Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAF5_LEIMA

TriTrypDb:

LmjF.24.1760 , LMJLV39_240025200 , LMJSD75_240024500

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QAF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.600
CLV_C14_Caspase3-7	169	173	PF00656	0.574
CLV_NRD_NRD_1	100	102	PF00675	0.528
CLV_NRD_NRD_1	236	238	PF00675	0.594
CLV_NRD_NRD_1	28	30	PF00675	0.523
CLV_PCSK_KEX2_1	100	102	PF00082	0.549
CLV_PCSK_KEX2_1	139	141	PF00082	0.451
CLV_PCSK_KEX2_1	236	238	PF00082	0.594
CLV_PCSK_KEX2_1	27	29	PF00082	0.520
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.451
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.520
CLV_PCSK_PC7_1	232	238	PF00082	0.538
CLV_PCSK_SKI1_1	106	110	PF00082	0.410
CLV_PCSK_SKI1_1	211	215	PF00082	0.496
CLV_PCSK_SKI1_1	228	232	PF00082	0.658
DEG_SPOP_SBC_1	129	133	PF00917	0.420
DEG_SPOP_SBC_1	81	85	PF00917	0.597
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.465
DOC_MAPK_MEF2A_6	253	261	PF00069	0.476
DOC_USP7_MATH_1	147	151	PF00917	0.665
DOC_USP7_MATH_1	160	164	PF00917	0.585
DOC_USP7_MATH_1	207	211	PF00917	0.412
DOC_USP7_MATH_1	226	230	PF00917	0.464
DOC_USP7_MATH_1	74	78	PF00917	0.734
DOC_USP7_MATH_1	86	90	PF00917	0.663
DOC_WW_Pin1_4	40	45	PF00397	0.417
DOC_WW_Pin1_4	62	67	PF00397	0.592
DOC_WW_Pin1_4	75	80	PF00397	0.620
DOC_WW_Pin1_4	84	89	PF00397	0.572
LIG_Clathr_ClatBox_1	51	55	PF01394	0.504
LIG_deltaCOP1_diTrp_1	196	206	PF00928	0.501
LIG_FHA_1	129	135	PF00498	0.547
LIG_FHA_1	188	194	PF00498	0.425
LIG_FHA_1	260	266	PF00498	0.501
LIG_FHA_1	97	103	PF00498	0.665
LIG_FHA_2	162	168	PF00498	0.576
LIG_FHA_2	229	235	PF00498	0.542
LIG_LIR_Gen_1	190	198	PF02991	0.407
LIG_LIR_Nem_3	190	194	PF02991	0.498
LIG_MYND_1	88	92	PF01753	0.633
LIG_SH3_3	121	127	PF00018	0.428
LIG_SH3_3	85	91	PF00018	0.697
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.378
MOD_CK1_1	65	71	PF00069	0.719
MOD_CK1_1	77	83	PF00069	0.623
MOD_GlcNHglycan	140	143	PF01048	0.556
MOD_GlcNHglycan	158	161	PF01048	0.606
MOD_GlcNHglycan	183	186	PF01048	0.446
MOD_GlcNHglycan	265	268	PF01048	0.513
MOD_GlcNHglycan	55	59	PF01048	0.561
MOD_GlcNHglycan	84	87	PF01048	0.607
MOD_GSK3_1	156	163	PF00069	0.627
MOD_GSK3_1	259	266	PF00069	0.494
MOD_GSK3_1	75	82	PF00069	0.733
MOD_GSK3_1	96	103	PF00069	0.563
MOD_N-GLC_2	176	178	PF02516	0.331
MOD_N-GLC_2	9	11	PF02516	0.322
MOD_NEK2_1	112	117	PF00069	0.515
MOD_NEK2_1	171	176	PF00069	0.561
MOD_NEK2_1	181	186	PF00069	0.396
MOD_NEK2_1	60	65	PF00069	0.564
MOD_PIKK_1	241	247	PF00454	0.590
MOD_PKA_1	100	106	PF00069	0.440
MOD_PKA_2	100	106	PF00069	0.551
MOD_Plk_1	171	177	PF00069	0.539
MOD_Plk_4	130	136	PF00069	0.392
MOD_Plk_4	218	224	PF00069	0.437
MOD_Plk_4	260	266	PF00069	0.539
MOD_ProDKin_1	40	46	PF00069	0.418
MOD_ProDKin_1	62	68	PF00069	0.594
MOD_ProDKin_1	75	81	PF00069	0.616
MOD_ProDKin_1	84	90	PF00069	0.567
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.651
TRG_ER_diArg_1	100	102	PF00400	0.552
TRG_ER_diArg_1	235	237	PF00400	0.615
TRG_NLS_MonoExtC_3	26	32	PF00514	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV6	Leptomonas seymouri	49%	96%
A0A3S7WYI4	Leishmania donovani	93%	100%
A4HDN6	Leishmania braziliensis	78%	99%
A4HDN7	Leishmania braziliensis	75%	99%
E9AH83	Leishmania infantum	94%	100%
E9AX21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%