Putative short chain dehydrogenase/reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-ketoacyl-ACP reductase 2, putative

Species:

Leishmania major

UniProt:

Q4QAF0_LEIMA

TriTrypDb:

LmjF.24.1810 , LMJLV39_240025700 , LMJSD75_240025000

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 28
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	18
GO:0016020	membrane	2	15

Expansion

Sequence features

Q4QAF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAF0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030497	fatty acid elongation	6	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004312	fatty acid synthase activity	5	4
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	4
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0016740	transferase activity	2	4
GO:0016746	acyltransferase activity	3	4
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	183	189	PF00089	0.287
CLV_NRD_NRD_1	301	303	PF00675	0.599
CLV_NRD_NRD_1	308	310	PF00675	0.552
CLV_NRD_NRD_1	75	77	PF00675	0.409
CLV_PCSK_KEX2_1	159	161	PF00082	0.274
CLV_PCSK_KEX2_1	308	310	PF00082	0.560
CLV_PCSK_KEX2_1	75	77	PF00082	0.409
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.291
CLV_PCSK_PC7_1	155	161	PF00082	0.285
CLV_PCSK_SKI1_1	181	185	PF00082	0.210
CLV_PCSK_SKI1_1	81	85	PF00082	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DOC_CKS1_1	296	301	PF01111	0.788
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.181
DOC_MAPK_HePTP_8	183	195	PF00069	0.410
DOC_MAPK_MEF2A_6	186	195	PF00069	0.555
DOC_PP2B_LxvP_1	50	53	PF13499	0.181
DOC_PP4_FxxP_1	197	200	PF00568	0.484
DOC_USP7_MATH_1	133	137	PF00917	0.528
DOC_USP7_MATH_1	161	165	PF00917	0.517
DOC_USP7_MATH_1	273	277	PF00917	0.514
DOC_USP7_MATH_1	280	284	PF00917	0.633
DOC_USP7_MATH_1	319	323	PF00917	0.766
DOC_USP7_UBL2_3	434	438	PF12436	0.383
DOC_WW_Pin1_4	116	121	PF00397	0.588
DOC_WW_Pin1_4	242	247	PF00397	0.549
DOC_WW_Pin1_4	295	300	PF00397	0.793
DOC_WW_Pin1_4	345	350	PF00397	0.542
DOC_WW_Pin1_4	357	362	PF00397	0.562
LIG_14-3-3_CanoR_1	18	22	PF00244	0.572
LIG_14-3-3_CanoR_1	341	349	PF00244	0.509
LIG_BRCT_BRCA1_1	358	362	PF00533	0.616
LIG_CSL_BTD_1	243	246	PF09270	0.589
LIG_eIF4E_1	370	376	PF01652	0.306
LIG_FHA_1	18	24	PF00498	0.573
LIG_FHA_1	202	208	PF00498	0.455
LIG_FHA_1	331	337	PF00498	0.714
LIG_FHA_1	78	84	PF00498	0.666
LIG_FHA_1	92	98	PF00498	0.479
LIG_FHA_2	296	302	PF00498	0.737
LIG_FHA_2	377	383	PF00498	0.321
LIG_GBD_Chelix_1	42	50	PF00786	0.300
LIG_HCF-1_HBM_1	11	14	PF13415	0.599
LIG_LIR_Apic_2	276	280	PF02991	0.665
LIG_LIR_Gen_1	149	157	PF02991	0.467
LIG_LIR_Gen_1	20	29	PF02991	0.567
LIG_LIR_Gen_1	363	374	PF02991	0.384
LIG_LIR_Nem_3	149	154	PF02991	0.434
LIG_LIR_Nem_3	363	369	PF02991	0.357
LIG_Pex14_2	362	366	PF04695	0.446
LIG_PTB_Apo_2	395	402	PF02174	0.318
LIG_PTB_Phospho_1	395	401	PF10480	0.320
LIG_RPA_C_Fungi	64	76	PF08784	0.474
LIG_SH2_GRB2like	402	405	PF00017	0.359
LIG_SH2_PTP2	373	376	PF00017	0.481
LIG_SH2_SRC	371	374	PF00017	0.443
LIG_SH2_SRC	407	410	PF00017	0.481
LIG_SH2_STAP1	312	316	PF00017	0.684
LIG_SH2_STAT5	128	131	PF00017	0.314
LIG_SH2_STAT5	157	160	PF00017	0.394
LIG_SH2_STAT5	182	185	PF00017	0.235
LIG_SH2_STAT5	201	204	PF00017	0.394
