SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QAF6_LEIMA

TriTrypDb:

LmjF.24.1750 , LMJLV39_240025100 , LMJSD75_240024400

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAF6

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.588
CLV_C14_Caspase3-7	366	370	PF00656	0.449
CLV_NRD_NRD_1	123	125	PF00675	0.586
CLV_NRD_NRD_1	289	291	PF00675	0.686
CLV_NRD_NRD_1	379	381	PF00675	0.514
CLV_NRD_NRD_1	705	707	PF00675	0.418
CLV_PCSK_KEX2_1	123	125	PF00082	0.586
CLV_PCSK_KEX2_1	156	158	PF00082	0.495
CLV_PCSK_KEX2_1	289	291	PF00082	0.697
CLV_PCSK_KEX2_1	379	381	PF00082	0.514
CLV_PCSK_KEX2_1	704	706	PF00082	0.394
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.495
CLV_PCSK_SKI1_1	290	294	PF00082	0.605
CLV_PCSK_SKI1_1	452	456	PF00082	0.377
CLV_PCSK_SKI1_1	520	524	PF00082	0.508
CLV_PCSK_SKI1_1	706	710	PF00082	0.493
DEG_APCC_DBOX_1	383	391	PF00400	0.404
DEG_APCC_DBOX_1	428	436	PF00400	0.523
DEG_SPOP_SBC_1	404	408	PF00917	0.582
DOC_CKS1_1	274	279	PF01111	0.579
DOC_CYCLIN_RxL_1	391	402	PF00134	0.516
DOC_MAPK_gen_1	379	387	PF00069	0.428
DOC_MAPK_MEF2A_6	384	392	PF00069	0.371
DOC_PP1_RVXF_1	392	399	PF00149	0.505
DOC_PP1_RVXF_1	413	420	PF00149	0.469
DOC_PP1_RVXF_1	58	64	PF00149	0.480
DOC_PP4_FxxP_1	274	277	PF00568	0.538
DOC_USP7_MATH_1	117	121	PF00917	0.696
DOC_USP7_MATH_1	131	135	PF00917	0.755
DOC_USP7_MATH_1	19	23	PF00917	0.674
DOC_USP7_MATH_1	334	338	PF00917	0.479
DOC_USP7_MATH_1	370	374	PF00917	0.498
DOC_USP7_MATH_1	404	408	PF00917	0.612
DOC_USP7_MATH_1	507	511	PF00917	0.635
DOC_USP7_MATH_1	571	575	PF00917	0.636
DOC_USP7_MATH_1	595	599	PF00917	0.560
DOC_USP7_MATH_2	80	86	PF00917	0.662
DOC_USP7_UBL2_3	94	98	PF12436	0.676
DOC_WW_Pin1_4	118	123	PF00397	0.677
DOC_WW_Pin1_4	127	132	PF00397	0.598
DOC_WW_Pin1_4	198	203	PF00397	0.738
DOC_WW_Pin1_4	207	212	PF00397	0.740
DOC_WW_Pin1_4	252	257	PF00397	0.714
DOC_WW_Pin1_4	273	278	PF00397	0.549
DOC_WW_Pin1_4	4	9	PF00397	0.665
DOC_WW_Pin1_4	405	410	PF00397	0.606
DOC_WW_Pin1_4	497	502	PF00397	0.543
DOC_WW_Pin1_4	503	508	PF00397	0.588
DOC_WW_Pin1_4	554	559	PF00397	0.506
DOC_WW_Pin1_4	625	630	PF00397	0.531
LIG_14-3-3_CanoR_1	191	197	PF00244	0.660
LIG_14-3-3_CanoR_1	257	266	PF00244	0.634
LIG_14-3-3_CanoR_1	290	298	PF00244	0.656
LIG_14-3-3_CanoR_1	456	460	PF00244	0.370
