RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4QAF2_LEIMA

TriTrypDb:

LmjF.24.1790 , LMJLV39_240025500 , LMJSD75_240024800

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAF2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	127	131	PF00082	0.352
DEG_Nend_UBRbox_2	1	3	PF02207	0.578
DEG_ODPH_VHL_1	29	41	PF01847	0.517
DOC_CKS1_1	81	86	PF01111	0.658
DOC_MAPK_MEF2A_6	200	208	PF00069	0.516
DOC_USP7_MATH_1	108	112	PF00917	0.595
DOC_USP7_MATH_1	99	103	PF00917	0.644
DOC_WW_Pin1_4	111	116	PF00397	0.644
DOC_WW_Pin1_4	138	143	PF00397	0.481
DOC_WW_Pin1_4	208	213	PF00397	0.514
DOC_WW_Pin1_4	75	80	PF00397	0.660
LIG_BRCT_BRCA1_1	210	214	PF00533	0.555
LIG_BRCT_BRCA1_1	69	73	PF00533	0.664
LIG_CtBP_PxDLS_1	146	150	PF00389	0.469
LIG_EH_1	70	74	PF12763	0.668
LIG_FHA_1	112	118	PF00498	0.655
LIG_FHA_1	174	180	PF00498	0.484
LIG_FHA_1	201	207	PF00498	0.469
LIG_FHA_1	208	214	PF00498	0.457
LIG_FHA_1	42	48	PF00498	0.568
LIG_FHA_2	142	148	PF00498	0.469
LIG_LIR_Gen_1	176	186	PF02991	0.502
LIG_LIR_Nem_3	176	181	PF02991	0.502
LIG_PAM2_1	71	83	PF00658	0.659
LIG_RPA_C_Fungi	6	18	PF08784	0.574
LIG_SH2_STAT3	89	92	PF00017	0.661
LIG_SH2_STAT5	178	181	PF00017	0.304
LIG_SH2_STAT5	184	187	PF00017	0.304
LIG_SH3_3	28	34	PF00018	0.509
LIG_SH3_3	43	49	PF00018	0.615
LIG_SH3_3	59	65	PF00018	0.559
LIG_SH3_3	66	72	PF00018	0.606
LIG_SH3_3	76	82	PF00018	0.498
LIG_TRAF2_1	145	148	PF00917	0.304
LIG_WRC_WIRS_1	117	122	PF05994	0.565
MOD_CK1_1	111	117	PF00069	0.615
MOD_CK1_1	121	127	PF00069	0.454
MOD_CK1_1	3	9	PF00069	0.582
MOD_CK2_1	141	147	PF00069	0.304
MOD_GlcNHglycan	101	104	PF01048	0.577
MOD_GlcNHglycan	110	113	PF01048	0.545
MOD_GlcNHglycan	4	8	PF01048	0.578
MOD_GSK3_1	121	128	PF00069	0.489
MOD_GSK3_1	138	145	PF00069	0.453
MOD_GSK3_1	208	215	PF00069	0.470
MOD_N-GLC_1	160	165	PF02516	0.304
MOD_N-GLC_1	75	80	PF02516	0.660
MOD_NEK2_1	160	165	PF00069	0.304
MOD_NEK2_1	199	204	PF00069	0.304
MOD_NEK2_1	41	46	PF00069	0.665
MOD_NEK2_1	57	62	PF00069	0.516
MOD_PIKK_1	57	63	PF00454	0.611
MOD_PIKK_1	87	93	PF00454	0.646
MOD_PKA_2	135	141	PF00069	0.325
MOD_PKA_2	167	173	PF00069	0.304
MOD_Plk_1	160	166	PF00069	0.304
MOD_Plk_1	182	188	PF00069	0.394
MOD_Plk_4	160	166	PF00069	0.299
MOD_Plk_4	200	206	PF00069	0.304
MOD_Plk_4	34	40	PF00069	0.583
MOD_ProDKin_1	111	117	PF00069	0.644
MOD_ProDKin_1	138	144	PF00069	0.320
MOD_ProDKin_1	208	214	PF00069	0.522
MOD_ProDKin_1	75	81	PF00069	0.659
MOD_SUMO_rev_2	167	176	PF00179	0.304
TRG_ENDOCYTIC_2	178	181	PF00928	0.304
TRG_ENDOCYTIC_2	184	187	PF00928	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMV3	Leishmania donovani	91%	91%
A0A3R7NAM0	Trypanosoma rangeli	49%	100%
A4HDP0	Leishmania braziliensis	85%	92%
E9AH86	Leishmania infantum	91%	90%
E9AX24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	83%