GCV_T domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate-binding protein YgfZ, putative

Species:

Leishmania major

UniProt:

Q4QAF7_LEIMA

TriTrypDb:

LmjF.24.1740 , LMJLV39_240025000 , LMJSD75_240024300

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	2
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10

Expansion

Sequence features

Q4QAF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAF7

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	2
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016226	iron-sulfur cluster assembly	4	2
GO:0022607	cellular component assembly	4	2
GO:0031163	metallo-sulfur cluster assembly	5	2
GO:0044237	cellular metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005542	folic acid binding	3	2
GO:0019842	vitamin binding	3	2
GO:0031406	carboxylic acid binding	4	2
GO:0033218	amide binding	2	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043177	organic acid binding	3	2
GO:0072341	modified amino acid binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0004047	aminomethyltransferase activity	5	1
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.609
CLV_C14_Caspase3-7	200	204	PF00656	0.347
CLV_NRD_NRD_1	14	16	PF00675	0.461
CLV_NRD_NRD_1	186	188	PF00675	0.490
CLV_NRD_NRD_1	261	263	PF00675	0.414
CLV_NRD_NRD_1	356	358	PF00675	0.521
CLV_NRD_NRD_1	96	98	PF00675	0.255
CLV_PCSK_KEX2_1	14	16	PF00082	0.461
CLV_PCSK_KEX2_1	263	265	PF00082	0.371
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.371
CLV_PCSK_PC7_1	10	16	PF00082	0.476
CLV_PCSK_SKI1_1	14	18	PF00082	0.430
CLV_PCSK_SKI1_1	358	362	PF00082	0.472
CLV_PCSK_SKI1_1	82	86	PF00082	0.297
DEG_SPOP_SBC_1	169	173	PF00917	0.599
DOC_ANK_TNKS_1	211	218	PF00023	0.482
DOC_CYCLIN_RxL_1	222	230	PF00134	0.390
DOC_MAPK_DCC_7	331	341	PF00069	0.539
DOC_MAPK_gen_1	262	270	PF00069	0.380
DOC_MAPK_gen_1	95	102	PF00069	0.455
DOC_MAPK_MEF2A_6	262	270	PF00069	0.395
DOC_PP1_RVXF_1	235	242	PF00149	0.378
DOC_PP4_FxxP_1	155	158	PF00568	0.412
DOC_PP4_FxxP_1	164	167	PF00568	0.595
DOC_USP7_MATH_1	122	126	PF00917	0.665
DOC_USP7_MATH_1	134	138	PF00917	0.740
DOC_USP7_MATH_1	170	174	PF00917	0.699
DOC_USP7_MATH_1	41	45	PF00917	0.454
DOC_USP7_UBL2_3	358	362	PF12436	0.473
DOC_USP7_UBL2_3	95	99	PF12436	0.515
DOC_WW_Pin1_4	140	145	PF00397	0.624
DOC_WW_Pin1_4	171	176	PF00397	0.630
DOC_WW_Pin1_4	178	183	PF00397	0.513
DOC_WW_Pin1_4	198	203	PF00397	0.568
DOC_WW_Pin1_4	342	347	PF00397	0.578
LIG_14-3-3_CanoR_1	150	158	PF00244	0.542
LIG_14-3-3_CanoR_1	262	267	PF00244	0.385
LIG_14-3-3_CanoR_1	82	91	PF00244	0.491
LIG_Actin_WH2_2	312	329	PF00022	0.412
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.531
LIG_BRCT_BRCA1_1	180	184	PF00533	0.383
LIG_BRCT_BRCA1_1	225	229	PF00533	0.420
LIG_EVH1_1	164	168	PF00568	0.422
LIG_FHA_1	204	210	PF00498	0.517
LIG_FHA_1	263	269	PF00498	0.386
LIG_FHA_1	290	296	PF00498	0.596
LIG_FHA_1	31	37	PF00498	0.474
LIG_FHA_1	331	337	PF00498	0.577
LIG_FHA_1	51	57	PF00498	0.465
LIG_FHA_1	83	89	PF00498	0.392
LIG_FHA_2	116	122	PF00498	0.559
LIG_FHA_2	144	150	PF00498	0.617
LIG_LIR_Apic_2	152	158	PF02991	0.423
LIG_LIR_Apic_2	161	167	PF02991	0.467
LIG_LIR_Apic_2	194	198	PF02991	0.555
LIG_LIR_Gen_1	203	210	PF02991	0.440
LIG_LIR_LC3C_4	108	111	PF02991	0.516
LIG_LIR_Nem_3	203	208	PF02991	0.409
LIG_LIR_Nem_3	44	49	PF02991	0.451
LIG_SH2_CRK	205	209	PF00017	0.504
LIG_SH2_STAP1	205	209	PF00017	0.417
LIG_SH2_STAT3	246	249	PF00017	0.359
LIG_SH2_STAT5	205	208	PF00017	0.450
LIG_SH2_STAT5	246	249	PF00017	0.374