LIG_Actin_WH2_2	440	458	PF00022	0.523
LIG_BIR_III_4	575	579	PF00653	0.698
LIG_BRCT_BRCA1_1	30	34	PF00533	0.633
LIG_BRCT_BRCA1_1	530	534	PF00533	0.452
LIG_BRCT_BRCA1_1	65	69	PF00533	0.372
LIG_Clathr_ClatBox_1	446	450	PF01394	0.446
LIG_CSL_BTD_1	490	493	PF09270	0.464
LIG_FAT_LD_1	182	190	PF03623	0.607
LIG_FHA_1	11	17	PF00498	0.660
LIG_FHA_1	128	134	PF00498	0.742
LIG_FHA_1	211	217	PF00498	0.643
LIG_FHA_1	279	285	PF00498	0.606
LIG_FHA_1	341	347	PF00498	0.359
LIG_FHA_1	473	479	PF00498	0.469
LIG_FHA_1	521	527	PF00498	0.518
LIG_FHA_1	682	688	PF00498	0.494
LIG_FHA_1	694	700	PF00498	0.390
LIG_FHA_1	720	726	PF00498	0.383
LIG_FHA_2	145	151	PF00498	0.635
LIG_FHA_2	243	249	PF00498	0.732
LIG_FHA_2	259	265	PF00498	0.582
LIG_FHA_2	364	370	PF00498	0.443
LIG_FHA_2	510	516	PF00498	0.634
LIG_FHA_2	97	103	PF00498	0.667
LIG_GBD_Chelix_1	388	396	PF00786	0.369
LIG_LIR_Gen_1	212	222	PF02991	0.660
LIG_LIR_Gen_1	458	467	PF02991	0.408
LIG_LIR_Gen_1	472	481	PF02991	0.449
LIG_LIR_Gen_1	684	692	PF02991	0.528
LIG_LIR_Nem_3	106	111	PF02991	0.669
LIG_LIR_Nem_3	212	217	PF02991	0.653
LIG_LIR_Nem_3	458	462	PF02991	0.334
LIG_LIR_Nem_3	463	468	PF02991	0.332
LIG_LIR_Nem_3	472	477	PF02991	0.393
LIG_LIR_Nem_3	603	609	PF02991	0.503
LIG_LIR_Nem_3	680	686	PF02991	0.480
LIG_LIR_Nem_3	690	695	PF02991	0.384
LIG_NRBOX	181	187	PF00104	0.592
LIG_NRBOX	386	392	PF00104	0.473
LIG_PCNA_yPIPBox_3	332	340	PF02747	0.479
LIG_PDZ_Class_2	733	738	PF00595	0.596
LIG_PTB_Apo_2	653	660	PF02174	0.536
LIG_Rb_LxCxE_1	463	485	PF01857	0.442
LIG_SH2_CRK	108	112	PF00017	0.669
LIG_SH2_CRK	474	478	PF00017	0.405
LIG_SH2_NCK_1	643	647	PF00017	0.470
LIG_SH2_PTP2	686	689	PF00017	0.367
LIG_SH2_SRC	439	442	PF00017	0.546
LIG_SH2_STAP1	474	478	PF00017	0.405
LIG_SH2_STAT5	242	245	PF00017	0.752
LIG_SH2_STAT5	259	262	PF00017	0.611
LIG_SH2_STAT5	273	276	PF00017	0.457
LIG_SH2_STAT5	474	477	PF00017	0.497
LIG_SH2_STAT5	539	542	PF00017	0.357
LIG_SH2_STAT5	553	556	PF00017	0.471
LIG_SH2_STAT5	560	563	PF00017	0.545
LIG_SH2_STAT5	686	689	PF00017	0.370
LIG_SH2_STAT5	707	710	PF00017	0.397
LIG_SH3_2	410	415	PF14604	0.482
LIG_SH3_3	295	301	PF00018	0.643
LIG_SH3_3	407	413	PF00018	0.561
LIG_SH3_3	552	558	PF00018	0.480
LIG_SUMO_SIM_anti_2	523	532	PF11976	0.293
LIG_SUMO_SIM_anti_2	597	603	PF11976	0.620
