991	0.543
LIG_LIR_Gen_1	261	268	PF02991	0.490
LIG_LIR_LC3C_4	213	217	PF02991	0.438
LIG_LIR_Nem_3	247	251	PF02991	0.545
LIG_LIR_Nem_3	261	267	PF02991	0.489
LIG_LIR_Nem_3	93	99	PF02991	0.532
LIG_PCNA_TLS_4	398	405	PF02747	0.409
LIG_PCNA_yPIPBox_3	209	221	PF02747	0.441
LIG_PTB_Apo_2	506	513	PF02174	0.557
LIG_PTB_Phospho_1	506	512	PF10480	0.592
LIG_SH2_CRK	177	181	PF00017	0.429
LIG_SH2_NCK_1	177	181	PF00017	0.542
LIG_SH2_STAT3	194	197	PF00017	0.555
LIG_SH2_STAT3	95	98	PF00017	0.517
LIG_SH2_STAT5	177	180	PF00017	0.537
LIG_SH2_STAT5	194	197	PF00017	0.534
LIG_SH2_STAT5	96	99	PF00017	0.558
LIG_SH3_3	467	473	PF00018	0.641
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.554
LIG_SUMO_SIM_par_1	236	241	PF11976	0.413
LIG_TRAF2_1	155	158	PF00917	0.590
LIG_TRAF2_1	259	262	PF00917	0.504
LIG_TRAF2_1	459	462	PF00917	0.713
LIG_UBA3_1	237	242	PF00899	0.433
MOD_CDK_SPK_2	523	528	PF00069	0.586
MOD_CK1_1	179	185	PF00069	0.489
MOD_CK1_1	372	378	PF00069	0.543
MOD_CK1_1	430	436	PF00069	0.658
MOD_CK1_1	456	462	PF00069	0.721
MOD_CK2_1	263	269	PF00069	0.508
MOD_CK2_1	396	402	PF00069	0.453
MOD_CK2_1	456	462	PF00069	0.709
MOD_CK2_1	523	529	PF00069	0.630
MOD_CK2_1	68	74	PF00069	0.702
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	20	23	PF01048	0.629
MOD_GlcNHglycan	32	35	PF01048	0.696
MOD_GlcNHglycan	418	422	PF01048	0.571
MOD_GlcNHglycan	432	435	PF01048	0.618
MOD_GlcNHglycan	445	448	PF01048	0.669
MOD_GlcNHglycan	450	453	PF01048	0.664
MOD_GlcNHglycan	484	487	PF01048	0.631
MOD_GlcNHglycan	57	60	PF01048	0.672
MOD_GlcNHglycan	86	89	PF01048	0.425
MOD_GSK3_1	10	17	PF00069	0.651
MOD_GSK3_1	133	140	PF00069	0.494
MOD_GSK3_1	175	182	PF00069	0.411
MOD_GSK3_1	369	376	PF00069	0.620
MOD_GSK3_1	419	426	PF00069	0.606
MOD_GSK3_1	469	476	PF00069	0.637
MOD_GSK3_1	478	485	PF00069	0.647
MOD_GSK3_1	51	58	PF00069	0.762
MOD_GSK3_1	514	521	PF00069	0.684
MOD_GSK3_1	60	67	PF00069	0.664
MOD_GSK3_1	76	83	PF00069	0.573
MOD_NEK2_1	126	131	PF00069	0.587
MOD_NEK2_1	14	19	PF00069	0.706
MOD_NEK2_1	240	245	PF00069	0.450
MOD_NEK2_1	268	273	PF00069	0.562
MOD_NEK2_1	370	375	PF00069	0.464
MOD_NEK2_1	404	409	PF00069	0.571
MOD_NEK2_1	419	424	PF00069	0.685
MOD_NEK2_1	482	487	PF00069	0.559
MOD_NEK2_1	64	69	PF00069	0.733
MOD_NEK2_1	76	81	PF00069	0.555
MOD_NEK2_2	478	483	PF00069	0.532
MOD_PIKK_1	143	149	PF00454	0.554
MOD_PIKK_1	94	100	PF00454	0.543
MOD_PK_1	176	182	PF00069	0.445
MOD_PK_1	263	269	PF00069	0.520
MOD_PKA_2	14	20	PF00069	0.711
MOD_PKA_2	175	181	PF00069	0.489
MOD_PKA_2	373	379	PF00069	0.492
MOD_PKA_2	456	462	PF00069	0.693
MOD_PKA_2	64	70	PF00069	0.724
MOD_PKB_1	386	394	PF00069	0.589
MOD_Plk_1	199	205	PF00069	0.525
MOD_Plk_1	240	246	PF00069	0.486
MOD_Plk_1	490	496	PF00069	0.421
MOD_Plk_2-3	490	496	PF00069	0.466
MOD_Plk_4	263	269	PF00069	0.514
MOD_Plk_4	500	506	PF00069	0.419
MOD_Plk_4	76	82	PF00069	0.644
MOD_ProDKin_1	469	475	PF00069	0.624
MOD_ProDKin_1	514	520	PF00069	0.682
MOD_ProDKin_1	523	529	PF00069	0.592
MOD_SUMO_rev_2	275	280	PF00179	0.573
MOD_SUMO_rev_2	328	334	PF00179	0.458
MOD_SUMO_rev_2	364	373	PF00179	0.564
TRG_DiLeu_BaEn_1	247	252	PF01217	0.459
TRG_ENDOCYTIC_2	163	166	PF00928	0.431
TRG_ENDOCYTIC_2	177	180	PF00928	0.403
TRG_ER_diArg_1	270	273	PF00400	0.527
TRG_ER_diArg_1	302	304	PF00400	0.405
TRG_NES_CRM1_1	206	220	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	132	137	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM1	Leptomonas seymouri	53%	100%
A0A0S4JCG1	Bodo saltans	27%	86%
A0A1X0NPU9	Trypanosomatidae	36%	88%
A0A3Q8ICZ4	Leishmania donovani	94%	100%
A0A422NJA6	Trypanosoma rangeli	23%	91%
A0A422NQP6	Trypanosoma rangeli	34%	96%
A4HDM5	Leishmania braziliensis	75%	97%
D0A3Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	91%
D0A6S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
E9AH72	Leishmania infantum	94%	100%
E9AX10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BJY8	Trypanosoma cruzi	32%	94%
V5DK07	Trypanosoma cruzi	22%	92%