LIG_SH2_STAT5	328	331	PF00017	0.423
LIG_SH2_STAT5	51	54	PF00017	0.515
LIG_SH3_3	162	168	PF00018	0.599
LIG_SH3_3	176	182	PF00018	0.663
LIG_SH3_3	272	278	PF00018	0.594
LIG_SH3_3	294	300	PF00018	0.527
LIG_SUMO_SIM_anti_2	108	113	PF11976	0.481
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.424
LIG_SUMO_SIM_par_1	292	299	PF11976	0.559
LIG_SUMO_SIM_par_1	74	81	PF11976	0.496
LIG_TRAF2_1	114	117	PF00917	0.552
LIG_TRAF2_1	146	149	PF00917	0.669
LIG_UBA3_1	323	331	PF00899	0.495
LIG_UBA3_1	87	95	PF00899	0.485
MOD_CK1_1	125	131	PF00069	0.725
MOD_CK1_1	137	143	PF00069	0.673
MOD_CK1_1	171	177	PF00069	0.686
MOD_CK1_1	201	207	PF00069	0.465
MOD_CK2_1	143	149	PF00069	0.649
MOD_CK2_1	80	86	PF00069	0.524
MOD_GlcNHglycan	116	121	PF01048	0.552
MOD_GlcNHglycan	127	130	PF01048	0.723
MOD_GlcNHglycan	302	305	PF01048	0.497
MOD_GlcNHglycan	81	85	PF01048	0.335
MOD_GSK3_1	134	141	PF00069	0.717
MOD_GSK3_1	197	204	PF00069	0.584
MOD_GSK3_1	258	265	PF00069	0.412
MOD_GSK3_1	342	349	PF00069	0.516
MOD_LATS_1	80	86	PF00433	0.392
MOD_N-GLC_1	223	228	PF02516	0.524
MOD_NEK2_1	115	120	PF00069	0.504
MOD_NEK2_1	208	213	PF00069	0.403
MOD_NEK2_1	258	263	PF00069	0.443
MOD_NEK2_1	50	55	PF00069	0.454
MOD_NEK2_2	41	46	PF00069	0.515
MOD_PK_1	135	141	PF00069	0.741
MOD_PKA_1	262	268	PF00069	0.379
MOD_PKA_2	125	131	PF00069	0.678
MOD_PKA_2	134	140	PF00069	0.647
MOD_PKA_2	149	155	PF00069	0.569
MOD_PKA_2	19	25	PF00069	0.508
MOD_Plk_1	135	141	PF00069	0.744
MOD_Plk_1	223	229	PF00069	0.494
MOD_Plk_4	204	210	PF00069	0.472
MOD_Plk_4	41	47	PF00069	0.446
MOD_Plk_4	71	77	PF00069	0.470
MOD_ProDKin_1	140	146	PF00069	0.613
MOD_ProDKin_1	171	177	PF00069	0.630
MOD_ProDKin_1	178	184	PF00069	0.494
MOD_ProDKin_1	198	204	PF00069	0.564
MOD_ProDKin_1	342	348	PF00069	0.576
MOD_SUMO_rev_2	353	363	PF00179	0.443
MOD_SUMO_rev_2	89	96	PF00179	0.540
TRG_ENDOCYTIC_2	205	208	PF00928	0.372
TRG_ENDOCYTIC_2	46	49	PF00928	0.515
TRG_ER_diArg_1	14	16	PF00400	0.461
TRG_ER_diArg_1	17	20	PF00400	0.540
TRG_ER_diArg_1	324	327	PF00400	0.386
TRG_NLS_MonoExtN_4	95	101	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM11	Leptomonas seymouri	60%	84%
A0A0S4JL83	Bodo saltans	39%	100%
A0A1X0NVS6	Trypanosomatidae	44%	100%
A0A3Q8IEZ2	Leishmania donovani	86%	94%
A0A3R7K245	Trypanosoma rangeli	50%	100%
A2R472	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	29%	83%
A4HDN4	Leishmania braziliensis	78%	93%
A4R8F9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	95%
B8JMH0	Danio rerio	30%	100%
C9ZWC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AH81	Leishmania infantum	86%	94%
E9AX19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%
P0CM52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	98%
P0CM53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	98%
Q09929	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q0UE25	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	91%
Q1DK38	Coccidioides immitis (strain RS)	27%	87%
Q2H6N9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	84%
Q2U664	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	82%
Q4P7A4	Ustilago maydis (strain 521 / FGSC 9021)	29%	91%
Q54NS1	Dictyostelium discoideum	28%	90%
Q5T440	Homo sapiens	30%	100%
Q6C8Y7	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	77%
Q6FSH5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	74%
Q7RYZ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	84%
Q8CAK1	Mus musculus	32%	100%
Q8L733	Arabidopsis thaliana	26%	94%
V5AJ90	Trypanosoma cruzi	49%	100%