LIG_SUMO_SIM_par_1	445	450	PF11976	0.454
LIG_SUMO_SIM_par_1	721	727	PF11976	0.324
LIG_TRAF2_1	147	150	PF00917	0.630
LIG_TRAF2_2	54	59	PF00917	0.426
LIG_TYR_ITSM	682	689	PF00017	0.545
LIG_UBA3_1	387	394	PF00899	0.477
LIG_UBA3_1	601	607	PF00899	0.559
LIG_WRC_WIRS_1	347	352	PF05994	0.439
MOD_CDC14_SPxK_1	121	124	PF00782	0.572
MOD_CDK_SPK_2	118	123	PF00069	0.677
MOD_CDK_SPK_2	198	203	PF00069	0.685
MOD_CDK_SPK_2	252	257	PF00069	0.681
MOD_CDK_SPxK_1	118	124	PF00069	0.574
MOD_CDK_SPxxK_3	118	125	PF00069	0.681
MOD_CDK_SPxxK_3	497	504	PF00069	0.409
MOD_CK1_1	132	138	PF00069	0.765
MOD_CK1_1	142	148	PF00069	0.809
MOD_CK1_1	29	35	PF00069	0.658
MOD_CK1_1	373	379	PF00069	0.457
MOD_CK1_1	427	433	PF00069	0.451
MOD_CK1_1	482	488	PF00069	0.535
MOD_CK1_1	510	516	PF00069	0.588
MOD_CK1_1	72	78	PF00069	0.597
MOD_CK2_1	144	150	PF00069	0.735
MOD_CK2_1	190	196	PF00069	0.758
MOD_CK2_1	209	215	PF00069	0.611
MOD_CK2_1	242	248	PF00069	0.648
MOD_CK2_1	280	286	PF00069	0.599
MOD_CK2_1	427	433	PF00069	0.521
MOD_CK2_1	435	441	PF00069	0.459
MOD_CK2_1	497	503	PF00069	0.489
MOD_CK2_1	509	515	PF00069	0.582
MOD_CK2_1	96	102	PF00069	0.669
MOD_CMANNOS	563	566	PF00535	0.581
MOD_Cter_Amidation	287	290	PF01082	0.693
MOD_GlcNHglycan	17	20	PF01048	0.526
MOD_GlcNHglycan	316	319	PF01048	0.578
MOD_GlcNHglycan	329	332	PF01048	0.405
MOD_GlcNHglycan	4	7	PF01048	0.638
MOD_GlcNHglycan	401	404	PF01048	0.546
MOD_GlcNHglycan	484	487	PF01048	0.651
MOD_GlcNHglycan	509	512	PF01048	0.601
MOD_GlcNHglycan	91	94	PF01048	0.792
MOD_GSK3_1	127	134	PF00069	0.698
MOD_GSK3_1	15	22	PF00069	0.770
MOD_GSK3_1	26	33	PF00069	0.658
MOD_GSK3_1	323	330	PF00069	0.669
MOD_GSK3_1	369	376	PF00069	0.511
MOD_GSK3_1	399	406	PF00069	0.488
MOD_GSK3_1	420	427	PF00069	0.341
MOD_GSK3_1	480	487	PF00069	0.564
MOD_GSK3_1	503	510	PF00069	0.601
MOD_GSK3_1	554	561	PF00069	0.493
MOD_LATS_1	732	738	PF00433	0.558
MOD_N-GLC_1	649	654	PF02516	0.274
MOD_N-GLC_2	77	79	PF02516	0.641
MOD_NEK2_1	2	7	PF00069	0.679
MOD_NEK2_1	291	296	PF00069	0.685
MOD_NEK2_1	323	328	PF00069	0.669
MOD_NEK2_1	396	401	PF00069	0.460
MOD_NEK2_1	420	425	PF00069	0.466
MOD_NEK2_1	435	440	PF00069	0.579
MOD_NEK2_1	455	460	PF00069	0.238
MOD_NEK2_1	608	613	PF00069	0.677
MOD_NEK2_1	635	640	PF00069	0.581
