SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania major

UniProt:

Q4QAG5_LEIMA

TriTrypDb:

LmjF.24.1660 , LMJLV39_240024200 , LMJSD75_240023500

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAG5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.427
CLV_C14_Caspase3-7	250	254	PF00656	0.666
CLV_NRD_NRD_1	14	16	PF00675	0.728
CLV_NRD_NRD_1	145	147	PF00675	0.475
CLV_NRD_NRD_1	161	163	PF00675	0.305
CLV_NRD_NRD_1	205	207	PF00675	0.534
CLV_NRD_NRD_1	30	32	PF00675	0.655
CLV_PCSK_FUR_1	28	32	PF00082	0.721
CLV_PCSK_KEX2_1	14	16	PF00082	0.728
CLV_PCSK_KEX2_1	161	163	PF00082	0.437
CLV_PCSK_KEX2_1	205	207	PF00082	0.547
CLV_PCSK_KEX2_1	30	32	PF00082	0.655
CLV_PCSK_KEX2_1	382	384	PF00082	0.278
CLV_PCSK_KEX2_1	68	70	PF00082	0.731
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.317
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.764
CLV_PCSK_PC7_1	10	16	PF00082	0.747
CLV_PCSK_SKI1_1	206	210	PF00082	0.409
CLV_PCSK_SKI1_1	229	233	PF00082	0.344
DEG_APCC_DBOX_1	5	13	PF00400	0.676
DEG_Nend_Nbox_1	1	3	PF02207	0.734
DEG_SCF_FBW7_2	121	126	PF00400	0.630
DEG_SPOP_SBC_1	58	62	PF00917	0.762
DEG_SPOP_SBC_1	92	96	PF00917	0.561
DOC_CKS1_1	494	499	PF01111	0.600
DOC_CYCLIN_RxL_1	203	212	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.674
DOC_MAPK_RevD_3	193	206	PF00069	0.516
DOC_PP2B_LxvP_1	234	237	PF13499	0.607
DOC_PP2B_LxvP_1	291	294	PF13499	0.487
DOC_PP2B_LxvP_1	367	370	PF13499	0.487
DOC_PP2B_LxvP_1	411	414	PF13499	0.542
DOC_PP2B_LxvP_1	448	451	PF13499	0.518
DOC_PP4_FxxP_1	221	224	PF00568	0.392
DOC_SPAK_OSR1_1	383	387	PF12202	0.580
DOC_USP7_MATH_1	241	245	PF00917	0.773
DOC_USP7_MATH_1	247	251	PF00917	0.701
DOC_USP7_MATH_1	254	258	PF00917	0.575
DOC_USP7_MATH_1	349	353	PF00917	0.538
DOC_USP7_MATH_1	368	372	PF00917	0.367
DOC_USP7_MATH_1	394	398	PF00917	0.590
DOC_USP7_MATH_1	405	409	PF00917	0.559
DOC_USP7_MATH_1	59	63	PF00917	0.721
DOC_USP7_MATH_1	91	95	PF00917	0.799
DOC_USP7_UBL2_3	143	147	PF12436	0.579
DOC_WW_Pin1_4	119	124	PF00397	0.487
DOC_WW_Pin1_4	197	202	PF00397	0.387
DOC_WW_Pin1_4	332	337	PF00397	0.500
DOC_WW_Pin1_4	493	498	PF00397	0.571
DOC_WW_Pin1_4	513	518	PF00397	0.703
DOC_WW_Pin1_4	78	83	PF00397	0.796
LIG_14-3-3_CanoR_1	102	107	PF00244	0.572
LIG_14-3-3_CanoR_1	162	168	PF00244	0.465
LIG_14-3-3_CanoR_1	327	334	PF00244	0.517
LIG_14-3-3_CanoR_1	77	82	PF00244	0.704
LIG_14-3-3_CanoR_1	90	99	PF00244	0.719
LIG_Actin_WH2_2	286	304	PF00022	0.562
LIG_AP2alpha_2	275	277	PF02296	0.620
LIG_DCNL_PONY_1	1	4	PF03556	0.651
LIG_EH1_1	279	287	PF00400	0.517
LIG_eIF4E_1	309	315	PF01652	0.562
LIG_FHA_1	116	122	PF00498	0.518
LIG_FHA_1	134	140	PF00498	0.329
LIG_FHA_1	149	155	PF00498	0.395
LIG_FHA_1	164	170	PF00498	0.442
LIG_FHA_1	192	198	PF00498	0.397
LIG_FHA_1	230	236	PF00498	0.551
LIG_FHA_1	335	341	PF00498	0.506
LIG_FHA_1	394	400	PF00498	0.521
LIG_FHA_1	445	451	PF00498	0.575
LIG_FHA_1	46	52	PF00498	0.791
LIG_FHA_1	478	484	PF00498	0.574
LIG_FHA_2	48	54	PF00498	0.654
LIG_FHA_2	61	67	PF00498	0.704
LIG_Integrin_isoDGR_2	436	438	PF01839	0.321
LIG_LIR_Apic_2	220	224	PF02991	0.388
LIG_LIR_Gen_1	477	485	PF02991	0.454
LIG_LIR_Nem_3	477	482	PF02991	0.431
LIG_LRP6_Inhibitor_1	223	229	PF00058	0.358
