Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAG4_LEIMA

TriTrypDb:

LmjF.24.1670 , LMJLV39_240024300 , LMJSD75_240023600

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.555
CLV_NRD_NRD_1	151	153	PF00675	0.535
CLV_NRD_NRD_1	174	176	PF00675	0.544
CLV_NRD_NRD_1	198	200	PF00675	0.551
CLV_NRD_NRD_1	201	203	PF00675	0.552
CLV_NRD_NRD_1	206	208	PF00675	0.542
CLV_PCSK_FUR_1	178	182	PF00082	0.594
CLV_PCSK_FUR_1	199	203	PF00082	0.556
CLV_PCSK_KEX2_1	137	139	PF00082	0.478
CLV_PCSK_KEX2_1	180	182	PF00082	0.577
CLV_PCSK_KEX2_1	200	202	PF00082	0.367
CLV_PCSK_KEX2_1	205	207	PF00082	0.540
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.577
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.367
CLV_PCSK_PC7_1	201	207	PF00082	0.594
CLV_PCSK_SKI1_1	129	133	PF00082	0.612
CLV_PCSK_SKI1_1	238	242	PF00082	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DEG_SPOP_SBC_1	33	37	PF00917	0.561
DOC_MAPK_gen_1	180	189	PF00069	0.554
DOC_MAPK_gen_1	9	18	PF00069	0.471
DOC_PP4_FxxP_1	87	90	PF00568	0.420
DOC_USP7_MATH_1	216	220	PF00917	0.624
DOC_USP7_UBL2_3	176	180	PF12436	0.545
DOC_WW_Pin1_4	16	21	PF00397	0.551
LIG_14-3-3_CanoR_1	152	158	PF00244	0.519
LIG_14-3-3_CanoR_1	265	271	PF00244	0.678
LIG_Actin_WH2_2	225	240	PF00022	0.591
LIG_Actin_WH2_2	95	111	PF00022	0.455
LIG_deltaCOP1_diTrp_1	222	228	PF00928	0.563
LIG_deltaCOP1_diTrp_1	79	87	PF00928	0.460
LIG_FHA_1	227	233	PF00498	0.565
LIG_FHA_1	39	45	PF00498	0.629
LIG_LIR_Apic_2	84	90	PF02991	0.430
LIG_LIR_Gen_1	140	147	PF02991	0.527
LIG_LIR_Gen_1	222	233	PF02991	0.546
LIG_LIR_Gen_1	56	67	PF02991	0.406
LIG_LIR_Gen_1	79	90	PF02991	0.409
LIG_LIR_Nem_3	140	146	PF02991	0.523
LIG_LIR_Nem_3	222	228	PF02991	0.543
LIG_LIR_Nem_3	56	62	PF02991	0.416
LIG_LIR_Nem_3	79	85	PF02991	0.427
LIG_Pex14_1	77	81	PF04695	0.381
LIG_SH2_GRB2like	101	104	PF00017	0.416
LIG_SH2_STAT5	171	174	PF00017	0.569
LIG_SH2_STAT5	31	34	PF00017	0.511
LIG_SH2_STAT5	59	62	PF00017	0.494
LIG_TRAF2_1	212	215	PF00917	0.591
LIG_TRAF2_1	40	43	PF00917	0.405
LIG_TRFH_1	87	91	PF08558	0.430
MOD_CK1_1	21	27	PF00069	0.501
MOD_CK1_1	266	272	PF00069	0.664
MOD_CK2_1	216	222	PF00069	0.558
MOD_CMANNOS	77	80	PF00535	0.374
MOD_GlcNHglycan	12	15	PF01048	0.625
MOD_GlcNHglycan	218	221	PF01048	0.563
MOD_GlcNHglycan	55	58	PF01048	0.489
MOD_GSK3_1	113	120	PF00069	0.534
MOD_GSK3_1	12	19	PF00069	0.645
MOD_GSK3_1	216	223	PF00069	0.563
MOD_GSK3_1	251	258	PF00069	0.605
MOD_GSK3_1	34	41	PF00069	0.563
MOD_GSK3_1	85	92	PF00069	0.462
MOD_N-GLC_1	113	118	PF02516	0.541
MOD_N-GLC_1	226	231	PF02516	0.557
MOD_N-GLC_1	53	58	PF02516	0.525
MOD_NEK2_1	10	15	PF00069	0.629
MOD_NEK2_1	158	163	PF00069	0.499
MOD_NEK2_1	53	58	PF00069	0.498
MOD_NEK2_1	85	90	PF00069	0.453
MOD_NEK2_2	263	268	PF00069	0.757
MOD_PK_1	12	18	PF00069	0.464
MOD_PKA_2	151	157	PF00069	0.524
MOD_PKA_2	174	180	PF00069	0.544
MOD_PKA_2	2	8	PF00069	0.696
MOD_PKA_2	242	248	PF00069	0.605
MOD_PKA_2	251	257	PF00069	0.594
MOD_Plk_1	185	191	PF00069	0.545
MOD_Plk_4	158	164	PF00069	0.497
MOD_ProDKin_1	16	22	PF00069	0.542
MOD_SUMO_rev_2	70	75	PF00179	0.526
TRG_ENDOCYTIC_2	59	62	PF00928	0.395
TRG_ENDOCYTIC_2	82	85	PF00928	0.415
TRG_ER_diArg_1	199	202	PF00400	0.554
TRG_ER_diArg_1	205	207	PF00400	0.554
TRG_NLS_MonoExtN_4	199	204	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U3	Leptomonas seymouri	84%	100%
A0A0S4JQ00	Bodo saltans	53%	100%
A0A1X0NW91	Trypanosomatidae	78%	100%
A0A3S7WYJ0	Leishmania donovani	96%	100%
A4HDM7	Leishmania braziliensis	92%	100%
C9ZWD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AH74	Leishmania infantum	96%	100%
E9AX12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BK26	Trypanosoma cruzi	75%	99%