MOD_NEK2_1	649	654	PF00069	0.508
MOD_NEK2_1	682	687	PF00069	0.573
MOD_NEK2_1	69	74	PF00069	0.484
MOD_NEK2_2	370	375	PF00069	0.509
MOD_PIKK_1	80	86	PF00454	0.632
MOD_PKA_2	142	148	PF00069	0.765
MOD_PKA_2	190	196	PF00069	0.720
MOD_PKA_2	455	461	PF00069	0.338
MOD_Plk_1	177	183	PF00069	0.477
MOD_Plk_1	420	426	PF00069	0.422
MOD_Plk_1	472	478	PF00069	0.405
MOD_Plk_1	63	69	PF00069	0.363
MOD_Plk_1	649	655	PF00069	0.463
MOD_Plk_2-3	190	196	PF00069	0.655
MOD_Plk_2-3	280	286	PF00069	0.599
MOD_Plk_4	280	286	PF00069	0.596
MOD_Plk_4	334	340	PF00069	0.454
MOD_Plk_4	460	466	PF00069	0.436
MOD_Plk_4	487	493	PF00069	0.677
MOD_Plk_4	558	564	PF00069	0.486
MOD_Plk_4	595	601	PF00069	0.628
MOD_Plk_4	64	70	PF00069	0.546
MOD_Plk_4	666	672	PF00069	0.548
MOD_Plk_4	682	688	PF00069	0.470
MOD_ProDKin_1	118	124	PF00069	0.679
MOD_ProDKin_1	127	133	PF00069	0.600
MOD_ProDKin_1	198	204	PF00069	0.737
MOD_ProDKin_1	207	213	PF00069	0.740
MOD_ProDKin_1	252	258	PF00069	0.712
MOD_ProDKin_1	273	279	PF00069	0.548
MOD_ProDKin_1	4	10	PF00069	0.666
MOD_ProDKin_1	405	411	PF00069	0.597
MOD_ProDKin_1	497	503	PF00069	0.547
MOD_ProDKin_1	505	511	PF00069	0.622
MOD_ProDKin_1	554	560	PF00069	0.509
MOD_ProDKin_1	625	631	PF00069	0.531
MOD_SUMO_rev_2	575	585	PF00179	0.611
TRG_DiLeu_BaEn_1	280	285	PF01217	0.547
TRG_DiLeu_BaEn_1	383	388	PF01217	0.401
TRG_DiLeu_BaEn_1	450	455	PF01217	0.502
TRG_DiLeu_BaEn_3	286	292	PF01217	0.711
TRG_DiLeu_BaEn_4	177	183	PF01217	0.535
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.580
TRG_ENDOCYTIC_2	108	111	PF00928	0.671
TRG_ENDOCYTIC_2	474	477	PF00928	0.510
TRG_ENDOCYTIC_2	539	542	PF00928	0.450
TRG_ENDOCYTIC_2	606	609	PF00928	0.537
TRG_ENDOCYTIC_2	686	689	PF00928	0.392
TRG_ER_diArg_1	122	124	PF00400	0.574
TRG_ER_diArg_1	289	291	PF00400	0.686
TRG_ER_diArg_1	428	431	PF00400	0.499
TRG_ER_diArg_1	703	706	PF00400	0.480
TRG_NES_CRM1_1	715	727	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I099	Leptomonas seymouri	41%	100%
A0A3R7RB97	Trypanosoma rangeli	29%	100%
A0A3S7WYH5	Leishmania donovani	90%	100%
A4HDN5	Leishmania braziliensis	72%	100%
C9ZWC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AH82	Leishmania infantum	90%	100%
E9AX20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
V5CZP8	Trypanosoma cruzi	30%	100%