LIG_MYND_1	84	88	PF01753	0.726
LIG_PDZ_Class_1	513	518	PF00595	0.786
LIG_Pex14_1	439	443	PF04695	0.517
LIG_SH2_CRK	443	447	PF00017	0.537
LIG_SH2_STAP1	217	221	PF00017	0.420
LIG_SH2_STAP1	309	313	PF00017	0.537
LIG_SH2_STAT5	11	14	PF00017	0.661
LIG_SH2_STAT5	175	178	PF00017	0.395
LIG_SH3_1	10	16	PF00018	0.743
LIG_SH3_3	10	16	PF00018	0.701
LIG_SH3_3	171	177	PF00018	0.382
LIG_SH3_3	235	241	PF00018	0.648
LIG_SH3_3	443	449	PF00018	0.487
LIG_SUMO_SIM_par_1	107	113	PF11976	0.504
LIG_SUMO_SIM_par_1	421	428	PF11976	0.476
LIG_SUMO_SIM_par_1	480	486	PF11976	0.564
LIG_TRAF2_1	123	126	PF00917	0.641
LIG_TRAF2_1	320	323	PF00917	0.562
LIG_TRAF2_1	370	373	PF00917	0.562
LIG_TYR_ITIM	441	446	PF00017	0.537
LIG_WRC_WIRS_1	455	460	PF05994	0.536
LIG_WW_3	414	418	PF00397	0.418
MOD_CDK_SPxxK_3	332	339	PF00069	0.500
MOD_CK1_1	256	262	PF00069	0.703
MOD_CK1_1	329	335	PF00069	0.522
MOD_CK1_1	352	358	PF00069	0.537
MOD_CK1_1	474	480	PF00069	0.558
MOD_CK1_1	60	66	PF00069	0.714
MOD_CK2_1	47	53	PF00069	0.760
MOD_CK2_1	59	65	PF00069	0.753
MOD_GlcNHglycan	157	160	PF01048	0.425
MOD_GlcNHglycan	180	183	PF01048	0.477
MOD_GlcNHglycan	209	212	PF01048	0.419
MOD_GlcNHglycan	262	265	PF01048	0.741
MOD_GlcNHglycan	473	476	PF01048	0.525
MOD_GlcNHglycan	485	488	PF01048	0.455
MOD_GSK3_1	115	122	PF00069	0.459
MOD_GSK3_1	207	214	PF00069	0.538
MOD_GSK3_1	243	250	PF00069	0.785
MOD_GSK3_1	252	259	PF00069	0.627
MOD_GSK3_1	292	299	PF00069	0.537
MOD_GSK3_1	349	356	PF00069	0.527
MOD_GSK3_1	41	48	PF00069	0.806
MOD_GSK3_1	454	461	PF00069	0.500
MOD_LATS_1	100	106	PF00433	0.446
MOD_N-GLC_1	458	463	PF02516	0.300
MOD_NEK2_1	139	144	PF00069	0.441
MOD_NEK2_1	262	267	PF00069	0.684
MOD_NEK2_1	353	358	PF00069	0.529
MOD_NEK2_1	458	463	PF00069	0.504
MOD_PIKK_1	121	127	PF00454	0.594
MOD_PIKK_1	318	324	PF00454	0.562
MOD_PIKK_1	368	374	PF00454	0.500
MOD_PIKK_1	394	400	PF00454	0.560
MOD_PIKK_1	75	81	PF00454	0.730
MOD_PKA_2	139	145	PF00069	0.419
MOD_PKA_2	29	35	PF00069	0.765
MOD_PKA_2	326	332	PF00069	0.476
MOD_PKA_2	471	477	PF00069	0.559
MOD_PKB_1	102	110	PF00069	0.559
MOD_Plk_1	148	154	PF00069	0.538
MOD_Plk_1	229	235	PF00069	0.565
MOD_Plk_1	458	464	PF00069	0.517
MOD_Plk_4	18	24	PF00069	0.557
MOD_Plk_4	191	197	PF00069	0.446
MOD_Plk_4	296	302	PF00069	0.537
MOD_Plk_4	349	355	PF00069	0.562
MOD_Plk_4	462	468	PF00069	0.487
MOD_ProDKin_1	119	125	PF00069	0.482
MOD_ProDKin_1	197	203	PF00069	0.388
MOD_ProDKin_1	332	338	PF00069	0.500
MOD_ProDKin_1	493	499	PF00069	0.579
MOD_ProDKin_1	78	84	PF00069	0.796
MOD_SUMO_rev_2	60	70	PF00179	0.668
TRG_ENDOCYTIC_2	443	446	PF00928	0.518
TRG_ER_diArg_1	13	15	PF00400	0.725
TRG_ER_diArg_1	160	162	PF00400	0.436
TRG_ER_diArg_1	204	206	PF00400	0.468
TRG_ER_diArg_1	28	31	PF00400	0.672
TRG_ER_diArg_1	37	40	PF00400	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U8	Leptomonas seymouri	61%	100%
A0A0S4JI78	Bodo saltans	41%	100%
A0A1X0NVU0	Trypanosomatidae	45%	100%
A0A3Q8IBF1	Leishmania donovani	91%	100%
A0A3R7R8W6	Trypanosoma rangeli	45%	100%
A4HDM6	Leishmania braziliensis	81%	100%
C9ZWD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AH73	Leishmania infantum	91%	100%
E9AX11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BFK4	Trypanosoma cruzi	45%	100%