LIG_SH2_STAT5	220	223	PF00017	0.316
LIG_SH2_STAT5	237	240	PF00017	0.318
LIG_SH2_STAT5	368	371	PF00017	0.321
LIG_SH2_STAT5	373	376	PF00017	0.296
LIG_SH2_STAT5	41	44	PF00017	0.388
LIG_SH3_3	240	246	PF00018	0.522
LIG_SUMO_SIM_anti_2	111	116	PF11976	0.396
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.360
LIG_TYR_ITIM	369	374	PF00017	0.378
MOD_CDK_SPK_2	242	247	PF00069	0.468
MOD_CDK_SPxxK_3	295	302	PF00069	0.553
MOD_CK1_1	164	170	PF00069	0.485
MOD_CK1_1	283	289	PF00069	0.585
MOD_CK1_1	307	313	PF00069	0.655
MOD_CK1_1	322	328	PF00069	0.712
MOD_CK2_1	295	301	PF00069	0.689
MOD_CK2_1	3	9	PF00069	0.639
MOD_CK2_1	376	382	PF00069	0.378
MOD_Cter_Amidation	73	76	PF01082	0.524
MOD_GlcNHglycan	238	241	PF01048	0.470
MOD_GlcNHglycan	26	29	PF01048	0.561
MOD_GlcNHglycan	309	312	PF01048	0.680
MOD_GlcNHglycan	324	327	PF01048	0.638
MOD_GlcNHglycan	362	365	PF01048	0.410
MOD_GlcNHglycan	94	97	PF01048	0.331
MOD_GSK3_1	280	287	PF00069	0.667
MOD_GSK3_1	356	363	PF00069	0.439
MOD_GSK3_1	41	48	PF00069	0.462
MOD_GSK3_1	77	84	PF00069	0.538
MOD_GSK3_1	88	95	PF00069	0.291
MOD_N-GLC_1	164	169	PF02516	0.494
MOD_N-GLC_2	389	391	PF02516	0.346
MOD_N-GLC_2	404	406	PF02516	0.458
MOD_N-GLC_2	77	79	PF02516	0.354
MOD_NEK2_1	24	29	PF00069	0.495
MOD_NEK2_1	356	361	PF00069	0.437
MOD_NEK2_1	362	367	PF00069	0.313
MOD_NEK2_1	412	417	PF00069	0.531
MOD_NEK2_1	65	70	PF00069	0.437
MOD_NEK2_2	402	407	PF00069	0.234
MOD_PIKK_1	319	325	PF00454	0.709
MOD_PIKK_1	381	387	PF00454	0.333
MOD_PKA_2	161	167	PF00069	0.396
MOD_PKA_2	17	23	PF00069	0.493
MOD_PKA_2	24	30	PF00069	0.439
MOD_PKA_2	287	293	PF00069	0.703
MOD_PKA_2	307	313	PF00069	0.692
MOD_PKA_2	340	346	PF00069	0.401
MOD_PKA_2	77	83	PF00069	0.471
MOD_Plk_1	110	116	PF00069	0.345
MOD_Plk_1	164	170	PF00069	0.448
MOD_Plk_4	233	239	PF00069	0.417
MOD_Plk_4	3	9	PF00069	0.625
MOD_Plk_4	362	368	PF00069	0.387
MOD_Plk_4	383	389	PF00069	0.328
MOD_Plk_4	46	52	PF00069	0.398
MOD_ProDKin_1	116	122	PF00069	0.484
MOD_ProDKin_1	242	248	PF00069	0.428
MOD_ProDKin_1	295	301	PF00069	0.774
MOD_ProDKin_1	345	351	PF00069	0.427
MOD_ProDKin_1	357	363	PF00069	0.444
MOD_SUMO_for_1	437	440	PF00179	0.511
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.279
TRG_ENDOCYTIC_2	371	374	PF00928	0.356
TRG_ER_diArg_1	75	78	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S7	Leptomonas seymouri	33%	86%
A0A0N1HZ81	Leptomonas seymouri	70%	79%
A0A0S4IWT0	Bodo saltans	33%	94%
A0A0S4IZG2	Bodo saltans	35%	97%
A0A0S4J1I6	Bodo saltans	42%	100%
A0A1X0NVT8	Trypanosomatidae	37%	88%
A0A1X0NVV6	Trypanosomatidae	50%	86%
A0A3Q8ID46	Leishmania donovani	34%	87%
A0A3R7K071	Trypanosoma rangeli	52%	91%
A0A3S5H7D5	Leishmania donovani	93%	100%
A0A3S7X986	Leishmania donovani	24%	91%
A0A422N2B6	Trypanosoma rangeli	34%	92%
A4HDP2	Leishmania braziliensis	85%	90%
A4HDP3	Leishmania braziliensis	34%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF41	Leishmania major	23%	100%
E9AH88	Leishmania infantum	93%	88%
E9AH89	Leishmania infantum	34%	87%
E9AHV8	Leishmania infantum	24%	91%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
Q4QAE9	Leishmania major	34%	100%
V5BAF4	Trypanosoma cruzi	36%	92%
V5BJC7	Trypanosoma cruzi	28%	100%
V5BNY6	Trypanosoma cruzi	29%	100%